{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9WTU3","secondaryAccessions":["Q3TYI3","Q60828","Q60858","Q62449"],"uniProtkbId":"SCN8A_MOUSE","entryAudit":{"firstPublicDate":"2003-08-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1999-11-01","entryVersion":184,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAD20438.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Sodium channel protein type 8 subunit alpha"}},"alternativeNames":[{"fullName":{"value":"Sodium channel protein type VIII subunit alpha"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19136557"}],"value":"Voltage-gated sodium channel subunit alpha Nav1.6"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:103169"}],"value":"Scn8a"},"synonyms":[{"value":"Nbna1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20678086"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23942337"}],"value":"Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19136557"}],"value":"More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement"}],"commentType":"FUNCTION","molecule":"Isoform 5"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Na(+)(in) = Na(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34963"},{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20678086"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23942337"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88420"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UQD0"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15123669"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20678086"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23942337"}],"value":"The voltage-sensitive sodium channel consists of an ion-conducting pore-forming alpha subunit regulated by one or more beta-1 (SCN1B), beta-2 (SCN2B), beta-3 (SCN3B) and/or beta-4 (SCN4B) subunits. Beta-1 (SCN1B) and beta-3 (SCN3B) are non-covalently associated with alpha, while beta-2 (SCN2B) and beta-4 (SCN4B) are covalently linked by disulfide bonds. Interacts with FGF13 (By similarity). Interacts with NEDD4 and NEDD4L (PubMed:15123669). Interacts with FGF14, GBG3, GBB2 and SCN1B (By similarity). Interacts with TMEM233 (By similarity). Interacts with the conotoxin GVIIJ (By similarity). Interacts with the scorpion toxin BMK M1 (PubMed:20678086). Interacts with CALM1; the interaction modulates the inactivation rate of SCN8A (PubMed:23942337)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9WTU3","intActId":"EBI-6396042"},"interactantTwo":{"uniProtKBAccession":"P14873","geneName":"Map1b","intActId":"EBI-764653"},"numberOfExperiments":7,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28842554"}],"value":"Mainly localizes to the axon initial segment"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28842554"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UQD0"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28842554"}],"value":"Cell projection, axon","id":"SL-0279"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 5","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19136557"}],"value":"Cytoplasmic vesicle","id":"SL-0088"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UQD0"}],"value":"Cell projection, podosome","id":"SL-0295"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9295353"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9828131"}],"value":"1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9295353"}],"value":"18A"}],"isoformIds":["Q9WTU3-1"],"isoformSequenceStatus":"Displayed"},{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7670495"}],"value":"2"},"isoformIds":["Q9WTU3-2"],"sequenceIds":["VSP_050594"],"isoformSequenceStatus":"Described"},{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9828131"}],"value":"3"},"isoformIds":["Q9WTU3-3"],"sequenceIds":["VSP_050595"],"isoformSequenceStatus":"Described"},{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9295353"}],"value":"4"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9295353"}],"value":"18N"}],"isoformIds":["Q9WTU3-4"],"sequenceIds":["VSP_050596","VSP_050597"],"isoformSequenceStatus":"Described"},{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9295353"}],"value":"5"},"isoformIds":["Q9WTU3-5"],"sequenceIds":["VSP_050598"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28842554"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7670495"}],"value":"Expressed in the hippocampus (at protein level) (PubMed:28842554). Expressed in brain, cerebellum and spinal cord"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19136557"}],"value":"Expressed in non-neuronal tissues, such as monocytes/macrophages"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform 5"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15123669"}],"value":"May be ubiquitinated by NEDD4L; which would promote its endocytosis"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Phosphorylation at Ser-1495 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents"}],"commentType":"PTM"},{"commentType":"DISEASE","note":{"texts":[{"value":"Defects in Scn8a are the cause of motor endplate disease (med). Med is a recessive neuromuscular disorder that is characterized by