{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P02771","secondaryAccessions":["B2RBU3"],"uniProtkbId":"FETA_HUMAN","entryAudit":{"firstPublicDate":"1986-07-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1986-07-21","entryVersion":230,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Alpha-fetoprotein"}},"alternativeNames":[{"fullName":{"value":"Alpha-1-fetoprotein"}},{"fullName":{"value":"Alpha-fetoglobulin"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"AFP"},"synonyms":[{"value":"HPAFP"}]}],"comments":[{"texts":[{"value":"Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties"}],"commentType":"FUNCTION"},{"texts":[{"value":"Dimeric and trimeric forms have been found in addition to the monomeric form"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P02771","intActId":"EBI-722498"},"interactantTwo":{"uniProtKBAccession":"P51654","geneName":"GPC3","intActId":"EBI-5654198"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P02771","intActId":"EBI-722498"},"interactantTwo":{"uniProtKBAccession":"Q99IB8","chainId":"PRO_0000045596","intActId":"EBI-6901449"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"value":"Plasma. Synthesized by the fetal liver and yolk sac"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP also occurs at high levels in the plasma and ascitic fluid of adults with hepatoma"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"value":"Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2414772"}],"value":"Sulfated"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Alpha-fetoprotein deficiency","diseaseAccession":"DI-04204","acronym":"AFPD","description":"A benign condition characterized by undetectable AFP levels in the amniotic fluid. Affected individuals are asymptomatic and present normal development.","diseaseCrossReference":{"database":"MIM","id":"615969"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15280901"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18854864"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Alpha-fetoprotein, hereditary persistence","diseaseAccession":"DI-04205","acronym":"HPAFP","description":"A benign autosomal dominant condition characterized by continued expression of alpha-fetoprotein in adult life.","diseaseCrossReference":{"database":"MIM","id":"615970"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7684942"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00769"}],"value":"Belongs to the ALB/AFP/VDB family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Alpha-fetoprotein","ftp":false,"note":"Alpha-fetoprotein entry"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/44248/AFP","ftp":false}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1709810"}]},{"type":"Chain","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"Alpha-fetoprotein","featureId":"PRO_0000001097"},{"type":"Domain","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Albumin 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00769"}]},{"type":"Domain","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"Albumin 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00769"}]},{"type":"Domain","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"Albumin 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00769"}]},{"type":"Binding site","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29036"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"80265"}],"ligand":{"name":"Cu(2+)","id":"ChEBI:CHEBI:29036"}},{"type":"Modified residue","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":444,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":445,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Glycosylation","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000070"},{"type":"Disulfide bond","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":461,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":501,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":500,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":538,"modifier":"EXACT"},"end":{"value":583,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":591,"modifier":"EXACT"}},"description":""},{"type":"Natural variant","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"in dbSNP:rs35765619","featureCrossReferences":[{"database":"dbSNP","id":"rs35765619"}],"featureId":"VAR_033928","alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":570,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"in dbSNP:rs7790","featureCrossReferences":[{"database":"dbSNP","id":"rs7790"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"}],"featureId":"VAR_012049","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Helix","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8X1N"}]},{"type":"Helix","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Beta