{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q92887","secondaryAccessions":["B2RMT8","Q14022","Q5T2B1","Q92500","Q92798","Q99663","Q9UMS2"],"uniProtkbId":"MRP2_HUMAN","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-10-05","entryVersion":228,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"ATP-binding cassette sub-family C member 2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10421658"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16332456"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29175180"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30959153"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31704245"}],"value":"7.6.2.-"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10220572"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11500505"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12441801"}],"value":"7.6.2.2"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10220572"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11500505"}],"value":"7.6.2.3"}]},"alternativeNames":[{"fullName":{"value":"Canalicular multidrug resistance protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Canalicular multispecific organic anion transporter 1"}},{"fullName":{"value":"Multidrug resistance-associated protein 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"31704245"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:53"}],"value":"ABCC2"},"synonyms":[{"value":"CMOAT"},{"value":"CMOAT1"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8662992"}],"value":"CMRP"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"31704245"}],"value":"MRP2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10220572"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10421658"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11500505"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12441801"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16332456"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29175180"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30959153"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31704245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39993711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9355767"}],"value":"ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at apical membranes of polarized cells such as hepatocytes, renal and intestinal epithelial cells where it mediates hepatobiliary and renal excretion of conjugated substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456, PubMed:29175180, PubMed:30959153, PubMed:31704245). Involved in canalicular bile production. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin, enabling bilirubin detoxification (PubMed:9355767, PubMed:10421658). Mediates the efflux of steroid glucuronates from intestine and liver into the intestinal lumen. Shares substrate specificity with MRP3 but displays lower affinity and higher transport velocity toward androgen conjugates such as testosterone and dihydrotestosterone glucuronates as well as toward estrogen conjugates including estradiol, estrone and estriol glucuronates (PubMed:29175180, PubMed:30959153, PubMed:31704245). Transports glutathione conjugate leukotriene C4 (LTC4) and related cysteinyl leukotrienes (PubMed:11500505). Displays selective transporter activity toward sulfated conjugates, transports sulfated bile salts such as taurolithocholate sulfate but is inactive toward androgen sulfates (PubMed:16332456, PubMed:39993711). Transports various xenobiotics including anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors. Confers resistance to several anticancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine, by decreasing accumulation of these drugs in cells (PubMed:10220572, PubMed:11500505, PubMed:12441801)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-D-glucuronoside(in) + ATP + H2O = a beta-D-glucuronoside(out) + ADP + phosphate + 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