lack of signal transmission at the neuromuscular junction, excess preterminal arborization and degeneration of cerebellar Purkinje cells. It produces early onset progressive paralysis of hind limbs, severe muscle atrophy and juvenile lethality"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7670495"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8815882"}],"value":"Defects in Scn8a are the cause of the jolting mutant (medjo), a mild form of motor endplate disease which is characterized by the absence of spontaneous, regular, simple discharges from Purkinje cells. After 3 weeks of age, jolting mice are unsteady and have wide-based gait and a rhythmical tremor of head and neck induced by attempted movement"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11532991"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8663325"}],"value":"Defects in Scn8a are a cause of degenerating muscle (dmu). Dmu is an autosomal recessive neuromuscular disorder that is characterized by skeletal and cardiac muscle degeneration. It produces early onset progressive loss of mobility of the hind limbs and subsequent lethality in the first month of life"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Due to aberrant splicing"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1978,"modifier":"EXACT"}},"description":"Sodium channel protein type 8 subunit alpha","featureId":"PRO_0000048501"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"Helical; Name=S1 of repeat I","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"Helical; Name=S2 of repeat I","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"Helical; Name=S3 of repeat I","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Helical; Name=S4 of repeat I","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Helical; Name=S5 of repeat I","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Intramembrane","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"Helical; Name=S6 of repeat I","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":751,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":752,"modifier":"EXACT"},"end":{"value":770,"modifier":"EXACT"}},"description":"Helical; Name=S1 of repeat II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":771,"modifier":"EXACT"},"end":{"value":781,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":782,"modifier":"EXACT"},"end":{"value":801,"modifier":"EXACT"}},"description":"Helical; Name=S2 of repeat II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":802,"modifier":"EXACT"},"end":{"value":815,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":816,"modifier":"EXACT"},"end":{"value":835,"modifier":"EXACT"}},"description":"Helical; Name=S3 of repeat II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":836,"modifier":"EXACT"},"end":{"value":837,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":838,"modifier":"EXACT"},"end":{"value":855,"modifier":"EXACT"}},"description":"Helical; Name=S4 of repeat II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":856,"modifier":"EXACT"},"end":{"value":871,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":872,"modifier":"EXACT"},"end":{"value":890,"modifier":"EXACT"}},"description":"Helical; Name=S5 of repeat II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":891,"modifier":"EXACT"},"end":{"value":919,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Intramembrane","location":{"start":{"value":920,"modifier":"EXACT"},"end":{"value":940,"modifier":"EXACT"}},"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":941,"modifier":"EXACT"},"end":{"value":953,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":954,"modifier":"EXACT"},"end":{"value":974,"modifier":"EXACT"}},"description":"Helical; Name=S6 of repeat II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":975,"modifier":"EXACT"},"end":{"value":1197,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1198,"modifier":"EXACT"},"end":{"value":1215,"modifier":"EXACT"}},"description":"Helical; Name=S1 of repeat III","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1216,"modifier":"EXACT"},"end":{"value":1228,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1229,"modifier":"EXACT"},"end":{"value":1247,"modifier":"EXACT"}},"description":"Helical; Name=S2 of repeat III","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1248,"modifier":"EXACT"},"end":{"value":1261,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1262,"modifier":"EXACT"},"end":{"value":1280,"modifier":"EXACT"}},"description":"Helical; Name=S3 of repeat III","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1281,"modifier":"EXACT"},"end":{"value":1288,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1289,"modifier":"EXACT"},"end":{"value":1307,"modifier":"EXACT"}},"description":"Helical; Name=S4 of repeat III","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1308,"modifier":"EXACT"},"end":{"value":1324,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1325,"modifier":"EXACT"},"end":{"value":1344,"modifier":"EXACT"}},"description":"Helical; Name=S5 of repeat