{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q15109","secondaryAccessions":["A2BFI7","A6NKF0","A7Y2U9","B0V176","Q15279","Q3L1R4","Q3L1R5","Q3L1R6","Q3L1R7","Q3L1R8","Q3L1S0","Q86SN1","Q9H2X7","Q9Y3R3","V5R6A3"],"uniProtkbId":"RAGE_HUMAN","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1997-11-01","entryVersion":237,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18089847"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1378843"}],"value":"Advanced glycosylation end product-specific receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18089847"}],"value":"Receptor for advanced glycation end products"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1378843"}],"value":"Receptor for advanced glycosylation end products"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"AGER"},"synonyms":[{"value":"RAGE"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19906677"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20943659"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21559403"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21565706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21829704"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24081950"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25401185"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27572515"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28515150"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33436632"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33918759"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34743181"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35974093"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36807739"}],"value":"Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, histones, phospholipids and glycosaminoglycans (PubMed:27572515, PubMed:28515150, PubMed:34743181, PubMed:35974093, PubMed:24081950). Advanced glycation end products (AGEs) are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes (PubMed:21565706). These ligands accumulate at inflammatory sites during the pathogenesis of various diseases including diabetes, vascular complications, neurodegenerative disorders and cancers, and RAGE transduces their binding into pro-inflammatory responses. Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction of inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B (PubMed:21829704, PubMed:33436632). Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (PubMed:19386136). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons (PubMed:19906677). ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability (PubMed:27572515). Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome (PubMed:34743181). Binds to DNA and promotes extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (PubMed:24081950, PubMed:28515150). Mediates phagocytosis by non-professional phagocytes (NPP) and this is enhanced by binding to ligands including RNA, DNA, HMGB1 and histones (PubMed:35974093). Promotes NPP-mediated phagocytosis of Saccharomyces cerevisiae spores by binding to RNA attached to the spore wall (PubMed:35974093). Also promotes NPP-mediated phagocytosis of apoptotic cells (PubMed:35974093). Following DNA damage, recruited to DNA double-strand break sites where it colocalizes with the MRN repair complex via interaction with double-strand break repair protein MRE11 (By similarity). Enhances the endonuclease activity of MRE11, promoting the end resection of damaged DNA (By similarity). Promotes DNA damage repair in trophoblasts which enhances trophoblast invasion and contributes to placental development and maintenance (PubMed:33918759). Protects cells from DNA replication stress by localizing to damaged replication forks where it stabilizes the MCM2-7 complex and promotes faithful progression of the replication fork (PubMed:36807739). Mediates the production of reactive oxygen species (ROS) in human endothelial cells (PubMed:25401185)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19386136"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20943659"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20947022"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21559403"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21565706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21829704"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23284645"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24081950"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25401185"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33436632"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33918759"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34743181"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36807739"}],"value":"Constitutive homodimer; disulfide-linked (PubMed:24081950). Forms homooligomers (PubMed:24081950). Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Interacts with TIRAP (PubMed:21829704). Interacts with HMGB1 (PubMed:34743181). Interacts with LGP2; this interaction plays an important role in AGER-mediated pro-inflammatory responses and cytokine release (PubMed:33436632). Interacts with double-strand break repair protein MRE11 which is a core component of the MRN complex (PubMed:33918759). The interaction enhances MRE11 endonuclease activity and promotes DNA repair (By similarity). Interacts with the MCM2-7 complex via interaction with complex member MCM2; the interaction is increased following DNA replication stress and stabilizes the MCM2-7 complex at replication forks (PubMed:36807739). Interacts with longistatin, a protein from the saliva of the tick, Haemaphysalis longicornis; the interaction attenuates AGER-mediated production of reactive oxygen species (ROS), activation of NF-kappa-B and expression of adhesion molecules and cytokines in human endothelial cells (PubMed:25401185)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"Q15109","geneName":"AGER","intActId":"EBI-1646426"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"P23560-2","geneName":"BDNF","intActId":"EBI-12275524"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"Q8WU43","geneName":"C2orf15","intActId":"EBI-12904676"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"Q96FZ5","geneName":"CMTM7","intActId":"EBI-2807956"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"O43889-2","geneName":"CREB3","intActId":"EBI-625022"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"O60610","geneName":"DIAPH1","intActId":"EBI-3959709"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"P00533","geneName":"EGFR","intActId":"EBI-297353"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"P62993","geneName":"GRB2","intActId":"EBI-401755"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"P09429","geneName":"HMGB1","intActId":"EBI-389432"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"Q8IW41","geneName":"MAPKAPK5","intActId":"EBI-1201460"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"Q8N108-16","geneName":"MIER1","intActId":"EBI-25830642"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"P16333","geneName":"NCK1","intActId":"EBI-389883"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"Q05513","geneName":"PRKCZ","intActId":"EBI-295351"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"P61586","geneName":"RHOA","intActId":"EBI-446668"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"P80511","geneName":"S100A12","intActId":"EBI-2823305"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"P04271","geneName":"S100B","intActId":"EBI-458391"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"P25815","geneName":"S100P","intActId":"EBI-743700"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"P58753","geneName":"TIRAP","intActId":"EBI-528644"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"Q5BVD1","geneName":"TTMP","intActId":"EBI-10243654"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"P02766","geneName":"TTR","intActId":"EBI-711909"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15109","intActId":"EBI-1646426"},"interactantTwo":{"uniProtKBAccession":"Q01279","geneName":"Egfr","intActId":"EBI-6296235"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22509345"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33918759"}],"value":"Detected on the surface of CD11c+ peripheral blood mononuclear cells under basal conditions and after activation (PubMed:22509345). No surface expression is observed on resting T cells (PubMed:22509345). Localizes intracellularly in early endosomes in activated T cells of healthy controls and in resting T cells of patients with type I diabetes (PubMed:22509345). Nuclear translocation is enhanced by irradiation, hypoxia and reperfusion injury to brain or kidney (By similarity). Nuclear localization is enhanced by DNA damage in trophoblasts and increases in pre-term labor and preeclampsia placentas compared to control placentas (PubMed:33918759)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22509345"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35974093"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22509345"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33918759"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36807739"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 1","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24081950"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27572515"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33436632"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 2","subcellularLocations":[{"location":{"value":"Secreted","id":"SL-0243"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 10","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24260107"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24260107"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q15109-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"RAGESEC"}],"isoformIds":["Q15109-2"],"sequenceIds":["VSP_002551","VSP_002552"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q15109-3"],"sequenceIds":["VSP_042011"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q15109-4"],"sequenceIds":["VSP_043528","VSP_042011"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"synonyms":[{"value":"del exon3-7"}],"isoformIds":["Q15109-5"],"sequenceIds":["VSP_047884","VSP_047885"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"isoformIds":["Q15109-6"],"sequenceIds":["VSP_043528"],"isoformSequenceStatus":"Described"},{"name":{"value":"7"},"synonyms":[{"value":"del exon3"}],"isoformIds":["Q15109-7"],"sequenceIds":["VSP_002551"],"isoformSequenceStatus":"Described"},{"name":{"value":"8"},"isoformIds":["Q15109-8"],"sequenceIds":["VSP_047886","VSP_047888"],"isoformSequenceStatus":"Described"},{"name":{"value":"9"},"synonyms":[{"value":"del exon8-9"}],"isoformIds":["Q15109-9"],"sequenceIds":["VSP_047887","VSP_047889"],"isoformSequenceStatus":"Described"},{"name":{"value":"10"},"synonyms":[{"value":"delta-ICD"},{"value":"variant 20"}],"isoformIds":["Q15109-10"],"sequenceIds":["VSP_055321"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33918759"}],"value":"Endothelial cells. Increased expression in pre-term labor and preeclampsia placentas compared to controls (PubMed:33918759)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22509345"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33918759"}],"value":"Induced in T cells by antigen stimulation and by the S100B ligand (PubMed:22509345). Induced in trophoblasts by DNA damage (PubMed:33918759)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21829704"}],"value":"Phosphorylated on its cytoplasmic domain by PKCzeta/PRKCZ upon ligand binding (PubMed:21829704). Phosphorylated by ATM following DNA damage (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28515150"}],"value":"Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Detected in lung, brain, heart and kidney"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 10"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/594/AGER","ftp":false}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","featureId":"PRO_0000014923"},{"type":"Topological domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Ig-like V-type"},{"type":"Domain","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"Ig-like C2-type 1"},{"type":"Domain","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Ig-like C2-type 2"},{"type":"Region","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"Phosphoserine; by PKC/PRKCZ and ATM","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21829704"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28977635"}]},{"type":"Glycosylation","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20943659"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20947022"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21565706"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.29"}]},{"type":"Disulfide bond","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20943659"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20947022"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21565706"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.29"}]},{"type":"Disulfide bond","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Interchain","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23284645"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"Interchain","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23284645"}]},{"type":"Alternative sequence","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 7","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18089847"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"featureId":"VSP_002551","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18089847"}],"featureId":"VSP_047884","alternativeSequence":{"originalSequence":"YRVRVYQIP","alternativeSequences":["WWWSQKVEQ"]}},{"type":"Alternative sequence","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18089847"}],"featureId":"VSP_047885","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in isoform 4 and isoform 6","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18089847"}],"featureId":"VSP_043528","alternativeSequence":{"originalSequence":"K","alternativeSequences":["KVVEESRRSRKRPCEQE"]}},{"type":"Alternative sequence","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"featureId":"VSP_002552","alternativeSequence":{"originalSequence":"GVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP","alternativeSequences":["VSDLERGAGRTRRGGANCRLCGRIRAGNSSPGPGDPGRPGDSRPAHWGHLVAKAATPRRGEEGPRKPGGRGGACRTESVGGT"]}},{"type":"Alternative sequence","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"in isoform 8","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18089847"}],"featureId":"VSP_047886","alternativeSequence":{"originalSequence":"GVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGE","alternativeSequences":["NQARRGQLQVRGLIKSGKQKIAPNTCDWGDGQQERNGRPQKTRRKRRSVQN"]}},{"type":"Alternative sequence","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"in isoform 9","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18089847"}],"featureId":"VSP_047887","alternativeSequence":{"originalSequence":"VPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAA","alternativeSequences":["LRTREPTAVWPPIPATGPRKAVLSASASSNQARRGQLQVRGLIKSGKQKIAPNTCDWGDGQQERNGRPQKTRRKRRSVQN"]}},{"type":"Alternative sequence","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"in isoform 8","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18089847"}],"featureId":"VSP_047888","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"in isoform 3 and isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12495433"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18089847"}],"featureId":"VSP_042011","alternativeSequence":{"originalSequence":"SVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP","alternativeSequences":["EGFDKVREAEDSPQHM"]}},{"type":"Alternative sequence","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"in isoform 9","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18089847"}],"featureId":"VSP_047889","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"in isoform 10","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24260107"}],"featureId":"VSP_055321","alternativeSequence":{"originalSequence":"KAPENQEEEEERAELNQSEEPEAGESSTGGP","alternativeSequences":["PQKTRRKRRSVQN"]}},{"type":"Natural variant","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"in dbSNP:rs2070600","featureCrossReferences":[{"database":"dbSNP","id":"rs2070600"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14574404"}],"featureId":"VAR_024500","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"}],"featureId":"VAR_011338","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"Less monoubiquitinated product and resistant to degradation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28515150"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"Complete loss of phosphorylation by PKC/PRKCZ and by ATM.