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Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation (PubMed:29263213). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15496415"}],"value":"Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. 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The affinity for CD6 is much higher than the affinity for self-association (PubMed:15048703). Interacts (via glycosylated extracellular domain) with LGALS1 and LGALS3 (PubMed:24945728). Interaction with LGALS1 or LGALS3 inhibits interaction with CD6 (PubMed:24945728)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q13740","intActId":"EBI-1188108"},"interactantTwo":{"uniProtKBAccession":"Q13740","geneName":"ALCAM","intActId":"EBI-1188108"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13740","intActId":"EBI-1188108"},"interactantTwo":{"uniProtKBAccession":"P30203","geneName":"CD6","intActId":"EBI-2873748"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13740","intActId":"EBI-1188108"},"interactantTwo":{"uniProtKBAccession":"P09382","geneName":"LGALS1","intActId":"EBI-1048875"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13740","intActId":"EBI-1188108"},"interactantTwo":{"uniProtKBAccession":"P17931","geneName":"LGALS3","intActId":"EBI-1170392"},"numberOfExperiments":7,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15294938"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16352806"}],"value":"Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse (PubMed:15294938)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15048703"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15294938"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16352806"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23169771"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24740813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24945728"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7760007"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q61490"}],"value":"Cell projection, axon","id":"SL-0279"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q61490"}],"value":"Cell projection, dendrite","id":"SL-0283"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 3","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15496415"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q13740-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q13740-2"],"sequenceIds":["VSP_021797"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"sALCAM"}],"isoformIds":["Q13740-3"],"sequenceIds":["VSP_053530","VSP_053531"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q13740-4"],"sequenceIds":["VSP_053529","VSP_053532"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15048703"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24740813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7760007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9502422"}],"value":"Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806). Detected at low levels in spleen, placenta, liver (PubMed:9502422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23169771"}],"value":"Up-regulated by TNF and IFNG (at protein level)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8823162"}],"value":"The CD6 binding site is located in the N-terminal Ig-like domain"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15496415"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24945728"}],"value":"Glycosylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Secreted form, inhibits isoform 1 homophilic interaction"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 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