III","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1345,"modifier":"EXACT"},"end":{"value":1397,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Intramembrane","location":{"start":{"value":1398,"modifier":"EXACT"},"end":{"value":1419,"modifier":"EXACT"}},"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1420,"modifier":"EXACT"},"end":{"value":1436,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1437,"modifier":"EXACT"},"end":{"value":1458,"modifier":"EXACT"}},"description":"Helical; Name=S6 of repeat III","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1459,"modifier":"EXACT"},"end":{"value":1521,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1522,"modifier":"EXACT"},"end":{"value":1539,"modifier":"EXACT"}},"description":"Helical; Name=S1 of repeat IV","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1540,"modifier":"EXACT"},"end":{"value":1550,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1551,"modifier":"EXACT"},"end":{"value":1569,"modifier":"EXACT"}},"description":"Helical; Name=S2 of repeat IV","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1570,"modifier":"EXACT"},"end":{"value":1581,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1582,"modifier":"EXACT"},"end":{"value":1599,"modifier":"EXACT"}},"description":"Helical; Name=S3 of repeat IV","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1600,"modifier":"EXACT"},"end":{"value":1612,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1613,"modifier":"EXACT"},"end":{"value":1629,"modifier":"EXACT"}},"description":"Helical; Name=S4 of repeat IV","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1630,"modifier":"EXACT"},"end":{"value":1648,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1649,"modifier":"EXACT"},"end":{"value":1666,"modifier":"EXACT"}},"description":"Helical; Name=S5 of repeat IV","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1667,"modifier":"EXACT"},"end":{"value":1688,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Intramembrane","location":{"start":{"value":1689,"modifier":"EXACT"},"end":{"value":1711,"modifier":"EXACT"}},"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1712,"modifier":"EXACT"},"end":{"value":1740,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1741,"modifier":"EXACT"},"end":{"value":1763,"modifier":"EXACT"}},"description":"Helical; Name=S6 of repeat IV","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Topological domain","location":{"start":{"value":1764,"modifier":"EXACT"},"end":{"value":1978,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":442,"modifier":"EXACT"}},"description":"I","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":733,"modifier":"EXACT"},"end":{"value":1005,"modifier":"EXACT"}},"description":"II","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1178,"modifier":"EXACT"},"end":{"value":1493,"modifier":"EXACT"}},"description":"III","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":1502,"modifier":"EXACT"},"end":{"value":1799,"modifier":"EXACT"}},"description":"IV","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Domain","location":{"start":{"value":1893,"modifier":"EXACT"},"end":{"value":1922,"modifier":"EXACT"}},"description":"IQ","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00116"},{"evidenceCode":"ECO:0000305"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":446,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":576,"modifier":"EXACT"},"end":{"value":597,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1105,"modifier":"EXACT"},"end":{"value":1146,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1924,"modifier":"EXACT"},"end":{"value":1978,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":486,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":586,"modifier":"EXACT"},"end":{"value":597,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1936,"modifier":"EXACT"},"end":{"value":1947,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1949,"modifier":"EXACT"},"end":{"value":1978,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UQD0"}],"ligand":{"name":"Na(+)","id":"ChEBI:CHEBI:29101","label":"2"}},{"type":"Binding site","location":{"start":{"value":934,"modifier":"EXACT"},"end":{"value":934,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UQD0"}],"ligand":{"name":"Na(+)","id":"ChEBI:CHEBI:29101","label":"1"}},{"type":"Binding site","location":{"start":{"value":937,"modifier":"EXACT"},"end":{"value":937,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UQD0"}],"ligand":{"name":"Na(+)","id":"ChEBI:CHEBI:29101","label":"1"}},{"type":"Modified residue","location":{"start":{"value":518,"modifier":"EXACT"},"end":{"value":518,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88420"}]},{"type":"Modified residue","location":{"start":{"value":520,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88420"}]},{"type":"Modified residue","location":{"start":{"value":1495,"modifier":"EXACT"},"end":{"value":1495,"modifier":"EXACT"}},"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Glycosylation","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1356,"modifier":"EXACT"},"end":{"value":1356,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1370,"modifier":"EXACT"},"end":{"value":1370,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1381,"modifier":"EXACT"},"end":{"value":1381,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Disulfide