{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9BZ11","secondaryAccessions":["A0A1K6","Q5JT75","Q5JT76","Q8N0W6"],"uniProtkbId":"ADA33_HUMAN","entryAudit":{"firstPublicDate":"2002-03-27","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-03-27","entryVersion":210,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Disintegrin and metalloproteinase domain-containing protein 33"},"shortNames":[{"value":"ADAM 33"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12535637"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14676211"}],"value":"3.4.24.-"}]},"flag":"Precursor"},"genes":[{"geneName":{"value":"ADAM33"},"synonyms":[{"value":"C20orf153"}],"orfNames":[{"value":"UNQ873/PRO1891"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14676211"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33982767"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36091328"}],"value":"Metalloprotease that cleaves and sheds the ectodomains of cell-surface proteins and thereby contributes to angiogenesis, cell differentiation, inflammation, and cell proliferation (PubMed:14676211, PubMed:33982767). Modulates the activity of adhesion molecules and cytokines by generating soluble forms, leading to either attenuation of cell-surface signaling or initiation of downstream intracellular signaling pathways. For instance, acts as a constitutive sheddase of kit ligand/KITLG (PubMed:14676211). Promotes and maintains a proliferative phenotype in vascular smooth muscle cells through regulation of the PI3K/AKT and ERK signaling pathways (PubMed:33982767). Additionally, enhances cell migration and regulates cytokine secretion during airway vascular remodeling via the same signaling cascades (PubMed:36091328)"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14659745"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14659745"}],"value":"Binds 1 zinc ion per subunit."}]}},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9BZ11-2","intActId":"EBI-10303054"},"interactantTwo":{"uniProtKBAccession":"Q9BXN2","geneName":"CLEC7A","intActId":"EBI-3939278"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BZ11-2","intActId":"EBI-10303054"},"interactantTwo":{"uniProtKBAccession":"Q9BRI3","geneName":"SLC30A2","intActId":"EBI-8644112"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12535637"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9BZ11-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9BZ11-2"],"sequenceIds":["VSP_005495"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q9BZ11-3"],"sequenceIds":["VSP_015421","VSP_005495"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11814695"}],"value":"Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"The precursor is cleaved by a furin endopeptidase"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Asthma","diseaseAccession":"DI-02482","acronym":"ASTHMA","description":"The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.","diseaseCrossReference":{"database":"MIM","id":"600807"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12110844"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16773130"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19237393"}]},"note":{"texts":[{"value":"Disease susceptibility is associated with variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"By similarity with mouse isoform"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 3"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}],"featureId":"PRO_0000029142"},{"type":"Chain","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":813,"modifier":"EXACT"}},"description":"Disintegrin and metalloproteinase domain-containing protein 33","featureId":"PRO_0000029143"},{"type":"Topological domain","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":701,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":702,"modifier":"EXACT"},"end":{"value":722,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":723,"modifier":"EXACT"},"end":{"value":813,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Domain","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":503,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Domain","location":{"start":{"value":649,"modifier":"EXACT"},"end":{"value":681,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Region","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":746,"modifier":"EXACT"},"end":{"value":813,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Cysteine switch","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Compositional bias","location":{"start":{"value":780,"modifier":"EXACT"},"end":{"value":791,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00276"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10095"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12535637"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14676211"}]},{"type":"Binding site","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"in inhibited form","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14659745"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14659745"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14659745"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Glycosylation","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Glycosylation","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Glycosylation","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":448,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14659745"}]},{"type":"Disulfide bond","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14659745"}]},{"type":"Disulfide bond","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14659745"}]},{"type":"Disulfide bond","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":653,"modifier":"EXACT"},"end":{"value":663,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":657,"modifier":"EXACT"},"end":{"value":669,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":671,"modifier":"EXACT"},"end":{"value":680,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_015421","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":636,"modifier":"EXACT"},"end":{"value":661,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11814695"}],"featureId":"VSP_005495","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"in dbSNP:rs41467948","featureCrossReferences":[{"database":"dbSNP","id":"rs41467948"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_030512","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in dbSNP:rs3918392","featureCrossReferences":[{"database":"dbSNP","id":"rs3918392"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_029143","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"in dbSNP:rs41534847","featureCrossReferences":[{"database":"dbSNP","id":"rs41534847"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_030513","alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"in a cutaneous metastatic melanoma sample; somatic mutation; dbSNP:rs1169229302","featureCrossReferences":[{"database":"dbSNP","id":"rs1169229302"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21618342"}],"featureId":"VAR_066337","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"in dbSNP:rs41459049","featureCrossReferences":[{"database":"dbSNP","id":"rs41459049"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_030514","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"in dbSNP:rs41483049","featureCrossReferences":[{"database":"dbSNP","id":"rs41483049"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_030515","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"in dbSNP:rs41419248","featureCrossReferences":[{"database":"dbSNP","id":"rs41419248"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_030516","alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":441,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"in dbSNP:rs41382144","featureCrossReferences":[{"database":"dbSNP","id":"rs41382144"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_030517","alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":515,"modifier":"EXACT"},"end":{"value":515,"modifier":"EXACT"}},"description":"in dbSNP:rs615436","featureCrossReferences":[{"database":"dbSNP","id":"rs615436"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_030518","alternativeSequence":{"originalSequence":"W","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":612,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"in dbSNP:rs41453444","featureCrossReferences":[{"database":"dbSNP","id":"rs41453444"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_030519","alternativeSequence":{"originalSequence":"L","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":710,"modifier":"EXACT"},"end":{"value":710,"modifier":"EXACT"}},"description":"in dbSNP:rs3918396","featureCrossReferences":[{"database":"dbSNP","id":"rs3918396"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_030520","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":739,"modifier":"EXACT"},"end":{"value":739,"modifier":"EXACT"}},"description":"in dbSNP:rs41434648","featureCrossReferences":[{"database":"dbSNP","id":"rs41434648"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_030521","alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":742,"modifier":"EXACT"},"end":{"value":742,"modifier":"EXACT"}},"description":"in dbSNP:rs41462450","featureCrossReferences":[{"database":"dbSNP","id":"rs41462450"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_030522","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":764,"modifier":"EXACT"},"end":{"value":764,"modifier":"EXACT"}},"description":"in