{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9Y4E8","secondaryAccessions":["Q08AL5","Q9H8G9","Q9HCA6","Q9UNP0","Q9Y5B5"],"uniProtkbId":"UBP15_HUMAN","entryAudit":{"firstPublicDate":"2000-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-02-12","entryVersion":229,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Ubiquitin carboxyl-terminal hydrolase 15"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10444327"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16005295"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947082"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22344298"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24852371"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27368102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33093067"}],"value":"3.4.19.12"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10444327"}],"value":"Deubiquitinating enzyme 15"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10444327"}],"value":"Ubiquitin thioesterase 15"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10444327"}],"value":"Ubiquitin-specific-processing protease 15"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.9"}],"value":"Unph-2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"}],"value":"Unph4"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10444327"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:12613"}],"value":"USP15"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9628581"}],"value":"KIAA0529"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16005295"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17318178"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19576224"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19826004"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947082"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22344298"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24526689"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24852371"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27368102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33093067"}],"value":"Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004, PubMed:21947082, PubMed:22344298, PubMed:24852371). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19553310"}],"value":"(Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).","ecNumber":"3.4.19.12","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10444327"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16005295"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947082"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22344298"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27368102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33093067"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16005295"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21750715"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947082"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22001210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22344298"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24526689"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24852371"}],"value":"A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in vivo (PubMed:22001210). Identified in a complex with the COP9 signalosome complex (CSN) (PubMed:16005295). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct (PubMed:21947082). Forms a complex with SMURF2 and SMAD7 (PubMed:22344298). Interacts with TGFBR1 (PubMed:22344298). Interacts with SART3; the interaction is direct (PubMed:24526689). May interact with RNF20 and RNF40 (PubMed:24526689). May interact with PRKN (PubMed:24852371). Interacts with INCA1 (PubMed:21750715)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19553310"}],"value":"(Microbial infection) Interacts with human papillomavirus type 16 protein E6"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9Y4E8","intActId":"EBI-1043104"},"interactantTwo":{"uniProtKBAccession":"Q9H257","geneName":"CARD9","intActId":"EBI-751319"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8","intActId":"EBI-1043104"},"interactantTwo":{"uniProtKBAccession":"Q2TAC2","geneName":"CCDC57","intActId":"EBI-2808286"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8","intActId":"EBI-1043104"},"interactantTwo":{"uniProtKBAccession":"Q0VD86","geneName":"INCA1","intActId":"EBI-6509505"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8","intActId":"EBI-1043104"},"interactantTwo":{"uniProtKBAccession":"Q9Y6D9","geneName":"MAD1L1","intActId":"EBI-742610"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8","intActId":"EBI-1043104"},"interactantTwo":{"uniProtKBAccession":"Q96EA4","geneName":"SPDL1","intActId":"EBI-715381"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8","intActId":"EBI-1043104"},"interactantTwo":{"uniProtKBAccession":"Q86TM6","geneName":"SYVN1","intActId":"EBI-947849"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8","intActId":"EBI-1043104"},"interactantTwo":{"uniProtKBAccession":"Q6ZNK6","geneName":"TIFAB","intActId":"EBI-26453465"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8","intActId":"EBI-1043104"},"interactantTwo":{"uniProtKBAccession":"P19474","geneName":"TRIM21","intActId":"EBI-81290"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8","intActId":"EBI-1043104"},"interactantTwo":{"uniProtKBAccession":"Q9BTM9","geneName":"URM1","intActId":"EBI-714589"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8","intActId":"EBI-1043104"},"interactantTwo":{"uniProtKBAccession":"Q9Y4E8","geneName":"USP15","intActId":"EBI-1043104"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8-2","intActId":"EBI-12041225"},"interactantTwo":{"uniProtKBAccession":"G5E9A7","geneName":"DMWD","intActId":"EBI-10976677"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8-2","intActId":"EBI-12041225"},"interactantTwo":{"uniProtKBAccession":"P57678","geneName":"GEMIN4","intActId":"EBI-356700"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8-2","intActId":"EBI-12041225"},"interactantTwo":{"uniProtKBAccession":"Q08379","geneName":"GOLGA2","intActId":"EBI-618309"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8-2","intActId":"EBI-12041225"},"interactantTwo":{"uniProtKBAccession":"Q9NYA3","geneName":"GOLGA6A","intActId":"EBI-11163335"