bond","location":{"start":{"value":902,"modifier":"EXACT"},"end":{"value":902,"modifier":"EXACT"}},"description":"Interchain; with SCN2B or SCN4B","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04775"}]},{"type":"Disulfide bond","location":{"start":{"value":902,"modifier":"EXACT"},"end":{"value":902,"modifier":"EXACT"}},"description":"Interchain; with the conotoxin GVIIJ (when the channel is not linked to SCN2B or SCN4B; the bond to SCN2B or SCN4B protects the channel from the inhibition by toxin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04775"}]},{"type":"Disulfide bond","location":{"start":{"value":904,"modifier":"EXACT"},"end":{"value":910,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UQD0"}]},{"type":"Disulfide bond","location":{"start":{"value":942,"modifier":"EXACT"},"end":{"value":951,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D0E0C2"}]},{"type":"Disulfide bond","location":{"start":{"value":1354,"modifier":"EXACT"},"end":{"value":1374,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UQD0"}]},{"type":"Disulfide bond","location":{"start":{"value":1719,"modifier":"EXACT"},"end":{"value":1734,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UQD0"}]},{"type":"Alternative sequence","location":{"start":{"value":428,"modifier":"EXACT"},"end":{"value":673,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7670495"}],"featureId":"VSP_050594","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":664,"modifier":"EXACT"},"end":{"value":664,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9828131"}],"featureId":"VSP_050595","alternativeSequence":{"originalSequence":"E","alternativeSequences":["EVKIDKAATDS"]}},{"type":"Alternative sequence","location":{"start":{"value":1272,"modifier":"EXACT"},"end":{"value":1312,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9295353"}],"featureId":"VSP_050598","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1273,"modifier":"EXACT"},"end":{"value":1280,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9295353"}],"featureId":"VSP_050596","alternativeSequence":{"originalSequence":"SLVSLIAN","alternativeSequences":["PLSLSGLI"]}},{"type":"Alternative sequence","location":{"start":{"value":1281,"modifier":"EXACT"},"end":{"value":1978,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9295353"}],"featureId":"VSP_050597","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141072"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8815882"}],"featureId":"","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":1317,"modifier":"EXACT"},"end":{"value":1317,"modifier":"EXACT"}},"description":"in medjo","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8815882"}],"featureId":"","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Mutagenesis","location":{"start":{"value":1602,"modifier":"EXACT"},"end":{"value":1602,"modifier":"EXACT"}},"description":"Decrease in sensitivity to the scorpion toxin BMKM1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20678086"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":1901,"modifier":"EXACT"},"end":{"value":1901,"modifier":"EXACT"}},"description":"Decreases interaction with CALM1 in the absence of calcium.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23942337"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":1902,"modifier":"EXACT"},"end":{"value":1902,"modifier":"EXACT"}},"description":"Decreases interaction with CALM1 in the presence and absence of calcium and reduces rate of channel inactivation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23942337"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":1904,"modifier":"EXACT"},"end":{"value":1904,"modifier":"EXACT"}},"description":"Decreases interaction with CALM1 in the presence and absence of calcium and reduces rate of channel inactivation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23942337"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":1905,"modifier":"EXACT"},"end":{"value":1905,"modifier":"EXACT"}},"description":"Decreases interaction with CALM1 in the absence of calcium.","alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"in Ref. 3; BAE34580","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in Ref. 3; BAE34580","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":554,"modifier":"EXACT"},"end":{"value":554,"modifier":"EXACT"}},"description":"in Ref. 3; BAE34580","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":596,"modifier":"EXACT"},"end":{"value":596,"modifier":"EXACT"}},"description":"in Ref. 3; BAE34580","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":1498,"modifier":"EXACT"},"end":{"value":1498,"modifier":"EXACT"}},"description":"in Ref. 5; AAA65599","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":1504,"modifier":"EXACT"},"end":{"value":1504,"modifier":"EXACT"}},"description":"in Ref. 5; AAA65599","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["E"]}},{"type":"Helix","location":{"start":{"value":1893,"modifier":"EXACT"},"end":{"value":1912,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3WFN"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0915","category":"Ligand","name":"Sodium"},{"id":"KW-0894","category":"Molecular