{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P16442","secondaryAccessions":["B0JDB9","O14758","Q14490","Q53I57","Q6ISD4","Q6KFZ2","Q70V27","Q99484","Q99485","Q9NY01","Q9UQ68","Q9UQ69"],"uniProtkbId":"BGAT_HUMAN","entryAudit":{"firstPublicDate":"1990-08-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1992-12-01","entryVersion":238,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Histo-blood group ABO system transferase"}},"alternativeNames":[{"fullName":{"value":"Fucosylglycoprotein 3-alpha-galactosyltransferase"}},{"fullName":{"value":"Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase"}},{"fullName":{"value":"Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12198488"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17259183"}],"value":"2.4.1.40"}]},{"fullName":{"value":"Glycoprotein-fucosylgalactoside alpha-galactosyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12198488"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17259183"}],"value":"2.4.1.37"}]},{"fullName":{"value":"Histo-blood group A transferase"},"shortNames":[{"value":"A transferase"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16326711"}],"value":"GTA"}]},{"fullName":{"value":"Histo-blood group B transferase"},"shortNames":[{"value":"B transferase"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16326711"}],"value":"GTB"}]},{"fullName":{"value":"NAGAT"}}],"contains":[{"recommendedName":{"fullName":{"value":"Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form"}}}]},"genes":[{"geneName":{"value":"ABO"}}],"comments":[{"texts":[{"value":"This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of N-acetyl-alpha-D-galactosamine (GalNAc)) or to the B antigen (by addition of galactose (Gal)), whereas O individuals lack such activity and express the H antigen precursor unmodified"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12198488"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12529355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16326711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17259183"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2121736"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"value":"Catalyzes the transfer of GalNAc or Gal in an alpha1,3 linkage to the terminal Gal of all five types of naturally occurring H antigens, forming the antigenic structures of the A and B blood groups"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + UDP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19021"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:58223"},{"database":"ChEBI","id":"CHEBI:67138"},{"database":"ChEBI","id":"CHEBI:140327"},{"database":"ChEBI","id":"CHEBI:140559"}],"ecNumber":"2.4.1.40","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12198488"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12529355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16326711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17259183"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:19022"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"12198488"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16326711"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17259183"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + UDP + 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H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84527"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:58223"},{"database":"ChEBI","id":"CHEBI:66914"},{"database":"ChEBI","id":"CHEBI:233962"},{"database":"ChEBI","id":"CHEBI:233963"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84528"},"evidences":[{"evidenceCode":"ECO:0000305","source":"Reference","id":"Ref.20"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GalNAc derivative + UDP-alpha-D-galactose = an alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-beta-D-GalNAc derivative + UDP + 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H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:84743"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:58223"},{"database":"ChEBI","id":"CHEBI:66914"},{"database":"ChEBI","id":"CHEBI:233964"},{"database":"ChEBI","id":"CHEBI:233965"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:84744"},"evidences":[{"evidenceCode":"ECO:0000305","source":"Reference","id":"Ref.20"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17259183"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17259183"}],"value":"Binds 1 Mn(2+) ion per subunit."}]}},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":1300.0,"unit":"uM","substrate":"type I H-antigen (A transferase)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16326711"}]},{"constant":1600.0,"unit":"uM","substrate":"type I H-antigen (B transferase)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16326711"}]},{"constant":490.0,"unit":"uM","substrate":"type II H-antigen (A transferase)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16326711"}]},{"constant":184.0,"unit":"uM","substrate":"type II H-antigen (B transferase)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16326711"}]}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16326711"}],"value":"kcat is 1.3 sec(-1) for type I H-antigen (A transferase) (PubMed:16326711). kcat is 0.5 sec(-1) for type I H-antigen (B transferase) (PubMed:16326711). kcat is 1.8 sec(-1) for type II H-antigen (A transferase) (PubMed:16326711). kcat is 1.2 sec(-1) for type II H-antigen (B transferase) (PubMed:16326711)."}]}}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Protein modification; protein glycosylation"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid"}]},"subcellularLocations":[{"location":{"value":"Golgi apparatus, Golgi stack membrane","id":"SL-0136"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18513251"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}},{"location":{"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7598760"}],"value":"Expressed at high levels in testis. Also expressed in pancreas, uterus and lung and salivary gland"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis"}],"commentType":"DOMAIN"},{"texts":[{"value":"The soluble form derives from the membrane form by proteolytic processing"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10462501"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12829588"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1449469"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15104652"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18513251"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2121736"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2333095"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7598760"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8839869"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.16"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.9"}],"value":"Genetic variations in ABO define the ABO blood group system [MIM:616093]. The ABO blood group system is one of the most important blood group systems in transfusion medicine. The ABO blood group involves 3 carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of GalNAc) or to the B antigen (by addition of Gal). There are only 4 amino acid differences between A and B transferases in the catalytic domain, two of which (Leu266Met and Gly268Ala) are primarily responsible for the substrate specificity. The group O phenotype results from variations in ABO that cause a loss of glycosyltransferase activity. The most common group O allele results from a single nucleotide deletion near the 5' end of the gene (NM_020469.2:c.261del) that causes a frameshift and early termination with no active enzyme production (p.Thr88Profs*31). The sequence shown is that of ABO*A1.01"}],"commentType":"POLYMORPHISM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the glycosyltransferase 6 family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Functional Glycomics Gateway - GTase","resourceUrl":"http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_450","ftp":false,"note":"Histo-blood group ABO system transferase"},{"commentType":"WEB RESOURCE","resourceName":"Functional Glycomics Gateway - GTase","resourceUrl":"http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_502","ftp":false,"note":"Histo-blood group ABO system transferase"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"Histo-blood group ABO system 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