dbSNP:rs2280091","featureCrossReferences":[{"database":"dbSNP","id":"rs2280091"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_021847","alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":774,"modifier":"EXACT"},"end":{"value":774,"modifier":"EXACT"}},"description":"in dbSNP:rs2280090","featureCrossReferences":[{"database":"dbSNP","id":"rs2280090"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_029144","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Complete loss of catalytic activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14676211"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":802,"modifier":"EXACT"},"end":{"value":802,"modifier":"EXACT"}},"description":"in Ref. 2; AAM80482/AAM80483","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{}},{"type":"Helix","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R54"}]},{"type":"Beta strand","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Helix","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Turn","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Helix","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Helix","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Beta strand","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Beta strand","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Helix","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Beta strand","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Helix","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Helix","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Turn","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Beta strand","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Beta strand","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Helix","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Helix","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Helix","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Helix","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":398,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Turn","location":{"start":{"value":399,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]},{"type":"Helix","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1R55"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1058","category":"Disease","name":"Asthma"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0482","category":"Molecular function","name":"Metalloprotease"},{"id":"KW-0645","category":"Molecular function","name":"Protease"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0865","category":"PTM","name":"Zymogen"}],"references":[{"referenceNumber":1,"citation":{"id":"11814695","citationType":"journal article","authors":["Yoshinaka T.","Nishii K.","Yamada K.","Sawada H.","Nishiwaki E.","Smith K.","Yoshino K.","Ishiguro H.","Higashiyama S."],"citationCrossReferences":[{"database":"PubMed","id":"11814695"},{"database":"DOI","id":"10.1016/s0378-1119(01)00818-6"}],"title":"Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity.","publicationDate":"2002","journal":"Gene","firstPage":"227","lastPage":"236","volume":"282"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"12110844","citationType":"journal article","authors":["Van Eerdewegh P.","Little R.D.","Dupuis J.","Del Mastro R.G.","Falls K.","Simon J.","Torrey D.","Pandit S.","McKenny J.","Braunschweiger K.","Walsh A.","Liu Z.","Hayward B.","Folz C.","Manning S.P.","Bawa A.","Saracino L.","Thackston M.","Benchekroun Y.","Capparell N.","Wang M.","Adair R.","Feng Y.","Dubois J.","FitzGerald M.G.","Huang H.","Gibson R.","Allen K.M.","Pedan A.","Danzig M.R.","Umland S.P.","Egan R.W.","Cuss F.M.","Rorke S.","Clough J.B.","Holloway J.W.","Holgate S.T.","Keith T.P."],"citationCrossReferences":[{"database":"PubMed","id":"12110844"},{"database":"DOI","id":"10.1038/nature00878"}],"title":"Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.","publicationDate":"2002","journal":"Nature","firstPage":"426","lastPage":"430","volume":"418"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)","INVOLVEMENT IN ASTHMA"],"referenceComments":[{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"12975309","citationType":"journal article","authors":["Clark H.F.","Gurney A.L.","Abaya E.","Baker K.","Baldwin D.T.","Brush J.","Chen J.","Chow B.","Chui C.","Crowley C.","Currell B.","Deuel B.","Dowd P.","Eaton D.","Foster J.S.","Grimaldi C.","Gu Q.","Hass P.E.","Heldens S.","Huang A.","Kim H.S.","Klimowski L.","Jin Y.","Johnson S.","Lee J.","Lewis L.","Liao D.","Mark M.R.","Robbie E.","Sanchez C.","Schoenfeld J.","Seshagiri S.","Simmons L.","Singh J.","Smith V.","Stinson J.","Vagts A.","Vandlen R.L.","Watanabe C.","Wieand D.","Woods K.","Xie M.-H.","Yansura D.G.","Yi S.","Yu G.","Yuan J.","Zhang M.","Zhang Z.","Goddard A.D.","Wood W.I.","Godowski P.J.","Gray A.M."],"citationCrossReferences":[{"database":"PubMed","id":"12975309"},{"database":"DOI","id":"10.1101/gr.1293003"}],"title":"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.","publicationDate":"2003","journal":"Genome Res.","firstPage":"2265","lastPage":"2270","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":4,"citation":{"id":"CI-DIALHV3PQHS4C","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS SER-109; ALA-178; MET-272; ILE-316; SER-336; SER-365; GLU-441; ARG-515; HIS-612; ILE-710; GLY-739; TYR-742; THR-764 AND SER-774"]},{"referenceNumber":5,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.L.","Burton J.","Gilbert J.G.R.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.D.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.E.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.D.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.D.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaeslaiho M.H.","Leversha M.A.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.A.","Mistry D.","Moore M.J.F.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.V.","Peck A.I.","Phillimore B.J.C.T.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann R.M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"12535637","citationType":"journal article","authors":["Garlisi C.G.","Zou J.","Devito K.E.","Tian F.","Zhu F.X.","Liu J.","Shah H.","Wan Y.","Motasim Billah M.","Egan R.W.","Umland S.P."],"citationCrossReferences":[{"database":"PubMed","id":"12535637"},{"database":"DOI","id":"10.1016/s0006-291x(02)02976-5"}],"title":"Human ADAM33: protein maturation and localization.","publicationDate":"2003","journal":"Biochem. Biophys. Res. Commun.","firstPage":"35","lastPage":"43","volume":"301"},"referencePositions":["SUBCELLULAR LOCATION","MUTAGENESIS OF GLU-346","CATALYTIC ACTIVITY"]},{"referenceNumber":7,"citation":{"id":"14676211","citationType":"journal article","authors":["Zou J.","Zhu F.","Liu J.","Wang W.","Zhang R.","Garlisi C.G.","Liu Y.H.","Wang S.","Shah H.","Wan Y.","Umland S.P."],"citationCrossReferences":[{"database":"PubMed","id":"14676211"},{"database":"DOI","id":"10.1074/jbc.m309696200"}],"title":"Catalytic activity of human ADAM33.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"9818","lastPage":"9830","volume":"279"},"referencePositions":["FUNCTION","MUTAGENESIS OF GLU-346","CATALYTIC ACTIVITY"]},{"referenceNumber":8,"citation":{"id":"16773130","citationType":"journal article","authors":["Kedda M.A.","Duffy D.L.","Bradley B.","O'Hehir R.E.","Thompson P.J."],"citationCrossReferences":[{"database":"PubMed","id":"16773130"},{"database":"DOI","id":"10.1038/sj.ejhg.5201662"}],"title":"ADAM33 haplotypes are associated with asthma in a large Australian population.","publicationDate":"2006","journal":"Eur. J. Hum. Genet.","firstPage":"1027","lastPage":"1036","volume":"14"},"referencePositions":["INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA"]},{"referenceNumber":9,"citation":{"id":"19237393","citationType":"journal article","authors":["Blakey J.D.","Sayers I.","Ring S.M.","Strachan D.P.","Hall I.P."],"citationCrossReferences":[{"database":"PubMed","id":"19237393"},{"database":"DOI","id":"10.1136/thx.2008.102053"}],"title":"Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort.","publicationDate":"2009","journal":"Thorax","firstPage":"381","lastPage":"387","volume":"64"},"referencePositions":["INVOLVEMENT IN SUSCEPTIBILITY TO ASTHMA"]},{"referenceNumber":10,"citation":{"id":"33982767","citationType":"journal article","authors":["Yan F.","Hao Y.","Gong X.","Sun H.","Ding J.","Wang J."],"citationCrossReferences":[{"database":"PubMed","id":"33982767"},{"database":"DOI","id":"10.3892/mmr.2021.12141"}],"title":"Silencing a disintegrin and metalloproteinase-33 attenuates the proliferation of vascular smooth muscle cells via PI3K/AKT pathway: Implications in the pathogenesis of airway vascular remodeling.","publicationDate":"2021","journal":"Mol. Med. Report.","firstPage":"0","lastPage":"0","volume":"24"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":11,"citation":{"id":"36091328","citationType":"journal article","authors":["Yan F.","Hu X.","He L.","Jiao K.","Hao Y.","Wang J."],"citationCrossReferences":[{"database":"PubMed","id":"36091328"},{"database":"DOI","id":"10.1155/2022/8437348"}],"title":"ADAM33 Silencing Inhibits Vascular Smooth Muscle Cell Migration and Regulates Cytokine Secretion in Airway Vascular Remodeling via the PI3K/AKT/mTOR Pathway.","publicationDate":"2022","journal":"Can. Respir. J.","firstPage":"8437348","lastPage":"8437348","volume":"2022"},"referencePositions":["FUNCTION"]},{"referenceNumber":12,"citation":{"id":"14659745","citationType":"journal article","authors":["Orth P.","Reichert P.","Wang W.","Prosise W.W.","Yarosh-Tomaine T.","Hammond G.","Ingram R.N.","Xiao L.","Mirza U.A.","Zou J.","Strickland C.","Taremi S.S.","Le H.V.","Madison V."],"citationCrossReferences":[{"database":"PubMed","id":"14659745"},{"database":"DOI","id":"10.1016/j.jmb.2003.10.037"}],"title":"Crystal structure of the catalytic domain of human ADAM33.","publicationDate":"2004","journal":"J. Mol. Biol.","firstPage":"129","lastPage":"137","volume":"335"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 204-410 IN COMPLEX WITH METALLOPROTEASE INHIBITOR MARIMASTAT AND ZINC","COFACTOR"]},{"referenceNumber":13,"citation":{"id":"21618342","citationType":"journal article","authors":["Wei X.","Moncada-Pazos A.","Cal S.","Soria-Valles C.","Gartner J.","Rudloff U.","Lin J.C.","Rosenberg S.A.","Lopez-Otin C.","Samuels Y."],"citationCrossReferences":[{"database":"PubMed","id":"21618342"},{"database":"DOI","id":"10.1002/humu.21477"}],"title":"Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.","publicationDate":"2011","journal":"Hum. Mutat.","firstPage":"E2148","lastPage":"E2175","volume":"32"},"referencePositions":["VARIANT VAL-305"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB055891","properties":[{"key":"ProteinId","value":"BAB83092.