{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P78563","secondaryAccessions":["A6NFK8","A6NJ84","C3TTQ1","C3TTQ2","C9JUP4","G5E9B4","O00395","O00465","O00691","O00692","P78555","Q4AE77","Q4AE79","Q6P0M9","Q8NFA1","Q8NFD1"],"uniProtkbId":"RED1_HUMAN","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1997-05-01","entryVersion":220,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Double-stranded RNA-specific editase 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9149227"}],"value":"3.5.4.37"}]},"alternativeNames":[{"fullName":{"value":"RNA-editing deaminase 1"}},{"fullName":{"value":"RNA-editing enzyme 1"}},{"fullName":{"value":"dsRNA adenosine deaminase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:226"}],"value":"ADARB1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"32220291"}],"value":"ADAR2"},{"value":"DRADA2"},{"value":"RED1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18178553"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19908260"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21289159"}],"value":"Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9149227"}],"value":"Has a lower catalytic activity than isoform 2"}],"commentType":"FUNCTION","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9149227"}],"value":"Has a higher catalytic activity than isoform 1"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"adenosine in double-stranded RNA + H2O + H(+) = inosine in double-stranded RNA + NH4(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10120"},{"database":"Rhea","id":"RHEA-COMP:13885"},{"database":"Rhea","id":"RHEA-COMP:13886"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28938"},{"database":"ChEBI","id":"CHEBI:74411"},{"database":"ChEBI","id":"CHEBI:82852"}],"ecNumber":"3.5.4.37","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9149227"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:10121"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"1D-myo-inositol hexakisphosphate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58130"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}],"value":"Binds 1 myo-inositol hexakisphosphate (IP6) per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18178553"}],"value":"Homodimer. Homodimerization is essential for its catalytic activity. Can form heterodimers with isoform 5 of ADAR/ADAR1"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P78563","intActId":"EBI-2967304"},"interactantTwo":{"uniProtKBAccession":"P68400","geneName":"CSNK2A1","intActId":"EBI-347804"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563","intActId":"EBI-2967304"},"interactantTwo":{"uniProtKBAccession":"P05412","geneName":"JUN","intActId":"EBI-852823"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563","intActId":"EBI-2967304"},"interactantTwo":{"uniProtKBAccession":"Q13526","geneName":"PIN1","intActId":"EBI-714158"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563","intActId":"EBI-2967304"},"interactantTwo":{"uniProtKBAccession":"O00308","geneName":"WWP2","intActId":"EBI-743923"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563","intActId":"EBI-2967304"},"interactantTwo":{"uniProtKBAccession":"P0DTC9","geneName":"N","intActId":"EBI-25475856"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"P78563-4","geneName":"ADARB1","intActId":"EBI-12002366"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"Q08426","geneName":"EHHADH","intActId":"EBI-2339219"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"P19525","geneName":"EIF2AK2","intActId":"EBI-640775"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"O15226","geneName":"NKRF","intActId":"EBI-766011"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"Q8TCS8","geneName":"PNPT1","intActId":"EBI-1052020"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"O75569","geneName":"PRKRA","intActId":"EBI-713955"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"O95793","geneName":"STAU1","intActId":"EBI-358174"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"Q6ZVD7","geneName":"STOX1","intActId":"EBI-3923644"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"Q96SI9","geneName":"STRBP","intActId":"EBI-740355"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"Q15633","geneName":"TARBP2","intActId":"EBI-978581"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"Q8N8B7-2","geneName":"TCEANC","intActId":"EBI-11955057"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"Q7KZS0","geneName":"UBE2I","intActId":"EBI-10180829"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"Q9H898-2","geneName":"ZMAT4","intActId":"EBI-11529334"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P78563-4","intActId":"EBI-12002366"},"interactantTwo":{"uniProtKBAccession":"Q9UL40","geneName":"ZNF346","intActId":"EBI-2462313"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32220291"}],"value":"Shuttles between nucleoli and the nucleoplasm"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"}],"value":"Nucleus, nucleolus","id":"SL-0188"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 1","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"}],"value":"Nucleus, nucleolus","id":"SL-0188"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 2","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"}],"value":"Nucleus, nucleolus","id":"SL-0188"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative promoter usage","Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"32220291"}],"value":"ADAR2b"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"32220291"}],"value":"ADAR2L"},{"value":"DRADA2B"},{"value":"RED1-L"}],"isoformIds":["P78563-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"32220291"}],"value":"ADAR2a"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"32220291"}],"value":"ADAR2S"},{"value":"DRADA2A"},{"value":"RED1-S"}],"isoformIds":["P78563-2"],"sequenceIds":["VSP_000865"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"DRADA2C"}],"isoformIds":["P78563-3"],"sequenceIds":["VSP_000866"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["P78563-4"],"sequenceIds":["VSP_019597","VSP_000865"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"synonyms":[{"value":"ADAR2R"}],"isoformIds":["P78563-5"],"sequenceIds":["VSP_041421"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"synonyms":[{"value":"ADAR2d"}],"isoformIds":["P78563-6"],"sequenceIds":["VSP_000865","VSP_000866"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"value":"Additional isoforms seem to exist."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18178553"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9149227"}],"value":"Highly expressed in brain and heart and at lower levels in placenta. Fair expression in lung, liver and kidney. Detected in brain, heart, kidney, lung and liver (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19156214"}],"value":"Highly expressed in hippocampus and colon. Expressed in pediatric astrocytomas and the protein has a decreased RNA-editing activity. The decrease in RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform 5"},{"commentType":"DISEASE","disease":{"diseaseId":"Neurodevelopmental disorder with hypotonia, microcephaly, and seizures","diseaseAccession":"DI-05827","acronym":"NEDHYMS","description":"An autosomal recessive neurodevelopmental disorder characterized by global developmental delay with axial hypotonia, inability to sit or walk, impaired intellectual development with absent language, and early-onset intractable seizures in most patients. Additional features include poor overall growth, microcephaly, dysmorphic features, poor eye contact due to cortical blindness, and non-specific brain abnormalities.","diseaseCrossReference":{"database":"MIM","id":"618862"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"value":"Alu insert from position 465 to 505. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19156214"}],"value":"Likely expressed from an alternative promoter. Contains a region highly similar to the so-called ssRNA-binding R-domain of ADARB2"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 5"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"ACN49027.