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21829704"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28977635"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"in Ref. 1; AAA03574","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["G"]}},{"type":"Beta strand","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6XQ1"}]},{"type":"Helix","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Turn","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2E5E"}]},{"type":"Beta strand","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Helix","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Turn","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4OF5"}]},{"type":"Beta strand","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Helix","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6XQ1"}]},{"type":"Turn","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6XQ9"}]},{"type":"Beta strand","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Turn","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3CJJ"}]},{"type":"Helix","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6XQ1"}]},{"type":"Helix","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O3U"}]},{"type":"Beta strand","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6XQ1"}]},{"type":"Helix","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4P2Y"}]},{"type":"Beta strand","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4P2Y"}]},{"type":"Beta strand","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4P2Y"}]},{"type":"Beta strand","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4P2Y"}]},{"type":"Beta strand","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4P2Y"}]},{"type":"Beta strand","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LE9"}]},{"type":"Beta strand","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4P2Y"}]},{"type":"Beta strand","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4P2Y"}]},{"type":"Helix","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4P2Y"}]},{"type":"Beta strand","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4P2Y"}]},{"type":"Beta strand","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4P2Y"}]},{"type":"Beta strand","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4P2Y"}]},{"type":"Beta strand","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LE9"}]},{"type":"Beta strand","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LMB"}]},{"type":"Turn","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LMB"}]},{"type":"Beta strand","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6VXG"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"1378843","citationType":"journal article","authors":["Neeper M.","Schmidt A.M.","Brett J.","Yan S.D.","Wang F.","Pan Y.C.","Elliston K.","Stern D.","Shaw A."],"citationCrossReferences":[{"database":"PubMed","id":"1378843"},{"database":"DOI","id":"10.1016/s0021-9258(18)42138-2"}],"title":"Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.","publicationDate":"1992","journal":"J. Biol. Chem.","firstPage":"14998","lastPage":"15004","volume":"267"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"7835890","citationType":"journal article","authors":["Sugaya K.","Fukagawa T.","Matsumoto K.","Mita K.","Takahashi E.","Ando A.","Inoko H.","Ikemura T."],"citationCrossReferences":[{"database":"PubMed","id":"7835890"},{"database":"DOI","id":"10.1006/geno.1994.1517"}],"title":"Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.","publicationDate":"1994","journal":"Genomics","firstPage":"408","lastPage":"419","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)"]},{"referenceNumber":3,"citation":{"id":"CI-7O48VFVHP9J30","citationType":"submission","authors":["Abedin M.J.","Yonekura H.","Migita H.","Karasawa J.","Yamamoto Y.","Yamamoto H."],"title":"Molecular heterogeneity of the receptor for advanced glycation endproducts.","publicationDate":"JAN-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","VARIANT ARG-100"]},{"referenceNumber":4,"citation":{"id":"CI-AE65LSMK4OBUL","citationType":"submission","authors":["Malherbe P.","Richards J.","Gaillard H.","Thompson A.","Diener C.","Schuler A.","Huber G."],"title":"cDNA cloning of a novel secreted isoform of the human receptor for advanced glycation end products (RAGE) and characterization of cells co-expressing cell-surface scavenger receptors and Swedish mutant amyloid precursor protein.","publicationDate":"MAY-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"]},{"referenceNumber":5,"citation":{"id":"12495433","citationType":"journal article","authors":["Yonekura H.","Yamamoto Y.","Sakurai S.","Petrova R.G.","Abedin J.","Li H.","Yasui K.","Takeuchi M.","Makita Z.","Takasawa S.","Okamoto H.","Watanabe T.","Yamamoto H."],"citationCrossReferences":[{"database":"PubMed","id":"12495433"},{"database":"DOI","id":"10.1042/bj20021371"}],"title":"Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury.","publicationDate":"2003","journal":"Biochem. J.","firstPage":"1097","lastPage":"1109","volume":"370"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)","ALTERNATIVE SPLICING"],"referenceComments":[{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"14656967","citationType":"journal article","authors":["Xie T.","Rowen L.","Aguado B.","Ahearn M.E.","Madan A.","Qin S.","Campbell R.D.","Hood L."],"citationCrossReferences":[{"database":"PubMed","id":"14656967"},{"database":"DOI","id":"10.1101/gr.1736803"}],"title":"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.","publicationDate":"2003","journal":"Genome Res.","firstPage":"2621","lastPage":"2636","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"18089847","citationType":"journal article","authors":["Hudson B.I.","Carter A.M.","Harja E.","Kalea A.Z.","Arriero M.","Yang H.","Grant P.J.","Schmidt A.M."],"citationCrossReferences":[{"database":"PubMed","id":"18089847"},{"database":"DOI","id":"10.1096/fj.07-9909com"}],"title":"Identification, classification, and expression of RAGE gene splice variants.","publicationDate":"2008","journal":"FASEB J.","firstPage":"1572","lastPage":"1580","volume":"22"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5; 6; 7; 8 AND 9)","ALTERNATIVE SPLICING"],"referenceComments":[{"value":"Aortic smooth muscle","type":"TISSUE"},{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"24260107","citationType":"journal article","authors":["Jules J.","Maiguel D.","Hudson B.I."],"citationCrossReferences":[{"database":"PubMed","id":"24260107"},{"database":"DOI","id":"10.1371/journal.pone.0078267"}],"title":"Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function.","publicationDate":"2013","journal":"PLoS ONE","firstPage":"E78267","lastPage":"E78267","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 10)","SUBCELLULAR LOCATION (ISOFORM 10)"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.R.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.S.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.E.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.N.D.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.F.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.J.C.T.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.M.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]","VARIANT SER-82"]},{"referenceNumber":11,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":12,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"11375354","citationType":"journal article","authors":["Hudson B.I.","Stickland M.H.","Futers T.S.","Grant P.J."],"citationCrossReferences":[{"database":"PubMed","id":"11375354"},{"database":"DOI","id":"10.2337/diabetes.50.6.1505"}],"title":"Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy.","publicationDate":"2001","journal":"Diabetes","firstPage":"1505","lastPage":"1511","volume":"50"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12"]},{"referenceNumber":14,"citation":{"id":"19386136","citationType":"journal article","authors":["Moroz O.V.","Burkitt W.","Wittkowski H.","He W.","Ianoul A.","Novitskaya V.","Xie J.","Polyakova O.","Lednev I.K.","Shekhtman A.","Derrick P.J.","Bjoerk P.","Foell D.","Bronstein I.B."],"citationCrossReferences":[{"database":"PubMed","id":"19386136"},{"database":"DOI","id":"10.1186/1471-2091-10-11"}],"title":"Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function.","publicationDate":"2009","journal":"BMC Biochem.","firstPage":"11","lastPage":"11","volume":"10"},"referencePositions":["INTERACTION WITH S100A12"]},{"referenceNumber":15,"citation":{"id":"19906677","citationType":"journal article","authors":["Fang F.","Lue L.-F.","Yan S.","Xu H.","Luddy J.S.","Chen D.","Walker D.G.","Stern D.M.","Yan S.","Schmidt A.M.","Chen J.X.","Yan S.S."],"citationCrossReferences":[{"database":"PubMed","id":"19906677"},{"database":"DOI","id":"10.1096/fj.09-139634"}],"title":"RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.","publicationDate":"2010","journal":"FASEB J.","firstPage":"1043","lastPage":"1055","volume":"24"},"referencePositions":["FUNCTION"]},{"referenceNumber":16,"citation":{"id":"21559403","citationType":"journal article","authors":["Jin Q.","Chen H.","Luo A.","Ding F.","Liu Z."],"citationCrossReferences":[{"database":"PubMed","id":"21559403"},{"database":"DOI","id":"10.1371/journal.pone.0019375"}],"title":"S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE).","publicationDate":"2011","journal":"PLoS ONE","firstPage":"E19375","lastPage":"E19375","volume":"6"},"referencePositions":["INTERACTION WITH S100A14","FUNCTION"]},{"referenceNumber":17,"citation":{"id":"21829704","citationType":"journal article","authors":["Sakaguchi M.","Murata H.","Yamamoto K.","Ono T.","Sakaguchi Y.","Motoyama A.","Hibino T.","Kataoka K.","Huh N.H."],"citationCrossReferences":[{"database":"PubMed","id":"21829704"},{"database":"DOI","id":"10.1371/journal.pone.0023132"}],"title":"TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding.","publicationDate":"2011","journal":"PLoS ONE","firstPage":"e23132","lastPage":"e23132","volume":"6"},"referencePositions":["FUNCTION","PHOSPHORYLATION AT SER-391","INTERACTION WITH TIRAP","MUTAGENESIS OF SER-391"]},{"referenceNumber":18,"citation":{"id":"22509345","citationType":"journal article","authors":["Akirav E.M.","Preston-Hurlburt P.","Garyu J.","Henegariu O.","Clynes R.","Schmidt A.M.","Herold K.C."],"citationCrossReferences":[{"database":"PubMed","id":"22509345"},{"database":"DOI","id":"10.1371/journal.pone.0034698"}],"title":"RAGE expression in human T cells: a link between environmental factors and adaptive immune responses.","publicationDate":"2012","journal":"PLoS ONE","firstPage":"e34698","lastPage":"e34698","volume":"7"},"referencePositions":["SUBCELLULAR LOCATION","INDUCTION"]},{"referenceNumber":19,"citation":{"id":"23284645","citationType":"journal article","authors":["Wei W.","Lampe L.","Park S.","Vangara B.S.","Waldo G.S.","Cabantous S.","Subaran S.S.","Yang D.","Lakatta E.G.","Lin L."],"citationCrossReferences":[{"database":"PubMed","id":"23284645"},{"database":"DOI","id":"10.1371/journal.pone.0050736"}],"title":"Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis.","publicationDate":"2012","journal":"PLoS ONE","firstPage":"E50736","lastPage":"E50736","volume":"7"},"referencePositions":["SUBUNIT","INTERCHAIN DISULFIDE BONDS"]},{"referenceNumber":20,"citation":{"id":"25401185","citationType":"journal article","authors":["Anisuzzaman X.","Hatta T.","Miyoshi T.","Matsubayashi M.","Islam M.K.","Alim M.A.","Anas M.A.","Hasan M.M.","Matsumoto Y.","Yamamoto Y.","Yamamoto H.","Fujisaki K.","Tsuji N."],"citationCrossReferences":[{"database":"PubMed","id":"25401185"},{"database":"DOI","id":"10.1172/jci74917"}],"title":"Longistatin in tick saliva blocks advanced glycation end-product receptor activation.","publicationDate":"2014","journal":"J. Clin. Invest.","firstPage":"4429","lastPage":"4444","volume":"124"},"referencePositions":["FUNCTION","INTERACTION WITH TICK LONGISTATIN"],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":21,"citation":{"id":"27572515","citationType":"journal article","authors":["Shang D.","Peng T.","Gou S.","Li Y.","Wu H.","Wang C.","Yang Z."],"citationCrossReferences":[{"database":"PubMed","id":"27572515"},{"database":"DOI","id":"10.1038/srep32180"}],"title":"High Mobility Group Box Protein 1 Boosts Endothelial Albumin Transcytosis through the RAGE/Src/Caveolin-1 Pathway.","publicationDate":"2016","journal":"Sci. Rep.","firstPage":"32180","lastPage":"32180","volume":"6"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":22,"citation":{"id":"28515150","citationType":"journal article","authors":["Evankovich J.","Lear T.","Mckelvey A.","Dunn S.","Londino J.","Liu Y.","Chen B.B.","Mallampalli R.K."],"citationCrossReferences":[{"database":"PubMed","id":"28515150"},{"database":"DOI","id":"10.1096/fj.201700031r"}],"title":"Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation.","publicationDate":"2017","journal":"FASEB J.","firstPage":"3894","lastPage":"3903","volume":"31"},"referencePositions":["FUNCTION","UBIQUITINATION AT LYS-374","MUTAGENESIS OF LYS-374"]},{"referenceNumber":23,"citation":{"id":"28977635","citationType":"journal article","authors":["Kumar V.","Fleming T.","Terjung S.","Gorzelanny C.","Gebhardt C.","Agrawal R.","Mall M.A.","Ranzinger J.","Zeier M.","Madhusudhan T.","Ranjan S.","Isermann B.","Liesz A.","Deshpande D.","Haering H.U.","Biswas S.K.","Reynolds P.R.","Hammes H.P.","Peperkok R.","Angel P.","Herzig S.","Nawroth P.P."],"citationCrossReferences":[{"database":"PubMed","id":"28977635"},{"database":"DOI","id":"10.1093/nar/gkx705"}],"title":"Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair.","publicationDate":"2017","journal":"Nucleic Acids