strand","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Turn","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Turn","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8X1N"}]},{"type":"Helix","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8X1N"}]},{"type":"Beta strand","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Beta strand","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":398,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Turn","location":{"start":{"value":399,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":438,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":444,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Beta strand","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":464,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":468,"modifier":"EXACT"},"end":{"value":490,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":502,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":508,"modifier":"EXACT"},"end":{"value":513,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":526,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8X1N"}]},{"type":"Helix","location":{"start":{"value":528,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Turn","location":{"start":{"value":535,"modifier":"EXACT"},"end":{"value":539,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":543,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":566,"modifier":"EXACT"},"end":{"value":581,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Beta strand","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":587,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":588,"modifier":"EXACT"},"end":{"value":591,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":592,"modifier":"EXACT"},"end":{"value":596,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]},{"type":"Helix","location":{"start":{"value":597,"modifier":"EXACT"},"end":{"value":607,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YIM"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0186","category":"Ligand","name":"Copper"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0533","category":"Ligand","name":"Nickel"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0765","category":"PTM","name":"Sulfation"}],"references":[{"referenceNumber":1,"citation":{"id":"6192439","citationType":"journal article","authors":["Morinaga T.","Sakai M.","Wegmann T.G.","Tamaoki T."],"citationCrossReferences":[{"database":"PubMed","id":"6192439"},{"database":"DOI","id":"10.1073/pnas.80.15.4604"}],"title":"Primary structures of human alpha-fetoprotein and its mRNA.","publicationDate":"1983","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"4604","lastPage":"4608","volume":"80"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"2436661","citationType":"journal article","authors":["Gibbs P.E.M.","Zielinski R.","Boyd C.","Dugaiczyk A."],"citationCrossReferences":[{"database":"PubMed","id":"2436661"},{"database":"DOI","id":"10.1021/bi00379a020"}],"title":"Structure, polymorphism, and novel repeated DNA elements revealed by a complete sequence of the human alpha-fetoprotein gene.","publicationDate":"1987","journal":"Biochemistry","firstPage":"1332","lastPage":"1343","volume":"26"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANT GLY-570"],"referenceComments":[{"value":"Heart","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"2580830","citationType":"journal article","authors":["Sakai M.","Morinaga T.","Urano Y.","Watanabe K.","Wegmann T.G.","Tamaoki T."],"citationCrossReferences":[{"database":"PubMed","id":"2580830"},{"database":"DOI","id":"10.1016/s0021-9258(18)89178-5"}],"title":"The human alpha-fetoprotein gene. Sequence organization and the 5' flanking region.","publicationDate":"1985","journal":"J. Biol. Chem.","firstPage":"5055","lastPage":"5060","volume":"260"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28 AND 596-609","GENE STRUCTURE"]},{"referenceNumber":6,"citation":{"id":"7684942","citationType":"journal article","authors":["McVey J.H.","Michaelides K.","Hansen L.P.","Ferguson-Smith M.","Tilghman S.","Krumlauf R.","Tuddenham E.G.D."],"citationCrossReferences":[{"database":"PubMed","id":"7684942"},{"database":"DOI","id":"10.1093/hmg/2.4.379"}],"title":"A G-->A substitution in an HNF I binding site in the human alpha-fetoprotein gene is associated with hereditary persistence of alpha-fetoprotein (HPAFP).","publicationDate":"1993","journal":"Hum. Mol. Genet.","firstPage":"379","lastPage":"384","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28","INVOLVEMENT IN HPAFP"]},{"referenceNumber":7,"citation":{"id":"CI-2PBF0JF5JFFMO","citationType":"submission","authors":["Lubec G.","Vishwanath V."],"publicationDate":"MAR-2007","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 311-332; 348-372 AND 