{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9XVT0","uniProtkbId":"RRS1_CAEEL","entryAudit":{"firstPublicDate":"2002-06-06","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1999-11-01","entryVersion":139,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Caenorhabditis elegans","taxonId":6239,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Nematoda","Chromadorea","Rhabditida","Rhabditina","Rhabditomorpha","Rhabditoidea","Rhabditidae","Peloderinae","Caenorhabditis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Ribosome biogenesis regulatory protein homolog"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"WormBase","id":"C15H11.9"}],"value":"rrsr-1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"WormBase","id":"C15H11.9"}],"value":"C15H11.9"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15050"}],"value":"Involved in ribosomal large subunit assembly"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15050"}],"value":"Nucleus, nucleolus","id":"SL-0188"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the RRS1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"Ribosome biogenesis regulatory protein homolog","featureId":"PRO_0000185376"},{"type":"Region","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0690","category":"Biological process","name":"Ribosome biogenesis"}],"references":[{"referenceNumber":1,"citation":{"id":"9851916","citationType":"journal article","authoringGroup":["The C. elegans sequencing consortium"],"citationCrossReferences":[{"database":"PubMed","id":"9851916"},{"database":"DOI","id":"10.1126/science.282.5396.2012"}],"title":"Genome sequence of the nematode C. elegans: a platform for investigating biology.","publicationDate":"1998","journal":"Science","firstPage":"2012","lastPage":"2018","volume":"282"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Bristol N2","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z81035","properties":[{"key":"ProteinId","value":"CAB02731.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"T19313","properties":[{"key":"EntryName","value":"T19313"}]},{"database":"RefSeq","id":"NP_506573.1","properties":[{"key":"NucleotideSequenceId","value":"NM_074172.6"}]},{"database":"AlphaFoldDB","id":"Q9XVT0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9XVT0","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"44946","properties":[{"key":"Interactions","value":"12"}]},{"database":"DIP","id":"DIP-24987N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9XVT0","properties":[{"key":"Number of interactors","value":"2351"}]},{"database":"STRING","id":"6239.C15H11.9.1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"6239-C15H11.9.1","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9XVT0","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"C15H11.9.1","properties":[{"key":"ProteinId","value":"C15H11.9.1"},{"key":"GeneId","value":"WBGene00007617"}]},{"database":"GeneID","id":"179942","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"cel:CELE_C15H11.9","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"C15H11.9.1","properties":[{"key":"OrganismName","value":"c. elegans"}]},{"database":"AGR","id":"WB:WBGene00007617","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"179942","properties":[{"key":"Description","value":"-"}]},{"database":"WormBase","id":"C15H11.9","properties":[{"key":"ProteinId","value":"CE08186"},{"key":"GeneId","value":"WBGene00007617"},{"key":"GeneName","value":"rrsr-1"}]},{"database":"eggNOG","id":"KOG1765","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_065163_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9XVT0","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ACDKNRI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"28455at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9XVT0","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9XVT0","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001940","properties":[{"key":"Component","value":"Chromosome V"}]},{"database":"Bgee","id":"WBGene00007617","properties":[{"key":"ExpressionPatterns","value":"Expressed in larva and 4 other cell types or tissues"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030687","properties":[{"key":"GoTerm","value":"C:preribosome, large subunit precursor"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000447","properties":[{"key":"GoTerm","value":"P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000027","properties":[{"key":"GoTerm","value":"P:ribosomal large subunit assembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042273","properties":[{"key":"GoTerm","value":"P:ribosomal large subunit biogenesis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR007023","properties":[{"key":"EntryName","value":"Ribosom_reg"}]},{"database":"PANTHER","id":"PTHR17602","properties":[{"key":"EntryName","value":"RIBOSOME BIOGENESIS REGULATORY PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR17602:SF4","properties":[{"key":"EntryName","value":"RIBOSOME BIOGENESIS REGULATORY PROTEIN HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04939","properties":[{"key":"EntryName","value":"RRS1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MADKSTEVEKAIDPIIDLGNLLFIDREPIQGDASEGLEERARKNTQLLFNNIWQLEQKRVEEAIIVTLPPATYRLPREKRLPEKKEPTKWEKYAAEKGIEKRKKDKKVFDEATKEWKPTYGYRRGNDDTKDWLIEIPDNAEDPNKDFFAERREKKKERVAKNDMQRMKNLARQMKTTVKSGPSTEKMIGVGVDAKEKSKQQVRFAVDRAKLATASAGKFQEGLKGEKANVKTGKKRKFEANEAPVSGEKERALQILQRMKSKKAKIVEEKAAAVAGPLREKKEKSERKGAKDQTRQKSQIHRQQWFKNKVDGKKKGTGGAGKKGANKAKARKG","length":333,"molWeight":37986,"crc64":"88E91737402FC4CE","md5":"127DD841EDDFDA5BEF9DF6848B43154B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Compositional bias":2},"uniParcId":"UPI0000134B89"}}