{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9VU08","uniProtkbId":"VP13D_DROME","entryAudit":{"firstPublicDate":"2018-10-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-03-03","entryVersion":164,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Drosophila melanogaster","commonName":"Fruit fly","taxonId":7227,"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000803"}],"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Diptera","Brachycera","Muscomorpha","Ephydroidea","Drosophilidae","Drosophila","Sophophora"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Intermembrane lipid transfer protein Vps13D"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29307555"}],"value":"Vacuolar protein sorting-associated protein 13D"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"FlyBase","id":"FBgn0052113"}],"value":"Vps13D"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"FlyBase","id":"FBgn0052113"}],"value":"CG32113"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q07878"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29307555"}],"value":"Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis (PubMed:29307555)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29307555"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29307555"}],"value":"Lysosome","id":"SL-0158"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29307555"}],"value":"Expressed in intestinal cells (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29307555"}],"value":"The UBA domain binds to 'Lys-63'-linked polyubiquitin chains, but neither to linear nor 'Lys-48'-linked polyubiquitin chains. Required for mitochondrial size regulation and for mitochondrial clearance in the intestine"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29307555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29604224"}],"value":"RNAi-mediated knockdown leads to 100% lethality at the larval or pupal stage"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the VPS13 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":3919,"modifier":"EXACT"}},"description":"Intermembrane lipid transfer protein Vps13D","featureId":"PRO_0000445548"},{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Chorein N-terminal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":2292,"modifier":"EXACT"},"end":{"value":2334,"modifier":"EXACT"}},"description":"UBA","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00212"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29307555"}]},{"type":"Domain","location":{"start":{"value":2837,"modifier":"EXACT"},"end":{"value":3113,"modifier":"EXACT"}},"description":"SHR-BD","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":706,"modifier":"EXACT"},"end":{"value":736,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":3749,"modifier":"EXACT"},"end":{"value":3768,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":3751,"modifier":"EXACT"},"end":{"value":3764,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Mutagenesis","location":{"start":{"value":2308,"modifier":"EXACT"},"end":{"value":2308,"modifier":"EXACT"}},"description":"Loss of 'Lys-63'-linked polyubiquitin chain binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29307555"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0430","category":"Ligand","name":"Lectin"},{"id":"KW-0445","category":"Biological process","name":"Lipid transport"},{"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"10731132","citationType":"journal article","authors":["Adams M.D.","Celniker S.E.","Holt R.A.","Evans C.A.","Gocayne J.D.","Amanatides P.G.","Scherer S.E.","Li P.W.","Hoskins R.A.","Galle R.F.","George R.A.","Lewis S.E.","Richards S.","Ashburner M.","Henderson S.N.","Sutton G.G.","Wortman J.R.","Yandell M.D.","Zhang Q.","Chen L.X.","Brandon R.C.","Rogers Y.