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Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38056460"}],"value":"(Microbial infection) Acts as a receptor for the malaria parasite Plasmodium vivax"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28800732"}],"value":"(Microbial infection) Acts as a receptor for the malaria parasite Plasmodium knowlesi"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11279211"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15720551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16024106"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24415938"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8879225"}],"value":"(Microbial infection) Interacts (via N-terminal extracellular domain) with Plasmodium vivax Duffy receptor (DBP) (via PvRII region)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8879225"}],"value":"(Microbial infection) Interacts (via N-terminal extracellular domain) with Plasmodium knowlesi Duffy receptor alpha form (DBPalpha) (via region II)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q16570-1","intActId":"EBI-15935975"},"interactantTwo":{"uniProtKBAccession":"P22290","geneName":"PVDR","intActId":"EBI-15935953"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q16570-2","intActId":"EBI-21403047"},"interactantTwo":{"uniProtKBAccession":"P51681","geneName":"CCR5","intActId":"EBI-489374"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane"}]},"subcellularLocations":[{"location":{"value":"Early endosome","id":"SL-0094"}},{"location":{"value":"Recycling endosome","id":"SL-0232"}},{"location":{"value":"Membrane","id":"SL-0162"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"2"},"isoformIds":["Q16570-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"1"},"isoformIds":["Q16570-2"],"sequenceIds":["VSP_001323"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15720550"}],"value":"Sulfation at Tyr-41 facilitates interaction with MGSA/CXCL1, RANTES/CCL5 and MCP-1/CCL2 but not IL8/CXCL8 (PubMed:15720550). Sulfation at Tyr-30 facilitates interaction with IL8/CXCL8 (PubMed:15720550)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15720550"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37336887"}],"value":"(Microbial infection) Sulfation at Tyr-41 facilitates interaction with Plasmodium vivax Duffy receptor (DBP) (PubMed:15720550). Sulfation at Tyr-30/Tyr-41 and Tyr-41 alone increases binding affinity of Plasmodium vivax parasites and likely promotes invasion of red blood cells (PubMed:37336887)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15720550"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37336887"}],"value":"(Microbial infection) Sulfation at Tyr-41 facilitates interaction with Plasmodium knowlesi Duffy receptor alpha form (DBPalpha) (PubMed:15720550). Sulfation at Tyr-30/Tyr-41 and Tyr-41 alone increases binding affinity of Plasmodium knowlesi parasites and likely promotes invasion of red blood cells (PubMed:37336887)"}],"commentType":"PTM"},{"texts":[{"value":"DARC is responsible for the Duffy blood group system (FY) [MIM:110700]. The molecular basis of the Fy(A)=Fy1/Fy(B)=Fy2 blood group antigens is a single variation in position 42; Gly-42 corresponds to Fy(A) and Asp-42 to Fy(B). Individuals that do not produce the Duffy antigen (FY(A-B-)) are more resistant to infection by the malarial parasite Plasmodium vivax. This allele is found predominantly in population of African origin [MIM:611162]"}],"commentType":"POLYMORPHISM"},{"texts":[{"value":"Genetic variations in DARC define the white blood cell count quantitative trait locus 1 (WBCQ1) [MIM:611862]. Peripheral white blood cell count (WBC) is a common clinical measurement, used to determine evidence of acute inflammation or infection. Peripheral WBC is the sum of several cell types including neutrophils and lymphocytes, which are the most common types of WBC, as well as less common cell types such as eosinophils, basophils, and monocytes. Elevated WBC has been associated with risk of coronary heart disease, cancer, and all-cause mortality. White blood cell levels have widespread clinical applications including assessment of patients undergoing chemotherapy and evaluation of infection"}],"commentType":"POLYMORPHISM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38056460"}],"value":"A subset of erythroblasts from genotypically Duffy-negative individuals transiently expresses ACKR1 during terminal erythroid differentiation and P.vivax merozoites can invade these ACKR1-expressing Duffy-negative erythroblasts"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the G protein-coupled receptor 1 family. Atypical chemokine receptor subfamily"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Duffy_antigen","ftp":false,"note":"Duffy antigen entry"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"Atypical chemokine receptor 1","featureId":"PRO_0000152585"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological 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