ID   FCGBP_HUMAN             Reviewed;        5405 AA.
AC   Q9Y6R7; O95784;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 3.
DT   27-MAR-2024, entry version 158.
DE   RecName: Full=IgGFc-binding protein;
DE   AltName: Full=Fcgamma-binding protein antigen;
DE            Short=FcgammaBP;
DE   Flags: Precursor;
GN   Name=FCGBP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-2814; SER-4465; HIS-4906 AND
RP   VAL-5017, FUNCTION, INTERACTION WITH IGG, AND TISSUE SPECIFICITY.
RC   TISSUE=Colon epithelium;
RX   PubMed=9182547; DOI=10.1074/jbc.272.24.15232;
RA   Harada N., Iijima S., Kobayashi K., Yoshida T., Brown W.R., Hibi T.,
RA   Oshima A., Morikawa M.;
RT   "Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells
RT   exhibits mucin-like structure.";
RL   J. Biol. Chem. 272:15232-15241(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=11600203; DOI=10.1016/s0165-2478(01)00288-7;
RA   Kobayashi K., Yagasaki M., Harada N., Chichibu K., Hibi T., Yoshida T.,
RA   Brown W.R., Morikawa M.;
RT   "Detection of Fcgamma binding protein antigen in human sera and its
RT   relation with autoimmune diseases.";
RL   Immunol. Lett. 79:229-235(2001).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=12208673; DOI=10.1677/joe.0.1740517;
RA   O'Donovan N., Fischer A., Abdo E.-M., Simon F., Peter H.J., Gerber H.,
RA   Buergi U., Marti U.;
RT   "Differential expression of IgG Fc binding protein (FcgammaBP) in human
RT   normal thyroid tissue, thyroid adenomas and thyroid carcinomas.";
RL   J. Endocrinol. 174:517-524(2002).
RN   [5]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-3719.
RC   TISSUE=Bile;
RX   PubMed=15084671; DOI=10.1074/mcp.m400015-mcp200;
RA   Kristiansen T.Z., Bunkenborg J., Gronborg M., Molina H., Thuluvath P.J.,
RA   Argani P., Goggins M.G., Maitra A., Pandey A.;
RT   "A proteomic analysis of human bile.";
RL   Mol. Cell. Proteomics 3:715-728(2004).
RN   [6]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-75; ASN-91; ASN-1743; ASN-2138
RP   AND ASN-2518.
RC   TISSUE=Plasma;
RX   PubMed=16335952; DOI=10.1021/pr0502065;
RA   Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J.,
RA   Smith R.D.;
RT   "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT   hydrazide chemistry, and mass spectrometry.";
RL   J. Proteome Res. 4:2070-2080(2005).
RN   [7]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2518.
RC   TISSUE=Saliva;
RX   PubMed=16740002; DOI=10.1021/pr050492k;
RA   Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.;
RT   "Identification of N-linked glycoproteins in human saliva by glycoprotein
RT   capture and mass spectrometry.";
RL   J. Proteome Res. 5:1493-1503(2006).
RN   [8]
RP   INTERACTION WITH MUC2.
RX   PubMed=19432394; DOI=10.1021/pr9002504;
RA   Johansson M.E.V., Thomsson K.A., Hansson G.C.;
RT   "Proteomic analyses of the two mucus layers of the colon barrier reveal
RT   that their main component, the Muc2 mucin, is strongly bound to the Fcgbp
RT   protein.";
RL   J. Proteome Res. 8:3549-3557(2009).
RN   [9]
RP   GLYCOSYLATION AT ASN-1317.
RX   PubMed=19139490; DOI=10.1074/mcp.m800504-mcp200;
RA   Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B.,
RA   Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L.,
RA   Ying W.T., He S.M., Qian X.H.;
RT   "A strategy for precise and large scale identification of core fucosylated
RT   glycoproteins.";
RL   Mol. Cell. Proteomics 8:913-923(2009).
CC   -!- FUNCTION: May be involved in the maintenance of the mucosal structure
CC       as a gel-like component of the mucosa. {ECO:0000269|PubMed:9182547}.
CC   -!- SUBUNIT: Interacts with the Fc portion of IgG and with MUC2.
CC       {ECO:0000269|PubMed:19432394, ECO:0000269|PubMed:9182547}.
