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With the RNA-binding protein (RBP) csdA, forms a post-transcriptional control network for secondary metabolites biosynthesis, csdA controlling the expression of rsdA at the post-transcriptional level by influencing the alternative splicing of its pre-mRNA (PubMed:37963872). Once translated, the rsdA protein is able to interact with csdA to form a regulatory complex to regulate the growth, development, and metabolism (PubMed:37963872). Controls the expression of 44 backbone genes of 76 biosynthetic gene clusters (BGCs) including in particular asperpentyn, ficiolide A, chloroisosulochrin, pestheic acid, iso-A82775C and melanin (PubMed:30421486, PubMed:37963872). Whereas most of the secondary metabolites are positively regulated by rsdA, the DHN-melanin pathway is negatively regulated (PubMed:30421486). Fungal development is controlled by the regulation of expression of key genes such as abaA, brlA, stuA, medA, flbA, flbB, fadA, vosA, velB, and nosA; and is independent of the DHN-melanin biosynthetic pathway (PubMed:30421486, PubMed:37963872)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37963872"}],"value":"Interacts with csdA"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37963872"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37963872"}],"value":"CsdA mediates rsdA expression by binding specific motif GUCGGUAU on rsdA pre-mRNA for alternative splicing, regulating the stability of intron 2 splicing, thereby producing normal levels of rsdA protein that interacts with csdA to regulate fungal growth, development and secondary metabolism"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30421486"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37963872"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"30421486"}],"value":"Significantly reduces asexual development, resulting in low sporulation and abnormal conidia (PubMed:30421486). Also decreases the production of the secondary metabolites asperpentyn, ficiolide A and chloroisosulochrin, completely abolishes the prodiction of pestheic acid, while remarkably increases the melanin production (PubMed:30421486). Overproduction of melanin leads to the formation of unusual, heavily pigmented hyphae (PubMed:30421486). Does nor affect the expression abundance of csdA (PubMed:37963872)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the laeB global regulator family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":730,"modifier":"EXACT"}},"description":"Global regulator 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