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"Double-stranded RNA-specific editase 1","featureId":"PRO_0000171779"},{"type":"Domain","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"DRBM 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00266"}]},{"type":"Domain","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"DRBM 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00266"}]},{"type":"Domain","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":737,"modifier":"EXACT"}},"description":"A to I editase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00240"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"Interaction with substrate RNA","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P51400"}]},{"type":"Region","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"Interaction with substrate RNA","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P51400"}]},{"type":"Region","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Interaction with substrate RNA","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P51400"}]},{"type":"Region","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Interaction with substrate RNA","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P51400"}]},{"type":"Region","location":{"start":{"value":486,"modifier":"EXACT"},"end":{"value":518,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":503,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}]},{"type":"Binding site","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58130"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}],"ligand":{"name":"1D-myo-inositol hexakisphosphate","id":"ChEBI:CHEBI:58130"}},{"type":"Binding site","location":{"start":{"value":401,"modifier":"EXACT"},"end":{"value":401,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58130"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}],"ligand":{"name":"1D-myo-inositol hexakisphosphate","id":"ChEBI:CHEBI:58130"}},{"type":"Binding site","location":{"start":{"value":451,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":556,"modifier":"EXACT"},"end":{"value":556,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":559,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58130"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}],"ligand":{"name":"1D-myo-inositol hexakisphosphate","id":"ChEBI:CHEBI:58130"}},{"type":"Binding site","location":{"start":{"value":562,"modifier":"EXACT"},"end":{"value":562,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58130"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}],"ligand":{"name":"1D-myo-inositol hexakisphosphate","id":"ChEBI:CHEBI:58130"}},{"type":"Binding site","location":{"start":{"value":669,"modifier":"EXACT"},"end":{"value":669,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58130"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}],"ligand":{"name":"1D-myo-inositol hexakisphosphate","id":"ChEBI:CHEBI:58130"}},{"type":"Binding site","location":{"start":{"value":702,"modifier":"EXACT"},"end":{"value":702,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58130"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}],"ligand":{"name":"1D-myo-inositol hexakisphosphate","id":"ChEBI:CHEBI:58130"}},{"type":"Binding site","location":{"start":{"value":712,"modifier":"EXACT"},"end":{"value":712,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58130"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}],"ligand":{"name":"1D-myo-inositol hexakisphosphate","id":"ChEBI:CHEBI:58130"}},{"type":"Binding site","location":{"start":{"value":730,"modifier":"EXACT"},"end":{"value":730,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58130"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141067"}],"ligand":{"name":"1D-myo-inositol hexakisphosphate","id":"ChEBI:CHEBI:58130"}},{"type":"Modified residue","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12459255"}],"featureId":"VSP_019597","alternativeSequence":{"originalSequence":"M","alternativeSequences":["MKIPRMKTPCQPDRNSLRQSRNPQKYFAM"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19156214"}],"featureId":"VSP_041421","alternativeSequence":{"originalSequence":"M","alternativeSequences":["MASSTTPPLHMGTFFSVMGRRYKRRRKKRSERKDRNSLRQSRNPQKYFAM"]}},{"type":"Alternative sequence","location":{"start":{"value":466,"modifier":"EXACT"},"end":{"value":505,"modifier":"EXACT"}},"description":"in isoform 2, isoform 4 and isoform 6","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12459255"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16297572"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9111310"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9143496"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9149227"}],"featureId":"VSP_000865","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":713,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"in isoform 3 and isoform 6","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16297572"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9111310"}],"featureId":"VSP_000866","alternativeSequence":{"originalSequence":"ARLFTAFIKAGLGAWVEKPTEQDQFSLTP","alternativeSequences":["VH"]}},{"type":"Natural variant","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"in NEDHYMS; uncertain significance; mild decreased editing activity","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"}],"featureId":"VAR_083947","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"in dbSNP:rs199697177","featureCrossReferences":[{"database":"dbSNP","id":"rs199697177"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"VAR_070931","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"in NEDHYMS; uncertain significance; mild decreased editing activity","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"}],"featureId":"VAR_083948","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":498,"modifier":"EXACT"},"end":{"value":498,"modifier":"EXACT"}},"description":"in NEDHYMS; uncertain significance; altered ratio of alternative splicing","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"}],"featureId":"VAR_083949","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":603,"modifier":"EXACT"},"end":{"value":603,"modifier":"EXACT"}},"description":"in NEDHYMS; decreased protein stability; strong decreased editing activity","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"}],"featureId":"VAR_083950","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":722,"modifier":"EXACT"},"end":{"value":722,"modifier":"EXACT"}},"description":"in NEDHYMS; uncertain significance; mild decreased editing activity","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32220291"}],"featureId":"VAR_083951","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"in Ref. 4; AAB58300 and 5; AAM83100/AAM97654/AAN10291","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":423,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"in Ref. 4; AAB58300 and 5; AAM83100/AAM97654/AAN10291","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"in Ref. 5; AAM83100/AAN10291","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Helix","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OP3"}]},{"type":"Beta strand","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OP3"}]},{"type":"Helix","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OP3"}]},{"type":"Beta strand","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OP3"}]},{"type":"Beta strand","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OP3"}]},{"type":"Helix","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OP3"}]},{"type":"Turn","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6VFF"}]},{"type":"Beta strand","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5ED1"}]},{"type":"Helix","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Turn","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Beta strand","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Beta strand","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Beta strand","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6VFF"}]},{"type":"Helix","location":{"start":{"value":380,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Beta strand","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6VFF"}]},{"type":"Helix","location":{"start":{"value":395,"modifier":"EXACT"},"end":{"value":416,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":418,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Beta strand","location":{"start":{"value":425,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Beta strand","location":{"start":{"value":432,"modifier":"EXACT"},"end":{"value":436,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Beta strand","location":{"start":{"value":440,"modifier":"EXACT"},"end":{"value":448,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":453,"modifier":"EXACT"},"end":{"value":456,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Turn","location":{"start":{"value":515,"modifier":"EXACT"},"end":{"value":518,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KFN"}]},{"type":"Beta strand","location":{"start":{"value":521,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Beta strand","location":{"start":{"value":527,"modifier":"EXACT"},"end":{"value":532,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KFN"}]},{"type":"Beta strand","location":{"start":{"value":535,"modifier":"EXACT"},"end":{"value":537,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KFN"}]},{"type":"Helix","location":{"start":{"value":542,"modifier":"EXACT"},"end":{"value":546,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Beta strand","location":{"start":{"value":552,"modifier":"EXACT"},"end":{"value":554,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":556,"modifier":"EXACT"},"end":{"value":566,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":570,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Beta strand","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":589,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":593,"modifier":"EXACT"},"end":{"value":600,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Beta strand","location":{"start":{"value":620,"modifier":"EXACT"},"end":{"value":623,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":627,"modifier":"EXACT"},"end":{"value":631,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9OP3"}]},{"type":"Beta strand","location":{"start":{"value":637,"modifier":"EXACT"},"end":{"value":643,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Beta