{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UNQ0","secondaryAccessions":["A0A1W3","A8K1T5","O95374","Q4W5I3","Q53ZQ1","Q569L4","Q5YLG4","Q86V64","Q8IX16","Q96LD6","Q96TA8","Q9BY73","Q9NUS0"],"uniProtkbId":"ABCG2_HUMAN","entryAudit":{"firstPublicDate":"2001-01-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-05-10","entryVersion":231,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Broad substrate specificity ATP-binding cassette transporter ABCG2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12682043"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29175180"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30959153"}],"value":"7.6.2.-"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11306452"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31254042"}],"value":"7.6.2.2"}]},"alternativeNames":[{"fullName":{"value":"ATP-binding cassette sub-family G member 2"}},{"fullName":{"value":"Breast cancer resistance protein"}},{"fullName":{"value":"CDw338"}},{"fullName":{"value":"Mitoxantrone resistance-associated protein"}},{"fullName":{"value":"Placenta-specific ATP-binding cassette transporter"}},{"fullName":{"value":"Urate exporter"}}],"cdAntigenNames":[{"value":"CD338"}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:74"}],"value":"ABCG2"},"synonyms":[{"value":"ABCP"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29175180"}],"value":"BCRP"},{"value":"BCRP1"},{"value":"MXR"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TMS5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11306452"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12477054"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12682043"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12958161"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15670731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18056989"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19506252"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20110355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20368174"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20705604"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22132962"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23189181"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28554189"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29175180"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30405239"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30959153"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31003562"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31254042"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36749388"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38181789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39337371"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39993711"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"12958161"}],"value":"Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562, PubMed:36749388). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the vitamins riboflavin and biotin into milk (By similarity). Involved in the excretion of the riboflavin-derived compound lumichrome into the intestinal lumen and in its secretion into milk (PubMed:39337371). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response (PubMed:38181789). Operates at apical membranes of polarized cells such as hepatocytes and intestinal epithelial cells, where it may contribute to the efflux of conjugated substrates from intestine and liver into the intestinal lumen as well as their enterohepatic recycling. Can transport estrogen and androgen substrates conjugated with glucuronate or sulfate at C-3, C-16 and C-17 positions. Among androgen glucuronates, appears to selectively transport dihydrotestosterone-17-glucuronate while displaying no transporter activity toward testosterone, androsterone and etiocholanolone glucuronates (PubMed:29175180, PubMed:30959153, PubMed:39993711)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-D-glucuronoside(in) + ATP + H2O = a beta-D-glucuronoside(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:86935"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:83411"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12682043"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29175180"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30959153"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:86936"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"12682043"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"29175180"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"30959153"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 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H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:61384"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:144584"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12682043"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:61385"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12682043"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + phosphate + 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H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:61376"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:144583"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12682043"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:61377"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12682043"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60128"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:82961"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12682043"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60129"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12682043"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"methotrexate(in) + ATP + H2O = methotrexate(out) + ADP + phosphate + 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