422-437","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Cajal-Retzius cell","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"6187626","citationType":"journal article","authors":["Beattie W.G.","Dugaiczyk A."],"citationCrossReferences":[{"database":"PubMed","id":"6187626"},{"database":"DOI","id":"10.1016/0378-1119(82)90210-4"}],"title":"Structure and evolution of human alpha-fetoprotein deduced from partial sequence of cloned cDNA.","publicationDate":"1982","journal":"Gene","firstPage":"415","lastPage":"422","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 429-556"]},{"referenceNumber":9,"citation":{"id":"1709810","citationType":"journal article","authors":["Pucci P.","Siciliano R.","Malorni A.","Marino G.","Tecce M.F.","Ceccarini C.","Terrana B."],"citationCrossReferences":[{"database":"PubMed","id":"1709810"},{"database":"DOI","id":"10.1021/bi00234a032"}],"title":"Human alpha-fetoprotein primary structure: a mass spectrometric study.","publicationDate":"1991","journal":"Biochemistry","firstPage":"5061","lastPage":"5066","volume":"30"},"referencePositions":["PROTEIN SEQUENCE OF 19-609"]},{"referenceNumber":10,"citation":{"id":"70228","citationType":"journal article","authors":["Yachnin S.","Hsu R.","Heinrikson R.L.","Miller J.B."],"citationCrossReferences":[{"database":"PubMed","id":"70228"},{"database":"DOI","id":"10.1016/0005-2795(77)90198-2"}],"title":"Studies on human alpha-fetoprotein. Isolation and characterization of monomeric and polymeric forms and amino-terminal sequence analysis.","publicationDate":"1977","journal":"Biochim. Biophys. Acta","firstPage":"418","lastPage":"428","volume":"493"},"referencePositions":["PRELIMINARY PROTEIN SEQUENCE OF 19-35"]},{"referenceNumber":11,"citation":{"id":"71198","citationType":"journal article","authors":["Aoyagi Y.","Ikenaka T.","Ichida F."],"citationCrossReferences":[{"database":"PubMed","id":"71198"}],"title":"Comparative chemical structures of human alpha-fetoproteins from fetal serum and from ascites fluid of a patient with hepatoma.","publicationDate":"1977","journal":"Cancer Res.","firstPage":"3663","lastPage":"3667","volume":"37"},"referencePositions":["PRELIMINARY PROTEIN SEQUENCE OF 19-38"]},{"referenceNumber":12,"citation":{"id":"4138095","citationType":"journal article","authors":["Ruoslahti E.","Pihko H.","Vaheri A.","Seppala M.","Virolainen M.","Konttinen A."],"citationCrossReferences":[{"database":"PubMed","id":"4138095"}],"title":"Alpha fetoprotein: structure and expression in man and inbred mouse strains under normal conditions and liver injury.","publicationDate":"1974","journal":"Johns Hopkins Med. J. Suppl.","firstPage":"249","lastPage":"255","volume":"3"},"referencePositions":["PRELIMINARY PROTEIN SEQUENCE OF 19-39"]},{"referenceNumber":13,"citation":{"id":"80265","citationType":"journal article","authors":["Aoyagi Y.","Ikenaka T.","Ichida F."],"citationCrossReferences":[{"database":"PubMed","id":"80265"}],"title":"Copper(II)-binding ability of human alpha-fetoprotein.","publicationDate":"1978","journal":"Cancer Res.","firstPage":"3483","lastPage":"3486","volume":"38"},"referencePositions":["METAL-BINDING"]},{"referenceNumber":14,"citation":{"id":"89900","citationType":"journal article","authors":["Aoyagi Y.","Ikenaka T.","Ichida F."],"citationCrossReferences":[{"database":"PubMed","id":"89900"}],"title":"Alpha-fetoprotein as a carrier protein in plasma and its bilirubin-binding ability.","publicationDate":"1979","journal":"Cancer Res.","firstPage":"3571","lastPage":"3574","volume":"39"},"referencePositions":["BILIRUBIN-BINDING"]},{"referenceNumber":15,"citation":{"id":"2414772","citationType":"journal article","authors":["Liu M.C.","Yu S.","Sy J.","Redman C.M.","Lipmann F."],"citationCrossReferences":[{"database":"PubMed","id":"2414772"},{"database":"DOI","id":"10.1073/pnas.82.21.7160"}],"title":"Tyrosine sulfation of proteins from the human hepatoma cell line HepG2.","publicationDate":"1985","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"7160","lastPage":"7164","volume":"82"},"referencePositions":["SULFATION"]},{"referenceNumber":16,"citation":{"id":"15280901","citationType":"journal article","authors":["Sharony R.","Zadik I.","Parvari R."],"citationCrossReferences":[{"database":"PubMed","id":"15280901"},{"database":"DOI","id":"10.1038/sj.ejhg.5201246"}],"title":"Congenital deficiency of alpha feto-protein.","publicationDate":"2004","journal":"Eur. J. Hum. Genet.","firstPage":"871","lastPage":"874","volume":"12"},"referencePositions":["INVOLVEMENT IN AFPD"]},{"referenceNumber":17,"citation":{"id":"18854864","citationType":"journal article","authors":["Petit F.M.","Hebert M.","Picone O.","Brisset S.","Maurin M.L.","Parisot F.","Capel L.","Benattar C.","Senat M.V.","Tachdjian G.","Labrune P."],"citationCrossReferences":[{"database":"PubMed","id":"18854864"},{"database":"DOI","id":"10.1038/ejhg.2008.186"}],"title":"A