Res.","firstPage":"10595","lastPage":"10613","volume":"45"},"referencePositions":["PHOSPHORYLATION AT SER-391","MUTAGENESIS OF SER-391"]},{"referenceNumber":24,"citation":{"id":"34743181","citationType":"journal article","authors":["Wang G.","Jin S.","Huang W.","Li Y.","Wang J.","Ling X.","Huang Y.","Hu Y.","Li C.","Meng Y.","Li X."],"citationCrossReferences":[{"database":"PubMed","id":"34743181"},{"database":"DOI","id":"10.1038/s41420-021-00729-0"}],"title":"LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome.","publicationDate":"2021","journal":"Cell. Death. Discov.","firstPage":"337","lastPage":"337","volume":"7"},"referencePositions":["FUNCTION","INTERACTION WITH HMGB1"]},{"referenceNumber":25,"citation":{"id":"33918759","citationType":"journal article","authors":["Tsai K.Y.F.","Tullis B.","Breithaupt K.L.","Fowers R.","Jones N.","Grajeda S.","Reynolds P.R.","Arroyo J.A."],"citationCrossReferences":[{"database":"PubMed","id":"33918759"},{"database":"DOI","id":"10.3390/cells10040857"}],"title":"A Role for RAGE in DNA Double Strand Breaks (DSBs) Detected in Pathological Placentas and Trophoblast Cells.","publicationDate":"2021","journal":"Cells","firstPage":"0","lastPage":"0","volume":"10"},"referencePositions":["FUNCTION","INTERACTION WITH MRE11","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","INDUCTION"]},{"referenceNumber":26,"citation":{"id":"33436632","citationType":"journal article","authors":["Yan Z.","Luo H.","Xie B.","Tian T.","Li S.","Chen Z.","Liu J.","Zhao X.","Zhang L.","Deng Y.","Billiar T.R.","Jiang Y."],"citationCrossReferences":[{"database":"PubMed","id":"33436632"},{"database":"DOI","id":"10.1038/s41467-020-20577-3"}],"title":"Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis.","publicationDate":"2021","journal":"Nat. Commun.","firstPage":"308","lastPage":"308","volume":"12"},"referencePositions":["FUNCTION","INTERACTION WITH LGP2","SUBCELLULAR LOCATION"]},{"referenceNumber":27,"citation":{"id":"35974093","citationType":"journal article","authors":["Yang Y.","Liu G.","Li F.","Carey L.B.","Sun C.","Ling K.","Tachikawa H.","Fujita M.","Gao X.D.","Nakanishi H."],"citationCrossReferences":[{"database":"PubMed","id":"35974093"},{"database":"DOI","id":"10.1038/s42003-022-03791-1"}],"title":"Receptor for advanced glycation end-products (RAGE) mediates phagocytosis in nonprofessional phagocytes.","publicationDate":"2022","journal":"Commun. Biol.","firstPage":"824","lastPage":"824","volume":"5"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":28,"citation":{"id":"36807739","citationType":"journal article","authors":["Han Z.","Andrs M.","Madhavan B.K.","Kaymak S.","Sulaj A.","Kender Z.","Kopf S.","Kihm L.","Pepperkok R.","Janscak P.","Nawroth P.","Kumar V."],"citationCrossReferences":[{"database":"PubMed","id":"36807739"},{"database":"DOI","id":"10.1093/nar/gkad085"}],"title":"The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress.","publicationDate":"2023","journal":"Nucleic Acids Res.","firstPage":"2298","lastPage":"2318","volume":"51"},"referencePositions":["FUNCTION","INTERACTION WITH MCM2","SUBCELLULAR LOCATION"]},{"referenceNumber":29,"citation":{"id":"CI-2VUNTL80ETMLA","citationType":"submission","authoringGroup":["RIKEN structural genomics initiative (RSGI)"],"title":"Solution structure of the third Ig-like domain from human advanced glycosylation end product-specific receptor.","publicationDate":"APR-2008","submissionDatabase":"PDB data bank"},"referencePositions":["STRUCTURE BY NMR OF 23-121","STRUCTURE BY NMR OF 235-323","DISULFIDE BONDS"]},{"referenceNumber":30,"citation":{"id":"20943659","citationType":"journal article","authors":["Park H.","Adsit F.G.","Boyington J.C."],"citationCrossReferences":[{"database":"PubMed","id":"20943659"},{"database":"DOI","id":"10.1074/jbc.m110.169276"}],"title":"The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"40762","lastPage":"40770","volume":"285"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 23-231","FUNCTION","DNA-BINDING","INTERACTION WITH S100B","DISULFIDE BOND"]},{"referenceNumber":31,"citation":{"id":"20947022","citationType":"journal article","authors":["Koch M.","Chitayat S.","Dattilo B.M.","Schiefner A.","Diez J.","Chazin W.J.","Fritz G."],"citationCrossReferences":[{"database":"PubMed","id":"20947022"},{"database":"DOI","id":"10.1016/j.str.2010.05.017"}],"title":"Structural basis for ligand recognition and activation of RAGE.","publicationDate":"2010","journal":"Structure","firstPage":"1342","lastPage":"1352","volume":"18"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 23-240","INTERACTION WITH S100B","DISULFIDE BONDS"]},{"referenceNumber":32,"citation":{"id":"21565706","citationType":"journal article","authors":["Xue J.","Rai V.","Singer D.","Chabierski S.","Xie J.","Reverdatto S.","Burz D.S.","Schmidt A.M.","Hoffmann R.","Shekhtman A."],"citationCrossReferences":[{"database":"PubMed","id":"21565706"},{"database":"DOI","id":"10.1016/j.str.2011.02.013"}],"title":"Advanced glycation end product recognition by the receptor for AGEs.","publicationDate":"2011","journal":"Structure","firstPage":"722","lastPage":"732","volume":"19"},"referencePositions":["STRUCTURE BY NMR OF 23-125","FUNCTION","DISULFIDE BONDS"]},{"referenceNumber":33,"citation":{"id":"24081950","citationType":"journal article","authors":["Sirois C.M.","Jin T.","Miller A.L.","Bertheloot D.","Nakamura H.","Horvath G.L.","Mian A.","Jiang J.","Schrum J.","Bossaller L.","Pelka K.","Garbi N.","Brewah Y.","Tian J.","Chang C.","Chowdhury P.S.","Sims G.P.","Kolbeck R.","Coyle A.J.","Humbles A.A.","Xiao T.S.","Latz E."],"citationCrossReferences":[{"database":"PubMed","id":"24081950"},{"database":"DOI","id":"10.1084/jem.20120201"}],"title":"RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.","publicationDate":"2013","journal":"J. Exp. Med.","firstPage":"2447","lastPage":"2463","volume":"210"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 23-237 IN COMPLEX WITH DNA","FUNCTION","SUBUNIT","SUBCELLULAR LOCATION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4OI7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4OI8"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M91211","properties":[{"key":"ProteinId","value":"AAA03574.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D28769","properties":[{"key":"ProteinId","value":"BAA05958.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB036432","properties":[{"key":"ProteinId","value":"BAA89369.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ133822","properties":[{"key":"ProteinId","value":"CAB43108.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB061668","properties":[{"key":"ProteinId","value":"BAC65465.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U89336","properties":[{"key":"ProteinId","value":"AAB47491.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY755619","properties":[{"key":"ProteinId","value":"AAX07272.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY755620","properties":[{"key":"ProteinId","value":"AAX07273.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY755621","properties":[{"key":"ProteinId","value":"AAX07274.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY755622","properties":[{"key":"ProteinId","value":"AAX07275.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY755623","properties":[{"key":"ProteinId","value":"AAX07276.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY755624","properties":[{"key":"ProteinId","value":"AAX07277.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY755625","properties":[{"key":"ProteinId","value":"AAX07278.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY755628","properties":[{"key":"ProteinId","value":"AAX07281.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ104252","properties":[{"key":"ProteinId","value":"AAZ32413.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EU117141","properties":[{"key":"ProteinId","value":"ABV03807.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KC692917","properties":[{"key":"ProteinId","value":"AHB30241.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK313178","properties":[{"key":"ProteinId","value":"BAG35995.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL662830","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL662884","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL845464","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX284686","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX927239","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CR812478","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CR933878","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471081","properties":[{"key":"ProteinId","value":"EAX03610.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471081","properties":[{"key":"ProteinId","value":"EAX03611.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC020669","properties":[{"key":"ProteinId","value":"AAH20669.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF208289","properties":[{"key":"ProteinId","value":"AAG35728.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS4746.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q15109-1"},{"database":"CCDS","id":"CCDS4747.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q15109-2"},{"database":"CCDS","id":"CCDS56417.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q15109-4"},{"database":"CCDS","id":"CCDS56418.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q15109-3"},{"database":"CCDS","id":"CCDS75429.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q15109-6"},{"database":"PIR","id":"I61596","properties":[{"key":"EntryName","value":"I61596"}]},{"database":"RefSeq","id":"NP_001127.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001136.5"}],"isoformId":"Q15109-1"},{"database":"RefSeq","id":"NP_001193858.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001206929.2"}],"isoformId":"Q15109-6"},{"database":"RefSeq","id":"NP_001193861.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001206932.2"}],"isoformId":"Q15109-7"},{"database":"RefSeq","id":"NP_001193863.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001206934.2"}],"isoformId":"Q15109-4"},{"database":"RefSeq","id":"NP_001193865.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001206936.2"}],"isoformId":"Q15109-9"},{"database":"RefSeq","id":"NP_001193869.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001206940.2"}],"isoformId":"Q15109-3"},{"database":"RefSeq","id":"NP_001193883.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001206954.2"}],"isoformId":"Q15109-8"},{"database":"RefSeq","id":"NP_001193895.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001206966.2"}],"isoformId":"Q15109-3"},{"database":"RefSeq","id":"NP_751947.1","properties":[{"key":"NucleotideSequenceId","value":"NM_172197.3"}],"isoformId":"Q15109-2"},{"database":"PDB","id":"2E5E","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=23-121"}]},{"database":"PDB","id":"2ENS","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=235-323"}]},{"database":"PDB","id":"2L7U","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=23-125"}]},{"database":"PDB","id":"2LE9","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/D=235-327"}]},{"database":"PDB","id":"2LMB","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=362-404"}]},{"database":"PDB","id":"2M1K","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/C=23-121"}]},{"database":"PDB","id":"2MJW","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/C=23-121"}]},{"database":"PDB","id":"2MOV","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=23-125"}]},{"database":"PDB","id":"3CJJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A=23-240"}]},{"database":"PDB","id":"3O3U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"N=23-231"}]},{"database":"PDB","id":"4LP4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B=23-231"}]},{"database":"PDB","id":"4LP5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"A/B=23-323"}]},{"database":"PDB","id":"4OF5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B=23-237"}]},{"database":"PDB","id":"4OFV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B=23-237"}]},{"database":"PDB","id":"4OI7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B=23-237"}]},{"database":"PDB","id":"4OI8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B=23-237"}]},{"database":"PDB","id":"4P2Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=23-323"}]},{"database":"PDB","id":"4XYN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"P=54-68"}]},{"database":"PDB","id":"4YBH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=23-323"}]},{"database":"PDB","id":"5D7F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"P=65-79"}]},{"database":"PDB","id":"6VXG","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=362-404"}]},{"database":"PDB","id":"6XQ1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.51 A"},{"key":"Chains","value":"A/B=23-231"}]},{"database":"PDB","id":"6XQ3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.71 A"},{"key":"Chains","value":"A/B=23-231"}]},{"database":"PDB","id":"6XQ5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=23-231"}]},{"database":"PDB","id":"6XQ6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=23-231"}]},{"database":"PDB","id":"6XQ7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=23-231"}]},{"database":"PDB","id":"6XQ8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"A/B=23-231"}]},{"database":"PDB","id":"6XQ9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B=23-231"}]},{"database":"PDB","id":"7LML","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A/B=23-231"}]},{"database":"PDB","id":"7LMW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B=23-231"}]},{"database":"PDB","id":"8I9M","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.19 A"},{"key":"Chains","value":"B=23-233"}]},{"database":"PDB","id":"9D36","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=362-404"}]},{"database":"PDBsum","id":"2E5E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2ENS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2L7U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2LE9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2LMB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2M1K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2MJW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2MOV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3CJJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3O3U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4LP4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4LP5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4OF5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4OFV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4OI7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4OI8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4P2Y","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4XYN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4YBH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5D7F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6VXG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XQ1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XQ3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XQ5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XQ6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XQ7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XQ8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XQ9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7LML","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7LMW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8I9M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9D36","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35276","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"106685","properties":[{"key":"Interactions","value":"22"}]},{"database":"DIP","id":"DIP-40658N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q15109","properties":[{"key":"Number