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8-2","intActId":"EBI-12041225"},"interactantTwo":{"uniProtKBAccession":"P02545","geneName":"LMNA","intActId":"EBI-351935"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8-2","intActId":"EBI-12041225"},"interactantTwo":{"uniProtKBAccession":"Q9Y6D9","geneName":"MAD1L1","intActId":"EBI-742610"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8-2","intActId":"EBI-12041225"},"interactantTwo":{"uniProtKBAccession":"Q4G0R1","geneName":"PIBF1","intActId":"EBI-14066006"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8-2","intActId":"EBI-12041225"},"interactantTwo":{"uniProtKBAccession":"Q7Z699","geneName":"SPRED1","intActId":"EBI-5235340"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y4E8-2","intActId":"EBI-12041225"},"interactantTwo":{"uniProtKBAccession":"Q8IYF3-3","geneName":"TEX11","intActId":"EBI-11523345"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947082"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24526689"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947082"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24526689"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24852371"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9Y4E8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9Y4E8-2"],"sequenceIds":["VSP_005261"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q9Y4E8-3"],"sequenceIds":["VSP_005260"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q9Y4E8-4"],"sequenceIds":["VSP_045165","VSP_045166"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16005295"}],"value":"Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16005295"}],"value":"Ubiquitinated, leading to degradation by the proteasome"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the peptidase C19 family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/44585/USP15","ftp":false}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.8"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22223895"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":981,"modifier":"EXACT"}},"description":"Ubiquitin carboxyl-terminal hydrolase 15","featureId":"PRO_0000080641"},{"type":"Domain","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"DUSP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00613"}]},{"type":"Domain","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":933,"modifier":"EXACT"}},"description":"USP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01035"}]},{"type":"Region","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"Mediates interaction with SART3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24526689"}]},{"type":"Region","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":629,"modifier":"EXACT"},"end":{"value":694,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":952,"modifier":"EXACT"},"end":{"value":981,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":656,"modifier":"EXACT"},"end":{"value":673,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":960,"modifier":"EXACT"},"end":{"value":974,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01035"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19553310"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21947082"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"22344298"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24852371"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27368102"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"33093067"}]},{"type":"Active site","location":{"start":{"value":891,"modifier":"EXACT"},"end":{"value":891,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10092"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10093"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.8"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22223895"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16964243"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":602,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8R5H1"}]},{"type":"Modified residue","location":{"start":{"value":961,"modifier":"EXACT"},"end":{"value":961,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":965,"modifier":"EXACT"},"end":{"value":965,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Alternative sequence","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.9"}],"featureId":"VSP_005260","alternativeSequence":{"originalSequence":"DGTWPRGPSTPKSPGASNFSTLPKISPSSLSNNYNNMNNR","alternativeSequences":["QKNEDGTWPRGPSTP"]}},{"type":"Alternative sequence","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9628581"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"}],"featureId":"VSP_005261","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_045165","alternativeSequence":{"originalSequence":"SPGASNF","alternativeSequences":["KPLEQSC"]}},{"type":"Alternative sequence","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":981,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_045166","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Loss of enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19553310"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21947082"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22344298"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24852371"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27368102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33093067"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":812,"modifier":"EXACT"},"end":{"value":812,"modifier":"EXACT"}},"description":"Loss of activity towards polyubiquitin.