new mutation in the AFP gene responsible for a total absence of alpha feto-protein on second trimester maternal serum screening for Down syndrome.","publicationDate":"2009","journal":"Eur. J. Hum. Genet.","firstPage":"387","lastPage":"390","volume":"17"},"referencePositions":["INVOLVEMENT IN AFPD"]},{"referenceNumber":18,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":19,"citation":{"id":"26091039","citationType":"journal article","authors":["Tagliabracci V.S.","Wiley S.E.","Guo X.","Kinch L.N.","Durrant E.","Wen J.","Xiao J.","Cui J.","Nguyen K.B.","Engel J.L.","Coon J.J.","Grishin N.","Pinna L.A.","Pagliarini D.J.","Dixon J.E."],"citationCrossReferences":[{"database":"PubMed","id":"26091039"},{"database":"DOI","id":"10.1016/j.cell.2015.05.028"}],"title":"A single kinase generates the majority of the secreted phosphoproteome.","publicationDate":"2015","journal":"Cell","firstPage":"1619","lastPage":"1632","volume":"161"},"referencePositions":["PHOSPHORYLATION AT SER-111; SER-115; SER-117; SER-344; SER-444 AND SER-445"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"V01514","properties":[{"key":"ProteinId","value":"CAA24758.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M16110","properties":[{"key":"ProteinId","value":"AAB58754.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK314817","properties":[{"key":"ProteinId","value":"BAG37340.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC027881","properties":[{"key":"ProteinId","value":"AAH27881.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M10949","properties":[{"key":"ProteinId","value":"AAA51674.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M10950","properties":[{"key":"ProteinId","value":"AAA51675.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z19532","properties":[{"key":"ProteinId","value":"CAA79592.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS3556.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A26624","properties":[{"key":"EntryName","value":"FPHU"}]},{"database":"RefSeq","id":"NP_001125.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001134.3"}]},{"database":"PDB","id":"3MRK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"P=137-145"}]},{"database":"PDB","id":"7RE7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"C/F=158-166"}]},{"database":"PDB","id":"7RE8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.82 A"},{"key":"Chains","value":"C/F=158-166"}]},{"database":"PDB","id":"7YIM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=1-609"}]},{"database":"PDB","id":"8X1N","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.31 A"},{"key":"Chains","value":"A=1-609"}]},{"database":"PDBsum","id":"3MRK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7RE7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7RE8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7YIM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8X1N","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33861","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37997","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"106682","properties":[{"key":"Interactions","value":"27"}]},{"database":"FunCoup","id":"P02771","properties":[{"key":"Number of interactors","value":"255"}]},{"database":"IntAct","id":"P02771","properties":[{"key":"Interactions","value":"15"}]},{"database":"NDEx","id":"IQUERY-CP-AFP","properties":[{"key":"Evidences","value":"4 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000379138","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3712864","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P02771","properties":[{"key":"glycosylation","value":"31 N-Linked glycans (2 sites)"}]},{"database":"GlyCosmos","id":"P02771","properties":[{"key":"glycosylation","value":"2 sites, 48 glycans"}]},{"database":"GlyGen","id":"P02771","properties":[{"key":"glycosylation","value":"4 sites, 47 N-linked glycans (3 sites), 2 O-linked glycans (2 sites)"}]},{"database":"iPTMnet","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"AFP","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"120042","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000379138","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"51589","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P02771","properties":[{"key":"antibodies","value":"16 sequenced antibodies"}]},{"database":"Antibodypedia","id":"1359","properties":[{"key":"antibodies","value":"3653 antibodies from 62 providers"}]},{"database":"DNASU","id":"174","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000395792.7","properties":[{"key":"ProteinId","value":"ENSP00000379138.2"},{"key":"GeneId","value":"ENSG00000081051.8"}]},{"database":"GeneID","id":"174","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:174","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000395792.7","properties":[{"key":"ProteinId","value":"ENSP00000379138.2"},{"key":"RefSeqNucleotideId","value":"NM_001134.3"},{"key":"RefSeqProteinId","value":"NP_001125.1"}]},{"database":"UCSC","id":"uc003hgz.