function","name":"Sodium channel"},{"id":"KW-0739","category":"Biological process","name":"Sodium transport"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0851","category":"Molecular function","name":"Voltage-gated channel"}],"references":[{"referenceNumber":1,"citation":{"id":"9828131","citationType":"journal article","authors":["Plummer N.W.","Galt J.","Jones J.M.","Burgess D.L.","Sprunger L.K.","Kohrman D.C.","Meisler M.H."],"citationCrossReferences":[{"database":"PubMed","id":"9828131"},{"database":"DOI","id":"10.1006/geno.1998.5550"}],"title":"Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A.","publicationDate":"1998","journal":"Genomics","firstPage":"287","lastPage":"296","volume":"54"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3)"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAD20438.1"}],"value":"C57BL/6J","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":2,"citation":{"id":"7670495","citationType":"journal article","authors":["Burgess D.L.","Kohrman D.C.","Galt J.","Plummer N.W.","Jones J.M.","Spear B.","Meisler M.H."],"citationCrossReferences":[{"database":"PubMed","id":"7670495"},{"database":"DOI","id":"10.1038/ng0895-461"}],"title":"Mutation of a new sodium channel gene, Scn8a, in the mouse mutant 'motor endplate disease'.","publicationDate":"1995","journal":"Nat. Genet.","firstPage":"461","lastPage":"465","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)","TISSUE SPECIFICITY","DISEASE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7670495"}],"value":"C57BL/6J","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7670495"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":3,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-804","VARIANT LEU-5"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Visual cortex","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"8663325","citationType":"journal article","authors":["Kohrman D.C.","Harris J.B.","Meisler M.H."],"citationCrossReferences":[{"database":"PubMed","id":"8663325"},{"database":"DOI","id":"10.1074/jbc.271.29.17576"}],"title":"Mutation detection in the med and medJ alleles of the sodium channel Scn8a. Unusual splicing due to a minor class AT-AC intron.","publicationDate":"1996","journal":"J. Biol. Chem.","firstPage":"17576","lastPage":"17581","volume":"271"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 93-205","DISEASE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8663325"}],"value":"129/Sv","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8663325"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":5,"citation":{"id":"CI-892ATU5Q48T6T","citationType":"submission","authors":["Fan Z.","Kyle J.W.","Makielski J.C."],"title":"A putative novel Na channel alpha subunit cDNA isolated from mouse NB2a neuroblastoma cells.","publicationDate":"MAR-1995","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1411-1686"],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":6,"citation":{"id":"9295353","citationType":"journal article","authors":["Plummer N.W.","McBurney M.W.","Meisler M.H."],"citationCrossReferences":[{"database":"PubMed","id":"9295353"},{"database":"DOI","id":"10.1074/jbc.272.38.24008"}],"title":"Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"24008","lastPage":"24015","volume":"272"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORMS 1; 4 AND 5)"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9295353"}],"value":"Brain","type":"TISSUE"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9295353"}],"value":"Fetal brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":7,"citation":{"id":"15123669","citationType":"journal article","authors":["Fotia A.B.","Ekberg J.","Adams D.J.","Cook D.I.","Poronnik P.","Kumar S."],"citationCrossReferences":[{"database":"PubMed","id":"15123669"},{"database":"DOI","id":"10.1074/jbc.m402820200"}],"title":"Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"28930","lastPage":"28935","volume":"279"},"referencePositions":["INTERACTION WITH NEDD4 AND NEDD4L","ACTIVITY REGULATION"]},{"referenceNumber":8,"citation":{"id":"19136557","citationType":"journal article","authors":["Carrithers M.D.","Chatterjee G.","Carrithers L.M.","Offoha R.","Iheagwara U.","Rahner C.","Graham M.","Waxman S.G."],"citationCrossReferences":[{"database":"PubMed","id":"19136557"},{"database":"DOI","id":"10.1074/jbc.m801892200"}],"title":"Regulation of podosome formation in macrophages by a splice variant of the sodium channel SCN8A.