strand","location":{"start":{"value":650,"modifier":"EXACT"},"end":{"value":653,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Turn","location":{"start":{"value":654,"modifier":"EXACT"},"end":{"value":657,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":669,"modifier":"EXACT"},"end":{"value":680,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":685,"modifier":"EXACT"},"end":{"value":687,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":698,"modifier":"EXACT"},"end":{"value":703,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":706,"modifier":"EXACT"},"end":{"value":721,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]},{"type":"Helix","location":{"start":{"value":732,"modifier":"EXACT"},"end":{"value":735,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZY7"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0877","category":"Coding sequence diversity","name":"Alternative promoter usage"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0051","category":"Biological process","name":"Antiviral defense"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"id":"KW-0991","category":"Disease","name":"Intellectual disability"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0507","category":"Biological process","name":"mRNA processing"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"9149227","citationType":"journal article","authors":["Gerber A.","O'Connell M.A.","Keller W."],"citationCrossReferences":[{"database":"PubMed","id":"9149227"},{"database":"DOI","id":"10.5451/unibas-ep2494"}],"title":"Two forms of human double-stranded RNA-specific editase 1 (hRED1) generated by the insertion of an Alu cassette.","publicationDate":"1997","journal":"RNA","firstPage":"453","lastPage":"463","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)","TISSUE SPECIFICITY","CATALYTIC ACTIVITY"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"9143496","citationType":"journal article","authors":["Mittaz L.","Scott H.S.","Rossier C.","Seeburg P.H.","Higuchi M.","Antonarakis S.E."],"citationCrossReferences":[{"database":"PubMed","id":"9143496"},{"database":"DOI","id":"10.1006/geno.1997.4655"}],"title":"Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3.","publicationDate":"1997","journal":"Genomics","firstPage":"210","lastPage":"217","volume":"41"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"9111310","citationType":"journal article","authors":["Lai F.","Chen C.-X.","Carter K.C.","Nishikura K."],"citationCrossReferences":[{"database":"PubMed","id":"9111310"},{"database":"DOI","id":"10.1128/mcb.17.5.2413"}],"title":"Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases.","publicationDate":"1997","journal":"Mol. Cell. Biol.","firstPage":"2413","lastPage":"2424","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)"]},{"referenceNumber":4,"citation":{"id":"9330641","citationType":"journal article","authors":["Villard L.","Tassone F.","Haymowicz M.","Welborn R.","Gardiner K."],"citationCrossReferences":[{"database":"PubMed","id":"9330641"},{"database":"DOI","id":"10.1007/bf02679972"}],"title":"Map location, genomic organization and expression patterns of the human RED1 RNA editase.","publicationDate":"1997","journal":"Somat. Cell Mol. Genet.","firstPage":"135","lastPage":"145","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":5,"citation":{"id":"12459255","citationType":"journal article","authors":["Slavov D.","Gardiner K."],"citationCrossReferences":[{"database":"PubMed","id":"12459255"},{"database":"DOI","id":"10.1016/s0378-1119(02)01016-8"}],"title":"Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns.","publicationDate":"2002","journal":"Gene","firstPage":"83","lastPage":"94","volume":"299"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4)"]},{"referenceNumber":6,"citation":{"id":"16297572","citationType":"journal article","authors":["Kawahara Y.","Ito K.","Ito M.","Tsuji S.","Kwak S."],"citationCrossReferences":[{"database":"PubMed","id":"16297572"},{"database":"DOI","id":"10.1016/j.gene.2005.07.028"}],"title":"Novel splice variants of human ADAR2 mRNA: skipping of the exon encoding the dsRNA-binding domains, and multiple C-terminal splice sites.","publicationDate":"2005","journal":"Gene","firstPage":"193","lastPage":"201","volume":"363"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 6)"]},{"referenceNumber":7,"citation":{"id":"10830953","citationType":"journal article","authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.-S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.-K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Shibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brandt P.","Scharfe M.","Schoen O.","Desario A.","Reichelt J.","Kauer G.","Bloecker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.-L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":9,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)","VARIANT ALA-224"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"19156214","citationType":"journal article","authors":["Maas S.","Gommans W.M."],"citationCrossReferences":[{"database":"PubMed","id":"19156214"},{"database":"DOI","id":"10.1371/journal.pone.0004225"}],"title":"Novel exon of mammalian ADAR2 extends open reading frame.","publicationDate":"2009","journal":"PLoS ONE","firstPage":"E4225","lastPage":"E4225","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-75 (ISOFORM 5)","ALTERNATIVE PROMOTER USAGE","TISSUE SPECIFICITY"]},{"referenceNumber":11,"citation":{"id":"14759258","citationType":"journal article","authors":["Hillman R.T.","Green R.E.","Brenner S.E."],"citationCrossReferences":[{"database":"PubMed","id":"14759258"},{"database":"DOI","id":"10.1186/gb-2004-5-2-r8"}],"title":"An unappreciated role for RNA surveillance.","publicationDate":"2004","journal":"Genome Biol.","firstPage":"R8.1","lastPage":"R8.16","volume":"5"},"referencePositions":["SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)"]},{"referenceNumber":12,"citation":{"id":"18178553","citationType":"journal article","authors":["Cenci C.","Barzotti R.","Galeano F.","Corbelli S.","Rota R.","Massimi L.","Di Rocco C.","O'Connell M.A.","Gallo A."],"citationCrossReferences":[{"database":"PubMed","id":"18178553"},{"database":"DOI","id":"10.1074/jbc.m708316200"}],"title":"Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"7251","lastPage":"7260","volume":"283"},"referencePositions":["FUNCTION","SUBUNIT","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":13,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"20192758","citationType":"journal article","authors":["Nishikura K."],"citationCrossReferences":[{"database":"PubMed","id":"20192758"},{"database":"DOI","id":"10.1146/annurev-biochem-060208-105251"}],"title":"Functions and regulation of RNA editing by ADAR deaminases.","publicationDate":"2010","journal":"Annu. Rev. Biochem.","firstPage":"321","lastPage":"349","volume":"79"},"referencePositions":["REVIEW"]},{"referenceNumber":16,"citation":{"id":"19908260","citationType":"journal article","authors":["Galeano F.","Leroy A.","Rossetti C.","Gromova I.","Gautier P.","Keegan L.P.","Massimi L.","Di Rocco C.","O'Connell M.A.","Gallo A."],"citationCrossReferences":[{"database":"PubMed","id":"19908260"},{"database":"DOI","id":"10.1002/ijc.25022"}],"title":"Human BLCAP transcript: new editing events in normal and cancerous tissues.","publicationDate":"2010","journal":"Int. J. Cancer","firstPage":"127","lastPage":"137","volume":"127"},"referencePositions":["FUNCTION"]},{"referenceNumber":17,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"22022963","citationType":"journal article","authors":["Wang Q."],"citationCrossReferences":[{"database":"PubMed","id":"22022963"},{"database":"DOI","id":"10.1134/s0006297911080050"}],"title":"RNA editing catalyzed by ADAR1 and its function in mammalian cells.","publicationDate":"2011","journal":"Biochemistry (Mosc.)","firstPage":"900","lastPage":"911","volume":"76"},"referencePositions":["REVIEW"]},{"referenceNumber":19,"citation":{"id":"21289159","citationType":"journal article","authors":["Doria M.","Tomaselli S.","Neri F.","Ciafre S.A.","Farace M.G.","Michienzi A.","Gallo A."],"citationCrossReferences":[{"database":"PubMed","id":"21289159"},{"database":"DOI","id":"10.1099/vir.0.028043-0"}],"title":"ADAR2 editing enzyme is a novel human immunodeficiency virus-1 proviral factor.","publicationDate":"2011","journal":"J. Gen. Virol.","firstPage":"1228","lastPage":"1232","volume":"92"},"referencePositions":["FUNCTION"]},{"referenceNumber":20,"citation":{"id":"21182352","citationType":"journal article","authors":["George C.X.","Gan Z.","Liu Y.","Samuel C.E."],"citationCrossReferences":[{"database":"PubMed","id":"21182352"},{"database":"DOI","id":"10.1089/jir.2010.0097"}],"title":"Adenosine deaminases acting on RNA, RNA editing, and interferon action.","publicationDate":"2011","journal":"J. Interferon Cytokine Res.","firstPage":"99","lastPage":"117","volume":"31"},"referencePositions":["REVIEW"]},{"referenceNumber":21,"citation":{"id":"21211811","citationType":"journal article","authors":["Samuel C.E."],"citationCrossReferences":[{"database":"PubMed","id":"21211811"},{"database":"DOI","id":"10.1016/j.virol.2010.12.004"}],"title":"Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral.","publicationDate":"2011","journal":"Virology","firstPage":"180","lastPage":"193","volume":"411"},"referencePositions":["REVIEW"]},{"referenceNumber":22,"citation":{"id":"22988838","citationType":"journal