CC   -!- INTERACTION:
CC       Q9Y6R7; Q07654: TFF3; NbExp=2; IntAct=EBI-2869882, EBI-10224676;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in placenta and colon epithelium.
CC       Expressed in thyroid, and down-regulated in thyroid carcinomas. Present
CC       in serum, with higher levels in patients with various autoimmune
CC       diseases (at protein level). {ECO:0000269|PubMed:11600203,
CC       ECO:0000269|PubMed:12208673, ECO:0000269|PubMed:9182547}.
CC   -!- DOMAIN: The N-terminal IgGFc-binding region is primate-specific.
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DR   EMBL; D84239; BAA19526.1; -; mRNA.
DR   EMBL; AC006950; AAD15624.1; -; Genomic_DNA.
DR   EMBL; AC007842; AAD39266.1; -; Genomic_DNA.
DR   EMBL; AC011536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_003881.2; NM_003890.2.
DR   SMR; Q9Y6R7; -.
DR   BioGRID; 114381; 18.
DR   IntAct; Q9Y6R7; 8.
DR   STRING; 9606.ENSP00000481056; -.
DR   MEROPS; I08.954; -.
DR   GlyConnect; 1386; 21 N-Linked glycans (10 sites).
DR   GlyCosmos; Q9Y6R7; 18 sites, 28 glycans.
DR   GlyGen; Q9Y6R7; 18 sites, 27 N-linked glycans (10 sites), 1 O-linked glycan (3 sites).
DR   iPTMnet; Q9Y6R7; -.
DR   PhosphoSitePlus; Q9Y6R7; -.
DR   BioMuta; FCGBP; -.
DR   DMDM; 224471888; -.
DR   CPTAC; non-CPTAC-1133; -.
DR   EPD; Q9Y6R7; -.
DR   jPOST; Q9Y6R7; -.
DR   MassIVE; Q9Y6R7; -.
DR   MaxQB; Q9Y6R7; -.
DR   PeptideAtlas; Q9Y6R7; -.
DR   ProteomicsDB; 86780; -.
DR   DNASU; 8857; -.
DR   Ensembl; ENST00000628705.2; ENSP00000487490.3; ENSG00000281123.4.
DR   GeneID; 8857; -.
DR   KEGG; hsa:8857; -.
DR   MANE-Select; ENST00000628705.3; ENSP00000487490.3; NM_003890.3; NP_003881.2.
DR   AGR; HGNC:13572; -.
DR   CTD; 8857; -.
DR   DisGeNET; 8857; -.
DR   GeneCards; FCGBP; -.
DR   HGNC; HGNC:13572; FCGBP.
DR   MIM; 617553; gene.
DR   neXtProt; NX_Q9Y6R7; -.
DR   PharmGKB; PA28059; -.
DR   InParanoid; Q9Y6R7; -.
DR   OrthoDB; 2872912at2759; -.
DR   PhylomeDB; Q9Y6R7; -.
DR   TreeFam; TF316399; -.
DR   PathwayCommons; Q9Y6R7; -.
DR   SignaLink; Q9Y6R7; -.
DR   BioGRID-ORCS; 8857; 16 hits in 1055 CRISPR screens.
DR   ChiTaRS; FCGBP; human.
DR   GeneWiki; FCGBP; -.
DR   GenomeRNAi; 8857; -.
DR   Pharos; Q9Y6R7; Tbio.
DR   PRO; PR:Q9Y6R7; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q9Y6R7; Protein.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   CDD; cd19941; TIL; 12.
DR   Gene3D; 2.10.25.10; Laminin; 12.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR003645; Fol_N.
DR   InterPro; IPR035234; IgGFc-bd_N.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR025615; TILa_dom.
DR   InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR   PANTHER; PTHR11339:SF244; IGGFC-BINDING PROTEIN; 1.
DR   Pfam; PF08742; C8; 12.
DR   Pfam; PF17517; IgGFc_binding; 1.
DR   Pfam; PF01826; TIL; 12.
DR   Pfam; PF12714; TILa; 11.
DR   Pfam; PF00094; VWD; 13.
DR   SMART; SM00832; C8; 12.
DR   SMART; SM00181; EGF; 7.
