{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9W4J9","uniProtkbId":"ADPR2_DROME","entryAudit":{"firstPublicDate":"2025-02-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-10-01","entryVersion":155,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Drosophila melanogaster","commonName":"Fruit fly","taxonId":7227,"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000803"}],"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Diptera","Brachycera","Muscomorpha","Ephydroidea","Drosophilidae","Drosophila","Sophophora"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"ADP-ribosylarginine hydrolase CG3568"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"}],"value":"3.2.2.19"}]}},"genes":[{"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"FlyBase","id":"FBgn0029710"}],"value":"CG3568"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"}],"value":"Protein ADP-ribosyl hydrolase that specifically removes mono-ADP-ribosyl modifications from protein arginine residues"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + H2O = ADP-D-ribose + L-arginyl-[protein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:14885"},{"database":"Rhea","id":"RHEA-COMP:10532"},{"database":"Rhea","id":"RHEA-COMP:15087"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:29965"},{"database":"ChEBI","id":"CHEBI:57967"},{"database":"ChEBI","id":"CHEBI:142554"}],"ecNumber":"3.2.2.19","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20784"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:32682"},{"database":"ChEBI","id":"CHEBI:57967"},{"database":"ChEBI","id":"CHEBI:60267"}],"ecNumber":"3.2.2.19","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"}]}}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"ADP-ribosylarginine hydrolase CG3568","featureId":"PRO_0000461645"},{"type":"Binding site","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57967"},{"database":"ChEBI","id":"CHEBI:30756"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8DMU"}],"ligand":{"name":"ADP-D-ribose","id":"ChEBI:CHEBI:57967"},"ligandPart":{"name":"adenine group","id":"ChEBI:CHEBI:30756"}},{"type":"Binding site","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57967"},{"database":"ChEBI","id":"CHEBI:68549"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8DMU"}],"ligand":{"name":"ADP-D-ribose","id":"ChEBI:CHEBI:57967"},"ligandPart":{"name":"diphosphate group","id":"ChEBI:CHEBI:68549"}},{"type":"Binding site","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57967"},{"database":"ChEBI","id":"CHEBI:68549"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8DMU"}],"ligand":{"name":"ADP-D-ribose","id":"ChEBI:CHEBI:57967"},"ligandPart":{"name":"diphosphate group","id":"ChEBI:CHEBI:68549"}},{"type":"Binding site","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57967"},{"database":"ChEBI","id":"CHEBI:68549"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8DMU"}],"ligand":{"name":"ADP-D-ribose","id":"ChEBI:CHEBI:57967"},"ligandPart":{"name":"diphosphate group","id":"ChEBI:CHEBI:68549"}},{"type":"Binding site","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57967"},{"database":"ChEBI","id":"CHEBI:68549"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8DMU"}],"ligand":{"name":"ADP-D-ribose","id":"ChEBI:CHEBI:57967"},"ligandPart":{"name":"diphosphate group","id":"ChEBI:CHEBI:68549"}},{"type":"Binding site","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57967"},{"database":"ChEBI","id":"CHEBI:68549"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8DMU"}],"ligand":{"name":"ADP-D-ribose","id":"ChEBI:CHEBI:57967"},"ligandPart":{"name":"diphosphate group","id":"ChEBI:CHEBI:68549"}},{"type":"Binding site","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57967"},{"database":"ChEBI","id":"CHEBI:30756"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8DMU"}],"ligand":{"name":"ADP-D-ribose","id":"ChEBI:CHEBI:57967"},"ligandPart":{"name":"adenine group","id":"ChEBI:CHEBI:30756"}},{"type":"Binding site","location":{"start":{"value":441,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57967"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8DMU"}],"ligand":{"name":"ADP-D-ribose","id":"ChEBI:CHEBI:57967"}},{"type":"Binding site","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":448,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57967"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8DMU"}],"ligand":{"name":"ADP-D-ribose","id":"ChEBI:CHEBI:57967"}},{"type":"Binding site","location":{"start":{"value":449,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57967"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8DMU"}],"ligand":{"name":"ADP-D-ribose","id":"ChEBI:CHEBI:57967"}},{"type":"Binding site","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":459,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57967"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8DMU"}],"ligand":{"name":"ADP-D-ribose","id":"ChEBI:CHEBI:57967"}},{"type":"Binding