article","authors":["Mallela A.","Nishikura K."],"citationCrossReferences":[{"database":"PubMed","id":"22988838"},{"database":"DOI","id":"10.3109/10409238.2012.714350"}],"title":"A-to-I editing of protein coding and noncoding RNAs.","publicationDate":"2012","journal":"Crit. Rev. Biochem. Mol. Biol.","firstPage":"493","lastPage":"501","volume":"47"},"referencePositions":["REVIEW"]},{"referenceNumber":23,"citation":{"id":"21769729","citationType":"journal article","authors":["Goodman R.A.","Macbeth M.R.","Beal P.A."],"citationCrossReferences":[{"database":"PubMed","id":"21769729"},{"database":"DOI","id":"10.1007/82_2011_144"}],"title":"ADAR proteins: structure and catalytic mechanism.","publicationDate":"2012","journal":"Curr. Top. Microbiol. Immunol.","firstPage":"1","lastPage":"33","volume":"353"},"referencePositions":["REVIEW"]},{"referenceNumber":24,"citation":{"id":"22113393","citationType":"journal article","authors":["Orlandi C.","Barbon A.","Barlati S."],"citationCrossReferences":[{"database":"PubMed","id":"22113393"},{"database":"DOI","id":"10.1007/s12035-011-8220-2"}],"title":"Activity regulation of adenosine deaminases acting on RNA (ADARs).","publicationDate":"2012","journal":"Mol. Neurobiol.","firstPage":"61","lastPage":"75","volume":"45"},"referencePositions":["REVIEW"]},{"referenceNumber":25,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":26,"citation":{"id":"16141067","citationType":"journal article","authors":["Macbeth M.R.","Schubert H.L.","Vandemark A.P.","Lingam A.T.","Hill C.P.","Bass B.L."],"citationCrossReferences":[{"database":"PubMed","id":"16141067"},{"database":"DOI","id":"10.1126/science.1113150"}],"title":"Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.","publicationDate":"2005","journal":"Science","firstPage":"1534","lastPage":"1539","volume":"309"},"referencePositions":["X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH IP6 AND ZINC","CATALYTIC ACTIVITY"]},{"referenceNumber":27,"citation":{"id":"32220291","citationType":"journal article","authors":["Tan T.Y.","Sedmik J.","Fitzgerald M.P.","Halevy R.S.","Keegan L.P.","Helbig I.","Basel-Salmon L.","Cohen L.","Straussberg R.","Chung W.K.","Helal M.","Maroofian R.","Houlden H.","Juusola J.","Sadedin S.","Pais L.","Howell K.B.","White S.M.","Christodoulou J.","O'Connell M.A."],"citationCrossReferences":[{"database":"PubMed","id":"32220291"},{"database":"DOI","id":"10.1016/j.ajhg.2020.02.015"}],"title":"Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures.","publicationDate":"2020","journal":"Am. J. Hum. Genet.","firstPage":"467","lastPage":"483","volume":"106"},"referencePositions":["INVOLVEMENT IN NEDHYMS","FUNCTION","CATALYTIC ACTIVITY","VARIANTS NEDHYMS GLU-127; ASN-367; ALA-498; GLN-603 AND VAL-722","CHARACTERIZATION OF VARIANTS NEDHYMS GLU-127; ASN-367; ALA-498; GLN-603 AND VAL-722","SUBCELLULAR LOCATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U82120","properties":[{"key":"ProteinId","value":"AAB61686.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U82121","properties":[{"key":"ProteinId","value":"AAB61687.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X99227","properties":[{"key":"ProteinId","value":"CAA67611.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X99383","properties":[{"key":"ProteinId","value":"CAA67762.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U76420","properties":[{"key":"ProteinId","value":"AAC51240.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U76421","properties":[{"key":"ProteinId","value":"AAC51241.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U76422","properties":[{"key":"ProteinId","value":"AAC51242.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF001042","properties":[{"key":"ProteinId","value":"AAB58300.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF525422","properties":[{"key":"ProteinId","value":"AAM83100.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF533142","properties":[{"key":"ProteinId","value":"AAM97654.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY135659","properties":[{"key":"ProteinId","value":"AAN10291.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB194370","properties":[{"key":"ProteinId","value":"BAE16326.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB194371","properties":[{"key":"ProteinId","value":"BAE16327.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB194372","properties":[{"key":"ProteinId","value":"BAE16328.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB194373","properties":[{"key":"ProteinId","value":"BAE16329.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL163301","properties":[{"key":"ProteinId","value":"CAB90493.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471079","properties":[{"key":"ProteinId","value":"EAX09357.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471079","properties":[{"key":"ProteinId","value":"EAX09359.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471079","properties":[{"key":"ProteinId","value":"EAX09360.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC065545","properties":[{"key":"ProteinId","value":"AAH65545.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"FJ169506","properties":[{"key":"ProteinId","value":"ACN49027.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS33589.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P78563-1"},{"database":"CCDS","id":"CCDS33590.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P78563-2"},{"database":"CCDS","id":"CCDS42970.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P78563-3"},{"database":"RefSeq","id":"NP_001103.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001112.4"}],"isoformId":"P78563-2"},{"database":"RefSeq","id":"NP_001153702.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160230.2"}],"isoformId":"P78563-6"},{"database":"RefSeq","id":"NP_001333616.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001346687.2"}]},{"database":"RefSeq","id":"NP_001333617.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001346688.2"}],"isoformId":"P78563-6"},{"database":"RefSeq","id":"NP_056648.1","properties":[{"key":"NucleotideSequenceId","value":"NM_015833.4"}],"isoformId":"P78563-1"},{"database":"RefSeq","id":"NP_056649.1","properties":[{"key":"NucleotideSequenceId","value":"NM_015834.4"}],"isoformId":"P78563-3"},{"database":"RefSeq","id":"XP_016883740.1","properties":[{"key":"NucleotideSequenceId","value":"XM_017028251.2"}],"isoformId":"P78563-1"},{"database":"RefSeq","id":"XP_047296620.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047440664.1"}],"isoformId":"P78563-1"},{"database":"RefSeq","id":"XP_047296621.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047440665.1"}],"isoformId":"P78563-1"},{"database":"RefSeq","id":"XP_047296622.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047440666.1"}],"isoformId":"P78563-3"},{"database":"RefSeq","id":"XP_047296623.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047440667.1"}],"isoformId":"P78563-6"},{"database":"RefSeq","id":"XP_054180281.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054324306.1"}],"isoformId":"P78563-1"},{"database":"RefSeq","id":"XP_054180282.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054324307.1"}],"isoformId":"P78563-1"},{"database":"RefSeq","id":"XP_054180283.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054324308.1"}],"isoformId":"P78563-1"},{"database":"RefSeq","id":"XP_054180285.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054324310.1"}],"isoformId":"P78563-3"},{"database":"RefSeq","id":"XP_054180286.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054324311.1"}],"isoformId":"P78563-6"},{"database":"PDB","id":"1ZY7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=299-741"}]},{"database":"PDB","id":"5ED1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.77 A"},{"key":"Chains","value":"A/D=299-741"}]},{"database":"PDB","id":"5ED2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"A/D=299-741"}]},{"database":"PDB","id":"5HP2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.98 A"},{"key":"Chains","value":"A/D=299-741"}]},{"database":"PDB","id":"5HP3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.09 A"},{"key":"Chains","value":"A/D=299-741"}]},{"database":"PDB","id":"6D06","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"A/D=299-741"}]},{"database":"PDB","id":"6VFF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B=215-741"}]},{"database":"PDB","id":"7KFN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/D=299-741"}]},{"database":"PDB","id":"8E0F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B=215-741"}]},{"database":"PDB","id":"8E4X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B=215-741"}]},{"database":"PDB","id":"9D5J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B=215-741"}]},{"database":"PDB","id":"9D5K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B=215-741"}]},{"database":"PDB","id":"9OP3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.59 A"},{"key":"Chains","value":"A/B=215-741"}]},{"database":"AlphaFoldDB","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"106618","properties":[{"key":"Interactions","value":"512"}]},{"database":"FunCoup","id":"P78563","properties":[{"key":"Number of