of interactors","value":"22"}]},{"database":"IntAct","id":"Q15109","properties":[{"key":"Interactions","value":"34"}]},{"database":"MINT","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-AGER","properties":[{"key":"Evidences","value":"5 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000364210","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2176846","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB12689","properties":[{"key":"GenericName","value":"Azeliragon"}]},{"database":"DrugBank","id":"DB00107","properties":[{"key":"GenericName","value":"Oxytocin"}]},{"database":"DrugBank","id":"DB11673","properties":[{"key":"GenericName","value":"Pyridoxamine"}]},{"database":"GuidetoPHARMACOLOGY","id":"2843","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"8.A.23.1.19","properties":[{"key":"FamilyName","value":"the basigin (basigin) family"}]},{"database":"GlyCosmos","id":"Q15109","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q15109","properties":[{"key":"glycosylation","value":"3 sites"}]},{"database":"iPTMnet","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"AGER","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"2497317","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000364210","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"60436","properties":[{"key":"Description","value":"-"}],"isoformId":"Q15109-1"},{"database":"ProteomicsDB","id":"60437","properties":[{"key":"Description","value":"-"}],"isoformId":"Q15109-2"},{"database":"ProteomicsDB","id":"60438","properties":[{"key":"Description","value":"-"}],"isoformId":"Q15109-3"},{"database":"ProteomicsDB","id":"60439","properties":[{"key":"Description","value":"-"}],"isoformId":"Q15109-4"},{"database":"ProteomicsDB","id":"61748","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28483","properties":[{"key":"antibodies","value":"883 antibodies from 48 providers"}]},{"database":"DNASU","id":"177","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000375055.6","properties":[{"key":"ProteinId","value":"ENSP00000364195.2"},{"key":"GeneId","value":"ENSG00000204305.17"}],"isoformId":"Q15109-3"},{"database":"Ensembl","id":"ENST00000375067.7","properties":[{"key":"ProteinId","value":"ENSP00000364208.3"},{"key":"GeneId","value":"ENSG00000204305.17"}],"isoformId":"Q15109-2"},{"database":"Ensembl","id":"ENST00000375069.7","properties":[{"key":"ProteinId","value":"ENSP00000364210.4"},{"key":"GeneId","value":"ENSG00000204305.17"}],"isoformId":"Q15109-6"},{"database":"Ensembl","id":"ENST00000375076.9","properties":[{"key":"ProteinId","value":"ENSP00000364217.4"},{"key":"GeneId","value":"ENSG00000204305.17"}],"isoformId":"Q15109-1"},{"database":"Ensembl","id":"ENST00000383275.6","properties":[{"key":"ProteinId","value":"ENSP00000372762.2"},{"key":"GeneId","value":"ENSG00000206320.12"}],"isoformId":"Q15109-3"},{"database":"Ensembl","id":"ENST00000383279.8","properties":[{"key":"ProteinId","value":"ENSP00000372766.4"},{"key":"GeneId","value":"ENSG00000206320.12"}],"isoformId":"Q15109-2"},{"database":"Ensembl","id":"ENST00000412470.6","properties":[{"key":"ProteinId","value":"ENSP00000387853.2"},{"key":"GeneId","value":"ENSG00000229058.10"}],"isoformId":"Q15109-2"},{"database":"Ensembl","id":"ENST00000426138.6","properties":[{"key":"ProteinId","value":"ENSP00000415144.2"},{"key":"GeneId","value":"ENSG00000230514.11"}]},{"database":"Ensembl","id":"ENST00000427822.6","properties":[{"key":"ProteinId","value":"ENSP00000416042.2"},{"key":"GeneId","value":"ENSG00000231268.9"}]},{"database":"Ensembl","id":"ENST00000432831.5","properties":[{"key":"ProteinId","value":"ENSP00000413391.1"},{"key":"GeneId","value":"ENSG00000237405.10"}],"isoformId":"Q15109-3"},{"database":"Ensembl","id":"ENST00000436456.6","properties":[{"key":"ProteinId","value":"ENSP00000397227.2"},{"key":"GeneId","value":"ENSG00000234729.9"}],"isoformId":"Q15109-1"},{"database":"Ensembl","id":"ENST00000438221.6","properties":[{"key":"ProteinId","value":"ENSP00000387887.2"},{"key":"GeneId","value":"ENSG00000204305.17"}],"isoformId":"Q15109-4"},{"database":"Ensembl","id":"ENST00000441180.6","properties":[{"key":"ProteinId","value":"ENSP00000388462.2"},{"key":"GeneId","value":"ENSG00000234729.9"}],"isoformId":"Q15109-2"},{"database":"Ensembl","id":"ENST00000441804.6","properties":[{"key":"ProteinId","value":"ENSP00000391743.2"},{"key":"GeneId","value":"ENSG00000237405.10"}],"isoformId":"Q15109-2"},{"database":"Ensembl","id":"ENST00000447921.6","properties":[{"key":"ProteinId","value":"ENSP00000395812.2"},{"key":"GeneId","value":"ENSG00000237405.10"}],"isoformId":"Q15109-1"},{"database":"Ensembl","id":"ENST00000449037.5","properties":[{"key":"ProteinId","value":"ENSP00000400667.1"},{"key":"GeneId","value":"ENSG00000229058.10"}],"isoformId":"Q15109-3"},{"database":"Ensembl","id":"ENST00000451115.6","properties":[{"key":"ProteinId","value":"ENSP00000401068.2"},{"key":"GeneId","value":"ENSG00000206320.12"}],"isoformId":"Q15109-1"},{"database":"Ensembl","id":"ENST00000453588.5","properties":[{"key":"ProteinId","value":"ENSP00000399686.1"},{"key":"GeneId","value":"ENSG00000234729.9"}],"isoformId":"Q15109-3"},{"database":"Ensembl","id":"ENST00000456918.6","properties":[{"key":"ProteinId","value":"ENSP00000409457.2"},{"key":"GeneId","value":"ENSG00000229058.10"}],"isoformId":"Q15109-1"},{"database":"Ensembl","id":"ENST00000547328.5","properties":[{"key":"ProteinId","value":"ENSP00000448579.2"},{"key":"GeneId","value":"ENSG00000206320.12"}],"isoformId":"Q15109-6"},{"database":"Ensembl","id":"ENST00000547651.2","properties":[{"key":"ProteinId","value":"ENSP00000449708.1"},{"key":"GeneId","value":"ENSG00000229058.10"}],"isoformId":"Q15109-4"},{"database":"Ensembl","id":"ENST00000548464.3","properties":[{"key":"ProteinId","value":"ENSP00000450134.2"},{"key":"GeneId","value":"ENSG00000234729.9"}],"isoformId":"Q15109-6"},{"database":"Ensembl","id":"ENST00000549758.5","properties":[{"key":"ProteinId","value":"ENSP00000447301.2"},{"key":"GeneId","value":"ENSG00000229058.10"}],"isoformId":"Q15109-6"},{"database":"Ensembl","id":"ENST00000550562.5","properties":[{"key":"ProteinId","value":"ENSP00000446835.1"},{"key":"GeneId","value":"ENSG00000234729.9"}],"isoformId":"Q15109-4"},{"database":"Ensembl","id":"ENST00000551254.5","properties":[{"key":"ProteinId","value":"ENSP00000449226.1"},{"key":"GeneId","value":"ENSG00000206320.12"}],"isoformId":"Q15109-4"},{"database":"Ensembl","id":"ENST00000551381.5","properties":[{"key":"ProteinId","value":"ENSP00000448979.2"},{"key":"GeneId","value":"ENSG00000237405.10"}],"isoformId":"Q15109-6"},{"database":"Ensembl","id":"ENST00000551827.4","properties":[{"key":"ProteinId","value":"ENSP00000449042.1"},{"key":"GeneId","value":"ENSG00000237405.10"}],"isoformId":"Q15109-4"},{"database":"Ensembl","id":"ENST00000851465.1","properties":[{"key":"ProteinId","value":"ENSP00000521524.1"},{"key":"GeneId","value":"ENSG00000204305.17"}],"isoformId":"Q15109-7"},{"database":"GeneID","id":"177","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:177","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000375076.9","properties":[{"key":"ProteinId","value":"ENSP00000364217.4"},{"key":"RefSeqNucleotideId","value":"NM_001136.5"},{"key":"RefSeqProteinId","value":"NP_001127.1"}]},{"database":"UCSC","id":"uc003oal.3","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q15109-1"},{"database":"AGR","id":"HGNC:320","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA24617","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"177","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"177","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"AGER","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:320","properties":[{"key":"GeneName","value":"AGER"}]},{"database":"HPA","id":"ENSG00000204305","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (lung)"}]},{"database":"MIM","id":"600214","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000204305","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000204305","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SQ8N","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00890000139566","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_051851_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VAMHPSH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q15109","properties":[{"key":"Number of GO annotations","value":"6 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-445989","properties":[{"key":"PathwayName","value":"TAK1-dependent IKK and NF-kappa-B activation"}]},{"database":"Reactome","id":"R-HSA-879415","properties":[{"key":"PathwayName","value":"Advanced glycosylation endproduct receptor signaling"}]},{"database":"Reactome","id":"R-HSA-933542","properties":[{"key":"PathwayName","value":"TRAF6 mediated NF-kB activation"}]},{"database":"SignaLink","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000204305","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"177","properties":[{"key":"hits","value":"12 hits in 1153 CRISPR screens"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"RAGE_(receptor)","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"177","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q15109","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:Q15109","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"RNAct","id":"Q15109","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000204305","properties":[{"key":"ExpressionPatterns","value":"Expressed in right lung and 95 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q15109","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016324","properties":[{"key":"GoTerm","value":"C:apical plasma membrane"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26005850"}]},{"database":"GO","id":"GO:0030054","properties":[{"key":"GoTerm","value":"C:cell junction"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35974093"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22509345"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36807739"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35974093"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0098794","properties":[{"key":"GoTerm","value":"C:postsynapse"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"26224839"}]},{"database":"GO","id":"GO:0050785","properties":[{"key":"GoTerm","value":"F:advanced glycation end-product receptor activity"},{"key":"GoEvidenceType","value":"NAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15457210"}]},{"database":"GO","id":"GO:0001540","properties":[{"key":"GoTerm","value":"F:amyloid-beta binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29518356"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35974093"}]},{"database":"GO","id":"GO:0042393","properties":[{"key":"GoTerm","value":"F:histone binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35974093"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"24119142"}]},{"database":"GO","id":"GO:0060090","properties":[{"key":"GoTerm","value":"F:molecular adaptor activity"},{"key":"GoEvidenceType","value":"EXP:DisProt"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22194616"}]},{"database":"GO","id":"GO:0044877","properties":[{"key":"GoTerm","value":"F:protein-containing complex binding"},{"key":"GoEvidenceType","value":"IPI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"29518356"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35974093"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15033494"}]},{"database":"GO","id":"GO:0005044","properties":[{"key":"GoTerm","value":"F:scavenger receptor activity"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"11240025"}]},{"database":"GO","id":"GO:0038023","properties":[{"key":"GoTerm","value":"F:signaling receptor activity"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15457210"}]},{"database":"GO","id":"GO:0004888","properties":[{"key":"GoTerm","value":"F:transmembrane signaling receptor activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1378843"}]},{"database":"GO","id":"GO:0048143","properties":[{"key":"GoTerm","value":"P:astrocyte activation"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"15457210"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10835680"}]},{"database":"GO","id":"GO:1904646","properties":[{"key":"GoTerm","value":"P:cellular response to amyloid-beta"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0010255","properties":[{"key":"GoTerm","value":"P:glucose mediated signaling pathway"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25689357"}]},{"database":"GO","id":"GO:0006954","properties":[{"key":"GoTerm","value":"P:inflammatory response"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10399917"}]},{"database":"GO","id":"GO:0035556","properties":[{"key":"GoTerm","value":"P:intracellular signal transduction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10391939"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"15457210"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"15457210"}]},{"database":"GO","id":"GO:1903523","properties":[{"key":"GoTerm","value":"P:negative regulation of blood circulation"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"12808450"}]},{"database":"GO","id":"GO:0032693","properties":[{"key":"GoTerm","value":"P:negative regulation of interleukin-10 production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22473704"}]},{"database":"GO","id":"GO:1900453","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic depression"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"20739563"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"15457210"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IGI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"10391939"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"35974093"}]},{"database":"GO","id":"GO:0042104","properties":[{"key":"GoTerm","value":"P:positive regulation of activated T cell proliferation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15944249"}]},{"database":"GO","id":"GO:1902993","properties":[{"key":"GoTerm","value":"P:positive regulation of amyloid precursor protein catabolic process"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"22406537"}]},{"database":"GO","id":"GO:0032722","properties":[{"key":"GoTerm","value":"P:positive regulation of chemokine production"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"22406537"}]},{"database":"GO","id":"GO:2001200","properties":[{"key":"GoTerm","value":"P:positive regulation of dendritic cell differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15944249"}]},{"database":"GO","id":"GO:2000105","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated DNA replication"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"36807739"}]},{"database":"GO","id":"GO:2000781","properties":[{"key":"GoTerm","value":"P:positive