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"8114","lastPage":"8126","volume":"284"},"referencePositions":["FUNCTION (ISOFORM 5)","SUBCELLULAR LOCATION (ISOFORM 5)","TISSUE SPECIFICITY (ISOFORM 5)"]},{"referenceNumber":9,"citation":{"id":"20678086","citationType":"journal article","authors":["He H.","Liu Z.","Dong B.","Zhou J.","Zhu H.","Ji Y."],"citationCrossReferences":[{"database":"PubMed","id":"20678086"},{"database":"DOI","id":"10.1042/bj20100517"}],"title":"Molecular determination of selectivity of the site 3 modulator (BmK I) to sodium channels in the CNS: a clue to the importance of Nav1.6 in BmK I-induced neuronal hyperexcitability.","publicationDate":"2010","journal":"Biochem. J.","firstPage":"289","lastPage":"298","volume":"431"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","INTERACTION WITH SCORPION TOXIN BMK M1","MUTAGENESIS OF ASP-1602"]},{"referenceNumber":10,"citation":{"id":"8815882","citationType":"journal article","authors":["Kohrman D.C.","Smith M.R.","Goldin A.L.","Harris J.","Meisler M.H."],"citationCrossReferences":[{"database":"PubMed","id":"8815882"},{"database":"DOI","id":"10.1523/jneurosci.16-19-05993.1996"}],"title":"A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting.","publicationDate":"1996","journal":"J. Neurosci.","firstPage":"5993","lastPage":"5999","volume":"16"},"referencePositions":["VARIANT MEDJO THR-1317","VARIANT LEU-5"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8815882"}],"value":"DBA/2WyDi","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":11,"citation":{"id":"11532991","citationType":"journal article","authors":["De Repentigny Y.","Cote P.D.","Pool M.","Bernier G.","Girard S.","Vidal S.M.","Kothary R."],"citationCrossReferences":[{"database":"PubMed","id":"11532991"},{"database":"DOI","id":"10.1093/hmg/10.17.1819"}],"title":"Pathological and genetic analysis of the degenerating muscle (dmu) mouse: a new allele of Scn8a.","publicationDate":"2001","journal":"Hum. Mol. Genet.","firstPage":"1819","lastPage":"1827","volume":"10"},"referencePositions":["DISEASE"],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":12,"citation":{"id":"28842554","citationType":"journal article","authors":["Liu Y.","Lai S.","Ma W.","Ke W.","Zhang C.","Liu S.","Zhang Y.","Pei F.","Li S.","Yi M.","Shu Y.","Shang Y.","Liang J.","Huang Z."],"citationCrossReferences":[{"database":"PubMed","id":"28842554"},{"database":"DOI","id":"10.1038/s41467-017-00368-z"}],"title":"CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression.","publicationDate":"2017","journal":"Nat. Commun.","firstPage":"355","lastPage":"355","volume":"8"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":13,"citation":{"id":"23942337","citationType":"journal article","authors":["Reddy Chichili V.P.","Xiao Y.","Seetharaman J.","Cummins T.R.","Sivaraman J."],"citationCrossReferences":[{"database":"PubMed","id":"23942337"},{"database":"DOI","id":"10.1038/srep02435"}],"title":"Structural basis for the modulation of the neuronal voltage-gated sodium channel NaV1.6 by calmodulin.","publicationDate":"2013","journal":"Sci. Rep.","firstPage":"2435","lastPage":"2435","volume":"3"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1893-1914 IN COMPLEX WITH CALM1","INTERACTION WITH CALM1","FUNCTION","TRANSPORTER ACTIVITY","MUTAGENESIS OF GLN-1901; ARG-1902; TYR-1904 AND ARG-1905"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3WFN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF049617","properties":[{"key":"ProteinId","value":"AAD20438.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U26707","properties":[{"key":"ProteinId","value":"AAC52242.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK158609","properties":[{"key":"ProteinId","value":"BAE34580.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U59964","properties":[{"key":"ProteinId","value":"AAC52708.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U59963","properties":[{"key":"ProteinId","value":"AAC52708.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U23158","properties":[{"key":"ProteinId","value":"AAA65599.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS57011.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9WTU3-1"},{"database":"RefSeq","id":"NP_001070967.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001077499.2"}]},{"database":"RefSeq","id":"NP_035453.2","properties":[{"key":"NucleotideSequenceId","value":"NM_011323.3"}]},{"database":"PDB","id":"3WFN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"B/C/D/E=1893-1914"}]},{"database":"PDBsum","id":"3WFN","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9WTU3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9WTU3","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"203103","properties":[{"key":"Interactions","value":"10"}]},{"database":"CORUM","id":"Q9WTU3","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9WTU3","properties":[{"key":"Number of interactors","value":"485"}]},{"database":"IntAct","id":"Q9WTU3","properties":[{"key":"Interactions","value":"2"}]},{"database":"MINT","id":"Q9WTU3","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10090.ENSMUSP00000080842","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9WTU3","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1914275","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"583","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q9WTU3","properties":[{"key":"glycosylation","value":"8 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q9WTU3","properties":[{"key":"glycosylation","value":"9 sites, 1 