interactors","value":"3802"}]},{"database":"IntAct","id":"P78563","properties":[{"key":"Interactions","value":"222"}]},{"database":"STRING","id":"9606.ENSP00000353920","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5725136","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"P78563","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ADARB1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"2829669","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000353920","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"11761","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"33889","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"57656","properties":[{"key":"Description","value":"-"}],"isoformId":"P78563-1"},{"database":"ProteomicsDB","id":"57657","properties":[{"key":"Description","value":"-"}],"isoformId":"P78563-2"},{"database":"ProteomicsDB","id":"57658","properties":[{"key":"Description","value":"-"}],"isoformId":"P78563-3"},{"database":"ProteomicsDB","id":"57659","properties":[{"key":"Description","value":"-"}],"isoformId":"P78563-4"},{"database":"Pumba","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"10404","properties":[{"key":"antibodies","value":"175 antibodies from 32 providers"}]},{"database":"DNASU","id":"104","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000348831.9","properties":[{"key":"ProteinId","value":"ENSP00000015877.6"},{"key":"GeneId","value":"ENSG00000197381.19"}],"isoformId":"P78563-2"},{"database":"Ensembl","id":"ENST00000360697.4","properties":[{"key":"ProteinId","value":"ENSP00000353920.3"},{"key":"GeneId","value":"ENSG00000197381.19"}],"isoformId":"P78563-1"},{"database":"Ensembl","id":"ENST00000389861.7","properties":[{"key":"ProteinId","value":"ENSP00000516121.1"},{"key":"GeneId","value":"ENSG00000197381.19"}],"isoformId":"P78563-2"},{"database":"Ensembl","id":"ENST00000389863.8","properties":[{"key":"ProteinId","value":"ENSP00000374513.4"},{"key":"GeneId","value":"ENSG00000197381.19"}],"isoformId":"P78563-3"},{"database":"Ensembl","id":"ENST00000449478.2","properties":[{"key":"ProteinId","value":"ENSP00000387480.2"},{"key":"GeneId","value":"ENSG00000197381.19"}],"isoformId":"P78563-1"},{"database":"Ensembl","id":"ENST00000492414.5","properties":[{"key":"ProteinId","value":"ENSP00000436367.1"},{"key":"GeneId","value":"ENSG00000197381.19"}],"isoformId":"P78563-2"},{"database":"Ensembl","id":"ENST00000496664.5","properties":[{"key":"ProteinId","value":"ENSP00000435381.1"},{"key":"GeneId","value":"ENSG00000197381.19"}],"isoformId":"P78563-1"},{"database":"Ensembl","id":"ENST00000874894.1","properties":[{"key":"ProteinId","value":"ENSP00000544953.1"},{"key":"GeneId","value":"ENSG00000197381.19"}],"isoformId":"P78563-2"},{"database":"Ensembl","id":"ENST00000913573.1","properties":[{"key":"ProteinId","value":"ENSP00000583632.1"},{"key":"GeneId","value":"ENSG00000197381.19"}],"isoformId":"P78563-2"},{"database":"Ensembl","id":"ENST00000962803.1","properties":[{"key":"ProteinId","value":"ENSP00000632862.1"},{"key":"GeneId","value":"ENSG00000197381.19"}],"isoformId":"P78563-2"},{"database":"Ensembl","id":"ENST00000962804.1","properties":[{"key":"ProteinId","value":"ENSP00000632863.1"},{"key":"GeneId","value":"ENSG00000197381.19"}],"isoformId":"P78563-2"},{"database":"GeneID","id":"104","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:104","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000348831.9","properties":[{"key":"ProteinId","value":"ENSP00000015877.6"},{"key":"RefSeqNucleotideId","value":"NM_001112.4"},{"key":"RefSeqProteinId","value":"NP_001103.1"}],"isoformId":"P78563-2"},{"database":"UCSC","id":"uc002zgr.3","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P78563-1"},{"database":"AGR","id":"HGNC:226","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA24556","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"104","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"104","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ADARB1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"HPA","id":"ENSG00000197381","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (blood)"}]},{"database":"MalaCards","id":"ADARB1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"601218","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"618862","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2777","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_005382_3_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AAHCCLI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10268011at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P78563","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.5.4.37","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-75102","properties":[{"key":"PathwayName","value":"C6 deamination of adenosine"}]},{"database":"Reactome","id":"R-HSA-77042","properties":[{"key":"PathwayName","value":"Formation of editosomes by ADAR proteins"}]},{"database":"SignaLink","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000197381","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"104","properties":[{"key":"hits","value":"8 hits in 1155 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"ADARB1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P78563","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"ADARB1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"104","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P78563","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P78563","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"RNAct","id":"P78563","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000197381","properties":[{"key":"ExpressionPatterns","value":"Expressed in blood vessel layer and 206 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P78563","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18178553"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21289159"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32220291"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32220291"}]},{"database":"GO","id":"GO:0003726","properties":[{"key":"GoTerm","value":"F:double-stranded RNA adenosine deaminase activity"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10836796"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32220291"}]},{"database":"GO","id":"GO:0003725","properties":[{"key":"GoTerm","value":"F:double-stranded RNA binding"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}]},{"database":"GO","id":"GO:0003729","properties":[{"key":"GoTerm","value":"F:mRNA binding"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9149227"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27065196"}]},{"database":"GO","id":"GO:0008251","properties":[{"key":"GoTerm","value":"F:tRNA-specific adenosine deaminase activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006382","properties":[{"key":"GoTerm","value":"P:adenosine to inosine editing"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10836796"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18178553"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21289159"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32220291"}]},{"database":"GO","id":"GO:0016553","properties":[{"key":"GoTerm","value":"P:base conversion or substitution editing"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32220291"}]},{"database":"GO","id":"GO:0016556","properties":[{"key":"GoTerm","value":"P:mRNA modification"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18178553"}]},{"database":"GO","id":"GO:0006397","properties":[{"key":"GoTerm","value":"P:mRNA processing"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030336","properties":[{"key":"GoTerm","value":"P:negative regulation of cell migration"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18178553"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18178553"}]},{"database":"GO","id":"GO:0044387","properties":[{"key":"GoTerm","value":"P:negative regulation of protein kinase activity by regulation of protein phosphorylation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21289159"}]},{"database":"GO","id":"GO:0045070","properties":[{"key":"GoTerm","value":"P:positive regulation of viral genome replication"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21289159"}]},{"database":"GO","id":"GO:0051726","properties":[{"key":"GoTerm","value":"P:regulation of cell cycle"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18178553"}]},{"database":"GO","id":"GO:0006396","properties":[{"key":"GoTerm","value":"P:RNA processing"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32220291"}]},{"database":"CDD","id":"cd19895","properties":[{"key":"EntryName","value":"DSRM_RED1_rpt1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd19898","properties":[{"key":"EntryName","value":"DSRM_RED1_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP03822","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"3.30.160.20:FF:000009","properties":[{"key":"EntryName","value":"Adenosine deaminase RNA-specific B2 (inactive)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.20:FF:000011","properties":[{"key":"EntryName","value":"double-stranded RNA-specific editase 1 