{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O43681","secondaryAccessions":["A6NHP8","A8K740","Q53FC6","Q92849"],"uniProtkbId":"GET3_HUMAN","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-30","entryVersion":217,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03112"}],"value":"ATPase GET3"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9712828"}],"value":"3.6.4.-"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03112"}],"value":"Arsenical pump-driving ATPase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03112"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9712828"}],"value":"Arsenite-stimulated ATPase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03112"}],"value":"Guided entry of tail-anchored proteins factor 3, ATPase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17382883"}],"value":"Transmembrane domain recognition complex 40 kDa ATPase subunit"}},{"fullName":{"value":"hARSA-I"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9712828"}],"value":"hASNA-I"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03112"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:752"}],"value":"GET3"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:752"}],"value":"ARSA"},{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03112"}],"value":"ASNA1"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17382883"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:752"}],"value":"TRC40"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03112"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17382883"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18477612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23041287"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25535373"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31461301"}],"value":"ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:17382883). Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9712828"}]}},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"maximumVelocities":[{"velocity":16.6,"unit":"nmol/min/mg","enzyme":"enzyme for ATP","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9712828"}]}],"michaelisConstants":[{"constant":0.22,"unit":"mM","substrate":"ATP","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9712828"}]}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"G3V9T7"},{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03112"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17382883"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18477612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21444755"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23041287"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24392163"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32910895"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34887561"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37963916"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9712828"}],"value":"Homodimer (PubMed:9712828). Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40 (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:32910895, PubMed:37963916). Within the complex, CAMLG and GET1 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (PubMed:32910895). Interacts with CAMLG (via N-terminus) (By similarity). GET3 shows a higher affinity for CAMLG than for GET1 (PubMed:24392163). Interacts with SERP1 and SEC61B (PubMed:17382883, PubMed:18477612). Interacts with GET4 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Exists both as a single chain of 58 kDa (component A) or as a chain of 50 kDa (component B) linked by disulfide bond(s) to a 7 kDa chain (component C). 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This post-translational modification is severely defective in multiple sulfatase deficiency (MSD)"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Metachromatic leukodystrophy","diseaseAccession":"DI-00652","acronym":"MLD","description":"An autosomal recessive disease caused by abnormal intralysosomal accumulation of cerebroside-3-sulfate in central and peripheral nervous systems, as well as other organs. MLD is clinically characterized by leukodystrophy, progressive demyelination and a variety of neurological symptoms, including gait disturbances, ataxias, optical atrophy, dementia, seizures, and spastic tetraparesis. Decreased arylsulfatase A activity is detected in urine, leukocytes, and fibroblasts of affected individuals. Several forms of the disease can be distinguished according to the age at onset and disease severity: late infantile, juvenile and adult forms, partial cerebroside sulfate deficiency, and pseudoarylsulfatase A deficiency. Individuals with pseudoarylsulfatase A deficiency have low arylsulfatase A activity but lack neurological manifestations and are apparently healthy.","diseaseCrossReference":{"database":"MIM","id":"250100"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10220151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10381328"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10477432"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10533072"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10751093"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11020646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11061266"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11456299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11941485"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12503099"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12788103"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1353340"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14517960"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14680985"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15026521"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15326627"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15710861"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1670590"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1673291"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1678251"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18693274"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19606494"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20339381"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21265945"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2574462"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7581401"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7825603"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7860068"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7902317"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7906588"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7909527"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8095918"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8101038"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8101083"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8104633"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8891236"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9090526"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9272717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9452102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9490297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9600244"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9819708"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Multiple sulfatase deficiency","diseaseAccession":"DI-00791","acronym":"MSD","description":"A clinically and biochemically heterogeneous disorder caused by the simultaneous impairment of all sulfatases, due to defective post-translational modification and activation. 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