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:317","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA24614","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"174","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"174","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"AFP","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:317","properties":[{"key":"GeneName","value":"AFP"}]},{"database":"HPA","id":"ENSG00000081051","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (liver)"}]},{"database":"MalaCards","id":"AFP","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"104150","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"615969","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"615970","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000081051","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"168612","properties":[{"key":"Disease","value":"Congenital deficiency in alpha-fetoprotein"}]},{"database":"Orphanet","id":"168615","properties":[{"key":"Disease","value":"Hereditary persistence of alpha-fetoprotein"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000081051","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502R7EA","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000000113","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_030161_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HEECCRG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9875082at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P02771","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-381426","properties":[{"key":"PathwayName","value":"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"}]},{"database":"Reactome","id":"R-HSA-8957275","properties":[{"key":"PathwayName","value":"Post-translational protein phosphorylation"}]},{"database":"SignaLink","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000081051","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"174","properties":[{"key":"hits","value":"14 hits in 1151 CRISPR screens"}]},{"database":"ChiTaRS","id":"AFP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P02771","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Alpha-fetoprotein","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"174","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P02771","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P02771","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"P02771","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000081051","properties":[{"key":"ExpressionPatterns","value":"Expressed in male germ line stem cell (sensu Vertebrata) in testis and 111 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P02771","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005788","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0036094","properties":[{"key":"GoTerm","value":"F:small molecule binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031667","properties":[{"key":"GoTerm","value":"P:response to nutrient levels"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd00015","properties":[{"key":"EntryName","value":"ALBUMIN"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.10.246.10:FF:000001","properties":[{"key":"EntryName","value":"Serum albumin"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.10.246.10:FF:000002","properties":[{"key":"EntryName","value":"Serum albumin"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"1.10.246.10:FF:000004","properties":[{"key":"EntryName","value":"Serum albumin"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.246.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"6"}]},{"database":"InterPro","id":"IPR000264","properties":[{"key":"EntryName","value":"ALB/AFP/VDB"}]},{"database":"InterPro","id":"IPR020858","properties":[{"key":"EntryName","value":"Serum_albumin-like"}]},{"database":"InterPro","id":"IPR021177","properties":[{"key":"EntryName","value":"Serum_albumin/AFP/Afamin"}]},{"database":"InterPro","id":"IPR020857","properties":[{"key":"EntryName","value":"Serum_albumin_CS"}]},{"database":"InterPro","id":"IPR014760","properties":[{"key":"EntryName","value":"Serum_albumin_N"}]},{"database":"PANTHER","id":"PTHR11385:SF7","properties":[{"key":"EntryName","value":"ALPHA-FETOPROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11385","properties":[{"key":"EntryName","value":"SERUM ALBUMIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00273","properties":[{"key":"EntryName","value":"Serum_albumin"},{"key":"MatchStatus","value":"3"}]},{"database":"PIRSF","id":"PIRSF002520","properties":[{"key":"EntryName","value":"Serum_albumin_subgroup"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00803","properties":[{"key":"EntryName","value":"AFETOPROTEIN"}]},{"database":"PRINTS","id":"PR00802","properties":[{"key":"EntryName","value":"SERUMALBUMIN"}]},{"database":"SMART","id":"SM00103","properties":[{"key":"EntryName","value":"ALBUMIN"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF48552","properties":[{"key":"EntryName","value":"Serum albumin-like"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS00212","properties":[{"key":"EntryName","value":"ALBUMIN_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51438","properties":[{"key":"EntryName","value":"ALBUMIN_2"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATYKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSEEGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLYAPTILLWAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSLLNQHACAVMKNFGTRTFQAITVTKLSQKFTKVNFTEIQKLVLDVAHVHEHCCRGDVLDCLQDGEKIMSYICSQQDTLSNKITECCKLTTLERGQCIIHAENDEKPEGLSPNLNRFLGDRDFNQFSSGEKNIFLASFVHEYSRRHPQLAVSVILRVAKGYQELLEKCFQTENPLECQDKGEEELQKYIQESQALAKRSCGLFQKLGEYYLQNAFLVAYTKKAPQLTSSELMAITRKMAATAATCCQLSEDKLLACGEGAADIIIGHLCIRHEMTPVNPGVGQCCTSSYANRRPCFSSLVVDETYVPPAFSDDKFIFHKDLCQAQGVALQTMKQEFLINLVKQKPQITEEQLEAVIADFSGLLEKCCQGQEQEVCFAEEGQKLISKTRAALGV","length":609,"molWeight":68678,"crc64":"4D4E45820E1C2D4F","md5":"2D64BE38D10692913A8E227DE3AFF5A4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"PTM":2,"DISEASE":2,"SIMILARITY":1,"WEB RESOURCE":2},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Binding site":1,"Modified residue":6,"Glycosylation":1,"Disulfide bond":15,"Natural variant":2,"Helix":35,"Beta strand":5,"Turn":4},"uniParcId":"UPI00000012A9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"J3KMX3","uniProtkbId":"J3KMX3_HUMAN","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-10-03","entryVersion":82,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000226359.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039821"}],"value":"Alpha-fetoprotein"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041316"}],"value":"Alpha-1-fetoprotein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042101"}],"value":"Alpha-fetoglobulin"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000226359.2"}],"value":"AFP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}],"value":"Belongs to the ALB/AFP/VDB family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"Alpha-fetoprotein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003771599"},{"type":"Domain","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Albumin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51438"}]},{"type":"Domain","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"Albumin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51438"}]},{"type":"Domain","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"Albumin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51438"}]},{"type":"Binding site","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Disulfide bond","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"}]},{"type":"Disulfide bond","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}]},{"type":"Disulfide bond","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}]},{"type":"Disulfide bond","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}]},{"type":"Disulfide bond","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}]},{"type":"Disulfide bond","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}]},{"type":"Disulfide bond","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"}]},{"type":"Disulfide bond","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}]},{"type":"Disulfide bond","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}]},{"type":"Disulfide bond","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}]},{"type":"Disulfide bond","location":{"start":{"value":461,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"}]},{"type":"Disulfide bond","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":501,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"}]},{"type":"Disulfide bond","location":{"start":{"value":500,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}]},{"type":"Disulfide bond","location":{"start":{"value":538,"modifier":"EXACT"},"end":{"value":583,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}]},{"type":"Disulfide bond","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":591,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-1"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-2"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"J3KMX3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"J3KMX3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00769"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022641"}],"id":"KW-0765","category":"PTM","name":"Sulfation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR002520-1"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000226359.