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF466287","properties":[{"key":"ProteinId","value":"AAM80482.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF466288","properties":[{"key":"ProteinId","value":"AAM80483.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY358314","properties":[{"key":"ProteinId","value":"AAQ88680.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ995342","properties":[{"key":"ProteinId","value":"ABI97387.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS13058.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9BZ11-1"},{"database":"RefSeq","id":"NP_001269376.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001282447.3"}]},{"database":"RefSeq","id":"NP_079496.1","properties":[{"key":"NucleotideSequenceId","value":"NM_025220.5"}],"isoformId":"Q9BZ11-1"},{"database":"RefSeq","id":"NP_694882.1","properties":[{"key":"NucleotideSequenceId","value":"NM_153202.4"}],"isoformId":"Q9BZ11-2"},{"database":"PDB","id":"1R54","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A=204-409"}]},{"database":"PDB","id":"1R55","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.58 A"},{"key":"Chains","value":"A=204-409"}]},{"database":"PDBsum","id":"1R54","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1R55","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"123243","properties":[{"key":"Interactions","value":"94"}]},{"database":"FunCoup","id":"Q9BZ11","properties":[{"key":"Number of interactors","value":"107"}]},{"database":"IntAct","id":"Q9BZ11","properties":[{"key":"Interactions","value":"48"}]},{"database":"STRING","id":"9606.ENSP00000348912","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL6121","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB07145","properties":[{"key":"GenericName","value":"(2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE"}]},{"database":"GuidetoPHARMACOLOGY","id":"1673","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"M12.244","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q9BZ11","properties":[{"key":"glycosylation","value":"5 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q9BZ11","properties":[{"key":"glycosylation","value":"5 sites"}]},{"database":"iPTMnet","id":"Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ADAM33","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"20137458","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000348912","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"79748","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9BZ11-1"},{"database":"ProteomicsDB","id":"79749","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9BZ11-2"},{"database":"Antibodypedia","id":"7461","properties":[{"key":"antibodies","value":"189 antibodies from 33 providers"}]},{"database":"DNASU","id":"80332","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000350009.6","properties":[{"key":"ProteinId","value":"ENSP00000322550.5"},{"key":"GeneId","value":"ENSG00000149451.20"}],"isoformId":"Q9BZ11-2"},{"database":"Ensembl","id":"ENST00000356518.7","properties":[{"key":"ProteinId","value":"ENSP00000348912.3"},{"key":"GeneId","value":"ENSG00000149451.20"}],"isoformId":"Q9BZ11-1"},{"database":"GeneID","id":"80332","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:80332","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000356518.7","properties":[{"key":"ProteinId","value":"ENSP00000348912.3"},{"key":"RefSeqNucleotideId","value":"NM_025220.5"},{"key":"RefSeqProteinId","value":"NP_079496.1"}]},{"database":"UCSC","id":"uc002wit.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9BZ11-1"},{"database":"AGR","id":"HGNC:15478","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA24526","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"80332","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"80332","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ADAM33","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"HPA","id":"ENSG00000149451","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (cervix)"}]},{"database":"MIM","id":"600807","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"607114","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3607","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_012714_7_2_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MGAQCAH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5951731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9BZ11","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.4.24.46","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9762292","properties":[{"key":"PathwayName","value":"Regulation of CDH11 function"}]},{"database":"SignaLink","id":"Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000149451","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"80332","properties":[{"key":"hits","value":"20 hits in 1153 CRISPR screens"}]},{"database":"EvolutionaryTrace","id":"Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"ADAM33","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"80332","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9BZ11","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:Q9BZ11","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"RNAct","id":"Q9BZ11","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000149451","properties":[{"key":"ExpressionPatterns","value":"Expressed in endocervix and 174 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9BZ11","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11814695"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004222","properties":[{"key":"GoTerm","value":"F:metalloendopeptidase activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11814695"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00142","properties":[{"key":"EntryName","value":"ZINC_PROTEASE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW","length":813,"molWeight":87739,"crc64":"90713A99668D5569","md5":"D3D6BCAED1087D8CB568EBDC8E4E96D0"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"DOMAIN":1,"PTM":1,"DISEASE":1,"MISCELLANEOUS":1},"countByFeatureType":{"Signal":1,"Propeptide":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":3,"Region":2,"Motif":1,"Compositional bias":1,"Active site":1,"Binding site":4,"Glycosylation":5,"Disulfide bond":7,"Alternative sequence":2,"Natural variant":15,"Mutagenesis":1,"Sequence conflict":1,"Helix":12,"Beta strand":6,"Turn":3},"uniParcId":"UPI0000048F2A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q08AM2","uniProtkbId":"Q08AM2_HUMAN","entryAudit":{"firstPublicDate":"2006-10-31","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-10-31","entryVersion":141,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI25114.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI25114.1"}],"value":"ADAM33 protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI25114.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"O43315","geneName":"AQP9","intActId":"EBI-17444777"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"P07307-3","geneName":"ASGR2","intActId":"EBI-12808270"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q6UXG8-3","geneName":"BTNL9","intActId":"EBI-17953245"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"P07766","geneName":"CD3E","intActId":"EBI-1211297"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"P57739","geneName":"CLDN2","intActId":"EBI-751440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q9BXN2-6","geneName":"CLEC7A","intActId":"EBI-11989440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q96BA8","geneName":"CREB3L1","intActId":"EBI-6942903"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"P00387","geneName":"CYB5R3","intActId":"EBI-1046040"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q6UW88-2","geneName":"EPGN","intActId":"EBI-17468158"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"P12318-2","geneName":"FCGR2A","intActId":"EBI-17187481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q6P531","geneName":"GGT6","intActId":"EBI-2868927"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"P31937","geneName":"HIBADH","intActId":"EBI-11427100"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q8N743","geneName":"KIR3DL3","intActId":"EBI-17272405"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"P15941-11","geneName":"MUC1","intActId":"EBI-17263240"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"O76036-6","geneName":"NCR1","intActId":"EBI-19