site","location":{"start":{"value":460,"modifier":"EXACT"},"end":{"value":460,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57967"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38503748"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8DMU"}],"ligand":{"name":"ADP-D-ribose","id":"ChEBI:CHEBI:57967"}},{"type":"Helix","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Turn","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Turn","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Turn","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Turn","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":429,"modifier":"EXACT"},"end":{"value":431,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":439,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":456,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":469,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Turn","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":477,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Turn","location":{"start":{"value":479,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":484,"modifier":"EXACT"},"end":{"value":486,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":488,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Turn","location":{"start":{"value":492,"modifier":"EXACT"},"end":{"value":494,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Beta strand","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":498,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]},{"type":"Helix","location":{"start":{"value":499,"modifier":"EXACT"},"end":{"value":505,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8DMU"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10731132","citationType":"journal article","authors":["Adams M.D.","Celniker S.E.","Holt R.A.","Evans C.A.","Gocayne J.D.","Amanatides P.G.","Scherer S.E.","Li P.W.","Hoskins R.A.","Galle R.F.","George R.A.","Lewis S.E.","Richards S.","Ashburner M.","Henderson S.N.","Sutton G.G.","Wortman J.R.","Yandell M.D.","Zhang Q.","Chen L.X.","Brandon R.C.","Rogers Y.-H.C.","Blazej R.G.","Champe M.","Pfeiffer B.D.","Wan K.H.","Doyle C.","Baxter E.G.","Helt G.","Nelson C.R.","Miklos G.L.G.","Abril J.F.","Agbayani A.","An H.-J.","Andrews-Pfannkoch C.","Baldwin D.","Ballew R.M.","Basu A.","Baxendale J.","Bayraktaroglu L.","Beasley E.M.","Beeson K.Y.","Benos P.V.","Berman B.P.","Bhandari D.","Bolshakov S.","Borkova D.","Botchan M.R.","Bouck J.","Brokstein P.","Brottier P.","Burtis K.C.","Busam D.A.","Butler H.","Cadieu E.","Center A.","Chandra I.","Cherry J.M.","Cawley S.","Dahlke C.","Davenport L.B.","Davies P.","de Pablos B.","Delcher A.","Deng Z.","Mays A.D.","Dew I.","Dietz S.M.","Dodson K.","Doup L.E.","Downes M.","Dugan-Rocha S.","Dunkov B.C.","Dunn P.","Durbin K.J.","Evangelista C.C.","Ferraz C.","Ferriera S.","Fleischmann W.","Fosler C.","Gabrielian A.E.","Garg N.S.","Gelbart W.M.","Glasser K.","Glodek A.","Gong F.","Gorrell J.H.","Gu Z.","Guan P.","Harris M.","Harris N.L.","Harvey D.A.","Heiman T.J.","Hernandez J.R.","Houck J.","Hostin D.","Houston K.A.","Howland T.J.","Wei M.-H.","Ibegwam C.","Jalali M.","Kalush F.","Karpen G.H.","Ke Z.","Kennison J.A.","Ketchum K.A.","Kimmel B.E.","Kodira C.D.","Kraft C.L.","Kravitz S.","Kulp D.","Lai Z.","Lasko P.","Lei Y.","Levitsky A.A.","Li J.H.","Li Z.","Liang Y.","Lin X.","Liu X.","Mattei B.","McIntosh T.C.","McLeod M.P.","McPherson D.","Merkulov G.","Milshina N.V.","Mobarry C.","Morris J.","Moshrefi A.","Mount S.M.","Moy M.","Murphy B.","Murphy L.","Muzny D.M.","Nelson D.L.","Nelson D.R.","Nelson K.A.","Nixon K.","Nusskern D.R.","Pacleb J.M.","Palazzolo M.","Pittman G.S.","Pan S.","Pollard J.","Puri V.","Reese M.G.","Reinert K.","Remington K.","Saunders R.D.C.","Scheeler F.","Shen H.","Shue B.C.","Siden-Kiamos I.","Simpson M.","Skupski M.P.","Smith T.J.","Spier E.","Spradling A.C.","Stapleton M.","Strong R.","Sun E.","Svirskas R.","Tector C.","Turner R.","Venter E.","Wang A.H.","Wang X.","Wang Z.-Y.","Wassarman D.A.","Weinstock G.M.","Weissenbach J.","Williams S.M.","Woodage T.","Worley K.C.","Wu D.","Yang S.","Yao Q.A.","Ye J.","Yeh R.-F.","Zaveri J.S.","Zhan M.","Zhang G.","Zhao Q.","Zheng L.","Zheng X.H.","Zhong F.N.","Zhong W.","Zhou X.","Zhu S.C.","Zhu X.","Smith H.O.","Gibbs R.A.","Myers E.W.","Rubin G.M.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"10731132"},{"database":"DOI","id":"10.1126/science.287.5461.2185"}],"title":"The genome sequence of Drosophila melanogaster.","publicationDate":"2000","journal":"Science","firstPage":"2185","lastPage":"2195","volume":"287"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000803"}],"value":"Berkeley","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000803"}]},{"referenceNumber":2,"citation":{"id":"12537572","citationType":"journal article","authors":["Misra S.","Crosby M.A.","Mungall C.J.","Matthews B.B.","Campbell K.S.","Hradecky P.","Huang Y.","Kaminker J.S.","Millburn G.H.","Prochnik S.E.","Smith C.D.","Tupy J.L.","Whitfield E.J.","Bayraktaroglu L.","Berman B.P.","Bettencourt B.R.","Celniker S.E.","de Grey A.D.N.J.","Drysdale R.A.","Harris N.L.","Richter J.","Russo S.","Schroeder A.J.","Shu S.Q.","Stapleton M.","Yamada C.","Ashburner M.","Gelbart W.M.","Rubin G.M.","Lewis S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537572"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0083"}],"title":"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0083.1","lastPage":"RESEARCH0083.22","volume":"3"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000803"}],"value":"Berkeley","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000803"}]},{"referenceNumber":3,"citation":{"id":"12537569","citationType":"journal article","authors":["Stapleton M.","Carlson J.W.","Brokstein P.","Yu C.","Champe M.","George R.A.","Guarin H.","Kronmiller B.","Pacleb J.M.","Park S.","Wan K.H.","Rubin G.M.","Celniker S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537569"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0080"}],"title":"A Drosophila full-length cDNA resource.