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000226359.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000226359.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000226359.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC108157","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"J3KMX3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"J3KMX3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"J3KMX3","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1359","properties":[{"key":"antibodies","value":"3653 antibodies from 62 providers"}]},{"database":"Ensembl","id":"ENST00000226359.2","properties":[{"key":"ProteinId","value":"ENSP00000226359.2"},{"key":"GeneId","value":"ENSG00000081051.8"}]},{"database":"UCSC","id":"uc062xgg.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:317","properties":[{"key":"GeneName","value":"AFP"}]},{"database":"OpenTargets","id":"ENSG00000081051","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000081051","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000000113","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9875082at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"J3KMX3","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"AFP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"Bgee","id":"ENSG00000081051","properties":[{"key":"ExpressionPatterns","value":"Expressed in male germ line stem cell (sensu Vertebrata) in testis and 111 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"J3KMX3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"CDD","id":"cd00015","properties":[{"key":"EntryName","value":"ALBUMIN"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.10.246.10:FF:000001","properties":[{"key":"EntryName","value":"Serum albumin"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.10.246.10:FF:000002","properties":[{"key":"EntryName","value":"Serum albumin"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"1.10.246.10:FF:000004","properties":[{"key":"EntryName","value":"Serum albumin"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.246.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"6"}]},{"database":"InterPro","id":"IPR000264","properties":[{"key":"EntryName","value":"ALB/AFP/VDB"}]},{"database":"InterPro","id":"IPR020858","properties":[{"key":"EntryName","value":"Serum_albumin-like"}]},{"database":"InterPro","id":"IPR021177","properties":[{"key":"EntryName","value":"Serum_albumin/AFP/Afamin"}]},{"database":"InterPro","id":"IPR020857","properties":[{"key":"EntryName","value":"Serum_albumin_CS"}]},{"database":"InterPro","id":"IPR014760","properties":[{"key":"EntryName","value":"Serum_albumin_N"}]},{"database":"PANTHER","id":"PTHR11385:SF7","properties":[{"key":"EntryName","value":"ALPHA-FETOPROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11385","properties":[{"key":"EntryName","value":"SERUM ALBUMIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00273","properties":[{"key":"EntryName","value":"Serum_albumin"},{"key":"MatchStatus","value":"3"}]},{"database":"PIRSF","id":"PIRSF002520","properties":[{"key":"EntryName","value":"Serum_albumin_subgroup"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00803","properties":[{"key":"EntryName","value":"AFETOPROTEIN"}]},{"database":"PRINTS","id":"PR00802","properties":[{"key":"EntryName","value":"SERUMALBUMIN"}]},{"database":"SMART","id":"SM00103","properties":[{"key":"EntryName","value":"ALBUMIN"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF48552","properties":[{"key":"EntryName","value":"Serum albumin-like"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS00212","properties":[{"key":"EntryName","value":"ALBUMIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51438","properties":[{"key":"EntryName","value":"ALBUMIN_2"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATYKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSEEGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLYAPTILLWAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSLLNQHACAVMKNFGTRTFQAITVTKLSQKFTKVNFTEIQKLVLDVAHVHEHCCRGDVLDCLQDGEKIMSYICSQQDTLSNKITECCKLTTLERGQCIIHAENDEKPEGLSPNLNRFLGDRDFNQFSSGEKNIFLASFVHEYSRRHPQLAVSVILRVAKGYQELLEKCFQTENPLECQDKGEEELQKYIQESQALAKRSCGLFQKLGEYYLQNAFLVAYTKKAPQLTSSELMAITRKMAATAATCCQLSEDKLLACGEGAADIIIGHLCIRHEMTPVNPGVGQCCTSSYANRRPCFSSLVVDETYVPPAFSDDKFIFHKDLCQAQGVALQTMKQEFLINLVKQKPQITEEQLEAVIADFSGLLEKCCQGQEQEVCFAEEGKRRQNESFIRCELFSLILTDLTLFVN","length":622,"molWeight":70450,"crc64":"DA036E52F6F52737","md5":"837B8018FFE4F1A8C0BD586BC4B8A7F2"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Binding site":1,"Disulfide bond":15},"uniParcId":"UPI0000D4D972"}}]}