DR   SMART; SM00274; FOLN; 9.
DR   SMART; SM00214; VWC; 7.
DR   SMART; SM00215; VWC_out; 11.
DR   SMART; SM00216; VWD; 13.
DR   SUPFAM; SSF57567; Serine protease inhibitors; 12.
DR   PROSITE; PS51233; VWFD; 13.
PE   1: Evidence at protein level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..5405
FT                   /note="IgGFc-binding protein"
FT                   /id="PRO_0000256698"
FT   DOMAIN          470..650
FT                   /note="VWFD 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          745..799
FT                   /note="TIL 1"
FT   DOMAIN          862..1041
FT                   /note="VWFD 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          1136..1189
FT                   /note="TIL 2"
FT   DOMAIN          1250..1429
FT                   /note="VWFD 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          1532..1585
FT                   /note="TIL 3"
FT   DOMAIN          1671..1854
FT                   /note="VWFD 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          1950..2007
FT                   /note="TIL 4"
FT   DOMAIN          2070..2253
FT                   /note="VWFD 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          2337..2390
FT                   /note="TIL 5"
FT   DOMAIN          2451..2630
FT                   /note="VWFD 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          2733..2786
FT                   /note="TIL 6"
FT   DOMAIN          2872..3055
FT                   /note="VWFD 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          3151..3208
FT                   /note="TIL 7"
FT   DOMAIN          3271..3454
FT                   /note="VWFD 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          3538..3591
FT                   /note="TIL 8"
FT   DOMAIN          3652..3831
FT                   /note="VWFD 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          3934..3987
FT                   /note="TIL 9"
FT   DOMAIN          4073..4256
FT                   /note="VWFD 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          4352..4409
FT                   /note="TIL 10"
FT   DOMAIN          4472..4655
FT                   /note="VWFD 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          4739..4792
FT                   /note="TIL 11"
FT   DOMAIN          4854..5025
FT                   /note="VWFD 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          5121..5174
FT                   /note="TIL 12"
FT   DOMAIN          5233..5404
FT                   /note="VWFD 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   REGION          24..450
FT                   /note="IgGFc-binding"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:16335952"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:16335952"
FT   CARBOHYD        1317
FT                   /note="N-linked (GlcNAc...) (complex) asparagine"
FT                   /evidence="ECO:0000269|PubMed:19139490"
FT   CARBOHYD        1743
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:16335952"
FT   CARBOHYD        2138
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:16335952"
FT   CARBOHYD        2518
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:16335952,
FT                   ECO:0000269|PubMed:16740002"
