{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9WU02","uniProtkbId":"V1BR_MOUSE","entryAudit":{"firstPublicDate":"2000-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1999-11-01","entryVersion":171,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Vasopressin V1b receptor"},"shortNames":[{"value":"V1bR"}]},"alternativeNames":[{"fullName":{"value":"AVPR V1b"}},{"fullName":{"value":"AVPR V3"}},{"fullName":{"value":"Antidiuretic hormone receptor 1b"}},{"fullName":{"value":"Vasopressin V3 receptor"}}]},"genes":[{"geneName":{"value":"Avpr1b"},"synonyms":[{"value":"V1br"}]}],"comments":[{"texts":[{"value":"Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Cell membrane","id":"SL-0039"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Belongs to the G protein-coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"Vasopressin V1b receptor","featureId":"PRO_0000070204"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":399,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Glycosylation","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10343284","citationType":"journal article","authors":["Ventura M.A.","Rene P.","de Keyzer Y.","Bertagna X.","Clauser E."],"citationCrossReferences":[{"database":"PubMed","id":"10343284"},{"database":"DOI","id":"10.1677/jme.0.0220251"}],"title":"Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor.","publicationDate":"1999","journal":"J. Mol. Endocrinol.","firstPage":"251","lastPage":"260","volume":"22"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"129/Sv","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"10669045","citationType":"journal article","authors":["Kikuchi S.","Tanoue A.","Goda N.","Matsuo N.","Tsujimoto G."],"citationCrossReferences":[{"database":"PubMed","id":"10669045"},{"database":"DOI","id":"10.1254/jjp.81.388"}],"title":"Structure and sequence of the mouse V1a and V1b vasopressin receptor genes.","publicationDate":"1999","journal":"Jpn. J. Pharmacol.","firstPage":"388","lastPage":"392","volume":"81"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"129/SvJ","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF098867","properties":[{"key":"ProteinId","value":"AAD27957.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF098866","properties":[{"key":"ProteinId","value":"AAD27957.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB030449","properties":[{"key":"ProteinId","value":"BAA89205.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS35703.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_036054.1","properties":[{"key":"NucleotideSequenceId","value":"NM_011924.3"}]},{"database":"AlphaFoldDB","id":"Q9WU02","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9WU02","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"204921","properties":[{"key":"Interactions","value":"1"}]},{"database":"CORUM","id":"Q9WU02","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9WU02","properties":[{"key":"Number of interactors","value":"1002"}]},{"database":"STRING","id":"10090.ENSMUSP00000027690","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q9WU02","properties":[{"key":"glycosylation","value":"1 site, No reported glycans"}]},{"database":"GlyGen","id":"Q9WU02","properties":[{"key":"glycosylation","value":"4 sites, 2 N-linked glycans (2 sites)"}]},{"database":"PhosphoSitePlus","id":"Q9WU02","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000027690","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"300100","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"20687","properties":[{"key":"antibodies","value":"381 antibodies from 37 providers"}]},{"database":"DNASU","id":"26361","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000027690.7","properties":[{"key":"ProteinId","value":"ENSMUSP00000027690.7"},{"key":"GeneId","value":"ENSMUSG00000026432.8"}]},{"database":"GeneID","id":"26361","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:26361","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007cnl.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1347010","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"553","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1347010","properties":[{"key":"GeneName","value":"Avpr1b"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000026432","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3656","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01050000244882","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_009579_15_3_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9WU02","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FNSHLWP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6435638at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9WU02","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-388479","properties":[{"key":"PathwayName","value":"Vasopressin-like