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16005295"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19576224"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":559,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"in Ref. 9; AAG28973","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":747,"modifier":"EXACT"},"end":{"value":747,"modifier":"EXACT"}},"description":"in Ref. 7; AAI25124","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":968,"modifier":"EXACT"},"end":{"value":968,"modifier":"EXACT"}},"description":"in Ref. 9; AAG28973","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["H"]}},{"type":"Beta strand","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1W6V"}]},{"type":"Helix","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Helix","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Beta strand","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Helix","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Turn","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3T9L"}]},{"type":"Turn","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Helix","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Helix","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Beta strand","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3T9L"}]},{"type":"Turn","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Beta strand","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Helix","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Beta strand","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Beta strand","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5JJW"}]},{"type":"Beta strand","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Beta strand","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Beta strand","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Helix","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Beta strand","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3O"}]},{"type":"Beta strand","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Beta strand","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Helix","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Beta strand","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4A3P"}]},{"type":"Helix","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Helix","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Turn","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GHA"}]},{"type":"Helix","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Helix","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Helix","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Helix","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CRN"}]},{"type":"Beta strand","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7R2G"}]},{"type":"Helix","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Helix","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Helix","location":{"start":{"value":415,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Helix","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":438,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":440,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Turn","location":{"start":{"value":449,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Helix","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":469,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CRN"}]},{"type":"Beta strand","location":{"start":{"value":784,"modifier":"EXACT"},"end":{"value":787,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Helix","location":{"start":{"value":788,"modifier":"EXACT"},"end":{"value":795,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":803,"modifier":"EXACT"},"end":{"value":805,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7R2G"}]},{"type":"Beta strand","location":{"start":{"value":807,"modifier":"EXACT"},"end":{"value":809,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Turn","location":{"start":{"value":810,"modifier":"EXACT"},"end":{"value":813,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":814,"modifier":"EXACT"},"end":{"value":816,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":819,"modifier":"EXACT"},"end":{"value":827,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":829,"modifier":"EXACT"},"end":{"value":835,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":838,"modifier":"EXACT"},"end":{"value":840,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CRN"}]},{"type":"Helix","location":{"start":{"value":841,"modifier":"EXACT"},"end":{"value":843,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Helix","location":{"start":{"value":846,"modifier":"EXACT"},"end":{"value":848,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":851,"modifier":"EXACT"},"end":{"value":853,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":859,"modifier":"EXACT"},"end":{"value":861,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Helix","location":{"start":{"value":862,"modifier":"EXACT"},"end":{"value":864,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GHA"}]},{"type":"Beta strand","location":{"start":{"value":873,"modifier":"EXACT"},"end":{"value":884,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":891,"modifier":"EXACT"},"end":{"value":897,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Turn","location":{"start":{"value":899,"modifier":"EXACT"},"end":{"value":901,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":904,"modifier":"EXACT"},"end":{"value":908,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":911,"modifier":"EXACT"},"end":{"value":914,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Helix","location":{"start":{"value":917,"modifier":"EXACT"},"end":{"value":919,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Beta strand","location":{"start":{"value":925,"modifier":"EXACT"},"end":{"value":932,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ML1"}]},{"type":"Helix","location":{"start":{"value":933,"modifier":"EXACT"},"end":{"value":935,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GHA"}]},{"type":"Helix","location":{"start":{"value":943,"modifier":"EXACT"},"end":{"value":948,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7R2G"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0645","category":"Molecular function","name":"Protease"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0788","category":"Molecular function","name":"Thiol protease"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-1A6P8RC3A6SQ2","citationType":"submission","authors":["Kim K.I.","Nagase T.","Chung C.H."],"title":"Identification and characterization of a new human deubiquitinating enzyme Unph4.","publicationDate":"NOV-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"9628581","citationType":"journal article","authors":["Nagase T.","Ishikawa K.","Miyajima N.","Tanaka A.","Kotani H.","Nomura N.