157577"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"P35372-10","geneName":"OPRM1","intActId":"EBI-12807478"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q53GL0","geneName":"PLEKHO1","intActId":"EBI-949945"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"P67812","geneName":"SEC11A","intActId":"EBI-1042500"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q16585","geneName":"SGCB","intActId":"EBI-5663627"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"A1A5C7-2","geneName":"SLC22A23","intActId":"EBI-12081840"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q9BRI3","geneName":"SLC30A2","intActId":"EBI-8644112"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"P0CK97","geneName":"SLC35E2A","intActId":"EBI-18054851"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"P02730","geneName":"SLC4A1","intActId":"EBI-7576138"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"O43278-2","geneName":"SPINT1","intActId":"EBI-12078338"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q8TAV4","geneName":"STOML3","intActId":"EBI-12900395"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q9BVX2","geneName":"TMEM106C","intActId":"EBI-2821497"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q9NUH8","geneName":"TMEM14B","intActId":"EBI-8638294"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q96Q45-2","geneName":"TMEM237","intActId":"EBI-10982110"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"O43557","geneName":"TNFSF14","intActId":"EBI-524131"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM2","intActId":"EBI-10225815"},"interactantTwo":{"uniProtKBAccession":"Q3ZAQ7","geneName":"VMA21","intActId":"EBI-1055364"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":692,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014306707"},{"type":"Region","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":626,"modifier":"EXACT"},"end":{"value":692,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":660,"modifier":"EXACT"},"end":{"value":671,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":533,"modifier":"EXACT"},"end":{"value":543,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":551,"modifier":"EXACT"},"end":{"value":560,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI25114.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC125113","properties":[{"key":"ProteinId","value":"AAI25114.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q08AM2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q08AM2","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"Q08AM2","properties":[{"key":"Interactions","value":"30"}]},{"database":"MEROPS","id":"M12.244","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q08AM2","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q08AM2","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"58679","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"7461","properties":[{"key":"antibodies","value":"189 antibodies from 33 providers"}]},{"database":"UCSC","id":"uc061vdr.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5951731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Bgee","id":"ENSG00000149451","properties":[{"key":"ExpressionPatterns","value":"Expressed in endocervix and 174 other cell types or tissues"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004222","properties":[{"key":"GoTerm","value":"F:metalloendopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW","length":692,"molWeight":75270,"crc64":"D1204B0CC0EFD8FD","md5":"74F6C6B6EFA1725C8228CB8B98EB5538"},"extraAttributes":{"countByCommentType":{"INTERACTION":30,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Region":2,"Compositional bias":1,"Disulfide bond":3},"uniParcId":"UPI0000E447F2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8Q116","uniProtkbId":"A0ACI8Q116_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552112.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552112.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552112.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051308497"},{"type":"Domain","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":497,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":643,"modifier":"EXACT"},"end":{"value":675,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":740,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":774,"modifier":"EXACT"},"end":{"value":785,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":469,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":647,"modifier":"EXACT"},"end":{"value":657,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":665,"modifier":"EXACT"},"end":{"value":674,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8Q116"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8Q116"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552112.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552112.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552112.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552112.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000882053.1","properties":[{"key":"ProteinId","value":"ENSP00000552112.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW","length":806,"molWeight":87083,"crc64":"0D9197042884F7BB","md5":"1F3AD335D19EF08320D5183E5BFE9B09"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI004032241D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8Q1G1","uniProtkbId":"A0ACI8Q1G1_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552105.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552105.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552105.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":825,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051334113"},{"type":"Domain","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":516,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":662,"modifier":"EXACT"},"end":{"value":694,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":759,"modifier":"EXACT"},"end":{"value":825,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":793,"modifier":"EXACT"},"end":{"value":804,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":362,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":488,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":684,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8Q1G1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8Q1G1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552105.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552105.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552105.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552105.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"XP_047296470.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047440514.1"}]},{"database":"RefSeq","id":"XP_054180022.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054324047.1"}]},{"database":"Ensembl","id":"ENST00000882046.1","properties":[{"key":"ProteinId","value":"ENSP00000552105.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"GeneID","id":"80332","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW","length":825,"molWeight":89177,"crc64":"BC2B1360B2F8490E","md5":"5B6C1FDE40A932D17A0A67EBF6C4A402"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI0003EB05AA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8Q314","uniProtkbId":"A0ACI8Q314_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552108.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552108.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552108.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":707,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051554270"},{"type":"Domain","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":543,"modifier":"EXACT"},"end":{"value":575,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":640,"modifier":"EXACT"},"end":{"value":707,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":674,"modifier":"EXACT"},"end":{"value":685,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":547,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":565,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8Q314"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8Q314"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552108.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552108.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552108.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552108.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000882049.1","properties":[{"key":"ProteinId","value":"ENSP00000552108.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW","length":707,"molWeight":76458,"crc64":"0CA2AF915FE0F207","md5":"83ED7A8C4046C104C0FD9F161A13AB78"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":2},"uniParcId":"UPI0040318C49"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QIS8","uniProtkbId":"A0ACI8QIS8_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552110.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552110.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":800,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051364677"},{"type":"Domain","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":516,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Region","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":733,"modifier":"EXACT"},"end":{"value":800,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":767,"modifier":"EXACT"},"end":{"value":778,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":362,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":488,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8QIS8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8QIS8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552110.