FT   CARBOHYD        3719
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:15084671"
FT   CARBOHYD        4145
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4540
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        472..611
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        494..649
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        864..1003
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        886..1040
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        1252..1390
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        1274..1428
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        1673..1815
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        1695..1853
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        1704..1812
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        2072..2211
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        2094..2252
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        2453..2591
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        2475..2629
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        2874..3016
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        2896..3054
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        2905..3013
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        3273..3412
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        3295..3453
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        3654..3792
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        3676..3830
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        4075..4217
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        4097..4255
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        4106..4214
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        4474..4613
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        4496..4654
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        4856..4986
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        4878..5024
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        5235..5372
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   VARIANT         732
FT                   /note="V -> A (in dbSNP:rs34181317)"
FT                   /id="VAR_054490"
FT   VARIANT         770
FT                   /note="N -> S (in dbSNP:rs34939346)"
FT                   /id="VAR_054491"
FT   VARIANT         929
FT                   /note="G -> R (in dbSNP:rs35338934)"
FT                   /id="VAR_054492"
FT   VARIANT         971
FT                   /note="V -> M (in dbSNP:rs35922811)"
FT                   /id="VAR_054493"
FT   VARIANT         1019
FT                   /note="G -> R (in dbSNP:rs34254649)"
FT                   /id="VAR_054494"
FT   VARIANT         1340
FT                   /note="V -> L (in dbSNP:rs11083543)"
FT                   /id="VAR_028903"
FT   VARIANT         1436
FT                   /note="P -> L (in dbSNP:rs36106401)"
FT                   /id="VAR_054495"
FT   VARIANT         1445
FT                   /note="H -> D (in dbSNP:rs2909229)"
FT                   /id="VAR_054496"
FT   VARIANT         1524