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"9628581"},{"database":"DOI","id":"10.1093/dnares/5.1.31"}],"title":"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.","publicationDate":"1998","journal":"DNA Res.","firstPage":"31","lastPage":"39","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"12168954","citationType":"journal article","authors":["Nakajima D.","Okazaki N.","Yamakawa H.","Kikuno R.","Ohara O.","Nagase T."],"citationCrossReferences":[{"database":"PubMed","id":"12168954"},{"database":"DOI","id":"10.1093/dnares/9.3.99"}],"title":"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.","publicationDate":"2002","journal":"DNA Res.","firstPage":"99","lastPage":"106","volume":"9"},"referencePositions":["SEQUENCE REVISION"]},{"referenceNumber":4,"citation":{"id":"CI-9BR19MTV4NLFO","citationType":"submission","authors":["Kim M.K.","Kim Y.H.","Seo J.M.","Lee H.M.","Chung H.J.","Sohn M.Y.","Hwang S.Y.","Im S.U.","Jung E.J.","Lee J.H.","Kim J.C."],"title":"A catalogue of genes in the human dermal papilla cells as identified by expressed sequence tags.","publicationDate":"MAY-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Hair follicle dermal papilla","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"16541075","citationType":"journal article","authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.H.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.-L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"CI-7O79CBPTUKG0L","citationType":"submission","authors":["Bienvenut W.V.","Matallanas D.","Cooper W.N.","Kolch W."],"publicationDate":"JUL-2007","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 2-21; 475-482 AND 924-932","CLEAVAGE OF INITIATOR METHIONINE","ACETYLATION AT ALA-2","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Mammary carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"CI-27I0ITT4LD5GS","citationType":"submission","authors":["Kimura Y.","Saya H.","Nakao M."],"title":"Cloning and identification of human Unph-2.","publicationDate":"JUL-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 19-981 (ISOFORM 3)"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"10444327","citationType":"journal article","authors":["Baker R.T.","Wang X.-W.","Woollatt E.","White J.A.","Sutherland G.R."],"citationCrossReferences":[{"database":"PubMed","id":"10444327"},{"database":"DOI","id":"10.1006/geno.1999.5879"}],"title":"Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases.","publicationDate":"1999","journal":"Genomics","firstPage":"264","lastPage":"274","volume":"59"},"referencePositions":["IDENTIFICATION (ISOFORM 2)","CATALYTIC ACTIVITY"]},{"referenceNumber":11,"citation":{"id":"12532266","citationType":"journal article","authors":["Angelats C.","Wang X.-W.","Jermiin L.S.","Copeland N.G.","Jenkins N.A.","Baker R.T."],"citationCrossReferences":[{"database":"PubMed","id":"12532266"},{"database":"DOI","id":"10.1007/s00335-002-3035-0"}],"title":"Isolation and characterization of the mouse ubiquitin-specific protease Usp15.","publicationDate":"2003","journal":"Mamm. Genome","firstPage":"31","lastPage":"46","volume":"14"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)"]},{"referenceNumber":12,"citation":{"id":"16005295","citationType":"journal article","authors":["Hetfeld B.K.","Helfrich A.","Kapelari B.","Scheel H.","Hofmann K.","Guterman A.","Glickman M.","Schade R.","Kloetzel P.M.","Dubiel W."],"citationCrossReferences":[{"database":"PubMed","id":"16005295"},{"database":"DOI","id":"10.1016/j.cub.2005.05.059"}],"title":"The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1.","publicationDate":"2005","journal":"Curr. Biol.","firstPage":"1217","lastPage":"1221","volume":"15"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","MUTAGENESIS OF CYS-812","IDENTIFICATION IN A COMPLEX WITH THE COP9 SIGNALOSOME","PHOSPHORYLATION","UBIQUITINATION"]},{"referenceNumber":13,"citation":{"id":"16964243","citationType":"journal article","authors":["Beausoleil S.A.","Villen J.","Gerber S.A.","Rush J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"16964243"},{"database":"DOI","id":"10.1038/nbt1240"}],"title":"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.","publicationDate":"2006","journal":"Nat. Biotechnol.","firstPage":"1285","lastPage":"1292","volume":"24"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"17318178","citationType":"journal article","authors":["Schweitzer K.","Bozko P.M.","Dubiel W.","Naumann M."],"citationCrossReferences":[{"database":"PubMed","id":"17318178"},{"database":"DOI","id":"10.1038/sj.emboj.7601600"}],"title":"CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha.","publicationDate":"2007","journal":"EMBO J.","firstPage":"1532","lastPage":"1541","volume":"26"},"referencePositions":["FUNCTION"]},{"referenceNumber":15,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229; SER-961 AND SER-965","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":17,"citation":{"id":"19826004","citationType":"journal article","authors":["Cayli S.","Klug J.","Chapiro J.","Frohlich S.","Krasteva G.","Orel L.","Meinhardt A."],"citationCrossReferences":[{"database":"PubMed","id":"19826004"},{"database":"DOI","id":"10.1074/jbc.m109.037952"}],"title":"COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein (VCP) and controls the ubiquitination status of proteins bound to p97/VCP.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"34944","lastPage":"34953","volume":"284"},"referencePositions":["FUNCTION"]},{"referenceNumber":18,"citation":{"id":"19576224","citationType":"journal article","authors":["Huang X.","Langelotz C.","Hetfeld-Pechoc B.K.","Schwenk W.","Dubiel W."],"citationCrossReferences":[{"database":"PubMed","id":"19576224"},{"database":"DOI","id":"10.1016/j.jmb.2009.06.066"}],"title":"The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.","publicationDate":"2009","journal":"J. Mol. Biol.","firstPage":"691","lastPage":"702","volume":"391"},"referencePositions":["FUNCTION","MUTAGENESIS OF CYS-812"]},{"referenceNumber":19,"citation":{"id":"19553310","citationType":"journal article","authors":["Vos R.M.","Altreuter J.","White E.A.","Howley P.M."],"citationCrossReferences":[{"database":"PubMed","id":"19553310"},{"database":"DOI","id":"10.1128/jvi.00605-09"}],"title":"The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability.","publicationDate":"2009","journal":"J. Virol.","firstPage":"8885","lastPage":"8892","volume":"83"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","MUTAGENESIS