{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P29972","secondaryAccessions":["B5BU39","E7EM69","E9PC21","F5GY19","Q8TBI5","Q8TDC1"],"uniProtkbId":"AQP1_HUMAN","entryAudit":{"firstPublicDate":"1993-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":251,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Aquaporin-1"},"shortNames":[{"value":"AQP-1"}]},"alternativeNames":[{"fullName":{"value":"Aquaporin-CHIP"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1722319"}],"value":"Channel-like integral membrane protein of 28 kDa"}},{"fullName":{"value":"Urine water channel"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:633"}],"value":"AQP1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1722319"}],"value":"CHIP28"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1373524"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16682607"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17012249"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19273840"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23219802"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33028705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35835865"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36949749"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8584435"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8703053"}],"value":"Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"H2O(in) = H2O(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29667"},{"database":"ChEBI","id":"CHEBI:15377"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35835865"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36949749"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8584435"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"nitric oxide(out) = nitric oxide(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:74895"},{"database":"ChEBI","id":"CHEBI:16480"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16682607"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"CO2(out) = CO2(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:74891"},{"database":"ChEBI","id":"CHEBI:16526"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17012249"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19273840"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycerol(in) = glycerol(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29675"},{"database":"ChEBI","id":"CHEBI:17754"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8584435"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"H2O2(out) = H2O2(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:74375"},{"database":"ChEBI","id":"CHEBI:16240"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"33028705"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"K(+)(in) = K(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29463"},{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"36949749"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8703053"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Na(+)(in) = Na(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34963"},{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"36949749"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7677994"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8584435"}],"value":"The water channel activity is inhibited by P-choloromercuribenzene sulphonate and diethylpyrocarbonate(DPPC) (PubMed:8584435). The glycerol channel activity is inhibited by P-choloromercuribenzene sulphonate, diethylpyrocarbonate(DPPC), phloretin and Cu(2+) (PubMed:8584435). Inhibited by mercury (PubMed:7677994)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q02013"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23219802"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35835865"}],"value":"Homotetramer; each monomer provides an independent water pore (PubMed:11171962, PubMed:35835865). Component of the ankyrin-1 complex in the erythrocyte, composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1 (PubMed:35835865). Interacts with EPHB2; involved in endolymph production in the inner ear (By similarity). Identified in a complex with STOM (PubMed:23219802). Interacts (via the N-terminal) with ANK1 (via ANK 1-5 repeats) (PubMed:35835865). Interacts (via the C-terminal) with EPB42 (PubMed:35835865)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"A2BDD9","geneName":"AMOT","intActId":"EBI-17286414"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"P29972","geneName":"AQP1","intActId":"EBI-745213"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q13520","geneName":"AQP6","intActId":"EBI-13059134"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q9BXK5","geneName":"BCL2L13","intActId":"EBI-747430"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q9BUH8","geneName":"BEGAIN","intActId":"EBI-742722"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q9H2G9","geneName":"BLZF1","intActId":"EBI-2548012"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q96LC9","geneName":"BMF","intActId":"EBI-3919268"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q96JN2-2","geneName":"CCDC136","intActId":"EBI-10171416"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q2TAC2","geneName":"CCDC57","intActId":"EBI-2808286"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"O95273","geneName":"CCNDBP1","intActId":"EBI-748961"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"P11912","geneName":"CD79A","intActId":"EBI-7797864"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q01850","geneName":"CDR2","intActId":"EBI-1181367"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q9C0F1","geneName":"CEP44","intActId":"EBI-744115"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"O00501","geneName":"CLDN5","intActId":"EBI-18400628"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"P49747","geneName":"COMP","intActId":"EBI-2531022"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q7Z7G2","geneName":"CPLX4","intActId":"EBI-18013275"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"O43889-2","geneName":"CREB3","intActId":"EBI-625022"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q9NQ79","geneName":"CRTAC1","intActId":"EBI-10205543"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q96S65","geneName":"CSRNP1","intActId":"EBI-4311573"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"A8MQ03","geneName":"CYSRT1","intActId":"EBI-3867333"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q9NQ30","geneName":"ESM1","intActId":"EBI-12260294"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"P34910-2","geneName":"EVI2B","intActId":"EBI-17640610"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29972","intActId":"EBI-745213"},"interactantTwo":{"uniProtKBAccession":"Q3B820","geneName":"FAM161A","intActId":"EBI-719941"},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