FT                   /note="T -> N (in dbSNP:rs34938990)"
FT                   /id="VAR_054497"
FT   VARIANT         1616
FT                   /note="G -> V (in dbSNP:rs7248839)"
FT                   /id="VAR_028904"
FT   VARIANT         1617
FT                   /note="M -> V (in dbSNP:rs7249743)"
FT                   /id="VAR_028905"
FT   VARIANT         2089
FT                   /note="N -> D (in dbSNP:rs885723)"
FT                   /id="VAR_028906"
FT   VARIANT         2646
FT                   /note="E -> D (in dbSNP:rs140171218)"
FT                   /id="VAR_028907"
FT   VARIANT         2647
FT                   /note="E -> K (in dbSNP:rs1176978283)"
FT                   /id="VAR_028908"
FT   VARIANT         2793
FT                   /note="A -> V (in dbSNP:rs2542316)"
FT                   /id="VAR_028909"
FT   VARIANT         2814
FT                   /note="V -> A (in dbSNP:rs3746009)"
FT                   /evidence="ECO:0000269|PubMed:9182547"
FT                   /id="VAR_028910"
FT   VARIANT         3264
FT                   /note="G -> S (in dbSNP:rs1290971390)"
FT                   /id="VAR_028911"
FT   VARIANT         3920
FT                   /note="H -> Q (in dbSNP:rs2542318)"
FT                   /id="VAR_028912"
FT   VARIANT         4015
FT                   /note="V -> A (in dbSNP:rs3746009)"
FT                   /id="VAR_028913"
FT   VARIANT         4095
FT                   /note="G -> D (in dbSNP:rs1975181)"
FT                   /id="VAR_028914"
FT   VARIANT         4465
FT                   /note="G -> S (in dbSNP:rs6508919)"
FT                   /evidence="ECO:0000269|PubMed:9182547"
FT                   /id="VAR_028915"
FT   VARIANT         4906
FT                   /note="D -> H (in dbSNP:rs3746013)"
FT                   /evidence="ECO:0000269|PubMed:9182547"
FT                   /id="VAR_028916"
FT   VARIANT         5017
FT                   /note="A -> V (in dbSNP:rs741143)"
FT                   /evidence="ECO:0000269|PubMed:9182547"
FT                   /id="VAR_054498"
FT   CONFLICT        1961
FT                   /note="S -> P (in Ref. 1; BAA19526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2719
FT                   /note="Q -> H (in Ref. 1; BAA19526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2842
FT                   /note="N -> T (in Ref. 1; BAA19526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2976
FT                   /note="T -> A (in Ref. 1; BAA19526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3117
FT                   /note="R -> H (in Ref. 1; BAA19526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3668
FT                   /note="H -> R (in Ref. 1; BAA19526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3841
FT                   /note="A -> E (in Ref. 1; BAA19526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3847..3848
FT                   /note="DK -> EE (in Ref. 1; BAA19526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        4043
FT                   /note="T -> N (in Ref. 1; BAA19526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        4284
FT                   /note="S -> A (in Ref. 1; BAA19526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        4318
