{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P03971","secondaryAccessions":["O75246","Q6GTN3"],"uniProtkbId":"AMH_HUMAN","entryAudit":{"firstPublicDate":"1986-10-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-11-30","entryVersion":218,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20861221"}],"value":"Anti-Muellerian hormone"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20861221"}],"value":"AMH"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8162013"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8872466"}],"value":"Muellerian-inhibiting factor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3754790"}],"value":"Muellerian-inhibiting substance"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3754790"}],"value":"MIS"}]}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:464"}],"value":"AMH"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8162013"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8872466"}],"value":"MIF"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27106"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14742691"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20861221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34155118"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3754790"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8469238"}],"value":"The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions (PubMed:14742691, PubMed:34155118, PubMed:3754790, PubMed:8469238). Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction (PubMed:20861221, PubMed:34155118). Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation (PubMed:34155118, PubMed:3754790, PubMed:8469238). In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed:14742691). Also plays a role in Leydig cell differentiation and function (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20861221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2974034"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39805014"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8469238"}],"value":"Homodimer; disulfide-linked (PubMed:2974034, PubMed:39805014, PubMed:8469238). Anti-Muellerian hormone (AMH) is secreted as part of a non-covalent heterotetrameric complex consisting of AMH prodomain and anti-Muellerian hormone homodimers (PubMed:2974034, PubMed:39805014, PubMed:8469238). After proteolytic processing, the dimeric AMH prodomain remains non-covalently associated with the active homodimeric anti-Muellerian hormone, amplifying its biological activity (PubMed:2974034, PubMed:39805014, PubMed:8469238). The AMH prodomain homodimer is displaced upon binding of anti-Muellerian hormone to its receptor (PubMed:20861221, PubMed:39805014)"}],"commentType":"SUBUNIT","molecule":"Anti-Muellerian hormone"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2974034"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3754790"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14742691"}],"value":"In ovaries, AMH is detected in granulosa cells of early growing follicles"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14742691"}],"value":"Detected in primary follicles and continued to be expressed in follicles in the antral stage (PubMed:14742691). The highest level of AMH expression is present in granulosa cells of secondary, preantral and small antral follicles <4 mm in diameter, whereas expression is lost from follicles at sizes >8 mm (PubMed:14742691)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11779604"}],"value":"Plasma AMH levels in polycystic ovary syndrome (PCOS) patients are two- to threefold higher than in women with normal ovaries"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20861221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2974034"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8469238"}],"value":"The preproprotein is proteolytically processed to generate the AMH prodomain and the anti-Muellerian hormone (PubMed:20861221, PubMed:2974034, PubMed:8469238). Both homodimerize covalently, and homodimers associate to form a non-covalent heterotetrameric complex (PubMed:20861221, PubMed:2974034, PubMed:8469238)"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Persistent Muellerian duct syndrome 1","diseaseAccession":"DI-02155","acronym":"PMDS1","description":"A form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.","diseaseCrossReference":{"database":"MIM","id":"261550"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8162013"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8872466"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TGF-beta family"}],"commentType":"SIMILARITY"},{"commentType":"WEB 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