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"XP_047296471.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047440515.1"}]},{"database":"RefSeq","id":"XP_054180026.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054324051.1"}]},{"database":"Ensembl","id":"ENST00000882051.1","properties":[{"key":"ProteinId","value":"ENSP00000552110.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"GeneID","id":"80332","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW","length":800,"molWeight":86233,"crc64":"DDD4A3386084A5E4","md5":"1B3281ED82A8C9EDEC03DFBDAC687577"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":1},"uniParcId":"UPI0005D02E96"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8V110","uniProtkbId":"A0ACI8V110_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629353.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629353.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629353.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":724,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051215523"},{"type":"Domain","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":560,"modifier":"EXACT"},"end":{"value":592,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":657,"modifier":"EXACT"},"end":{"value":724,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":691,"modifier":"EXACT"},"end":{"value":702,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":564,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":591,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8V110"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8V110"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629353.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629353.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629353.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629353.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000959294.1","properties":[{"key":"ProteinId","value":"ENSP00000629353.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW","length":724,"molWeight":77774,"crc64":"FC9D1A95AEC49F46","md5":"80DCAB109EFA865C7E4007CCEE622AB1"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":1,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI0040315729"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8Q0Z9","uniProtkbId":"A0ACI8Q0Z9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552106.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552106.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552106.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":812,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051442905"},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":502,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":648,"modifier":"EXACT"},"end":{"value":680,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":745,"modifier":"EXACT"},"end":{"value":812,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":779,"modifier":"EXACT"},"end":{"value":790,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":494,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":652,"modifier":"EXACT"},"end":{"value":662,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":670,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8Q0Z9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8Q0Z9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552106.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552106.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552106.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552106.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"XP_011527669.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011529367.2"}]},{"database":"RefSeq","id":"XP_054180025.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054324050.1"}]},{"database":"Ensembl","id":"ENST00000882047.1","properties":[{"key":"ProteinId","value":"ENSP00000552106.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"GeneID","id":"80332","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNQLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW","length":812,"molWeight":87574,"crc64":"B571EF430A1882BE","md5":"E8AF6C09B1D953F55BC38857831C8767"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI0005D00D0D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8Q673","uniProtkbId":"A0ACI8Q673_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552104.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552104.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552104.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":826,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051276609"},{"type":"Domain","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":516,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":662,"modifier":"EXACT"},"end":{"value":694,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":759,"modifier":"EXACT"},"end":{"value":826,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":793,"modifier":"EXACT"},"end":{"value":804,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":362,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":488,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":684,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8Q673"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8Q673"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552104.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552104.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552104.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552104.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"XP_005260900.1","properties":[{"key":"NucleotideSequenceId","value":"XM_005260843.2"}]},{"database":"RefSeq","id":"XP_054180021.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054324046.1"}]},{"database":"Ensembl","id":"ENST00000882045.1","properties":[{"key":"ProteinId","value":"ENSP00000552104.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"GeneID","id":"80332","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW","length":826,"molWeight":89248,"crc64":"1145B99D300189A9","md5":"951C3283C63D6CCFEFB266FAA2B7A0A6"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI0000046727"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RXQ8","uniProtkbId":"A0ACI8RXQ8_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552107.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552107.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552107.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":786,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051464143"},{"type":"Domain","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":503,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Region","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":720,"modifier":"EXACT"},"end":{"value":786,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":754,"modifier":"EXACT"},"end":{"value":765,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RXQ8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RXQ8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552107.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552107.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552107.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552107.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000882048.1","properties":[{"key":"ProteinId","value":"ENSP00000552107.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW","length":786,"molWeight":84653,"crc64":"868986E2D0D9708D","md5":"F282BF38ABD80E8CA9CAE40B45344514"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":1},"uniParcId":"UPI004031DB44"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QR03","uniProtkbId":"A0ACI8QR03_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552111.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552111.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":822,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051236973"},{"type":"Domain","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":513,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":659,"modifier":"EXACT"},"end":{"value":691,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":756,"modifier":"EXACT"},"end":{"value":822,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":790,"modifier":"EXACT"},"end":{"value":801,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":505,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":663,"modifier":"EXACT"},"end":{"value":673,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":681,"modifier":"EXACT"},"end":{"value":690,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8QR03"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8QR03"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552111.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000882052.1","properties":[{"key":"ProteinId","value":"ENSP00000552111.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW","length":822,"molWeight":88889,"crc64":"27D87D958F6A6C98","md5":"C27F368558B302131834D3EA1C370FA3"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI0040315D7A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8S439","uniProtkbId":"A0ACI8S439_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552109.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552109.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552109.