N-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"Q9WTU3","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9WTU3","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9WTU3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000080842","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"253416","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9WTU3-1"},{"database":"ProteomicsDB","id":"253417","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9WTU3-2"},{"database":"ProteomicsDB","id":"253418","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9WTU3-3"},{"database":"ProteomicsDB","id":"253419","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9WTU3-4"},{"database":"ProteomicsDB","id":"253420","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9WTU3-5"},{"database":"ABCD","id":"Q9WTU3","properties":[{"key":"antibodies","value":"1 sequenced antibody"}]},{"database":"DNASU","id":"20273","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"20273","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:20273","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"MGI:103169","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6334","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:103169","properties":[{"key":"GeneName","value":"Scn8a"}]},{"database":"eggNOG","id":"KOG2301","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"Q9WTU3","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"2984333at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9WTU3","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"20273","properties":[{"key":"hits","value":"0 hits in 81 CRISPR screens"}]},{"database":"EvolutionaryTrace","id":"Q9WTU3","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9WTU3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"RNAct","id":"Q9WTU3","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043194","properties":[{"key":"GoTerm","value":"C:axon initial segment"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0030054","properties":[{"key":"GoTerm","value":"C:cell junction"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0031410","properties":[{"key":"GoTerm","value":"C:cytoplasmic vesicle"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19136557"}]},{"database":"GO","id":"GO:0030425","properties":[{"key":"GoTerm","value":"C:dendrite"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17928448"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17537961"}]},{"database":"GO","id":"GO:0043025","properties":[{"key":"GoTerm","value":"C:neuronal cell body"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17928448"}]},{"database":"GO","id":"GO:0033268","properties":[{"key":"GoTerm","value":"C:node of Ranvier"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11807096"}]},{"database":"GO","id":"GO:0098688","properties":[{"key":"GoTerm","value":"C:parallel fiber to Purkinje cell synapse"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28842554"}]},{"database":"GO","id":"GO:0002102","properties":[{"key":"GoTerm","value":"C:podosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0098839","properties":[{"key":"GoTerm","value":"C:postsynaptic density membrane"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0048787","properties":[{"key":"GoTerm","value":"C:presynaptic active zone membrane"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0034706","properties":[{"key":"GoTerm","value":"C:sodium channel complex"},{"key":"GoEvidenceType","value":"IPI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15272007"}]},{"database":"GO","id":"GO:0001518","properties":[{"key":"GoTerm","value":"C:voltage-gated sodium channel complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030018","properties":[{"key":"GoTerm","value":"C:Z disc"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17884088"}]},{"database":"GO","id":"GO:0031402","properties":[{"key":"GoTerm","value":"F:sodium ion binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005248","properties":[{"key":"GoTerm","value":"F:voltage-gated sodium channel activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001508","properties":[{"key":"GoTerm","value":"P:action potential"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0007628","properties":[{"key":"GoTerm","value":"P:adult walking behavior"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7670495"}]},{"database":"GO","id":"GO:0007626","properties":[{"key":"GoTerm","value":"P:locomotory behavior"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12920299"}]},{"database":"GO","id":"GO:0086010","properties":[{"key":"GoTerm","value":"P:membrane depolarization during action potential"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0007517","properties":[{"key":"GoTerm","value":"P:muscle organ development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15170223"}]},{"database":"GO","id":"GO:0021675","properties":[{"key":"GoTerm","value":"P:nerve development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21156207"}]},{"database":"GO","id":"GO:0019228","properties":[{"key":"GoTerm","value":"P:neuronal action potential"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0009636","properties":[{"key":"GoTerm","value":"P:response to toxic