receptors"}]},{"database":"Reactome","id":"R-MMU-416476","properties":[{"key":"PathwayName","value":"G alpha (q) signalling events"}]},{"database":"BioGRID-ORCS","id":"26361","properties":[{"key":"hits","value":"4 hits in 81 CRISPR screens"}]},{"database":"PRO","id":"PR:Q9WU02","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"Q9WU02","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000026432","properties":[{"key":"ExpressionPatterns","value":"Expressed in embryonic post-anal tail and 24 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9WU02","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030425","properties":[{"key":"GoTerm","value":"C:dendrite"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0017046","properties":[{"key":"GoTerm","value":"F:peptide hormone binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005000","properties":[{"key":"GoTerm","value":"F:vasopressin receptor activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0007188","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0032870","properties":[{"key":"GoTerm","value":"P:cellular response to hormone stimulus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007186","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0051452","properties":[{"key":"GoTerm","value":"P:intracellular pH reduction"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0007200","properties":[{"key":"GoTerm","value":"P:phospholipase C-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0090238","properties":[{"key":"GoTerm","value":"P:positive regulation of arachidonate secretion"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0014049","properties":[{"key":"GoTerm","value":"P:positive regulation of glutamate secretion"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0060732","properties":[{"key":"GoTerm","value":"P:positive regulation of inositol phosphate biosynthetic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043410","properties":[{"key":"GoTerm","value":"P:positive regulation of MAPK cascade"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0045907","properties":[{"key":"GoTerm","value":"P:positive regulation of vasoconstriction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008217","properties":[{"key":"GoTerm","value":"P:regulation of blood pressure"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26531127"}]},{"database":"GO","id":"GO:0042127","properties":[{"key":"GoTerm","value":"P:regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0001992","properties":[{"key":"GoTerm","value":"P:regulation of systemic arterial blood pressure by vasopressin"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"12486173"}]},{"database":"GO","id":"GO:0046718","properties":[{"key":"GoTerm","value":"P:symbiont entry into host cell"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"CDD","id":"cd15386","properties":[{"key":"EntryName","value":"7tmA_V1bR"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000094","properties":[{"key":"EntryName","value":"Vasopressin V1a receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"InterPro","id":"IPR015076","properties":[{"key":"EntryName","value":"V1R_C"}]},{"database":"InterPro","id":"IPR001817","properties":[{"key":"EntryName","value":"Vasoprsn_rcpt"}]},{"database":"InterPro","id":"IPR000628","properties":[{"key":"EntryName","value":"Vprs_rcpt_V1B"}]},{"database":"PANTHER","id":"PTHR24241","properties":[{"key":"EntryName","value":"NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24241:SF18","properties":[{"key":"EntryName","value":"VASOPRESSIN V1B RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08983","properties":[{"key":"EntryName","value":"V1R_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"PRINTS","id":"PR00896","properties":[{"key":"EntryName","value":"VASOPRESSINR"}]},{"database":"PRINTS","id":"PR00897","properties":[{"key":"EntryName","value":"VASOPRSNV1BR"}]},{"database":"SMART","id":"SM01164","properties":[{"key":"EntryName","value":"DUF1856"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDSEPSWTATPSPGGTLFVPNTTTPWLGRDEELAKVEIGILATVLVLATGGNLAVLLILGLQGHKRSRMHLFVLHLALTDLGVALFQVLPQLLWDITYRFQGSDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPSQSTYPLIAAPWLLAAILSLPQVFIFSLREVIQGSGVLDCWADFYFSWGPRAYITWTTMAIFVLPVVVLTACYGLICHEIYKNLKVKTQAGREERRGWPKSSSSAAAAATRGLPSRVSSISTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDENAPNEDSTNVAFTISMLLGNLSSCCNPWIYMGFNSHLLPRSLSHRACCRGSKPRVHRQLSNSSLASRRTTLLTHTCGPSTLRLSLNLSLHAKPKPAGSLKDLEQVDGEATMETSIS","length":421,"molWeight":46539,"crc64":"E867DC0C700F596F","md5":"F0F48EF23662911957A6299B2F15B141"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":8,"Transmembrane":7,"Region":1,"Glycosylation":1,"Disulfide bond":1},"uniParcId":"UPI0000028C65"}}