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":745,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051372947"},{"type":"Domain","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":503,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":614,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":679,"modifier":"EXACT"},"end":{"value":745,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":713,"modifier":"EXACT"},"end":{"value":724,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":586,"modifier":"EXACT"},"end":{"value":596,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":604,"modifier":"EXACT"},"end":{"value":613,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8S439"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8S439"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552109.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552109.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552109.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552109.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000882050.1","properties":[{"key":"ProteinId","value":"ENSP00000552109.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW","length":745,"molWeight":80864,"crc64":"094234C9013CE5C1","md5":"7A0254FBFBEFD8EA98A242A02907F18C"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI004031686C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8V452","uniProtkbId":"A0ACI8V452_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629356.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629356.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629356.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051268210"},{"type":"Domain","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":410,"modifier":"EXACT"},"end":{"value":496,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":674,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":739,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":773,"modifier":"EXACT"},"end":{"value":784,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":468,"modifier":"EXACT"},"end":{"value":488,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":646,"modifier":"EXACT"},"end":{"value":656,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":664,"modifier":"EXACT"},"end":{"value":673,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8V452"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8V452"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629356.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629356.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629356.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629356.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000959297.1","properties":[{"key":"ProteinId","value":"ENSP00000629356.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW","length":806,"molWeight":87067,"crc64":"EDE66458E2A8247D","md5":"2FF6E6D5827E8C59E37434663BC8E506"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI00403241B7"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8V6D2","uniProtkbId":"A0ACI8V6D2_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629359.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629359.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629359.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":811,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051510011"},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":502,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":648,"modifier":"EXACT"},"end":{"value":680,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":745,"modifier":"EXACT"},"end":{"value":811,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":779,"modifier":"EXACT"},"end":{"value":790,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":494,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":652,"modifier":"EXACT"},"end":{"value":662,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":670,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8V6D2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8V6D2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629359.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629359.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629359.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629359.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000959300.1","properties":[{"key":"ProteinId","value":"ENSP00000629359.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNQLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW","length":811,"molWeight":87503,"crc64":"C87DCD5AABF35ED2","md5":"25196632CFE9BA70AD1FC7C917F7BA16"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI0040322B89"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8V4R3","uniProtkbId":"A0ACI8V4R3_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629358.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629358.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629358.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":805,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051556789"},{"type":"Domain","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":401,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":641,"modifier":"EXACT"},"end":{"value":673,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":738,"modifier":"EXACT"},"end":{"value":805,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":772,"modifier":"EXACT"},"end":{"value":783,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":487,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":645,"modifier":"EXACT"},"end":{"value":655,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":663,"modifier":"EXACT"},"end":{"value":672,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8V4R3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629358.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629358.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629358.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629358.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000959299.1","properties":[{"key":"ProteinId","value":"ENSP00000629358.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW","length":805,"molWeight":86786,"crc64":"3C765E5848F546AF","md5":"536D1784886AA03CF2552CD7BA161371"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI004031E5E7"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8V1F1","uniProtkbId":"A0ACI8V1F1_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629354.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629354.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629354.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":818,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051522221"},{"type":"Domain","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":654,"modifier":"EXACT"},"end":{"value":686,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":751,"modifier":"EXACT"},"end":{"value":818,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":785,"modifier":"EXACT"},"end":{"value":796,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":350,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":480,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":658,"modifier":"EXACT"},"end":{"value":668,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":676,"modifier":"EXACT"},"end":{"value":685,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8V1F1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629354.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629354.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629354.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629354.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000959295.1","properties":[{"key":"ProteinId","value":"ENSP00000629354.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW","length":818,"molWeight":88294,"crc64":"CE1C15328B915368","md5":"DD37DF75210863E188DB2EE12127A477"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI004032678C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8V443","uniProtkbId":"A0ACI8V443_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629355.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629355.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629355.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":723,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051322819"},{"type":"Domain","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":560,"modifier":"EXACT"},"end":{"value":592,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":657,"modifier":"EXACT"},"end":{"value":723,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":691,"modifier":"EXACT"},"end":{"value":702,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":564,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":591,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8V443"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8V443"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629355.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629355.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629355.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629355.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000959296.1","properties":[{"key":"ProteinId","value":"ENSP00000629355.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW","length":723,"molWeight":77703,"crc64":"04881BFE77EEA6AC","md5":"D9FFE582E2579291FCA4D6C7CCB42E54"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":1,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI0040320FB1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8V4F6","uniProtkbId":"A0ACI8V4F6_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629357.