regulation of double-strand break repair"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1904472","properties":[{"key":"GoTerm","value":"P:positive regulation of endothelin production"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"12808450"}]},{"database":"GO","id":"GO:0070374","properties":[{"key":"GoTerm","value":"P:positive regulation of ERK1 and ERK2 cascade"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"15457210"}]},{"database":"GO","id":"GO:0034116","properties":[{"key":"GoTerm","value":"P:positive regulation of heterotypic cell-cell adhesion"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"11078691"}]},{"database":"GO","id":"GO:0032731","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-1 beta production"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"22406537"}]},{"database":"GO","id":"GO:0032735","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-12 production"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15944249"}]},{"database":"GO","id":"GO:0032755","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-6 production"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"22406537"}]},{"database":"GO","id":"GO:0046330","properties":[{"key":"GoTerm","value":"P:positive regulation of JNK cascade"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"20739563"}]},{"database":"GO","id":"GO:2000439","properties":[{"key":"GoTerm","value":"P:positive regulation of monocyte extravasation"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11078691"}]},{"database":"GO","id":"GO:1901224","properties":[{"key":"GoTerm","value":"P:positive regulation of non-canonical NF-kappaB signal transduction"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"15457210"}]},{"database":"GO","id":"GO:1900745","properties":[{"key":"GoTerm","value":"P:positive regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"20739563"}]},{"database":"GO","id":"GO:0032760","properties":[{"key":"GoTerm","value":"P:positive regulation of tumor necrosis factor production"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"22406537"}]},{"database":"GO","id":"GO:2000514","properties":[{"key":"GoTerm","value":"P:regulation of CD4-positive, alpha-beta T cell activation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22473704"}]},{"database":"GO","id":"GO:0050727","properties":[{"key":"GoTerm","value":"P:regulation of inflammatory response"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1900271","properties":[{"key":"GoTerm","value":"P:regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:1901222","properties":[{"key":"GoTerm","value":"P:regulation of non-canonical NF-kappaB signal transduction"},{"key":"GoEvidenceType","value":"NAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15457210"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0150003","properties":[{"key":"GoTerm","value":"P:regulation of spontaneous synaptic transmission"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"15457210"}]},{"database":"GO","id":"GO:0048167","properties":[{"key":"GoTerm","value":"P:regulation of synaptic plasticity"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"18367618"},{"evidenceCode":"ECO:0000304","source":"PubMed","id":"19221410"},{"evidenceCode":"ECO:0000304","source":"PubMed","id":"20739563"}]},{"database":"GO","id":"GO:0001914","properties":[{"key":"GoTerm","value":"P:regulation of T cell mediated cytotoxicity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22473704"}]},{"database":"GO","id":"GO:1904645","properties":[{"key":"GoTerm","value":"P:response to amyloid-beta"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0009611","properties":[{"key":"GoTerm","value":"P:response to wounding"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10399917"}]},{"database":"GO","id":"GO:0045056","properties":[{"key":"GoTerm","value":"P:transcytosis"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"12808450"},{"evidenceCode":"ECO:0000250","source":"PubMed","id":"22406537"}]},{"database":"GO","id":"GO:0150104","properties":[{"key":"GoTerm","value":"P:transport across blood-brain barrier"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23973487"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"2"}]},{"database":"DisProt","id":"DP02555","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP","length":404,"molWeight":42803,"crc64":"0D584C436C30CCE7","md5":"BBC6E8D1D523C4019EEDFB119E25E17E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":22,"SUBCELLULAR LOCATION":4,"ALTERNATIVE PRODUCTS":10,"TISSUE SPECIFICITY":1,"INDUCTION":1,"PTM":2,"MISCELLANEOUS":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":3,"Region":1,"Compositional bias":1,"Modified residue":1,"Glycosylation":2,"Disulfide bond":4,"Alternative sequence":11,"Natural variant":2,"Mutagenesis":2,"Sequence conflict":1,"Beta strand":33,"Helix":7,"Turn":5},"uniParcId":"UPI00001330EF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q5SSZ3","uniProtkbId":"Q5SSZ3_HUMAN","entryAudit":{"firstPublicDate":"2004-12-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-02-20","entryVersion":160,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398466.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398466.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014586900"},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398466.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"Q5SSZ3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"Q5SSZ3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398466.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398466.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398466.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398466.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL662884","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q5SSZ3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5SSZ3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"63891","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28483","properties":[{"key":"antibodies","value":"883 antibodies from 48 providers"}]},{"database":"Ensembl","id":"ENST00000415973.5","properties":[{"key":"ProteinId","value":"ENSP00000395578.1"},{"key":"GeneId","value":"ENSG00000206320.12"}]},{"database":"Ensembl","id":"ENST00000416532.5","properties":[{"key":"ProteinId","value":"ENSP00000412576.1"},{"key":"GeneId","value":"ENSG00000237405.10"}]},{"database":"Ensembl","id":"ENST00000444630.5","properties":[{"key":"ProteinId","value":"ENSP00000401896.1"},{"key":"GeneId","value":"ENSG00000229058.10"}]},{"database":"Ensembl","id":"ENST00000450110.5","properties":[{"key":"ProteinId","value":"ENSP00000398466.1"},{"key":"GeneId","value":"ENSG00000204305.17"}]},{"database":"Ensembl","id":"ENST00000455471.5","properties":[{"key":"ProteinId","value":"ENSP00000391024.1"},{"key":"GeneId","value":"ENSG00000234729.9"}]},{"database":"UCSC","id":"uc063npy.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:320","properties":[{"key":"GeneName","value":"AGER"}]},{"database":"OpenTargets","id":"ENSG00000204305","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000204305","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00890000139566","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000204305","properties":[{"key":"ExpressionPatterns","value":"Expressed in right lung and 95 other cell types or tissues"}]},{"database":"GO","id":"GO:0030054","properties":[{"key":"GoTerm","value":"C:cell junction"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0014002","properties":[{"key":"GoTerm","value":"P:astrocyte development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051054","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR013151","properties":[{"key":"EntryName","value":"Immunoglobulin_dom"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00047","properties":[{"key":"EntryName","value":"ig"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRSLRTFTITASDWIFPPSEIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALR","length":234,"molWeight":25177,"crc64":"9F9FA1CA1E2EBFE6","md5":"16F51035B87544B062720B014201EF61"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI0000E5AD2E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B5A982","uniProtkbId":"B5A982_HUMAN","entryAudit":{"firstPublicDate":"2008-09-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-09-23","entryVersion":112,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACF47656.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACF47656.1"}],"value":"RAGE"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACL80027.1"}],"value":"AGER"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014567711"},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"18593464","citationType":"journal article","authors":["Jin P.","Zhang J.","Sumariwalla P.F.","Ni I.","Jorgensen B.","Crawford D.","Phillips S.","Feldmann M.","Shepard H.M.","Paleolog E.M."],"citationCrossReferences":[{"database":"PubMed","id":"18593464"},{"database":"DOI","id":"10.1186/ar2447"}],"title":"Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.","publicationDate":"2008","journal":"Arthritis Res. Ther.","firstPage":"R73","lastPage":"R73","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACF47656.1"}]},{"referenceNumber":2,"citation":{"id":"CI-B8BDI1P9VLF3T","citationType":"submission","authors":["Rouhiainen A.","Kuja-Panula J.","Rauvala H."],"publicationDate":"DEC-2008","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACL80027.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EU826620","properties":[{"key":"ProteinId","value":"ACF47656.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"FJ545655","properties":[{"key":"ProteinId","value":"ACL80027.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"B5A982","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B5A982","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"5933","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28483","properties":[{"key":"antibodies","value":"883 antibodies from 48 providers"}]},{"database":"UCSC","id":"uc063nqa.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"OpenTargets","id":"ENSG00000204305","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000204305","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00890000139566","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2048864_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Bgee","id":"ENSG00000204305","properties":[{"key":"ExpressionPatterns","value":"Expressed in right lung and 95 other cell types or tissues"}]},{"database":"GO","id":"GO:0030054","properties":[{"key":"GoTerm","value":"C:cell junction"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0014002","properties":[{"key":"GoTerm","value":"P:astrocyte development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1901701","properties":[{"key":"GoTerm","value":"P:cellular response to oxygen-containing compound"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051054","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0040017","properties":[{"key":"GoTerm","value":"P:positive regulation of locomotion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13895","properties":[{"key":"EntryName","value":"Ig_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQFENLHNYSL","length":128,"molWeight":14017,"crc64":"687A511FB6879DE8","md5":"8530D1B40239E5FB5D69D14DB46CF954"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1},"uniParcId":"UPI00017A2FCA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9LVY5","uniProtkbId":"E9LVY5_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":68,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92535.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096755"}],"value":"Advanced glycosylation end product-specific receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076420"}],"value":"Receptor for advanced glycosylation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92535.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003243376"},{"type":"Transmembrane","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"15555779","citationType":"journal article","authors":["Ding Q.","Keller J.N."],"citationCrossReferences":[{"database":"PubMed","id":"15555779"},{"database":"DOI","id":"10.1016/j.neulet.2004.09.059"}],"title":"Splice variants of the receptor for advanced glycosylation end products (RAGE) in human brain.","publicationDate":"2005","journal":"Neurosci. Lett.","firstPage":"67","lastPage":"72","volume":"373"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92535.1"}],"value":"Hippocampus region of the brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92535.1"}]},{"referenceNumber":2,"citation":{"id":"CI-AVNLD8G3LG32T","citationType":"submission","authors":["Ding Q.","Keller J.N."],"publicationDate":"AUG-2010","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92535.1"}],"value":"Hippocampus region of the brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92535.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HQ148133","properties":[{"key":"ProteinId","value":"ADV92535.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"E9LVY5","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"E9LVY5","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0014002","properties":[{"key":"GoTerm","value":"P:astrocyte development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051054","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRAELNQSEEPEAGESSTGGP","length":388,"molWeight":40862,"crc64":"8EEC4C4880C7F907","md5":"C03076467A49F8862F207679477D7448"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":3},"uniParcId":"UPI000187ACD8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q101R2","uniProtkbId":"Q101R2_HUMAN","entryAudit":{"firstPublicDate":"2006-08-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-08-22","entryVersion":130,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAZ32415.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096755"}],"value":"Advanced glycosylation end product-specific receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076420"}],"value":"Receptor for advanced glycosylation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAZ32415.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAZ32415.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"18089847","citationType":"journal article","authors":["Hudson B.I.","Carter A.M.","Harja E.","Kalea A.Z.","Arriero M.","Yang H.","Grant P.J.","Schmidt A.M."],"citationCrossReferences":[{"database":"PubMed","id":"18089847"},{"database":"DOI","id":"10.1096/fj.07-9909com"}],"title":"Identification, classification, and expression of RAGE gene splice variants.","publicationDate":"2008","journal":"FASEB J.","firstPage":"1572","lastPage":"1580","volume":"22"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAZ32415.1"}]},{"referenceNumber":2,"citation":{"id":"19061941","citationType":"journal article","authors":["Sterenczak K.A.","Willenbrock S.","Barann M.","Klemke M.","Soller J.T.","Eberle N.","Nolte I.","Bullerdiek J.","Escobar H.M."],"citationCrossReferences":[{"database":"PubMed","id":"19061941"},{"database":"DOI","id":"10.1016/j.gene.2008.10.027"}],"title":"Cloning, characterisation, and comparative quantitative expression analyses of receptor for advanced glycation end products (RAGE) transcript forms.","publicationDate":"2009","journal":"Gene","firstPage":"35","lastPage":"42","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACE78168.1"}],"value":"Lipoma","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACE78168.