{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9Y6M1","secondaryAccessions":["A0A4Z0","B3FTN2","B3FTN3","B3FTN4"],"uniProtkbId":"IF2B2_HUMAN","entryAudit":{"firstPublicDate":"2006-06-27","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-03-03","entryVersion":204,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Insulin-like growth factor 2 mRNA-binding protein 2"},"shortNames":[{"value":"IGF2 mRNA-binding protein 2"},{"value":"IMP-2"}]},"alternativeNames":[{"fullName":{"value":"Hepatocellular carcinoma autoantigen p62"}},{"fullName":{"value":"IGF-II mRNA-binding protein 2"}},{"fullName":{"value":"VICKZ family member 2"}}]},"genes":[{"geneName":{"value":"IGF2BP2"},"synonyms":[{"value":"IMP2"},{"value":"VICKZ2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23640942"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29476152"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9891060"}],"value":"RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed:9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12674497"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17289661"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23640942"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29476152"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34457052"}],"value":"Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner (PubMed:23640942). Interacts with HNRPD (PubMed:12674497). Interacts with IGF2BP1 (PubMed:17289661). Interacts with ELAVL1, DHX9, HNRNPU, MATR3 and PABPC1 (PubMed:23640942, PubMed:29476152). Interacts with the HOXB-AS3 peptide; the interaction increases MYC stability (PubMed:34457052)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9Y6M1","intActId":"EBI-1024419"},"interactantTwo":{"uniProtKBAccession":"Q13627","geneName":"DYRK1A","intActId":"EBI-1053596"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6M1","intActId":"EBI-1024419"},"interactantTwo":{"uniProtKBAccession":"Q14103-4","geneName":"HNRNPD","intActId":"EBI-432545"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6M1","intActId":"EBI-1024419"},"interactantTwo":{"uniProtKBAccession":"P98179","geneName":"RBM3","intActId":"EBI-2949699"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6M1","intActId":"EBI-1024419"},"interactantTwo":{"uniProtKBAccession":"Q13148","geneName":"TARDBP","intActId":"EBI-372899"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules"}]},"subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}},{"location":{"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29476152"}],"value":"Cytoplasm, P-body","id":"SL-0230"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29476152"}],"value":"Cytoplasm, Stress granule","id":"SL-0496"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing","Alternative initiation"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9Y6M1-2"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9Y6M1-1"],"sequenceIds":["VSP_036553"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q9Y6M1-3"],"sequenceIds":["VSP_036550"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q9Y6M1-4"],"sequenceIds":["VSP_036550","VSP_036552"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["Q9Y6M1-5"],"sequenceIds":["VSP_036550","VSP_036553"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"isoformIds":["Q9Y6M1-6"],"sequenceIds":["VSP_043699"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10190901"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16049158"}],"value":"Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20080952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23640942"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29476152"}],"value":"Domains KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute (PubMed:29476152). The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules"}],"commentType":"DOMAIN"},{"texts":[{"value":"Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Generated by alternative initiation at Met-69"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 6"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the RRM IMP/VICKZ family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH21290.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":599,"modifier":"EXACT"}},"description":"Insulin-like growth factor 2 mRNA-binding protein 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