FT                   /note="R -> H (in Ref. 1; BAA19526)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   5405 AA;  572017 MW;  6E502F782261355F CRC64;
     MGALWSWWIL WAGATLLWGL TQEASVDLKN TGREEFLTAF LQNYQLAYSK AYPRLLISSL
     SESPASVSIL SQADNTSKKV TVRPGESVMV NISAKAEMIG SKIFQHAVVI HSDYAISVQA
     LNAKPDTAEL TLLRPIQALG TEYFVLTPPG TSARNVKEFA VVAGAAGASV SVTLKGSVTF
     NGKFYPAGDV LRVTLQPYNV AQLQSSVDLS GSKVTASSPV AVLSGHSCAQ KHTTCNHVVE
     QLLPTSAWGT HYVVPTLASQ SRYDLAFVVA SQATKLTYNH GGITGSRGLQ AGDVVEFEVR
     PSWPLYLSAN VGIQVLLFGT GAIRNEVTYD PYLVLIPDVA AYCPAYVVKS VPGCEGVALV
     VAQTKAISGL TIDGHAVGAK LTWEAVPGSE FSYAEVELGT ADMIHTAEAT TNLGLLTFGL
     AKAIGYATAA DCGRTVLSPV EPSCEGMQCA AGQRCQVVGG KAGCVAESTA VCRAQGDPHY
     TTFDGRRYDM MGTCSYTMVE LCSEDDTLPA FSVEAKNEHR GSRRVSYVGL VTVRAYSHSV
     SLTRGEVGFV LVDNQRSRLP VSLSEGRLRV YQSGPRAVVE LVFGLVVTYD WDCQLALSLP
     ARFQDQVCGL CGNYNGDPAD DFLTPDGALA PDAVEFASSW KLDDGDYLCE DGCQNNCPAC
     TPGQAQHYEG DRLCGMLTKL DGPFAVCHDT LDPRPFLEQC VYDLCVVGGE RLSLCRGLSA
     YAQACLELGI SVGDWRSPAN CPLSCPANSR YELCGPACPT SCNGAAAPSN CSGRPCVEGC
     VCLPGFVASG GACVPASSCG CTFQGLQLAP GQEVWADELC QRRCTCNGAT HQVTCRDKQS
     CPAGERCSVQ NGLLGCYPDR FGTCQGSGDP HYVSFDGRRF DFMGTCTYLL VGSCGQNAAL
     PAFRVLVENE HRGSQTVSYT RAVRVEARGV KVAVRREYPG QVLVDDVLQY LPFQAADGQV
     QVFRQGRDAV VRTDFGLTVT YDWNARVTAK VPSSYAEALC GLCGNFNGDP ADDLALRGGG
     QAANALAFGN SWQEETRPGC GATEPGDCPK LDSLVAQQLQ SKNECGILAD PKGPFRECHS
     KLDPQGAVRD CVYDRCLLPG QSGPLCDALA TYAAACQAAG ATVHPWRSEE LCPLSCPPHS
     HYEACSYGCP LSCGDLPVPG GCGSECHEGC VCDEGFALSG ESCLPLASCG CVHQGTYHPP
     GQTFYPGPGC DSLCHCQEGG LVSCESSSCG PHEACQPSGG SLGCVAVGSS TCQASGDPHY
     TTFDGRRFDF MGTCVYVLAQ TCGTRPGLHR FAVLQENVAW GNGRVSVTRV ITVQVANFTL
     RLEQRQWKVT VNGVDMKLPV VLANGQIRAS QHGSDVVIET DFGLRVAYDL VYYVRVTVPG
     NYYQQMCGLC GNYNGDPKDD FQKPNGSQAG NANEFGNSWE EVVPDSPCLP PTPCPPGSED
     CIPSHKCPPE LEKKYQKEEF CGLLSSPTGP LSSCHKLVDP QGPLKDCIFD LCLGGGNLSI
     LCSNIHAYVS ACQAAGGHVE PWRTETFCPM ECPPNSHYEL CADTCSLGCS ALSAPPQCQD
     GCAEGCQCDS GFLYNGQACV PIQQCGCYHN GVYYEPEQTV LIDNCRQQCT CHAGKGMVCQ
     EHSCKPGQVC QPSGGILSCV TKDPCHGVTC RPQETCKEQG GQGVCLPNYE ATCWLWGDPH
     YHSFDGRKFD FQGTCNYVLA TTGCPGVSTQ GLTPFTVTTK NQNRGNPAVS YVRVVTVAAL
     GTNISIHKDE IGKVRVNGVL TALPVSVADG RISVTQGASK ALLVADFGLQ VSYDWNWRVD
     VTLPSSYHGA VCGLCGNMDR NPNNDQVFPN GTLAPSIPIW GGSWRAPGWD PLCWDECRGS
     CPTCPEDRLE QYEGPGFCGP LAPGTGGPFT TCHAHVPPES FFKGCVLDVC MGGGDRDILC
     KALASYVAAC QAAGVVIEDW RAQVGCEITC PENSHYEVCG SPCPASCPSP APLTTPAVCE
     GPCVEGCQCD AGFVLSADRC VPLNNGCGCW ANGTYHEAGS EFWADGTCSQ WCRCGPGGGS
     LVCTPASCGL GEVCGLLPSG QHGCQPVSTA ECQAWGDPHY VTLDGHRFNF QGTCEYLLSA
     PCHGPPLGAE NFTVTVANEH RGSQAVSYTR SVTLQIYNHS LTLSARWPRK LQVDGVFVTL
     PFQLDSLLHA HLSGADVVVT TTSGLSLAFD GDSFVRLRVP AAYAGSLCGL CGNYNQDPAD
     DLKAVGGKPA GWQVGGAQGC GECVSKPCPS PCTPEQQESF GGPDACGVIS ATDGPLAPCH
     GLVPPAQYFQ GCLLDACQVQ GHPGGLCPAV ATYVAACQAA GAQLREWRRP DFCPFQCPAH
     SHYELCGDSC PGSCPSLSAP EGCESACREG CVCDAGFVLS GDTCVPVGQC GCLHDDRYYP
     LGQTFYPGPG CDSLCRCREG GEVSCEPSSC GPHETCRPSG GSLGCVAVGS TTCQASGDPH
     YTTFDGRRFD FMGTCVYVLA QTCGTRPGLH RFAVLQENVA WGNGRVSVTR VITVQVANFT
     LRLEQRQWKV TVNGVDMKLP VVLANGQIRA SQHGSDVVIE TDFGLRVAYD LVYYVRVTVP
     GNYYQLMCGL CGNYNGDPKD DFQKPNGSQA GNANEFGNSW EEVVPDSPCL PPPTCPPGSE