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ104254","properties":[{"key":"ProteinId","value":"AAZ32415.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EU428812","properties":[{"key":"ProteinId","value":"ACE78168.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q101R2","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q101R2","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051240","properties":[{"key":"GoTerm","value":"P:positive regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006950","properties":[{"key":"GoTerm","value":"P:response to stress"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP","length":303,"molWeight":32147,"crc64":"4BC3BDAFFBB7253C","md5":"96B39ED4885E90A0E6389818CF68DC18"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI000000D71F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0G2JL65","uniProtkbId":"A0A0G2JL65_HUMAN","entryAudit":{"firstPublicDate":"2015-07-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-07-22","entryVersion":56,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000449731.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096755"}],"value":"Advanced glycosylation end product-specific receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076420"}],"value":"Receptor for advanced glycosylation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000449731.2"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014514165"},{"type":"Transmembrane","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A0G2JL65"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A0G2JL65"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000449731.2"}]}],"uniProtKBCrossReferences":[{"database":"AlphaFoldDB","id":"A0A0G2JL65","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A0G2JL65","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000549227.5","properties":[{"key":"ProteinId","value":"ENSP00000449731.2"},{"key":"GeneId","value":"ENSG00000230514.11"}]},{"database":"Ensembl","id":"ENST00000551244.4","properties":[{"key":"ProteinId","value":"ENSP00000446682.2"},{"key":"GeneId","value":"ENSG00000231268.9"}]},{"database":"HGNC","id":"HGNC:320","properties":[{"key":"GeneName","value":"AGER"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0014002","properties":[{"key":"GoTerm","value":"P:astrocyte development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051054","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNSSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVVEESRRSRKRPCEQEVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP","length":420,"molWeight":44803,"crc64":"E0261BB0758EDAB7","md5":"A674CB6BC9C6F005D37149E566DB8527"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":3,"Region":1,"Compositional bias":1},"uniParcId":"UPI0004E4CB89"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A8MS87","secondaryAccessions":["C0IP17"],"uniProtkbId":"A8MS87_HUMAN","entryAudit":{"firstPublicDate":"2007-12-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-06-28","entryVersion":141,"sequenceVersion":2},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACE78170.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096755"}],"value":"Advanced glycosylation end product-specific receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076420"}],"value":"Receptor for advanced glycosylation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACE78170.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACE78170.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"19061941","citationType":"journal article","authors":["Sterenczak K.A.","Willenbrock S.","Barann M.","Klemke M.","Soller J.T.","Eberle N.","Nolte I.","Bullerdiek J.","Escobar H.M."],"citationCrossReferences":[{"database":"PubMed","id":"19061941"},{"database":"DOI","id":"10.1016/j.gene.2008.10.027"}],"title":"Cloning, characterisation, and comparative quantitative expression analyses of receptor for advanced glycation end products (RAGE) transcript forms.","publicationDate":"2009","journal":"Gene","firstPage":"35","lastPage":"42","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACE78170.1"}],"value":"Breast adenocarcinoma","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACE78170.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EU428815","properties":[{"key":"ProteinId","value":"ACE78170.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A8MS87","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A8MS87","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"1961","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28483","properties":[{"key":"antibodies","value":"883 antibodies from 48 providers"}]},{"database":"UCSC","id":"uc063npv.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"OpenTargets","id":"ENSG00000204305","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000204305","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00890000139566","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_051851_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Bgee","id":"ENSG00000204305","properties":[{"key":"ExpressionPatterns","value":"Expressed in right lung and 95 other cell types or tissues"}]},{"database":"GO","id":"GO:0030054","properties":[{"key":"GoTerm","value":"C:cell junction"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051240","properties":[{"key":"GoTerm","value":"P:positive regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006950","properties":[{"key":"GoTerm","value":"P:response to stress"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP","length":294,"molWeight":31279,"crc64":"041D8BD9546876CF","md5":"E468325B56F8A4FFFBF22F0D3E1DAAEC"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI000195E629"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q5SSZ2","secondaryAccessions":["Q5JP26"],"uniProtkbId":"Q5SSZ2_HUMAN","entryAudit":{"firstPublicDate":"2004-12-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-02-20","entryVersion":163,"sequenceVersion":2},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000364196.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000364196.2"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014586931"},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000364196.2"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"Q5SSZ2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"Q5SSZ2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000364196.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000364196.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000364196.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000364196.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL662884","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q5SSZ2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5SSZ2","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"63890","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28483","properties":[{"key":"antibodies","value":"883 antibodies from 48 providers"}]},{"database":"Ensembl","id":"ENST00000375056.6","properties":[{"key":"ProteinId","value":"ENSP00000364196.2"},{"key":"GeneId","value":"ENSG00000204305.17"}]},{"database":"Ensembl","id":"ENST00000424476.5","properties":[{"key":"ProteinId","value":"ENSP00000394516.1"},{"key":"GeneId","value":"ENSG00000229058.10"}]},{"database":"Ensembl","id":"ENST00000434502.5","properties":[{"key":"ProteinId","value":"ENSP00000399134.1"},{"key":"GeneId","value":"ENSG00000234729.9"}]},{"database":"Ensembl","id":"ENST00000441753.5","properties":[{"key":"ProteinId","value":"ENSP00000410918.1"},{"key":"GeneId","value":"ENSG00000237405.10"}]},{"database":"Ensembl","id":"ENST00000453119.5","properties":[{"key":"ProteinId","value":"ENSP00000411203.1"},{"key":"GeneId","value":"ENSG00000206320.12"}]},{"database":"UCSC","id":"uc063npz.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:320","properties":[{"key":"GeneName","value":"AGER"}]},{"database":"OpenTargets","id":"ENSG00000204305","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000204305","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00890000139566","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_051851_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000204305","properties":[{"key":"ExpressionPatterns","value":"Expressed in right lung and 95 other cell types or tissues"}]},{"database":"GO","id":"GO:0030054","properties":[{"key":"GoTerm","value":"C:cell junction"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0014002","properties":[{"key":"GoTerm","value":"P:astrocyte development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1901701","properties":[{"key":"GoTerm","value":"P:cellular response to oxygen-containing compound"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051054","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0040017","properties":[{"key":"GoTerm","value":"P:positive regulation of locomotion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13895","properties":[{"key":"EntryName","value":"Ig_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVVEESRRSRKRPCEQEVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRH","length":233,"molWeight":25246,"crc64":"4EF67B067BB5C582","md5":"89DE85AFDDAE3F57D6FEEAF64062220F"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI0000E5AD2F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0G2JJF5","uniProtkbId":"A0A0G2JJF5_HUMAN","entryAudit":{"firstPublicDate":"2015-07-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-07-22","entryVersion":55,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407467.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096755"}],"value":"Advanced glycosylation end product-specific receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076420"}],"value":"Receptor for advanced glycosylation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407467.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014514150"},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A0G2JJF5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A0G2JJF5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407467.1"}]}],"uniProtKBCrossReferences":[{"database":"AlphaFoldDB","id":"A0A0G2JJF5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A0G2JJF5","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000426320.5","properties":[{"key":"ProteinId","value":"ENSP00000407467.1"},{"key":"GeneId","value":"ENSG00000231268.9"}]},{"database":"Ensembl","id":"ENST00000452945.5","properties":[{"key":"ProteinId","value":"ENSP00000403322.1"},{"key":"GeneId","value":"ENSG00000230514.11"}]},{"database":"HGNC","id":"HGNC:320","properties":[{"key":"GeneName","value":"AGER"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0014002","properties":[{"key":"GoTerm","value":"P:astrocyte development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051054","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNSSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGEGFDKVREAEDSPQHM","length":347,"molWeight":37080,"crc64":"519A32284D6158EC","md5":"E0D2B4C8544C5855643A8CB317E22BA3"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":1,"Compositional bias":1},"uniParcId":"UPI000165DC8A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0G2JL37","uniProtkbId":"A0A0G2JL37_HUMAN","entryAudit":{"firstPublicDate":"2015-07-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-07-22","entryVersion":55,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000449040.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096755"}],"value":"Advanced glycosylation end product-specific receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076420"}],"value":"Receptor for advanced glycosylation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000449040.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014514156"},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A0G2JL37"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A0G2JL37"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000449040.1"}]}],"uniProtKBCrossReferences":[{"database":"AlphaFoldDB","id":"A0A0G2JL37","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A0G2JL37","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000551378.4","properties":[{"key":"ProteinId","value":"ENSP00000449040.1"},{"key":"GeneId","value":"ENSG00000231268.9"}]},{"database":"Ensembl","id":"ENST00000552891.5","properties":[{"key":"ProteinId","value":"ENSP00000446660.1"},{"key":"GeneId","value":"ENSG00000230514.11"}]},{"database":"HGNC","id":"HGNC:320","properties":[{"key":"GeneName","value":"AGER"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0014002","properties":[{"key":"GoTerm","value":"P:astrocyte development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051054","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNSSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVVEESRRSRKRPCEQEVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGEGFDKVREAEDSPQHM","length":363,"molWeight":39050,"crc64":"36C93FA1BDFB557F","md5":"46A21ADD8EA353AFB69050E11EDD6E46"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":1,"Compositional bias":1},"uniParcId":"UPI000215117A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q101R3","uniProtkbId":"Q101R3_HUMAN","entryAudit":{"firstPublicDate":"2006-08-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-08-22","entryVersion":94,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAZ32414.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAZ32414.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5004179696"},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAZ32414.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"18089847","citationType":"journal article","authors":["Hudson B.I.","Carter A.M.","Harja E.","Kalea A.Z.","Arriero M.","Yang H.","Grant P.J.","Schmidt A.M."],"citationCrossReferences":[{"database":"PubMed","id":"18089847"},{"database":"DOI","id":"10.1096/fj.07-9909com"}],"title":"Identification, classification, and expression of RAGE gene splice variants.","publicationDate":"2008","journal":"FASEB J.","firstPage":"1572","lastPage":"1580","volume":"22"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAZ32414.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ104253","properties":[{"key":"ProteinId","value":"AAZ32414.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"XP_047274217.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047418261.1"}]},{"database":"RefSeq","id":"XP_054185718.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054329743.1"}]},{"database":"RefSeq","id":"XP_054186506.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054330531.1"}]},{"database":"RefSeq","id":"XP_054186989.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054331014.1"}]},{"database":"RefSeq","id":"XP_054187255.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054331280.1"}]},{"database":"RefSeq","id":"XP_054210390.