{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P42127","secondaryAccessions":["Q3SXL2"],"uniProtkbId":"ASIP_HUMAN","entryAudit":{"firstPublicDate":"1995-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1995-11-01","entryVersion":195,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15701517"}],"value":"Agouti-signaling protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7757071"}],"value":"ASP"}]},"alternativeNames":[{"fullName":{"value":"Agouti switch protein"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:745"}],"value":"ASIP"},"synonyms":[{"value":"AGTI"},{"value":"AGTIL"},{"value":"ASP"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q03288"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11833005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36536132"}],"value":"Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptor MC1R, thereby playing a role in the regulation of melanogenesis (PubMed:36536132). Binding to MC1R prevents alpha-MSH-induced signaling and inhibits cAMP production, resulting in down-regulation of eumelanogenesis (brown/black pigment) and increased pheomelanin (yellow/red pigment) synthesis (By similarity). In higher primates, Agouti may affect the quality of hair pigmentation rather than the pattern of pigment deposition (PubMed:11833005). May also play a role in neuroendocrine aspects of melanocortin action"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36536132"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36536132"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7757071"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7937887"}],"value":"Widely expressed at low levels. Highly expressed in the skin. Expressed in adipose tissue"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11833005"}],"value":"Genetic variants in ASIP define the skin/hair/eye pigmentation variation locus 9 (SHEP9) [MIM:611742]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair"}],"commentType":"POLYMORPHISM"},{"commentType":"DISEASE","disease":{"diseaseId":"Obesity and hypopigmentation","diseaseAccession":"DI-06589","acronym":"OBHP","description":"An autosomal dominant disorder characterized by early-onset obesity, overgrowth, hyperinsulinemia, and hypopigmentation of the skin. Some affected individuals experience hyperphagia and exhibit reduced energy expenditure.","diseaseCrossReference":{"database":"MIM","id":"620195"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36536132"}]},"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36536132"}],"value":"The gene represented in this entry is involved in disease pathogenesis. A tandem duplication on chromosome 20 encompassing the neighboring genes ASIP and ITCH creates an ITCH-ASIP transcript consisting of the first two non-coding ITCH exons fused to the ASIP coding exons. This results in ASIP ectopic overexpression controlled by the ubiquitously active ITCH promoter. Ectopically expressed ASIP may antagonize MC4R signaling in the hypothalamus and may affect processes related to eating behavior and energy expenditure"}]}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"Agouti-signaling protein","featureId":"PRO_0000001028"},{"type":"Domain","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"Agouti","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00494"}]},{"type":"Region","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Glycosylation","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00494"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15701517"}]},{"type":"Disulfide bond","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00494"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15701517"}]},{"type":"Disulfide bond","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00494"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15701517"}]},{"type":"Disulfide bond","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00494"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15701517"}]},{"type":"Disulfide bond","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00494"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15701517"}]},{"type":"Natural variant","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"in dbSNP:rs2296151","featureCrossReferences":[{"database":"dbSNP","id":"rs2296151"}],"featureId":"VAR_022125","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"in dbSNP:rs1129414","featureCrossReferences":[{"database":"dbSNP","id":"rs1129414"}],"featureId":"VAR_005003","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Beta strand","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2KZA"}]},{"type":"Beta strand","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1Y7J"}]},{"type":"Beta strand","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1Y7J"}]},{"type":"Beta strand","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1Y7J"}]},{"type":"Beta strand","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1Y7J"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0160","category":"Coding sequence diversity","name":"Chromosomal rearrangement"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0960","category":"Domain","name":"Knottin"},{"id":"KW-0550","category":"Disease","name":"Obesity"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"7937887","citationType":"journal article","authors":["Kwon H.-Y.","Bultman S.J.","Loeffler C.","Chen W.-J.","Furdon P.J.","Powell J.G.","Usala A.-L.","Wilkison W.","Hansmann I.","Woychik R.P."],"citationCrossReferences":[{"database":"PubMed","id":"7937887"},{"database":"DOI","id":"10.1073/pnas.91.21.9760"}],"title":"Molecular structure and chromosomal mapping of the human homolog of the agouti gene.","publicationDate":"1994","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9760","lastPage":"9764","volume":"91"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","TISSUE SPECIFICITY"]},{"referenceNumber":2,"citation":{"id":"7757071","citationType":"journal article","authors":["Wilson B.D.","Ollmann M.M.","Kang L.","Stoffel M.","Bell G.I.","Barsh G.S."],"citationCrossReferences":[{"database":"PubMed","id":"7757071"},{"database":"DOI","id":"10.1093/hmg/4.2.223"}],"title":"Structure and function of ASP, the human homolog of the mouse agouti gene.","publicationDate":"1995","journal":"Hum. Mol. Genet.","firstPage":"223","lastPage":"230","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","TISSUE SPECIFICITY"]},{"referenceNumber":3,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.L.","Burton J.","Gilbert J.G.R.