{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9Z224","secondaryAccessions":["F6ZGI7","Q9D6Q0"],"uniProtkbId":"MOC2A_MOUSE","entryAudit":{"firstPublicDate":"2002-02-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-01-28","entryVersion":128,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03051"}],"value":"Molybdopterin synthase sulfur carrier subunit"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03051"}],"value":"Molybdenum cofactor synthesis protein 2 small subunit"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03051"}],"value":"Molybdenum cofactor synthesis protein 2A"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03051"}],"value":"MOCS2A"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03051"}],"value":"Sulfur carrier protein MOCS2A"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03051"}],"value":"Mocs2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O96033"}],"value":"Acts as a sulfur carrier required for molybdopterin biosynthesis. 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In serum and urine samples, the levels of hypoxanthine and xanthine are increased; the increased levels of xanthine leads to bladder and kidney stone formation, there's also an absence of uric acid and the activity of sulfite oxidase is undetectable with an increased level of S-sulfocysteine and occurrence of neuronal apoptosis (PubMed:27138983). The mean lifespan is 4.7 days, although most mice die either at postnatal day 1 or between postnatal days 5 and 10 (PubMed:27138983)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"value":"This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B) from an overlapping reading frame"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03051"}],"value":"Belongs to the MoaD family. 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