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0080.1","lastPage":"RESEARCH0080.8","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAM29295.1"}],"value":"Berkeley","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAM29295.1"}],"value":"Testis","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAM29295.1"}]},{"referenceNumber":4,"citation":{"id":"38503748","citationType":"journal article","authors":["Zhang Z.","Fu J.","Rack J.G.M.","Li C.","Voorneveld J.","Filippov D.V.","Ahel I.","Luo Z.Q.","Das C."],"citationCrossReferences":[{"database":"PubMed","id":"38503748"},{"database":"DOI","id":"10.1038/s41467-024-46649-2"}],"title":"Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain.","publicationDate":"2024","journal":"Nat. Commun.","firstPage":"2452","lastPage":"2452","volume":"15"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 25-508","FUNCTION","CATALYTIC ACTIVITY"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8DMU"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AE014298","properties":[{"key":"ProteinId","value":"AAF45952.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY113290","properties":[{"key":"ProteinId","value":"AAM29295.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_572166.1","properties":[{"key":"NucleotideSequenceId","value":"NM_131938.2"}]},{"database":"PDB","id":"8DMU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D=25-508"}]},{"database":"PDBsum","id":"8DMU","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9W4J9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9W4J9","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"7227.FBpp0070644","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"7227-FBpp0070644","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9W4J9","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"31383","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"FBtr0070676","properties":[{"key":"ProteinId","value":"FBpp0070644"},{"key":"GeneId","value":"FBgn0029710"}]},{"database":"GeneID","id":"31383","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dme:Dmel_CG3568","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"CG3568-RA","properties":[{"key":"OrganismName","value":"d. melanogaster"}]},{"database":"AGR","id":"FB:FBgn0029710","properties":[{"key":"Description","value":"-"}]},{"database":"FlyBase","id":"FBgn0029710","properties":[{"key":"GeneName","value":"CG3568"}]},{"database":"VEuPathDB","id":"VectorBase:FBgn0029710","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QV0E","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_042117_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PVVTYAW","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6357136at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"31383","properties":[{"key":"hits","value":"0 hits in 1 CRISPR screen"}]},{"database":"PRO","id":"PR:Q9W4J9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000803","properties":[{"key":"Component","value":"Chromosome X"}]},{"database":"Bgee","id":"FBgn0029710","properties":[{"key":"ExpressionPatterns","value":"Expressed in embryonic/larval hemocyte (Drosophila) and 39 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9W4J9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0003875","properties":[{"key":"GoTerm","value":"F:ADP-ribosylarginine-[protein] hydrolase activity"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38503748"}]},{"database":"InterPro","id":"IPR032063","properties":[{"key":"EntryName","value":"MavL-like"}]},{"database":"Pfam","id":"PF16062","properties":[{"key":"EntryName","value":"MavL-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRSFLYMLSQRPKLACLCGKSIIIWPGKRTNLPENAFTQRMLQECGQMAKPDASVDLDNFKAISEQSPAEFGIDSCRVKAQPEDRSDRIREQIASAYPVIHERTLLLFISFLEHKLTFGSEQEKAIYKDMTVVDLVQRLLAKRCVWFFGANDYYRTMQGNIGNEGFEAVGTPAEKEPLTLTSVLSYDEIKLSALLYVSCHSEFINNGSRVNGGEVLQNKDTIEREGVVIGLIGARFERPDVMEYQDIMITKTQNTEANGYGFDLEQISSETVTPASDLRRIWREFYEEPRDFIYADTPYDTTRFEEVSQGIFDHQVMRKRYAISFDTLLLEAQDRAFKAGKPAYIHVVGIGLGVWKAARQQERTFLESFEGRLRALGERLSHIGVVHFSWFHLACVGSLHDGAIIPVDKHPQGGIRIRNSVRNPGDKLTEDMLPVVTYAWDGNALPGNEFWANMLISTGDPAAACSTLISELQNPHINVHYMNGANLHIASVEHGLLHVGDYARRLIV","length":508,"molWeight":57376,"crc64":"23DD1859F0720106","md5":"2D2A5C9AE9F549DAB1552D73BAB08494"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2},"countByFeatureType":{"Chain":1,"Binding site":12,"Helix":24,"Beta strand":18,"Turn":7},"uniParcId":"UPI0000076BC2"}}