     GCIPSEECPP ELEKKYQKEE FCGLLSSPTG PLSSCHKLVD PQGPLKDCIF DLCLGGGNLS
     ILCSNIHAYV SACQAAGGQV EPWRNETFCP MECPQNSHYE LCADTCSLGC SALSAPLQCP
     DGCAEGCQCD SGFLYNGQAC VPIQQCGCYH NGAYYEPEQT VLIDNCRQQC TCHVGKVVVC
     QEHSCKPGQV CQPSGGILSC VNKDPCHGVT CRPQETCKEQ GGQGVCLPNY EATCWLWGDP
     HYHSFDGRKF DFQGTCNYVL ATTGCPGVST QGLTPFTVTT KNQNRGNPAV SYVRVVTVAA
     LGTNISIHKD EIGKVRVNGV LTALPVSVAD GRISVTQGAS KALLVADFGL QVSYDWNWRV
     DVTLPSSYHG AVCGLCGNMD RNPNNDQVFP NGTLAPSIPI WGGSWRAPGW DPLCWDECRG
     SCPTCPEDRL EQYEGPGFCG PLAPGTGGPF TTCHAHVPPE SFFKGCVLDV CMGGGDRDIL
     CKALASYVAA CQAAGVVIED WRAQVGCEIT CPENSHYEVC GPPCPASCPS PAPLTTPAVC
     EGPCVEGCQC DAGFVLSADR CVPLNNGCGC WANGTYHEAG SEFWADGTCS QWCRCGPGGG
     SLVCTPASCG LGEVCGLLPS GQHGCQPVST AECQAWGDPH YVTLDGHRFD FQGTCEYLLS
     APCHGPPLGA ENFTVTVANE HRGSQAVSYT RSVTLQIYNH SLTLSARWPR KLQVDGVFVT
     LPFQLDSLLH AHLSGADVVV TTTSGLSLAF DGDSFVRLRV PAAYAGSLCG LCGNYNQDPA
     DDLKAVGGKP AGWQVGGAQG CGECVSKPCP SPCTPEQQES FGGPDACGVI SATDGPLAPC
     HGLVPPAQYF QGCLLDACQV QGHPGGLCPA VATYVAACQA AGAQLREWRR PDFCPFQCPA
     HSHYELCGDS CPGSCPSLSA PEGCESACRE GCVCDAGFVL SGDTCVPVGQ CGCLHDDRYY
     PLGQTFYPGP GCDSLCRCRE GGEVSCEPSS CGPHETCRPS GGSLGCVAVG STTCQASGDP
     HYTTFDGHRF DFMGTCVYVL AQTCGTRPGL HRFAVLQENV AWGNGRVSVT RVITVQVANF
     TLRLEQRQWK VTVNGVDMKL PVVLANGQIR ASQHGSDVVI ETDFGLRVAY DLVYYVRVTV
     PGNYYQLMCG LCGNYNGDPK DDFQKPNGSQ AGNANEFGNS WEEVVPDSPC LPPPTCPPGS
     AGCIPSDKCP PELEKKYQKE EFCGLLSSPT GPLSSCHKLV DPQGPLKDCI FDLCLGGGNL
     SILCSNIHAY VSACQAAGGH VEPWRNETFC PMECPQNSHY ELCADTCSLG CSALSAPLQC
     PDGCAEGCQC DSGFLYNGQA CVPIQQCGCY HNGVYYEPEQ TVLIDNCRQQ CTCHVGKVVV
     CQEHSCKPGQ VCQPSGGILS CVTKDPCHGV TCRPQETCKE QGGQGVCLPN YEATCWLWGD
     PHYHSFDGRK FDFQGTCNYV LATTGCPGVS TQGLTPFTVT TKNQNRGNPA VSYVRVVTVA
     ALGTNISIHK DEIGKVRVNG VLTALPVSVA DGRISVAQGA SKALLVADFG LQVSYDWNWR
     VDVTLPSSYH GAVCGLCGNM DRNPNNDQVF PNGTLAPSIP IWGGSWRAPG WDPLCWDECR
     GSCPTCPEDR LEQYEGPGFC GPLSSGTGGP FTTCHAHVPP ESFFKGCVLD VCMGGGDRDI
     LCKALASYVA ACQAAGVVIE DWRAQVGCEI TCPENSHYEV CGPPCPASCP SPAPLTTPAV
     CEGPCVEGCQ CDAGFVLSAD RCVPLNNGCG CWANGTYHEA GSEFWADGTC SQWCRCGPGG
     GSLVCTPASC GLGEVCGLLP SGQHGCQPVS TAECQAWGDP HYVTLDGHRF DFQGTCEYLL
     SAPCHGPPLG AENFTVTVAN EHRGSQAVSY TRSVTLQIYN HSLTLSARWP RKLQVDGVFV
     ALPFQLDSLL HAHLSGADVV VTTTSGLSLA FDGDSFVRLR VPAAYAASLC GLCGNYNQDP
     ADDLKAVGGK PAGWQVGGAQ GCGECVSKPC PSPCTPEQQE SFGGPDACGV ISATDGPLAP
     CHGLVPPAQY FQGCLLDACQ VQGHPGGLCP AVATYVAACQ AAGAQLGEWR RPDFCPLQCP
     AHSHYELCGD SCPVSCPSLS APEGCESACR EGCVCDAGFV LSGDTCVPVG QCGCLHDGRY
     YPLGEVFYPG PECERRCECG PGGHVTCQEG AACGPHEECR LEDGVQACHA TGCGRCLANG
     GIHYITLDGR VYDLHGSCSY VLAQVCHPKP GDEDFSIVLE KNAAGDLQRL LVTVAGQVVS
     LAQGQQVTVD GEAVALPVAV GRVRVTAEGR NMVLQTTKGL RLLFDGDAHL LMSIPSPFRG
     RLCGLCGNFN GNWSDDFVLP NGSAASSVET FGAAWRAPGS SKGCGEGCGP QGCPVCLAEE
     TAPYESNEAC GQLRNPQGPF ATCQAVLSPS EYFRQCVYDL CAQKGDKAFL CRSLAAYTAA
     CQAAGVAVKP WRTDSFCPLH CPAHSHYSIC TRTCQGSCAA LSGLTGCTTR CFEGCECDDR
     FLLSQGVCIP VQDCGCTHNG RYLPVNSSLL TSDCSERCSC SSSSGLTCQA AGCPPGRVCE
     VKAEARNCWA TRGLCVLSVG ANLTTFDGAR GATTSPGVYE LSSRCPGLQN TIPWYRVVAE
     VQICHGKTEA VGQVHIFFQD GMVTLTPNKG VWVNGLRVDL PAEKLASVSV SRTPDGSLLV
     RQKAGVQVWL GANGKVAVIV SNDHAGKLCG ACGNFDGDQT NDWHDSQEKP AMEKWRAQDF
     SPCYG
//