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.D.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.E.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.D.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.D.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaeslaiho M.H.","Leversha M.A.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.A.","Mistry D.","Moore M.J.F.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.V.","Peck A.I.","Phillimore B.J.C.T.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann R.M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":5,"citation":{"id":"15701517","citationType":"journal article","authors":["McNulty J.C.","Jackson P.J.","Thompson D.A.","Chai B.","Gantz I.","Barsh G.S.","Dawson P.E.","Millhauser G.L."],"citationCrossReferences":[{"database":"PubMed","id":"15701517"},{"database":"DOI","id":"10.1016/j.jmb.2004.12.030"}],"title":"Structures of the agouti signaling protein.","publicationDate":"2005","journal":"J. Mol. Biol.","firstPage":"1059","lastPage":"1070","volume":"346"},"referencePositions":["STRUCTURE BY NMR OF 80-132","DISULFIDE BONDS"]},{"referenceNumber":6,"citation":{"id":"11833005","citationType":"journal article","authors":["Kanetsky P.A.","Swoyer J.","Panossian S.","Holmes R.","Guerry D.","Rebbeck T.R."],"citationCrossReferences":[{"database":"PubMed","id":"11833005"},{"database":"DOI","id":"10.1086/339076"}],"title":"A polymorphism in the agouti signaling protein gene is associated with human pigmentation.","publicationDate":"2002","journal":"Am. J. Hum. Genet.","firstPage":"770","lastPage":"775","volume":"70"},"referencePositions":["INVOLVEMENT IN SHEP9","FUNCTION"]},{"referenceNumber":7,"citation":{"id":"36536132","citationType":"journal article","authors":["Kempf E.","Landgraf K.","Stein R.","Hanschkow M.","Hilbert A.","Abou Jamra R.","Boczki P.","Herberth G.","Kuehnapfel A.","Tseng Y.H.","Staeubert C.","Schoeneberg T.","Kuehnen P.","Rayner N.W.","Zeggini E.","Kiess W.","Blueher M.","Koerner A."],"citationCrossReferences":[{"database":"PubMed","id":"36536132"},{"database":"DOI","id":"10.1038/s42255-022-00703-9"}],"title":"Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity.","publicationDate":"2022","journal":"Nat. Metab.","firstPage":"1697","lastPage":"1712","volume":"4"},"referencePositions":["INVOLVEMENT IN OBHP","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U12775","properties":[{"key":"ProteinId","value":"AAB61247.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U12770","properties":[{"key":"ProteinId","value":"AAB61247.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U12774","properties":[{"key":"ProteinId","value":"AAB61247.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L37019","properties":[{"key":"ProteinId","value":"AAA89208.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL035458","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC104238","properties":[{"key":"ProteinId","value":"AAI04239.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC104239","properties":[{"key":"ProteinId","value":"AAI04240.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS13232.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"I37143","properties":[{"key":"EntryName","value":"I37143"}]},{"database":"RefSeq","id":"NP_001372147.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001385218.1"}]},{"database":"RefSeq","id":"NP_001663.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001672.3"}]},{"database":"RefSeq","id":"XP_011527122.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011528820.2"}]},{"database":"RefSeq","id":"XP_011527123.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011528821.1"}]},{"database":"RefSeq","id":"XP_054179425.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054323450.1"}]},{"database":"RefSeq","id":"XP_054179426.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054323451.1"}]},{"database":"PDB","id":"1Y7J","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=80-132"}]},{"database":"PDB","id":"1Y7K","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=80-132"}]},{"database":"PDB","id":"2KZA","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=80-132"}]},{"database":"PDB","id":"2L1J","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=93-126"}]},{"database":"PDBsum","id":"1Y7J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1Y7K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2KZA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2L1J","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P42127","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P42127","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"106926","properties":[{"key":"Interactions","value":"19"}]},{"database":"FunCoup","id":"P42127","properties":[{"key":"Number of interactors","value":"267"}]},{"database":"IntAct","id":"P42127","properties":[{"key":"Interactions","value":"8"}]},{"database":"NDEx","id":"IQUERY-CP-ASIP","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000454804","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P42127","properties":[{"key":"glycosylation","value":"1 site, No reported glycans"}]},{"database":"GlyGen","id":"P42127","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"P42127","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P42127","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ASIP","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"1168389","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P42127","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000454804","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P42127","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"55487","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"25783","properties":[{"key":"antibodies","value":"81 antibodies from 14 providers"}]},{"database":"DNASU","id":"434","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000374954.4","properties":[{"key":"ProteinId","value":"ENSP00000364092.3"},{"key":"GeneId","value":"ENSG00000101440.11"}]},{"database":"Ensembl","id":"ENST00000568305.5","properties":[{"key":"ProteinId","value":"ENSP00000454804.1"},{"key":"GeneId","value":"ENSG00000101440.11"}]},{"database":"Ensembl","id":"ENST00000962459.1","properties":[{"key":"ProteinId","value":"ENSP00000632518.1"},{"key":"GeneId","value":"ENSG00000101440.11"}]},{"database":"Ensembl","id":"ENST00000962460.1","properties":[{"key":"ProteinId","value":"ENSP00000632519.1"},{"key":"GeneId","value":"ENSG00000101440.11"}]},{"database":"GeneID","id":"434","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:434","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000374954.4","properties":[{"key":"ProteinId","value":"ENSP00000364092.3"},{"key":"RefSeqNucleotideId","value":"NM_001672.3"},{"key":"RefSeqProteinId","value":"NP_001663.2"}]},{"database":"UCSC","id":"uc002xah.