OF CYS-298","INTERACTION WITH HUMAN PAPILLOMAVIRUS TYPE 16 PROTEIN E6 (MICROBIAL INFECTION)"]},{"referenceNumber":20,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":21,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229; SER-242; SER-961 AND SER-965","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":22,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":23,"citation":{"id":"21947082","citationType":"journal article","authors":["Inui M.","Manfrin A.","Mamidi A.","Martello G.","Morsut L.","Soligo S.","Enzo E.","Moro S.","Polo S.","Dupont S.","Cordenonsi M.","Piccolo S."],"citationCrossReferences":[{"database":"PubMed","id":"21947082"},{"database":"DOI","id":"10.1038/ncb2346"}],"title":"USP15 is a deubiquitylating enzyme for receptor-activated SMADs.","publicationDate":"2011","journal":"Nat. Cell Biol.","firstPage":"1368","lastPage":"1375","volume":"13"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","SUBCELLULAR LOCATION","INTERACTION WITH SMAD1; SMAD2 AND SMAD3","MUTAGENESIS OF CYS-298"]},{"referenceNumber":24,"citation":{"id":"21750715","citationType":"journal article","authors":["Zhang F.","Baeumer N.","Rode M.","Ji P.","Zhang T.","Berdel W.E.","Mueller-Tidow C."],"citationCrossReferences":[{"database":"PubMed","id":"21750715"},{"database":"DOI","id":"10.1371/journal.pone.0021505"}],"title":"The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.","publicationDate":"2011","journal":"PLoS ONE","firstPage":"E21505","lastPage":"E21505","volume":"6"},"referencePositions":["INTERACTION WITH INCA1"]},{"referenceNumber":25,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":26,"citation":{"id":"22223895","citationType":"journal article","authors":["Bienvenut W.V.","Sumpton D.","Martinez A.","Lilla S.","Espagne C.","Meinnel T.","Giglione C."],"citationCrossReferences":[{"database":"PubMed","id":"22223895"},{"database":"DOI","id":"10.1074/mcp.m111.015131"}],"title":"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.","publicationDate":"2012","journal":"Mol. Cell. Proteomics","firstPage":"M111.015131","lastPage":"M111.015131","volume":"11"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":27,"citation":{"id":"22344298","citationType":"journal article","authors":["Eichhorn P.J.","Rodon L.","Gonzalez-Junca A.","Dirac A.","Gili M.","Martinez-Saez E.","Aura C.","Barba I.","Peg V.","Prat A.","Cuartas I.","Jimenez J.","Garcia-Dorado D.","Sahuquillo J.","Bernards R.","Baselga J.","Seoane J."],"citationCrossReferences":[{"database":"PubMed","id":"22344298"},{"database":"DOI","id":"10.1038/nm.2619"}],"title":"USP15 stabilizes TGF-beta receptor I and promotes oncogenesis through the activation of TGF-beta signaling in glioblastoma.","publicationDate":"2012","journal":"Nat. Med.","firstPage":"429","lastPage":"435","volume":"18"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","INTERACTION WITH TGFBR1; SMAD7 AND SMURF2","MUTAGENESIS OF CYS-298"]},{"referenceNumber":28,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":29,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-226; SER-229 AND SER-242","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":30,"citation":{"id":"24526689","citationType":"journal article","authors":["Long L.","Thelen J.P.","Furgason M.","Haj-Yahya M.","Brik A.","Cheng D.","Peng J.","Yao T."],"citationCrossReferences":[{"database":"PubMed","id":"24526689"},{"database":"DOI","id":"10.1074/jbc.m114.551754"}],"title":"The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination.","publicationDate":"2014","journal":"J. Biol. Chem.","firstPage":"8916","lastPage":"8930","volume":"289"},"referencePositions":["FUNCTION","INTERACTION WITH RNF20; RNF40 AND SART3","REGION","SUBCELLULAR LOCATION"]},{"referenceNumber":31,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":32,"citation":{"id":"27368102","citationType":"journal article","authors":["Jongsma M.L.","Berlin I.","Wijdeven R.H.","Janssen L.","Janssen G.M.","Garstka M.A.","Janssen H.","Mensink M.","van Veelen P.A.","Spaapen R.M.","Neefjes J."],"citationCrossReferences":[{"database":"PubMed","id":"27368102"},{"database":"DOI","id":"10.1016/j.cell.2016.05.078"}],"title":"An ER-associated pathway defines endosomal architecture for controlled cargo transport.","publicationDate":"2016","journal":"Cell","firstPage":"152","lastPage":"166","volume":"166"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","MUTAGENESIS OF CYS-298"]},{"referenceNumber":33,"citation":{"id":"24852371","citationType":"journal article","authors":["Cornelissen T.","Haddad D.","Wauters F.","Van Humbeeck C.","Mandemakers W.","Koentjoro B.","Sue C.","Gevaert K.","De Strooper B.","Verstreken P.","Vandenberghe W."],"citationCrossReferences":[{"database":"PubMed","id":"24852371"},{"database":"DOI","id":"10.1093/hmg/ddu244"}],"title":"The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy.","publicationDate":"2014","journal":"Hum. Mol. Genet.","firstPage":"5227","lastPage":"5242","volume":"23"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","INTERACTION WITH PRKN","SUBCELLULAR LOCATION","MUTAGENESIS OF CYS-298"]},{"referenceNumber":34,"citation":{"id":"33093067","citationType":"journal article","authors":["Xu W.","Rush J.S.","Graham D.B.","Cao Z.","Xavier R.J."],"citationCrossReferences":[{"database":"PubMed","id":"33093067"},{"database":"DOI","id":"10.4049/immunohorizons.2000036"}],"title":"USP15 deubiquitinates CARD9 to downregulate C-type lectin receptor-mediated signaling.","publicationDate":"2020","journal":"Immunohorizons","firstPage":"670","lastPage":"678","volume":"4"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","ACTIVE SITE","MUTAGENESIS OF CYS-298"]},{"referenceNumber":35,"citation":{"id":"16298993","citationType":"journal article","authors":["de Jong R.N.","Ab E.","Diercks T.","Truffault V.","Danieels M.","Kaptein R.","Folkers G.E."],"citationCrossReferences":[{"database":"PubMed","id":"16298993"},{"database":"DOI","id":"10.1074/jbc.m510993200"}],"title":"Solution structure of the human ubiquitin-specific protease 15 DUSP domain.","publicationDate":"2006","journal":"J. Biol. Chem.","firstPage":"5026","lastPage":"5031","volume":"281"},"referencePositions":["STRUCTURE BY NMR OF 1-120"]},{"referenceNumber":36,"citation":{"id":"21848306","citationType":"journal article","authors":["Harper S.","Besong T.M.","Emsley