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"IDEAL","id":"IID00604","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR002466","properties":[{"key":"EntryName","value":"A_deamin"}]},{"database":"InterPro","id":"IPR044458","properties":[{"key":"EntryName","value":"ADAR2_DSRM_1"}]},{"database":"InterPro","id":"IPR044459","properties":[{"key":"EntryName","value":"ADAR2_DSRM_2"}]},{"database":"InterPro","id":"IPR014720","properties":[{"key":"EntryName","value":"dsRBD_dom"}]},{"database":"InterPro","id":"IPR008996","properties":[{"key":"EntryName","value":"IL1/FGF"}]},{"database":"PANTHER","id":"PTHR10910:SF58","properties":[{"key":"EntryName","value":"DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10910","properties":[{"key":"EntryName","value":"EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02137","properties":[{"key":"EntryName","value":"A_deamin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00035","properties":[{"key":"EntryName","value":"dsrm"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00552","properties":[{"key":"EntryName","value":"ADEAMc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00358","properties":[{"key":"EntryName","value":"DSRM"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF50353","properties":[{"key":"EntryName","value":"Cytokine"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54768","properties":[{"key":"EntryName","value":"dsRNA-binding domain-like"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50141","properties":[{"key":"EntryName","value":"A_DEAMIN_EDITASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50137","properties":[{"key":"EntryName","value":"DS_RBD"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEGSRSYTQAGVQWCNHGSLQPRPPGLLSDPSTSTFQGAGTTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLTP","length":741,"molWeight":80763,"crc64":"02B583414DD59C20","md5":"E06B4229B8B7C71819A9C4F8F0E1FE57"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBUNIT":1,"INTERACTION":19,"SUBCELLULAR LOCATION":3,"ALTERNATIVE PRODUCTS":6,"TISSUE SPECIFICITY":2,"DISEASE":1,"MISCELLANEOUS":2,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":3,"Region":6,"Compositional bias":3,"Active site":1,"Binding site":11,"Modified residue":2,"Alternative sequence":4,"Natural variant":6,"Sequence conflict":3,"Helix":21,"Beta strand":19,"Turn":4},"uniParcId":"UPI0000133622"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A994J7T5","uniProtkbId":"A0A994J7T5_HUMAN","entryAudit":{"firstPublicDate":"2023-05-03","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2023-05-03","entryVersion":18,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516122.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516122.1"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516122.1"}],"value":"ADARB1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"DRBM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50137"}]},{"type":"Domain","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"DRBM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50137"}]},{"type":"Domain","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":746,"modifier":"EXACT"}},"description":"A to I editase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50141"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":445,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00240"}]},{"type":"Binding site","location":{"start":{"value":443,"modifier":"EXACT"},"end":{"value":443,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00240"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":500,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00240"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":565,"modifier":"EXACT"},"end":{"value":565,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00240"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00240"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022664"}],"id":"KW-0507","category":"Biological process","name":"mRNA processing"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00266"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00240"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516122.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516122.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516122.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516122.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001397651.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001410722.1"}]},{"database":"AlphaFoldDB","id":"A0A994J7T5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A994J7T5","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000705392.1","properties":[{"key":"ProteinId","value":"ENSP00000516122.1"},{"key":"GeneId","value":"ENSG00000197381.20"}]},{"database":"GeneID","id":"104","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"104","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AAHCCLI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10268011at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"ExpressionAtlas","id":"A0A994J7T5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004000","properties":[{"key":"GoTerm","value":"F:adenosine deaminase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003729","properties":[{"key":"GoTerm","value":"F:mRNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006396","properties":[{"key":"GoTerm","value":"P:RNA processing"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd19895","properties":[{"key":"EntryName","value":"DSRM_RED1_rpt1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd19898","properties":[{"key":"EntryName","value":"DSRM_RED1_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.20:FF:000009","properties":[{"key":"EntryName","value":"Adenosine deaminase RNA-specific B2 (inactive)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.20:FF:000011","properties":[{"key":"EntryName","value":"double-stranded RNA-specific editase 1 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR002466","properties":[{"key":"EntryName","value":"A_deamin"}]},{"database":"InterPro","id":"IPR044458","properties":[{"key":"EntryName","value":"ADAR2_DSRM_1"}]},{"database":"InterPro","id":"IPR044459","properties":[{"key":"EntryName","value":"ADAR2_DSRM_2"}]},{"database":"InterPro","id":"IPR014720","properties":[{"key":"EntryName","value":"dsRBD_dom"}]},{"database":"InterPro","id":"IPR008996","properties":[{"key":"EntryName","value":"IL1/FGF"}]},{"database":"PANTHER","id":"PTHR10910:SF58","properties":[{"key":"EntryName","value":"DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10910","properties":[{"key":"EntryName","value":"EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02137","properties":[{"key":"EntryName","value":"A_deamin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00035","properties":[{"key":"EntryName","value":"dsrm"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00552","properties":[{"key":"EntryName","value":"ADEAMc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00358","properties":[{"key":"EntryName","value":"DSRM"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF50353","properties":[{"key":"EntryName","value":"Cytokine"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54768","properties":[{"key":"EntryName","value":"dsRNA-binding domain-like"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50141","properties":[{"key":"EntryName","value":"A_DEAMIN_EDITASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50137","properties":[{"key":"EntryName","value":"DS_RBD"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MASSTTGPLHMGTFFSIMGRRYKRRRKKRSERKDRNSLRQSRNPQKYFAMDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLTP","length":750,"molWeight":82536,"crc64":"DC62D3CF4D8A008D","md5":"C0C32F953B5E85EC31106A1520084A55"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":3,"Region":1,"Compositional bias":3,"Active site":1,"Binding site":3},"uniParcId":"UPI0007DC6298"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A994J4V7","uniProtkbId":"A0A994J4V7_HUMAN","entryAudit":{"firstPublicDate":"2023-05-03","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2023-05-03","entryVersion":18,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516123.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516123.1"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516123.1"}],"value":"ADARB1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"DRBM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50137"}]},{"type":"Domain","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"DRBM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50137"}]},{"type":"Domain","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":717,"modifier":"EXACT"}},"description":"A to I editase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50141"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":535,"modifier":"EXACT"},"end":{"value":567,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":542,"modifier":"EXACT"},"end":{"value":552,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":445,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00240"}]},{"type":"Binding site","location":{"start":{"value":443,"modifier":"EXACT"},"end":{"value":443,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00240"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":500,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00240"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":605,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00240"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00240"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022664"}],"id":"KW-0507","category":"Biological process","name":"mRNA processing"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00266"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00240"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516123.