{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9ULC5","secondaryAccessions":["A6GV77","D3DRB3","Q6UX44","Q9UIU4"],"uniProtkbId":"ACSL5_HUMAN","entryAudit":{"firstPublicDate":"2001-04-27","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2000-05-01","entryVersion":211,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Long-chain-fatty-acid--CoA ligase 5"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17681178"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22633490"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24269233"}],"value":"6.2.1.3"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Arachidonate--CoA ligase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88813"}],"value":"6.2.1.15"}]},{"fullName":{"value":"Long-chain acyl-CoA synthetase 5"},"shortNames":[{"value":"LACS 5"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:16526"}],"value":"ACSL5"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.8"}],"value":"ACS5"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.8"}],"value":"FACL5"}],"orfNames":[{"value":"UNQ633/PRO1250"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15285911"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17681178"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18806831"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19459852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22633490"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24269233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33191500"}],"value":"Catalyzes the conversion of long- and medium-chain fatty acids to their active form fatty acyl-CoA (PubMed:15285911, PubMed:17681178, PubMed:22633490, PubMed:24269233, PubMed:33191500). May drive cellular fatty acid uptake by metabolic trapping, and regulate the channeling of fatty acids towards specific metabolic pathways such as the generation of energy by beta-oxidation or the synthesis of membrane lipids (PubMed:15285911, PubMed:17681178, PubMed:22633490, PubMed:24269233, PubMed:33191500). May activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated and unsaturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). Participates in the conversion of sphingosine 1-phosphate to glycerophospholipid by catalyzing the CoA-dependent activation of (E)-hexadec-2-enoate to (2E)-hexadecenoyl-CoA (PubMed:22633490). ACSL5 may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL at the villus tip of the crypt-villus axis of the small intestine (PubMed:17681178). May have a role in the survival of glioma cells (PubMed:18806831, PubMed:19459852)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + 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