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The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:25512509, PubMed:27672113). The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy (PubMed:23723238, PubMed:25512509, PubMed:27672113). GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:25512509, PubMed:27672113). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509, PubMed:27672113). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:25512509, PubMed:27672113)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27166823"}],"value":"Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 (PubMed:27166823)"}],"commentType":"SUBUNIT"},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"evidences":[{"evidenceCode":"ECO:0000312","source":"FlyBase","id":"FBgn0035227"}],"value":"A"},"isoformIds":["Q9W0E3-1"],"isoformSequenceStatus":"Displayed"},{"name":{"evidences":[{"evidenceCode":"ECO:0000312","source":"FlyBase","id":"FBgn0035227"}],"value":"B"},"isoformIds":["Q9W0E3-2"],"sequenceIds":["VSP_060140","VSP_060141"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25512509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27672113"}],"value":"Pupal lethal (PubMed:27672113). Under nutrient-replete conditions, larvae display a significant increase in TORC1 activity, indicated by increased phosphorylation of S6K/p70S6K (PubMed:27672113). RNAi-mediated knockdown in the female germline results in a large percentage of ovarian cysts delaying mitotic exit (PubMed:25512509, PubMed:27672113). Instead, cysts undergo a fifth mitotic division before meiotic commitment to produce 32-cell cysts with a single oocyte (PubMed:25512509, PubMed:27672113). Double RNAi-mediated knockdown with GATOR1 complex member Nprl2 in the female germline increases the penetrance of ovarian cysts displaying delayed mitotic exit and producing 32-cell cysts (PubMed:25512509, PubMed:27672113). The number of ovarian cysts that delay meiotic commitment and undergo a fifth mitotic division are decreased when females are fed the mTORC1 complex inhibitor rapamycin (PubMed:25512509)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the IML1 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAL68237.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1544,"modifier":"EXACT"}},"description":"GATOR complex protein 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