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054354415.1"}]},{"database":"AlphaFoldDB","id":"Q101R3","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q101R3","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"177","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"177","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0014002","properties":[{"key":"GoTerm","value":"P:astrocyte development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051054","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDNQARRGQLQALWEDQGWEL","length":293,"molWeight":31720,"crc64":"E4D317F1684D33A5","md5":"A172507D1E5738F2CE8A86807A9DE2CE"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3},"uniParcId":"UPI0000DA735E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"C0IP16","uniProtkbId":"C0IP16_HUMAN","entryAudit":{"firstPublicDate":"2009-05-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-05-05","entryVersion":70,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACE78169.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096755"}],"value":"Advanced glycosylation end product-specific receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076420"}],"value":"Receptor for advanced glycosylation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACE78169.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACE78169.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"19061941","citationType":"journal article","authors":["Sterenczak K.A.","Willenbrock S.","Barann M.","Klemke M.","Soller J.T.","Eberle N.","Nolte I.","Bullerdiek J.","Escobar H.M."],"citationCrossReferences":[{"database":"PubMed","id":"19061941"},{"database":"DOI","id":"10.1016/j.gene.2008.10.027"}],"title":"Cloning, characterisation, and comparative quantitative expression analyses of receptor for advanced glycation end products (RAGE) transcript forms.","publicationDate":"2009","journal":"Gene","firstPage":"35","lastPage":"42","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACE78169.1"}],"value":"Lipoma","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACE78169.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EU428813","properties":[{"key":"ProteinId","value":"ACE78169.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"C0IP16","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051240","properties":[{"key":"GoTerm","value":"P:positive regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006950","properties":[{"key":"GoTerm","value":"P:response to stress"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGRPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSRGPQESRAVSISIIGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP","length":294,"molWeight":31326,"crc64":"23B720E3E7D5A9A2","md5":"28D7F3972F0924B5F116130FD371D55A"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI000195E628"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q101R5","uniProtkbId":"Q101R5_HUMAN","entryAudit":{"firstPublicDate":"2006-08-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-08-22","entryVersion":92,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAZ32412.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAZ32412.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5004179600"},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAZ32412.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"18089847","citationType":"journal article","authors":["Hudson B.I.","Carter A.M.","Harja E.","Kalea A.Z.","Arriero M.","Yang H.","Grant P.J.","Schmidt A.M."],"citationCrossReferences":[{"database":"PubMed","id":"18089847"},{"database":"DOI","id":"10.1096/fj.07-9909com"}],"title":"Identification, classification, and expression of RAGE gene splice variants.","publicationDate":"2008","journal":"FASEB J.","firstPage":"1572","lastPage":"1580","volume":"22"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAZ32412.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ104251","properties":[{"key":"ProteinId","value":"AAZ32412.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q101R5","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q101R5","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0014002","properties":[{"key":"GoTerm","value":"P:astrocyte development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051054","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGLRTREPTAVWPPIPATGPRKAVLSASASSNQARRGQLQALWEDQGWEL","length":323,"molWeight":34777,"crc64":"6779B45FE7B50025","md5":"5F8D65B44E7EB0D404467FFE171BBA1D"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3},"uniParcId":"UPI0000DA735D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F1ABN5","uniProtkbId":"F1ABN5_HUMAN","entryAudit":{"firstPublicDate":"2011-05-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-05-03","entryVersion":52,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42262.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42262.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003263265"},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42262.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"24273313","citationType":"journal article","authors":["Lopez-Diez R.","Rastrojo A.","Villate O.","Aguado B."],"citationCrossReferences":[{"database":"PubMed","id":"24273313"},{"database":"DOI","id":"10.1093/gbe/evt188"}],"title":"Complex Tissue-Specific Patterns and Distribution of Multiple RAGE Splice Variants in Different Mammals.","publicationDate":"2013","journal":"Genome Biol. Evol.","firstPage":"2420","lastPage":"2435","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42262.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GU139378","properties":[{"key":"ProteinId","value":"ADQ42262.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"F1ABN5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"F1ABN5","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"F1ABN5","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0014002","properties":[{"key":"GoTerm","value":"P:astrocyte development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051054","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13895","properties":[{"key":"EntryName","value":"Ig_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWGEHRWGGPQAHVSTFWKSDP","length":250,"molWeight":27083,"crc64":"EDAEEDD799DFF269","md5":"F29D8D95C43972723CBFC658934A6CE2"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2},"uniParcId":"UPI0001FF491A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F1ABN1","uniProtkbId":"F1ABN1_HUMAN","entryAudit":{"firstPublicDate":"2011-05-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-05-03","entryVersion":61,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42258.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096755"}],"value":"Advanced glycosylation end product-specific receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076420"}],"value":"Receptor for advanced glycosylation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42258.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42258.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"24273313","citationType":"journal article","authors":["Lopez-Diez R.","Rastrojo A.","Villate O.","Aguado B."],"citationCrossReferences":[{"database":"PubMed","id":"24273313"},{"database":"DOI","id":"10.1093/gbe/evt188"}],"title":"Complex Tissue-Specific Patterns and Distribution of Multiple RAGE Splice Variants in Different Mammals.","publicationDate":"2013","journal":"Genome Biol. Evol.","firstPage":"2420","lastPage":"2435","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42258.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GU139374","properties":[{"key":"ProteinId","value":"ADQ42258.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"F1ABN1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"F1ABN1","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"F1ABN1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051240","properties":[{"key":"GoTerm","value":"P:positive regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006950","properties":[{"key":"GoTerm","value":"P:response to stress"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGVVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGEGFDKVREAEDSPQHM","length":246,"molWeight":26423,"crc64":"2B6047BF8FC28695","md5":"83C598AEFE6746D79D9A1E2934CD5C63"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Domain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI0001FF4916"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0G2JKB6","uniProtkbId":"A0A0G2JKB6_HUMAN","entryAudit":{"firstPublicDate":"2015-07-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-07-22","entryVersion":55,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000415780.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000415780.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014514134"},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000415780.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A0G2JKB6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A0G2JKB6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000415780.1"}]}],"uniProtKBCrossReferences":[{"database":"AlphaFoldDB","id":"A0A0G2JKB6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A0G2JKB6","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000436653.5","properties":[{"key":"ProteinId","value":"ENSP00000388041.1"},{"key":"GeneId","value":"ENSG00000230514.11"}]},{"database":"Ensembl","id":"ENST00000454284.5","properties":[{"key":"ProteinId","value":"ENSP00000415780.1"},{"key":"GeneId","value":"ENSG00000231268.9"}]},{"database":"HGNC","id":"HGNC:320","properties":[{"key":"GeneName","value":"AGER"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051240","properties":[{"key":"GoTerm","value":"P:positive regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006950","properties":[{"key":"GoTerm","value":"P:response to stress"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR013151","properties":[{"key":"EntryName","value":"Immunoglobulin_dom"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00047","properties":[{"key":"EntryName","value":"ig"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNSSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRSLRTFTITASDWIFPPSEIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALR","length":234,"molWeight":25207,"crc64":"E703214B4A2EAAA7","md5":"2CC1DBB9932671B37D8FA76BBFF1373E"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI000165DC8C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9LVY6","uniProtkbId":"E9LVY6_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":73,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92536.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92536.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003241891"},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"15555779","citationType":"journal article","authors":["Ding Q.","Keller J.N."],"citationCrossReferences":[{"database":"PubMed","id":"15555779"},{"database":"DOI","id":"10.1016/j.neulet.2004.09.059"}],"title":"Splice variants of the receptor for advanced glycosylation end products (RAGE) in human brain.","publicationDate":"2005","journal":"Neurosci. Lett.","firstPage":"67","lastPage":"72","volume":"373"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92536.1"}],"value":"Hippocampus region of the brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92536.1"}]},{"referenceNumber":2,"citation":{"id":"CI-AVNLD8G3LG32T","citationType":"submission","authors":["Ding Q.","Keller J.N."],"publicationDate":"AUG-2010","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92536.1"}],"value":"Hippocampus region of the brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92536.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HQ148134","properties":[{"key":"ProteinId","value":"ADV92536.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"E9LVY6","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"E9LVY6","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0014002","properties":[{"key":"GoTerm","value":"P:astrocyte development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1901701","properties":[{"key":"GoTerm","value":"P:cellular response to oxygen-containing compound"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051054","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0040017","properties":[{"key":"GoTerm","value":"P:positive regulation of locomotion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGEGFDKVREAEDSPQHM","length":335,"molWeight":35755,"crc64":"2C1792A3BE11940D","md5":"1CF1EBEA3EAEFB0E32755CCF8DB41652"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":1,"Compositional bias":1},"uniParcId":"UPI000187AD48"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0G2JID9","uniProtkbId":"A0A0G2JID9_HUMAN","entryAudit":{"firstPublicDate":"2015-07-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-07-22","entryVersion":53,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000397777.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000397777.2"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014514159"},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A0G2JID9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A0G2JID9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000397777.2"}]}],"uniProtKBCrossReferences":[{"database":"AlphaFoldDB","id":"A0A0G2JID9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A0G2JID9","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000424145.6","properties":[{"key":"ProteinId","value":"ENSP00000391970.2"},{"key":"GeneId","value":"ENSG00000231268.9"}]},{"database":"Ensembl","id":"ENST00000448768.6","properties":[{"key":"ProteinId","value":"ENSP00000397777.2"},{"key":"GeneId","value":"ENSG00000230514.11"}]},{"database":"HGNC","id":"HGNC:320","properties":[{"key":"GeneName","value":"AGER"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051240","properties":[{"key":"GoTerm","value":"P:positive regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006950","properties":[{"key":"GoTerm","value":"P:response to stress"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13895","properties":[{"key":"EntryName","value":"Ig_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLGGGPWDSVARVLPNSSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDVSDLERGAGRTRRGGANCRLCGRIRAGNSSPGPGDPGRPGDSRPAHWGHLVAKAATPRRGEEGPRKPGGRGGACRTESVGGT","length":342,"molWeight":36223,"crc64":"F01DF0AD122394A3","md5":"D7A9B54E652E06E3D453074B95A0EB3A"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":1},"uniParcId":"UPI000165DC89"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0G2JJW2","uniProtkbId":"A0A0G2JJW2_HUMAN","entryAudit":{"firstPublicDate":"2015-07-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-07-22","entryVersion":55,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411652.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411652.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014514131"},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411652.