{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P24752","secondaryAccessions":["B2R6H1","G3XAB4","Q96FG8"],"uniProtkbId":"THIL_HUMAN","entryAudit":{"firstPublicDate":"1992-03-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1992-03-01","entryVersion":242,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Acetyl-CoA acetyltransferase, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10020"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1715688"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17371050"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7728148"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9744475"}],"value":"2.3.1.9"}]},"alternativeNames":[{"fullName":{"value":"Acetoacetyl-CoA thiolase"}},{"fullName":{"value":"T2"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"ACAT1"},"synonyms":[{"value":"ACAT"},{"value":"MAT"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1715688"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17371050"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7728148"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9744475"}],"value":"This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). 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