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516123.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516123.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516123.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001333616.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001346687.2"}]},{"database":"AlphaFoldDB","id":"A0A994J4V7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A994J4V7","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000705393.1","properties":[{"key":"ProteinId","value":"ENSP00000516123.1"},{"key":"GeneId","value":"ENSG00000197381.20"}]},{"database":"GeneID","id":"104","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"104","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10268011at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"ExpressionAtlas","id":"A0A994J4V7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004000","properties":[{"key":"GoTerm","value":"F:adenosine deaminase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003729","properties":[{"key":"GoTerm","value":"F:mRNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006396","properties":[{"key":"GoTerm","value":"P:RNA processing"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd19895","properties":[{"key":"EntryName","value":"DSRM_RED1_rpt1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd19898","properties":[{"key":"EntryName","value":"DSRM_RED1_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.20:FF:000009","properties":[{"key":"EntryName","value":"Adenosine deaminase RNA-specific B2 (inactive)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.20:FF:000011","properties":[{"key":"EntryName","value":"double-stranded RNA-specific editase 1 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR002466","properties":[{"key":"EntryName","value":"A_deamin"}]},{"database":"InterPro","id":"IPR044458","properties":[{"key":"EntryName","value":"ADAR2_DSRM_1"}]},{"database":"InterPro","id":"IPR044459","properties":[{"key":"EntryName","value":"ADAR2_DSRM_2"}]},{"database":"InterPro","id":"IPR014720","properties":[{"key":"EntryName","value":"dsRBD_dom"}]},{"database":"InterPro","id":"IPR008996","properties":[{"key":"EntryName","value":"IL1/FGF"}]},{"database":"PANTHER","id":"PTHR10910:SF58","properties":[{"key":"EntryName","value":"DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10910","properties":[{"key":"EntryName","value":"EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02137","properties":[{"key":"EntryName","value":"A_deamin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00035","properties":[{"key":"EntryName","value":"dsrm"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00552","properties":[{"key":"EntryName","value":"ADEAMc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00358","properties":[{"key":"EntryName","value":"DSRM"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF50353","properties":[{"key":"EntryName","value":"Cytokine"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54768","properties":[{"key":"EntryName","value":"dsRNA-binding domain-like"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50141","properties":[{"key":"EntryName","value":"A_DEAMIN_EDITASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50137","properties":[{"key":"EntryName","value":"DS_RBD"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MASSTTGPLHMGTFFSIMGRRYKRRRKKRSERKDRNSLRQSRNPQKYFAMDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEGSRSYTQAGVQWCNHGSLQPRPPGLLSDPSTSTFQGAGTTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDELGRASRLCSLPLTTLQDYQAQRVP","length":733,"molWeight":80117,"crc64":"582F10E015A4AA6A","md5":"9711DDCC1C8DD973721CFA7AA001DD5F"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":3,"Region":2,"Compositional bias":4,"Active site":1,"Binding site":3},"uniParcId":"UPI0007DC7786"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2E793","uniProtkbId":"A0ACP2E793_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715945.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715945.1"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715945.1"}],"value":"ADARB1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715945.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715945.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715945.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715945.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001046128.1","properties":[{"key":"ProteinId","value":"ENSP00000715945.1"},{"key":"GeneId","value":"ENSG00000197381.20"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]}],"sequence":{"value":"MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDELGRASRLCSLPLTTLQDYQAQRVP","length":644,"molWeight":70083,"crc64":"08B06BAC00C6BFF5","md5":"CD552CAE24C2369A89296F48E03BAD0F"},"extraAttributes":{"uniParcId":"UPI0005CFF4F2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2I8E1","uniProtkbId":"A0ACP2I8E1_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000785564.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000785564.1"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000785564.1"}],"value":"ADARB1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000785564.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000785564.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000785564.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000785564.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001115759.1","properties":[{"key":"ProteinId","value":"ENSP00000785564.1"},{"key":"GeneId","value":"ENSG00000197381.20"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]}],"sequence":{"value":"MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVRNYAAALKHGVIALGNASRQHFSFRITVDFPP","length":354,"molWeight":37934,"crc64":"07377E997DFCBF44","md5":"421B1B6F246737D3D2D22CB6C5DC984D"},"extraAttributes":{"uniParcId":"UPI00493295BE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2E7D7","uniProtkbId":"A0ACP2E7D7_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715946.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715946.1"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715946.1"}],"value":"ADARB1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715946.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715946.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715946.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715946.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001046129.1","properties":[{"key":"ProteinId","value":"ENSP00000715946.1"},{"key":"GeneId","value":"ENSG00000197381.20"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]}],"sequence":{"value":"MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSEFQWLTVK","length":590,"molWeight":64519,"crc64":"DD9CBEE769D213B8","md5":"B4786B4C08EEF431224ECB46F744C3CC"},"extraAttributes":{"uniParcId":"UPI0005D04094"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0A0MSG8","uniProtkbId":"A0A0A0MSG8_HUMAN","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-01-07","entryVersion":68,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000387480.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000387480.2"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000387480.2"}],"value":"ADARB1"}}],"features":[{"type":"Domain","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"DRBM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50137"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00266"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000387480.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":5,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"20068231"}]},{"referenceNumber":6,"citation":{"id":"CI-20IMLJLJTMBEJ","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"OCT-2022","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000387480.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A0A0MSG8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A0A0MSG8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A0A0MSG8","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0A0A0MSG8","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"10404","properties":[{"key":"antibodies","value":"175 antibodies from 32 providers"}]},{"database":"Ensembl","id":"ENST00000449478.2","properties":[{"key":"ProteinId","value":"ENSP00000387480.2"},{"key":"GeneId","value":"ENSG00000197381.18"}]},{"database":"UCSC","id":"uc062avj.