J.","Scott D.J.","Dreveny I."],"citationCrossReferences":[{"database":"PubMed","id":"21848306"},{"database":"DOI","id":"10.1021/bi200726e"}],"title":"Structure of the USP15 N-terminal domains: a beta-hairpin mediates close association between the DUSP and UBL domains.","publicationDate":"2011","journal":"Biochemistry","firstPage":"7995","lastPage":"8004","volume":"50"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 1-222"]},{"referenceNumber":37,"citation":{"id":"22001210","citationType":"journal article","authors":["Elliott P.R.","Liu H.","Pastok M.W.","Grossmann G.J.","Rigden D.J.","Clague M.J.","Urbe S.","Barsukov I.L."],"citationCrossReferences":[{"database":"PubMed","id":"22001210"},{"database":"DOI","id":"10.1016/j.febslet.2011.09.040"}],"title":"Structural variability of the ubiquitin specific protease DUSP-UBL double domains.","publicationDate":"2011","journal":"FEBS Lett.","firstPage":"3385","lastPage":"3390","volume":"585"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 1-223"]},{"referenceNumber":38,"citation":{"id":"CI-4775QASR2MRMC","citationType":"submission","authoringGroup":["Structural genomics consortium (SGC)"],"title":"Crystal structure of the human ubiquitin-specific protease 15 DUSP domain.","publicationDate":"APR-2010","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 1-133"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF106069","properties":[{"key":"ProteinId","value":"AAD52099.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB011101","properties":[{"key":"ProteinId","value":"BAA25455.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF153604","properties":[{"key":"ProteinId","value":"AAD41086.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK023703","properties":[{"key":"ProteinId","value":"BAB14648.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK292337","properties":[{"key":"ProteinId","value":"BAF85026.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC048342","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC079035","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC117370","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC020688","properties":[{"key":"ProteinId","value":"AAH20688.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC063454","properties":[{"key":"ProteinId","value":"AAH63454.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC125123","properties":[{"key":"ProteinId","value":"AAI25124.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF013990","properties":[{"key":"ProteinId","value":"AAG28973.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS58250.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y4E8-4"},{"database":"CCDS","id":"CCDS58251.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y4E8-1"},{"database":"CCDS","id":"CCDS8963.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y4E8-2"},{"database":"RefSeq","id":"NP_001239007.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001252078.2"}],"isoformId":"Q9Y4E8-1"},{"database":"RefSeq","id":"NP_001239008.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001252079.2"}],"isoformId":"Q9Y4E8-4"},{"database":"RefSeq","id":"NP_006304.1","properties":[{"key":"NucleotideSequenceId","value":"NM_006313.3"}],"isoformId":"Q9Y4E8-2"},{"database":"PDB","id":"1W6V","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-120"}]},{"database":"PDB","id":"3LMN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A/B=1-133"}]},{"database":"PDB","id":"3PPA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"A=6-223"}]},{"database":"PDB","id":"3PV1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/B=1-223"}]},{"database":"PDB","id":"3T9L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=1-222"}]},{"database":"PDB","id":"4A3O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B=4-223"}]},{"database":"PDB","id":"4A3P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A=6-223"}]},{"database":"PDB","id":"5JJW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.01 A"},{"key":"Chains","value":"B=1-223"}]},{"database":"PDB","id":"6CPM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.01 A"},{"key":"Chains","value":"C/D=275-862, C/D=873-934"}]},{"database":"PDB","id":"6CRN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C/D=275-934"}]},{"database":"PDB","id":"6DJ9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B/C/D/E/F=1-134"}]},{"database":"PDB","id":"6GH9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.09 A"},{"key":"Chains","value":"A/B=284-468, A/B=786-951"}]},{"database":"PDB","id":"6GHA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.98 A"},{"key":"Chains","value":"A=284-468, A=786-948"}]},{"database":"PDB","id":"6ML1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=275-862, A/B=873-934"}]},{"database":"PDB","id":"7R2G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.98 A"},{"key":"Chains","value":"A/B=284-948"}]},{"database":"PDBsum","id":"1W6V","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3LMN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3PPA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3PV1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3T9L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4A3O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4A3P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JJW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CPM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CRN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6DJ9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6GH9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6GHA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ML1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7R2G","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"115283","properties":[{"key":"Interactions","value":"514"}]},{"database":"DIP","id":"DIP-50239N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9Y4E8","properties":[{"key":"Number of