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Plays a key role in energy homeostasis by regulating the balance between energy storage and heat production. Functions by negatively regulating Ca(2+) signaling pathways that are involved in heat production and maintaining correct lipid storage in the fat body. Regulates Ca(2+) signaling pathways by reducing the activity of the calcium-transporting ATPase SERCA possibly by promoting uncoupling of SERCA ATP hydrolysis from calcium pumping. May also function in the nervous system to control feeding behavior (PubMed:28399403)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28399403"}],"value":"Interacts with SERCA"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28399403"}],"value":"Endoplasmic reticulum","id":"SL-0095"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28399403"}],"value":"Detected in the larval fat body, salivary glands and wing imaginal disks (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28399403"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31943105"}],"value":"Flies are hypersensitive to the cold, hyperphagic and display elevated triglyceride stores resulting in an increased resistance to starvation (PubMed:28399403). Heat production is impaired and flies are slow to recover after cold treatment (PubMed:28399403). The size of the lipid droplets in larval fat bodies are significantly increased and flies display increased feeding (PubMed:28399403). Total body glycogen is also significantly increased in adult females but not in males (PubMed:28399403). Mutants also display an increase in calcium-dependent SERCA activity (PubMed:28399403). No effect on levels of circulating sugars, glucose and trehalose (PubMed:28399403). RNAi-mediated knockdown impairs small interfering RNA-mediated silencing (PubMed:31943105)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the THADA family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAM75097.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1746,"modifier":"EXACT"}},"description":"tRNA (32-2'-O)-methyltransferase regulator THADA","featureId":"PRO_0000441753"},{"type":"Coiled coil","location":{"start":{"value":1252,"modifier":"EXACT"},"end":{"value":1286,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Sequence conflict","location":{"start":{"value":938,"modifier":"EXACT"},"end":{"value":938,"modifier":"EXACT"}},"description":"in Ref. 3; 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