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:745","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA25045","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"434","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"434","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ASIP","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:745","properties":[{"key":"GeneName","value":"ASIP"}]},{"database":"HPA","id":"ENSG00000101440","properties":[{"key":"ExpressionPatterns","value":"Group enriched (epididymis, heart muscle, ovary)"}]},{"database":"MalaCards","id":"ASIP","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"600201","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"611742","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"620195","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000101440","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000101440","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S5XF","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000154258","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_138633_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P42127","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CHCRFFR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PAN-GO","id":"P42127","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P42127","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P42127","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"P42127","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P42127","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000101440","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"434","properties":[{"key":"hits","value":"17 hits in 1144 CRISPR screens"}]},{"database":"ChiTaRS","id":"ASIP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P42127","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"434","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P42127","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P42127","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"RNAct","id":"P42127","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000101440","properties":[{"key":"ExpressionPatterns","value":"Expressed in apex of heart and 97 other cell types or tissues"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36536132"}]},{"database":"GO","id":"GO:0031779","properties":[{"key":"GoTerm","value":"F:melanocortin receptor binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005184","properties":[{"key":"GoTerm","value":"F:neuropeptide hormone activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048019","properties":[{"key":"GoTerm","value":"F:receptor antagonist activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7757071"}]},{"database":"GO","id":"GO:0070996","properties":[{"key":"GoTerm","value":"F:type 1 melanocortin receptor binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0031781","properties":[{"key":"GoTerm","value":"F:type 3 melanocortin receptor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031782","properties":[{"key":"GoTerm","value":"F:type 4 melanocortin receptor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007267","properties":[{"key":"GoTerm","value":"P:cell-cell signaling"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7757071"}]},{"database":"GO","id":"GO:0006091","properties":[{"key":"GoTerm","value":"P:generation of precursor metabolites and energy"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7937887"}]},{"database":"GO","id":"GO:0009755","properties":[{"key":"GoTerm","value":"P:hormone-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042438","properties":[{"key":"GoTerm","value":"P:melanin biosynthetic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0106072","properties":[{"key":"GoTerm","value":"P:negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0048022","properties":[{"key":"GoTerm","value":"P:negative regulation of melanin biosynthetic process"},{"key":"GoEvidenceType","value":"IMP:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11833005"}]},{"database":"GO","id":"GO:0048023","properties":[{"key":"GoTerm","value":"P:positive regulation of melanin biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7757071"}]},{"database":"FunFam","id":"4.10.760.10:FF:000002","properties":[{"key":"EntryName","value":"Agouti-signaling protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.760.10","properties":[{"key":"EntryName","value":"Agouti domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007733","properties":[{"key":"EntryName","value":"Agouti"}]},{"database":"InterPro","id":"IPR027300","properties":[{"key":"EntryName","value":"Agouti_dom"}]},{"database":"InterPro","id":"IPR036836","properties":[{"key":"EntryName","value":"Agouti_dom_sf"}]},{"database":"PANTHER","id":"PTHR16551","properties":[{"key":"EntryName","value":"AGOUTI RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16551:SF1","properties":[{"key":"EntryName","value":"AGOUTI-SIGNALING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05039","properties":[{"key":"EntryName","value":"Agouti"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00792","properties":[{"key":"EntryName","value":"Agouti"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57055","properties":[{"key":"EntryName","value":"Agouti-related protein"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS60024","properties":[{"key":"EntryName","value":"AGOUTI_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51150","properties":[{"key":"EntryName","value":"AGOUTI_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC","length":132,"molWeight":14515,"crc64":"AF82CC3C747F2BE6","md5":"B4035B792C2666E01AF1AC9DD25C176A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DOMAIN":1,"POLYMORPHISM":1,"DISEASE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Compositional bias":1,"Glycosylation":1,"Disulfide bond":5,"Natural variant":2,"Beta strand":5},"uniParcId":"UPI0000125705"}}]}