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629357.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629357.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":824,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051243177"},{"type":"Domain","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":429,"modifier":"EXACT"},"end":{"value":515,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":661,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":758,"modifier":"EXACT"},"end":{"value":824,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":792,"modifier":"EXACT"},"end":{"value":803,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":487,"modifier":"EXACT"},"end":{"value":507,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":665,"modifier":"EXACT"},"end":{"value":675,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":683,"modifier":"EXACT"},"end":{"value":692,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8V4F6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8V4F6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629357.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629357.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629357.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629357.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000959298.1","properties":[{"key":"ProteinId","value":"ENSP00000629357.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNQLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW","length":824,"molWeight":89011,"crc64":"484573CAC888E1DF","md5":"9212A271DCBD59CD18BE9C0988B80123"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI0040319D95"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8V6C3","uniProtkbId":"A0ACI8V6C3_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629360.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629360.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629360.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":736,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051467382"},{"type":"Domain","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":427,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":573,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":670,"modifier":"EXACT"},"end":{"value":736,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":704,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":399,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":577,"modifier":"EXACT"},"end":{"value":587,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":595,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8V6C3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8V6C3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629360.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629360.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629360.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629360.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000959301.1","properties":[{"key":"ProteinId","value":"ENSP00000629360.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW","length":736,"molWeight":79211,"crc64":"38DF57F6F6939265","md5":"E55E5FA9C68BDEC0A4F90D418CEDCE6F"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":1,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI0040321E3B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8V6E2","uniProtkbId":"A0ACI8V6E2_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629361.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629361.1"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629361.1"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":809,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051272018"},{"type":"Domain","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":646,"modifier":"EXACT"},"end":{"value":678,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":743,"modifier":"EXACT"},"end":{"value":809,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":777,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":472,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":650,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":668,"modifier":"EXACT"},"end":{"value":677,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8V6E2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8V6E2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629361.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629361.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629361.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000629361.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000959302.1","properties":[{"key":"ProteinId","value":"ENSP00000629361.1"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW","length":809,"molWeight":87381,"crc64":"9154A1556D0027F2","md5":"38522683EAEBFBBF1F5EE1518F677C11"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI0040314807"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A2A2L3","uniProtkbId":"A2A2L3_HUMAN","entryAudit":{"firstPublicDate":"2007-02-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-02-20","entryVersion":157,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000369190.4"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000369190.4"}],"value":"ADAM metallopeptidase domain 33"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000369190.4"}],"value":"ADAM33"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":812,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014083392"},{"type":"Domain","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"Peptidase M12B","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50215"}]},{"type":"Domain","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":503,"modifier":"EXACT"}},"description":"Disintegrin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50214"}]},{"type":"Domain","location":{"start":{"value":649,"modifier":"EXACT"},"end":{"value":681,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":746,"modifier":"EXACT"},"end":{"value":812,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":780,"modifier":"EXACT"},"end":{"value":791,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}]},{"type":"Binding site","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Disulfide bond","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00068"}]},{"type":"Disulfide bond","location":{"start":{"value":653,"modifier":"EXACT"},"end":{"value":663,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":671,"modifier":"EXACT"},"end":{"value":680,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A2A2L3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A2A2L3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00276"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000369190.4"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000369190.4"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000369190.4"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000369190.4"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL109804","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001269376.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001282447.3"}]},{"database":"AlphaFoldDB","id":"A2A2L3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A2A2L3","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"M12.244","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"207","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"7461","properties":[{"key":"antibodies","value":"189 antibodies from 33 providers"}]},{"database":"DNASU","id":"80332","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000379861.8","properties":[{"key":"ProteinId","value":"ENSP00000369190.4"},{"key":"GeneId","value":"ENSG00000149451.20"}]},{"database":"GeneID","id":"80332","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc002wir.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"80332","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"80332","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:15478","properties":[{"key":"GeneName","value":"ADAM33"}]},{"database":"OpenTargets","id":"ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158971","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5951731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"80332","properties":[{"key":"hits","value":"20 hits in 1153 CRISPR screens"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"Bgee","id":"ENSG00000149451","properties":[{"key":"ExpressionPatterns","value":"Expressed in endocervix and 174 other cell types or tissues"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004222","properties":[{"key":"GoTerm","value":"F:metalloendopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd04269","properties":[{"key":"EntryName","value":"ZnMc_adamalysin_II_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000002","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.70.10:FF:000001","properties":[{"key":"EntryName","value":"Disintegrin and metalloproteinase domain-containing protein 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.70.10","properties":[{"key":"EntryName","value":"Disintegrin domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006586","properties":[{"key":"EntryName","value":"ADAM_Cys-rich"}]},{"database":"InterPro","id":"IPR018358","properties":[{"key":"EntryName","value":"Disintegrin_CS"}]},{"database":"InterPro","id":"IPR001762","properties":[{"key":"EntryName","value":"Disintegrin_dom"}]},{"database":"InterPro","id":"IPR036436","properties":[{"key":"EntryName","value":"Disintegrin_dom_sf"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001590","properties":[{"key":"EntryName","value":"Peptidase_M12B"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"InterPro","id":"IPR034027","properties":[{"key":"EntryName","value":"Reprolysin_adamalysin"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08516","properties":[{"key":"EntryName","value":"ADAM_CR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00200","properties":[{"key":"EntryName","value":"Disintegrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01421","properties":[{"key":"EntryName","value":"Reprolysin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00289","properties":[{"key":"EntryName","value":"DISINTEGRIN"}]},{"database":"SMART","id":"SM00608","properties":[{"key":"EntryName","value":"ACR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00050","properties":[{"key":"EntryName","value":"DISIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57552","properties":[{"key":"EntryName","value":"Blood coagulation inhibitor (disintegrin)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50215","properties":[{"key":"EntryName","value":"ADAM_MEPRO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00427","properties":[{"key":"EntryName","value":"DISINTEGRIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50214","properties":[{"key":"EntryName","value":"DISINTEGRIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW","length":812,"molWeight":87668,"crc64":"E8A817363E2489EC","md5":"B1D3BAA04B40D1F9C7E8B2C50F23EF9D"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Active site":1,"Binding site":3,"Disulfide bond":3},"uniParcId":"UPI00000375E0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6P5U4","uniProtkbId":"Q6P5U4_HUMAN","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2025-02-05","lastSequenceUpdateDate":"2004-07-05","entryVersion":58,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH62663.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH62663.1"}],"value":"ADAM33 protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH62663.1"}],"value":"ADAM33"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5004278015"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH62663.1"}],"value":"Blood vessels- blood vessel","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH62663.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC062663","properties":[{"key":"ProteinId","value":"AAH62663.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q6P5U4","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6P5U4","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5951731at2759","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNQ","length":85,"molWeight":9429,"crc64":"1A3CC65DC2490F20","md5":"92BA982224D058BA1CB6FBA45808CC6F"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI000022563E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q8N6B9","uniProtkbId":"Q8N6B9_HUMAN","entryAudit":{"firstPublicDate":"2002-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-10-01","entryVersion":63,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM80484.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM80484.1"}],"value":"A disintegrin and metalloprotease domain 33"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM80484.1"}],"value":"ADAM33"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5004311080"},{"type":"Non-terminal residue","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM80484.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM80484.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM80484.1"}],"id":"KW-0401","category":"Molecular function","name":"Integrin"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM80484.1"}],"id":"KW-0482","category":"Molecular function","name":"Metalloprotease"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM80484.1"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"12110844","citationType":"journal article","authors":["Van Eerdewegh P.","Little R.D.","Dupuis J.","Del Mastro R.G.","Falls K.","Simon J.","Torrey D.","Pandit S.","McKenny J.","Braunschweiger K.","Walsh A.","Liu Z.","Hayward B.","Folz C.","Manning S.P.","Bawa A.","Saracino L.","Thackston M.","Benchekroun Y.","Capparell N.","Wang M.","Adair R.","Feng Y.","Dubois J.","FitzGerald M.G.","Huang H.","Gibson R.","Allen K.M.","Pedan A.","Danzig M.R.","Umland S.P.","Egan R.W.","Cuss F.M.","Rorke S.","Clough J.B.","Holloway J.W.","Holgate S.T.","Keith T.P."],"citationCrossReferences":[{"database":"PubMed","id":"12110844"},{"database":"DOI","id":"10.1038/nature00878"}],"title":"Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.","publicationDate":"2002","journal":"Nature","firstPage":"426","lastPage":"430","volume":"418"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM80484.1"}],"value":"Whole lung","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAM80484.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF466289","properties":[{"key":"ProteinId","value":"AAM80484.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q8N6B9","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8N6B9","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5951731at2759","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDG","length":48,"molWeight":5269,"crc64":"F846874535C39BDB","md5":"080C5472A7E975560DC3597320E909E0"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Non-terminal residue":1},"uniParcId":"UPI000004672D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q08AM3","secondaryAccessions":["E7ENC8"],"uniProtkbId":"Q08AM3_HUMAN","entryAudit":{"firstPublicDate":"2006-10-31","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-10-31","entryVersion":113,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI25113.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI25113.1"}],"value":"ADAM33 protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI25113.1"}],"value":"ADAM33"}}],"features":[{"type":"Domain","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Peptidase M12B propeptide","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01562"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI25113.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC125112","properties":[{"key":"ProteinId","value":"AAI25113.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q08AM3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q08AM3","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q08AM3","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"7461","properties":[{"key":"antibodies","value":"189 antibodies from 33 providers"}]},{"database":"UCSC","id":"uc061vds.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000149451","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1895421_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5951731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Bgee","id":"ENSG00000149451","properties":[{"key":"ExpressionPatterns","value":"Expressed in endocervix and 174 other cell types or tissues"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEVPPHHSYPYSSLHS","length":138,"molWeight":15335,"crc64":"24911B62D4F54812","md5":"80B89322C4826546C38DAE1E87806388"},"extraAttributes":{"countByFeatureType":{"Domain":1},"uniParcId":"UPI000022B59A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q8N8Z9","uniProtkbId":"Q8N8Z9_HUMAN","entryAudit":{"firstPublicDate":"2002-10-01","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2002-10-01","entryVersion":105,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAC04660.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX10520.1"}],"value":"ADAM metallopeptidase domain 33, isoform CRA_b"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAC04660.1"}],"value":"cDNA FLJ38634 fis, clone HHDPC2001432, weakly similar to ADAM 12"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX10520.1"}],"value":"ADAM33"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX10520.1"}],"value":"hCG_39255"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5010146596"},{"type":"Domain","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Peptidase M12B propeptide","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01562"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX10520.1"}]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAC04660.1"}]},{"referenceNumber":3,"citation":{"id":"CI-56FTJV1JKRRTT","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX10520.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK095953","properties":[{"key":"ProteinId","value":"BAC04660.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471133","properties":[{"key":"ProteinId","value":"EAX10520.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q8N8Z9","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8N8Z9","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5951731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR002870","properties":[{"key":"EntryName","value":"Peptidase_M12B_N"}]},{"database":"PANTHER","id":"PTHR11905","properties":[{"key":"EntryName","value":"ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11905:SF38","properties":[{"key":"EntryName","value":"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01562","properties":[{"key":"EntryName","value":"Pep_M12B_propep"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQGRVRGFPDSWVVLCTCSGMRAGEKRAGPGSTWNCTLWQTTPCS","length":173,"molWeight":19171,"crc64":"3C6A0E45561B38E7","md5":"1C7ED7B255FE7874F6A40C85CB165CD3"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1},"uniParcId":"UPI0000073912"}}]}