substance"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16029194"}]},{"database":"GO","id":"GO:0019233","properties":[{"key":"GoTerm","value":"P:sensory perception of pain"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007605","properties":[{"key":"GoTerm","value":"P:sensory perception of sound"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12204355"}]},{"database":"GO","id":"GO:0035725","properties":[{"key":"GoTerm","value":"P:sodium ion transmembrane transport"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006814","properties":[{"key":"GoTerm","value":"P:sodium ion transport"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"CDD","id":"cd13433","properties":[{"key":"EntryName","value":"Na_channel_gate"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000002","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.70:FF:000001","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.70:FF:000006","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.350:FF:000002","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.350:FF:000004","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.350:FF:000005","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.1190:FF:000003","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.350:FF:000003","properties":[{"key":"EntryName","value":"Voltage-dependent sodium channel"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.70","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"4"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.1190","properties":[{"key":"EntryName","value":"iswi atpase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.350","properties":[{"key":"EntryName","value":"Voltage-gated potassium channels. Chain C"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR005821","properties":[{"key":"EntryName","value":"Ion_trans_dom"}]},{"database":"InterPro","id":"IPR000048","properties":[{"key":"EntryName","value":"IQ_motif_EF-hand-BS"}]},{"database":"InterPro","id":"IPR058542","properties":[{"key":"EntryName","value":"IQ_SCN5A_C"}]},{"database":"InterPro","id":"IPR008054","properties":[{"key":"EntryName","value":"Na_channel_a8su"}]},{"database":"InterPro","id":"IPR001696","properties":[{"key":"EntryName","value":"Na_channel_asu"}]},{"database":"InterPro","id":"IPR044564","properties":[{"key":"EntryName","value":"Na_chnl_inactivation_gate"}]},{"database":"InterPro","id":"IPR010526","properties":[{"key":"EntryName","value":"Na_trans_assoc_dom"}]},{"database":"InterPro","id":"IPR024583","properties":[{"key":"EntryName","value":"Na_trans_cytopl"}]},{"database":"InterPro","id":"IPR043203","properties":[{"key":"EntryName","value":"VGCC_Ca_Na"}]},{"database":"InterPro","id":"IPR027359","properties":[{"key":"EntryName","value":"Volt_channel_dom_sf"}]},{"database":"PANTHER","id":"PTHR10037:SF23","properties":[{"key":"EntryName","value":"SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10037","properties":[{"key":"EntryName","value":"VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00520","properties":[{"key":"EntryName","value":"Ion_trans"},{"key":"MatchStatus","value":"4"}]},{"database":"Pfam","id":"PF24609","properties":[{"key":"EntryName","value":"IQ_SCN5A_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06512","properties":[{"key":"EntryName","value":"Na_trans_assoc"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11933","properties":[{"key":"EntryName","value":"Na_trans_cytopl"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00170","properties":[{"key":"EntryName","value":"NACHANNEL"}]},{"database":"PRINTS","id":"PR01667","properties":[{"key":"EntryName","value":"NACHANNEL8"}]},{"database":"SMART","id":"SM00015","properties":[{"key":"EntryName","value":"IQ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81324","properties":[{"key":"EntryName","value":"Voltage-gated potassium channels"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50096","properties":[{"key":"EntryName","value":"IQ"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAARVLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGNSSDAGQCPEGFQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEDGVGSPRSSSELSKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGPGSHIGRLLPEATTEVEIKKKGPGSLLVSMEQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELGLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISQECKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWAKVKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGVDIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIDEVNNKTDCEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICRKITSNKLENGGTHREKKESTPSTASLPSYDSVTKPDKEKQQRAEEGRRERAKRQKEVRESKC","length":1978,"molWeight":225141,"crc64":"9EA4A8E610707220","md5":"4DC31CBC4D101CD60D139CAF6EEBB9C8"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":2,"ALTERNATIVE PRODUCTS":5,"TISSUE SPECIFICITY":2,"DOMAIN":1,"PTM":2,"DISEASE":3,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":29,"Transmembrane":24,"Intramembrane":4,"Repeat":4,"Domain":1,"Region":6,"Compositional bias":7,"Binding site":3,"Modified residue":3,"Glycosylation":8,"Disulfide bond":7,"Alternative sequence":5,"Natural variant":2,"Mutagenesis":5,"Sequence conflict":6,"Helix":1},"uniParcId":"UPI0000028CBA"}}