interactors","value":"4035"}]},{"database":"IntAct","id":"Q9Y4E8","properties":[{"key":"Interactions","value":"118"}]},{"database":"MINT","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000280377","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4523508","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"C19.022","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9Y4E8","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"USP15","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"28381406","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000280377","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"81207","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"86183","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y4E8-1"},{"database":"ProteomicsDB","id":"86184","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y4E8-2"},{"database":"ProteomicsDB","id":"86185","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y4E8-3"},{"database":"Pumba","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1729","properties":[{"key":"antibodies","value":"339 antibodies from 39 providers"}]},{"database":"DNASU","id":"9958","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000280377.10","properties":[{"key":"ProteinId","value":"ENSP00000280377.5"},{"key":"GeneId","value":"ENSG00000135655.17"}],"isoformId":"Q9Y4E8-1"},{"database":"Ensembl","id":"ENST00000312635.10","properties":[{"key":"ProteinId","value":"ENSP00000309240.6"},{"key":"GeneId","value":"ENSG00000135655.17"}],"isoformId":"Q9Y4E8-4"},{"database":"Ensembl","id":"ENST00000353364.7","properties":[{"key":"ProteinId","value":"ENSP00000258123.4"},{"key":"GeneId","value":"ENSG00000135655.17"}],"isoformId":"Q9Y4E8-2"},{"database":"GeneID","id":"9958","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:9958","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000280377.10","properties":[{"key":"ProteinId","value":"ENSP00000280377.5"},{"key":"RefSeqNucleotideId","value":"NM_001252078.2"},{"key":"RefSeqProteinId","value":"NP_001239007.1"}]},{"database":"UCSC","id":"uc001sra.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9Y4E8-1"},{"database":"AGR","id":"HGNC:12613","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA37239","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"9958","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"9958","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"USP15","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:12613","properties":[{"key":"GeneName","value":"USP15"}]},{"database":"HPA","id":"ENSG00000135655","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (bone)"}]},{"database":"MIM","id":"604731","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000135655","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000135655","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1870","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000154932","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_001060_7_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PCHAQQS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"265776at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9Y4E8","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-2173788","properties":[{"key":"PathwayName","value":"Downregulation of TGF-beta receptor signaling"}]},{"database":"Reactome","id":"R-HSA-5689603","properties":[{"key":"PathwayName","value":"UCH proteinases"}]},{"database":"Reactome","id":"R-HSA-5689880","properties":[{"key":"PathwayName","value":"Ub-specific processing proteases"}]},{"database":"SignaLink","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000135655","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"9958","properties":[{"key":"hits","value":"34 hits in 1159 CRISPR screens"}]},{"database":"CD-CODE","id":"1A0B17A6","properties":[{"key":"EntryName","value":"cGAS foci"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"USP15","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"USP15","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"9958","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9Y4E8","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9Y4E8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"Q9Y4E8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000135655","properties":[{"key":"ExpressionPatterns","value":"Expressed in monocyte and 199 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9Y4E8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21947082"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24526689"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24852371"}]},{"database":"GO","id":"GO:0016604","properties":[{"key":"GoTerm","value":"C:nuclear body"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21947082"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24526689"}]},{"database":"GO","id":"GO:0004843","properties":[{"key":"GoTerm","value":"F:cysteine-type deubiquitinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16005295"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21947082"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22344298"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24526689"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27368102"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33093067"}]},{"database":"GO","id":"GO:0004197","properties":[{"key":"GoTerm","value":"F:cysteine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21947082"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22344298"}]},{"database":"GO","id":"GO:0101005","properties":[{"key":"GoTerm","value":"F:deubiquitinase activity"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32101751"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32839293"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"22001210"}]},{"database":"GO","id":"GO:1990380","properties":[{"key":"GoTerm","value":"F:K48-linked deubiquitinase activity"},{"key":"GoEvidenceType","value":"IDA:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24399297"}]},{"database":"GO","id":"GO:0046332","properties":[{"key":"GoTerm","value":"F:SMAD binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"21947082"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"22344298"}]},{"database":"GO","id":"GO:0005160","properties":[{"key":"GoTerm","value":"F:transforming growth factor beta receptor binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"22344298"}]},{"database":"GO","id":"GO:0061649","properties":[{"key":"GoTerm","value":"F:ubiquitin-modified histone reader activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24526689"}]},{"database":"GO","id":"GO:0030509","properties":[{"key":"GoTerm","value":"P:BMP signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21947082"}]},{"database":"GO","id":"GO:0035520","properties":[{"key":"GoTerm","value":"P:monoubiquitinated protein deubiquitination"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21947082"}]},{"database":"GO","id":"GO:1905035","properties":[{"key":"GoTerm","value":"P:negative regulation of antifungal innate immune response"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33093067"}]},{"database":"GO","id":"GO:0030512","properties":[{"key":"GoTerm","value":"P:negative regulation of transforming growth factor beta receptor signaling pathway"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22344298"}]},{"database":"GO","id":"GO:1900246","properties":[{"key":"GoTerm","value":"P:positive regulation of RIG-I signaling pathway"},{"key":"GoEvidenceType","value":"IDA:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24399297"}]},{"database":"GO","id":"GO:0016579","properties":[{"key":"GoTerm","value":"P:protein deubiquitination"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16005295"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27368102"}]},{"database":"GO","id":"GO:1990167","properties":[{"key":"GoTerm","value":"P:protein K27-linked deubiquitination"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33093067"}]},{"database":"GO","id":"GO:0051252","properties":[{"key":"GoTerm","value":"P:regulation of RNA metabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32839293"}]},{"database":"GO","id":"GO:0140673","properties":[{"key":"GoTerm","value":"P:transcription elongation-coupled chromatin remodeling"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24526689"}]},{"database":"GO","id":"GO:0007179","properties":[{"key":"GoTerm","value":"P:transforming growth factor beta receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21947082"}]},{"database":"CDD","id":"cd02674","properties":[{"key":"EntryName","value":"Peptidase_C19R"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.2230.10:FF:000003","properties":[{"key":"EntryName","value":"ubiquitin carboxyl-terminal hydrolase 15 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.70.10:FF:000013","properties":[{"key":"EntryName","value":"ubiquitin carboxyl-terminal hydrolase 15 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.70.10:FF:000034","properties":[{"key":"EntryName","value":"ubiquitin carboxyl-terminal hydrolase 15 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000020","properties":[{"key":"EntryName","value":"ubiquitin carboxyl-terminal hydrolase 15 isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.70.10","properties":[{"key":"EntryName","value":"Cysteine proteinases"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.2230.10","properties":[{"key":"EntryName","value":"DUSP-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR035927","properties":[{"key":"EntryName","value":"DUSP-like_sf"}]},{"database":"InterPro","id":"IPR038765","properties":[{"key":"EntryName","value":"Papain-like_cys_pep_sf"}]},{"database":"InterPro","id":"IPR006615","properties":[{"key":"EntryName","value":"Pept_C19_DUSP"}]},{"database":"InterPro","id":"IPR001394","properties":[{"key":"EntryName","value":"Peptidase_C19_UCH"}]},{"database":"InterPro","id":"IPR013792","properties":[{"key":"EntryName","value":"RNA3'P_cycl/enolpyr_Trfase_a/b"}]},{"database":"InterPro","id":"IPR050185","properties":[{"key":"EntryName","value":"Ub_carboxyl-term_hydrolase"}]},{"database":"InterPro","id":"IPR028135","properties":[{"key":"EntryName","value":"Ub_USP-typ"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"InterPro","id":"IPR028889","properties":[{"key":"EntryName","value":"USP"}]},{"database":"InterPro","id":"IPR029346","properties":[{"key":"EntryName","value":"USP_C"}]},{"database":"InterPro","id":"IPR018200","properties":[{"key":"EntryName","value":"USP_CS"}]},{"database":"PANTHER","id":"PTHR21646","properties":[{"key":"EntryName","value":"UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21646:SF28","properties":[{"key":"EntryName","value":"UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06337","properties":[{"key":"EntryName","value":"DUSP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14836","properties":[{"key":"EntryName","value":"Ubiquitin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00443","properties":[{"key":"EntryName","value":"UCH"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14533","properties":[{"key":"EntryName","value":"USP7_C2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00695","properties":[{"key":"EntryName","value":"DUSP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54001","properties":[{"key":"EntryName","value":"Cysteine proteinases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143791","properties":[{"key":"EntryName","value":"DUSP-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55205","properties":[{"key":"EntryName","value":"EPT/RTPC-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51283","properties":[{"key":"EntryName","value":"DUSP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00972","properties":[{"key":"EntryName","value":"USP_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00973","properties":[{"key":"EntryName","value":"USP_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50235","properties":[{"key":"EntryName","value":"USP_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDTIEKEIRKIFSIPDEKETRLWNKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPKSPGASNFSTLPKISPSSLSNNYNNMNNRNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVIIPVCLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGGDNDSENGLCTEDTCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFLALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQDTFSGTGFFPLDRETKGASAATGIPLESDEDSNDNDNDIENENCMHTN","length":981,"molWeight":112419,"crc64":"E81FEB9DE57F7089","md5":"806E435BE4563E9D36494719225C31C1"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"SUBUNIT":2,"INTERACTION":19,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"TISSUE SPECIFICITY":1,"PTM":2,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Domain":2,"Region":4,"Compositional bias":3,"Active site":2,"Modified residue":7,"Alternative sequence":4,"Mutagenesis":2,"Sequence conflict":3,"Beta strand":32,"Helix":26,"Turn":7},"uniParcId":"UPI00001379F8"}}