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1829748_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10268011at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"ADARB1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"Bgee","id":"ENSG00000197381","properties":[{"key":"ExpressionPatterns","value":"Expressed in blood vessel layer and 206 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A0A0MSG8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"FunFam","id":"3.30.160.20:FF:000009","properties":[{"key":"EntryName","value":"Adenosine deaminase RNA-specific B2 (inactive)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR014720","properties":[{"key":"EntryName","value":"dsRBD_dom"}]},{"database":"PANTHER","id":"PTHR10910:SF62","properties":[{"key":"EntryName","value":"AT07585P-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10910","properties":[{"key":"EntryName","value":"EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00035","properties":[{"key":"EntryName","value":"dsrm"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00358","properties":[{"key":"EntryName","value":"DSRM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54768","properties":[{"key":"EntryName","value":"dsRNA-binding domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50137","properties":[{"key":"EntryName","value":"DS_RBD"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRS","length":141,"molWeight":15061,"crc64":"463FD5BBD94713C7","md5":"2761688D90A6D2C65DCE5C5E3B16FD58"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":2},"uniParcId":"UPI0000E5A411"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2E790","uniProtkbId":"A0ACP2E790_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715944.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715944.1"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715944.1"}],"value":"ADARB1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715944.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715944.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715944.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715944.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001046127.1","properties":[{"key":"ProteinId","value":"ENSP00000715944.1"},{"key":"GeneId","value":"ENSG00000197381.20"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]}],"sequence":{"value":"MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDELGRASRLCSLPLTTLQDYQAQRVP","length":644,"molWeight":70083,"crc64":"08B06BAC00C6BFF5","md5":"CD552CAE24C2369A89296F48E03BAD0F"},"extraAttributes":{"uniParcId":"UPI0005CFF4F2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2E7B7","uniProtkbId":"A0ACP2E7B7_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715940.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715940.1"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715940.1"}],"value":"ADARB1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715940.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715940.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715940.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715940.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001046123.1","properties":[{"key":"ProteinId","value":"ENSP00000715940.1"},{"key":"GeneId","value":"ENSG00000197381.20"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]}],"sequence":{"value":"MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSEFQWLTVK","length":590,"molWeight":64519,"crc64":"DD9CBEE769D213B8","md5":"B4786B4C08EEF431224ECB46F744C3CC"},"extraAttributes":{"uniParcId":"UPI0005D04094"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2E7E5","uniProtkbId":"A0ACP2E7E5_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715947.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715947.1"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715947.1"}],"value":"ADARB1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715947.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715947.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715947.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715947.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001046130.1","properties":[{"key":"ProteinId","value":"ENSP00000715947.1"},{"key":"GeneId","value":"ENSG00000197381.20"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]}],"sequence":{"value":"MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGEHHND","length":365,"molWeight":39012,"crc64":"B286B7B7AE7AF634","md5":"E29211067E861B4628905614DC687086"},"extraAttributes":{"uniParcId":"UPI00493338A5"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2HTU4","uniProtkbId":"A0ACP2HTU4_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780274.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780274.1"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780274.1"}],"value":"ADARB1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780274.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780274.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780274.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780274.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001110469.1","properties":[{"key":"ProteinId","value":"ENSP00000780274.1"},{"key":"GeneId","value":"ENSG00000197381.20"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]}],"sequence":{"value":"MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVRNYAAALKHGVIALGNASRQHFSFRITVDFPP","length":354,"molWeight":37934,"crc64":"07377E997DFCBF44","md5":"421B1B6F246737D3D2D22CB6C5DC984D"},"extraAttributes":{"uniParcId":"UPI00493295BE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2HTV7","uniProtkbId":"A0ACP2HTV7_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780273.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780273.1"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780273.1"}],"value":"ADARB1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780273.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780273.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780273.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000780273.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001110468.1","properties":[{"key":"ProteinId","value":"ENSP00000780273.1"},{"key":"GeneId","value":"ENSG00000197381.20"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]}],"sequence":{"value":"MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVRNYAAALKHGVIALGNASRQHFSFRITVDFPP","length":354,"molWeight":37934,"crc64":"07377E997DFCBF44","md5":"421B1B6F246737D3D2D22CB6C5DC984D"},"extraAttributes":{"uniParcId":"UPI00493295BE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2E787","uniProtkbId":"A0ACP2E787_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715943.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715943.1"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715943.1"}],"value":"ADARB1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715943.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715943.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715943.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715943.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001046126.1","properties":[{"key":"ProteinId","value":"ENSP00000715943.1"},{"key":"GeneId","value":"ENSG00000197381.20"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]}],"sequence":{"value":"MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEGSRSYTQAGVQWCNHGSLQPRPPGLLSDPSTSTFQGAGTTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDELGRASRLCSLPLTTLQDYQAQRVP","length":684,"molWeight":74214,"crc64":"55FBEFB8426FB01C","md5":"057BB8092CD341FD9430B99F834C12B9"},"extraAttributes":{"uniParcId":"UPI0049321CE4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2E7B2","uniProtkbId":"A0ACP2E7B2_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715941.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715941.1"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715941.1"}],"value":"ADARB1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715941.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715941.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715941.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715941.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001046124.1","properties":[{"key":"ProteinId","value":"ENSP00000715941.1"},{"key":"GeneId","value":"ENSG00000197381.20"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]}],"sequence":{"value":"MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEGSRSYTQAGVQWCNHGSLQPRPPGLLSDPSTSTFQGAGTTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSEFQWLTVK","length":630,"molWeight":68650,"crc64":"ABCAFBEC6C19391E","md5":"E17D971754C7673951B5E634C567F7AA"},"extraAttributes":{"uniParcId":"UPI0049360905"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2E7L0","uniProtkbId":"A0ACP2E7L0_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715942.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715942.1"}],"value":"Adenosine deaminase RNA specific B1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715942.1"}],"value":"ADARB1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715942.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715942.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715942.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000715942.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001579","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX322560","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001046125.1","properties":[{"key":"ProteinId","value":"ENSP00000715942.1"},{"key":"GeneId","value":"ENSG00000197381.20"}]},{"database":"HGNC","id":"HGNC:226","properties":[{"key":"GeneName","value":"ADARB1"}]},{"database":"OpenTargets","id":"ENSG00000197381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155992","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]}],"sequence":{"value":"MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEGSRSYTQAGVQWCNHGSLQPRPPGLLSDPSTSTFQGAGTTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDELGRASRLCSLPLTTLQDYQAQRVP","length":684,"molWeight":74214,"crc64":"55FBEFB8426FB01C","md5":"057BB8092CD341FD9430B99F834C12B9"},"extraAttributes":{"uniParcId":"UPI0049321CE4"}}]}