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A0G2JJW2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A0G2JJW2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411652.1"}]}],"uniProtKBCrossReferences":[{"database":"AlphaFoldDB","id":"A0A0G2JJW2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A0G2JJW2","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000412794.5","properties":[{"key":"ProteinId","value":"ENSP00000397350.1"},{"key":"GeneId","value":"ENSG00000230514.11"}]},{"database":"Ensembl","id":"ENST00000418313.5","properties":[{"key":"ProteinId","value":"ENSP00000411652.1"},{"key":"GeneId","value":"ENSG00000231268.9"}]},{"database":"HGNC","id":"HGNC:320","properties":[{"key":"GeneName","value":"AGER"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0014002","properties":[{"key":"GoTerm","value":"P:astrocyte development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1901701","properties":[{"key":"GoTerm","value":"P:cellular response to oxygen-containing compound"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051054","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0040017","properties":[{"key":"GoTerm","value":"P:positive regulation of locomotion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13895","properties":[{"key":"EntryName","value":"Ig_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNSSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVVEESRRSRKRPCEQEVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRH","length":233,"molWeight":25276,"crc64":"8276FA527BA084D9","md5":"8258502191623A482E7CC126DBA3B3A2"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI000165DC8B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F1ABN0","uniProtkbId":"F1ABN0_HUMAN","entryAudit":{"firstPublicDate":"2011-05-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-05-03","entryVersion":56,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42257.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096755"}],"value":"Advanced glycosylation end product-specific receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076420"}],"value":"Receptor for advanced glycosylation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42257.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42257.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"24273313","citationType":"journal article","authors":["Lopez-Diez R.","Rastrojo A.","Villate O.","Aguado B."],"citationCrossReferences":[{"database":"PubMed","id":"24273313"},{"database":"DOI","id":"10.1093/gbe/evt188"}],"title":"Complex Tissue-Specific Patterns and Distribution of Multiple RAGE Splice Variants in Different Mammals.","publicationDate":"2013","journal":"Genome Biol. Evol.","firstPage":"2420","lastPage":"2435","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42257.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GU139373","properties":[{"key":"ProteinId","value":"ADQ42257.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"F1ABN0","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"F1ABN0","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051240","properties":[{"key":"GoTerm","value":"P:positive regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006950","properties":[{"key":"GoTerm","value":"P:response to stress"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MERRPSPTTESVSTSLRTFTITASDWIFPPSEIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGEGFDKVREAEDSPQHM","length":260,"molWeight":27779,"crc64":"5012ED863493613A","md5":"073F55D64075BC22503872EF02B0949A"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Domain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI0001FF4915"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F1ABN2","uniProtkbId":"F1ABN2_HUMAN","entryAudit":{"firstPublicDate":"2011-05-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-05-03","entryVersion":54,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42259.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096755"}],"value":"Advanced glycosylation end product-specific receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076420"}],"value":"Receptor for advanced glycosylation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42259.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42259.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"24273313","citationType":"journal article","authors":["Lopez-Diez R.","Rastrojo A.","Villate O.","Aguado B."],"citationCrossReferences":[{"database":"PubMed","id":"24273313"},{"database":"DOI","id":"10.1093/gbe/evt188"}],"title":"Complex Tissue-Specific Patterns and Distribution of Multiple RAGE Splice Variants in Different Mammals.","publicationDate":"2013","journal":"Genome Biol. Evol.","firstPage":"2420","lastPage":"2435","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42259.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GU139375","properties":[{"key":"ProteinId","value":"ADQ42259.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"F1ABN2","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"F1ABN2","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051240","properties":[{"key":"GoTerm","value":"P:positive regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006950","properties":[{"key":"GoTerm","value":"P:response to stress"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MERRPSPTTESVSTSLRTFTITASDWIFPPSEIPGKPEIVDSASELTAGVPHKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGEGFDKVREAEDSPQHM","length":260,"molWeight":27802,"crc64":"F2CB721B104AFC1E","md5":"468D6EAF985CEC00444FAE0F2067B6E7"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Domain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI0001FF4917"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F1ABN4","uniProtkbId":"F1ABN4_HUMAN","entryAudit":{"firstPublicDate":"2011-05-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-05-03","entryVersion":69,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42261.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096755"}],"value":"Advanced glycosylation end product-specific receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076420"}],"value":"Receptor for advanced glycosylation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42261.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42261.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"24273313","citationType":"journal article","authors":["Lopez-Diez R.","Rastrojo A.","Villate O.","Aguado B."],"citationCrossReferences":[{"database":"PubMed","id":"24273313"},{"database":"DOI","id":"10.1093/gbe/evt188"}],"title":"Complex Tissue-Specific Patterns and Distribution of Multiple RAGE Splice Variants in Different Mammals.","publicationDate":"2013","journal":"Genome Biol. Evol.","firstPage":"2420","lastPage":"2435","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADQ42261.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GU139377","properties":[{"key":"ProteinId","value":"ADQ42261.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"F1ABN4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"F1ABN4","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"F1ABN4","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051240","properties":[{"key":"GoTerm","value":"P:positive regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006950","properties":[{"key":"GoTerm","value":"P:response to stress"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGEGFDKVREAEDSPQHM","length":246,"molWeight":26395,"crc64":"23D17CA171CC667B","md5":"E6D1E38C5EAF9F437AEA4D050AB73FA7"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Domain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI0001FF4919"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0G2JL23","uniProtkbId":"A0A0G2JL23_HUMAN","entryAudit":{"firstPublicDate":"2015-07-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-07-22","entryVersion":45,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000448525.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000448525.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014514137"},{"type":"Domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A0G2JL23"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A0G2JL23"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000448525.1"}]}],"uniProtKBCrossReferences":[{"database":"AlphaFoldDB","id":"A0A0G2JL23","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A0G2JL23","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000548009.4","properties":[{"key":"ProteinId","value":"ENSP00000449997.1"},{"key":"GeneId","value":"ENSG00000230514.11"}]},{"database":"Ensembl","id":"ENST00000548935.4","properties":[{"key":"ProteinId","value":"ENSP00000448525.1"},{"key":"GeneId","value":"ENSG00000231268.9"}]},{"database":"HGNC","id":"HGNC:320","properties":[{"key":"GeneName","value":"AGER"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0014002","properties":[{"key":"GoTerm","value":"P:astrocyte development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1901701","properties":[{"key":"GoTerm","value":"P:cellular response to oxygen-containing compound"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001774","properties":[{"key":"GoTerm","value":"P:microglial cell activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051241","properties":[{"key":"GoTerm","value":"P:negative regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006909","properties":[{"key":"GoTerm","value":"P:phagocytosis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001819","properties":[{"key":"GoTerm","value":"P:positive regulation of cytokine production"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051054","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0040017","properties":[{"key":"GoTerm","value":"P:positive regulation of locomotion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1900744","properties":[{"key":"GoTerm","value":"P:regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13895","properties":[{"key":"EntryName","value":"Ig_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNSSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQFENLHNYSL","length":128,"molWeight":14047,"crc64":"030C911FB6878DB9","md5":"C274588A73CF317B0B198CAAB2652F57"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1},"uniParcId":"UPI000215117C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9LVY7","uniProtkbId":"E9LVY7_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":40,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92537.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92537.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"15555779","citationType":"journal article","authors":["Ding Q.","Keller J.N."],"citationCrossReferences":[{"database":"PubMed","id":"15555779"},{"database":"DOI","id":"10.1016/j.neulet.2004.09.059"}],"title":"Splice variants of the receptor for advanced glycosylation end products (RAGE) in human brain.","publicationDate":"2005","journal":"Neurosci. Lett.","firstPage":"67","lastPage":"72","volume":"373"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92537.1"}],"value":"Hippocampus region of the brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92537.1"}]},{"referenceNumber":2,"citation":{"id":"CI-AVNLD8G3LG32T","citationType":"submission","authors":["Ding Q.","Keller J.N."],"publicationDate":"AUG-2010","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92537.1"}],"value":"Hippocampus region of the brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV92537.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HQ148135","properties":[{"key":"ProteinId","value":"ADV92537.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"E9LVY7","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"E9LVY7","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10055806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AGER","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001891","properties":[{"key":"GoTerm","value":"C:phagocytic cup"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031175","properties":[{"key":"GoTerm","value":"P:neuron projection development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051240","properties":[{"key":"GoTerm","value":"P:positive regulation of multicellular organismal process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006950","properties":[{"key":"GoTerm","value":"P:response to stress"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWGEHRWGGPQAHVSTFWKSDP","length":149,"molWeight":16428,"crc64":"89D0BAA9C08A8693","md5":"B8C145AE866F759678F036A63F94B725"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI000187AD49"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8Q1W6","uniProtkbId":"A0ACI8Q1W6_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000521522.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096647"}],"value":"Advanced glycation end product-specific receptor"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096755"}],"value":"Advanced glycosylation end product-specific receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096803"}],"value":"Receptor for advanced glycation end products"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076420"}],"value":"Receptor for advanced glycosylation end products"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000521522.1"}],"value":"AGER"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004231"}],"value":"Cell projection, phagocytic cup","id":"SL-0473"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004412"}],"value":"Early endosome","id":"SL-0094"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"Advanced glycation end product-specific receptor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051338096"},{"type":"Transmembrane","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023198"}],"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022907"}],"id":"KW-0581","category":"Biological process","name":"Phagocytosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8Q1W6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8Q1W6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000521522.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000521522.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000521522.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000521522.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL662884","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000851463.1","properties":[{"key":"ProteinId","value":"ENSP00000521522.1"},{"key":"GeneId","value":"ENSG00000204305.17"}]},{"database":"HGNC","id":"HGNC:320","properties":[{"key":"GeneName","value":"AGER"}]},{"database":"OpenTargets","id":"ENSG00000204305","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00890000139566","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"CDD","id":"cd00096","properties":[{"key":"EntryName","value":"Ig"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.10:FF:000649","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000969","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:001470","properties":[{"key":"EntryName","value":"Advanced glycosylation end product-specific receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR013162","properties":[{"key":"EntryName","value":"CD80_C2-set"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR051116","properties":[{"key":"EntryName","value":"Surface_Rcpt/Adhesion_Mol"}]},{"database":"PANTHER","id":"PTHR11973:SF20","properties":[{"key":"EntryName","value":"ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11973","properties":[{"key":"EntryName","value":"CELL SURFACE GLYCOPROTEIN MUC18-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08205","properties":[{"key":"EntryName","value":"C2-set_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAGTAVGAWVLVLSLWVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP","length":402,"molWeight":42675,"crc64":"ABCD11622242C2FB","md5":"329700B9764E42C8D3FF8D8C1D236932"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":3,"Region":1,"Compositional bias":1},"uniParcId":"UPI0040323C22"}}]}