{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"O94267","uniProtkbId":"SPT16_SCHPO","entryAudit":{"firstPublicDate":"1111-11-10","lastAnnotationUpdateDate":"1111-11-10","lastSequenceUpdateDate":"1111-11-10","entryVersion":1,"sequenceVersion":1},"annotationScore":0.0,"proteinExistence":"5: Uncertain","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0008006","source":"Google","id":"ProtNLM2","properties":[{"key":"model_score","value":"1.00"},{"key":"string_match_text","value":"FACT complex subunit spt16"},{"key":"string_match_location","value":"recommended_protein_name"},{"key":"string_match_type","value":"substring"}]}],"value":"FACT complex subunit"}}},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0008006","source":"Google","id":"ProtNLM2","properties":[{"key":"model_score","value":"0.98"},{"key":"string_match_text","value":"Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity)."},{"key":"string_match_location","value":"function_comment"},{"key":"string_match_type","value":"substring"}]}],"value":"Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II"}],"commentType":"FUNCTION"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-FC84BSHK1H4IL","citationType":"unpublished observations"},"referencePositions":["required field"]}],"extraAttributes":{"countByCommentType":{"FUNCTION":1}}}