{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P05023","secondaryAccessions":["B2RBR6","B7Z2T5","B7Z3U6","F5H3A1","Q16689","Q6LDM4","Q9UCN1","Q9UJ20","Q9UJ21"],"uniProtkbId":"AT1A1_HUMAN","entryAudit":{"firstPublicDate":"1987-08-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1987-08-13","entryVersion":266,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Sodium/potassium-transporting ATPase subunit alpha-1"},"shortNames":[{"value":"Na(+)/K(+) ATPase alpha-1 subunit"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35803952"}],"value":"7.2.2.13"}]},"alternativeNames":[{"fullName":{"value":"Sodium pump subunit alpha-1"}}]},"genes":[{"geneName":{"value":"ATP1A1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8VDN2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29499166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30388404"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35803952"}],"value":"Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients (PubMed:29499166, PubMed:30388404, PubMed:35803952). It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (PubMed:35803952). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 K(+)(out) + 3 Na(+)(in) + ATP + H2O = 2 K(+)(in) + 3 Na(+)(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18353"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29101"},{"database":"ChEBI","id":"CHEBI:29103"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"7.2.2.13","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35803952"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35803952"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P06685"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q08DA1"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8VDN2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1380674"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21454534"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22084111"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35803952"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18621045"}],"value":"The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit, called FXYD. 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