-H.C.","Blazej R.G.","Champe M.","Pfeiffer B.D.","Wan K.H.","Doyle C.","Baxter E.G.","Helt G.","Nelson C.R.","Miklos G.L.G.","Abril J.F.","Agbayani A.","An H.-J.","Andrews-Pfannkoch C.","Baldwin D.","Ballew R.M.","Basu A.","Baxendale J.","Bayraktaroglu L.","Beasley E.M.","Beeson K.Y.","Benos P.V.","Berman B.P.","Bhandari D.","Bolshakov S.","Borkova D.","Botchan M.R.","Bouck J.","Brokstein P.","Brottier P.","Burtis K.C.","Busam D.A.","Butler H.","Cadieu E.","Center A.","Chandra I.","Cherry J.M.","Cawley S.","Dahlke C.","Davenport L.B.","Davies P.","de Pablos B.","Delcher A.","Deng Z.","Mays A.D.","Dew I.","Dietz S.M.","Dodson K.","Doup L.E.","Downes M.","Dugan-Rocha S.","Dunkov B.C.","Dunn P.","Durbin K.J.","Evangelista C.C.","Ferraz C.","Ferriera S.","Fleischmann W.","Fosler C.","Gabrielian A.E.","Garg N.S.","Gelbart W.M.","Glasser K.","Glodek A.","Gong F.","Gorrell J.H.","Gu Z.","Guan P.","Harris M.","Harris N.L.","Harvey D.A.","Heiman T.J.","Hernandez J.R.","Houck J.","Hostin D.","Houston K.A.","Howland T.J.","Wei M.-H.","Ibegwam C.","Jalali M.","Kalush F.","Karpen G.H.","Ke Z.","Kennison J.A.","Ketchum K.A.","Kimmel B.E.","Kodira C.D.","Kraft C.L.","Kravitz S.","Kulp D.","Lai Z.","Lasko P.","Lei Y.","Levitsky A.A.","Li J.H.","Li Z.","Liang Y.","Lin X.","Liu X.","Mattei B.","McIntosh T.C.","McLeod M.P.","McPherson D.","Merkulov G.","Milshina N.V.","Mobarry C.","Morris J.","Moshrefi A.","Mount S.M.","Moy M.","Murphy B.","Murphy L.","Muzny D.M.","Nelson D.L.","Nelson D.R.","Nelson K.A.","Nixon K.","Nusskern D.R.","Pacleb J.M.","Palazzolo M.","Pittman G.S.","Pan S.","Pollard J.","Puri V.","Reese M.G.","Reinert K.","Remington K.","Saunders R.D.C.","Scheeler F.","Shen H.","Shue B.C.","Siden-Kiamos I.","Simpson M.","Skupski M.P.","Smith T.J.","Spier E.","Spradling A.C.","Stapleton M.","Strong R.","Sun E.","Svirskas R.","Tector C.","Turner R.","Venter E.","Wang A.H.","Wang X.","Wang Z.-Y.","Wassarman D.A.","Weinstock G.M.","Weissenbach J.","Williams S.M.","Woodage T.","Worley K.C.","Wu D.","Yang S.","Yao Q.A.","Ye J.","Yeh R.-F.","Zaveri J.S.","Zhan M.","Zhang G.","Zhao Q.","Zheng L.","Zheng X.H.","Zhong F.N.","Zhong W.","Zhou X.","Zhu S.C.","Zhu X.","Smith H.O.","Gibbs R.A.","Myers E.W.","Rubin G.M.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"10731132"},{"database":"DOI","id":"10.1126/science.287.5461.2185"}],"title":"The genome sequence of Drosophila melanogaster.","publicationDate":"2000","journal":"Science","firstPage":"2185","lastPage":"2195","volume":"287"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000803"}],"value":"Berkeley","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000803"}]},{"referenceNumber":2,"citation":{"id":"12537572","citationType":"journal article","authors":["Misra S.","Crosby M.A.","Mungall C.J.","Matthews B.B.","Campbell K.S.","Hradecky P.","Huang Y.","Kaminker J.S.","Millburn G.H.","Prochnik S.E.","Smith C.D.","Tupy J.L.","Whitfield E.J.","Bayraktaroglu L.","Berman B.P.","Bettencourt B.R.","Celniker S.E.","de Grey A.D.N.J.","Drysdale R.A.","Harris N.L.","Richter J.","Russo S.","Schroeder A.J.","Shu S.Q.","Stapleton M.","Yamada C.","Ashburner M.","Gelbart W.M.","Rubin G.M.","Lewis S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537572"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0083"}],"title":"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0083.1","lastPage":"RESEARCH0083.22","volume":"3"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000803"}],"value":"Berkeley","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000000803"}]},{"referenceNumber":3,"citation":{"id":"29604224","citationType":"journal article","authors":["Seong E.","Insolera R.","Dulovic M.","Kamsteeg E.J.","Trinh J.","Brueggemann N.","Sandford E.","Li S.","Ozel A.B.","Li J.Z.","Jewett T.","Kievit A.J.A.","Muenchau A.","Shakkottai V.","Klein C.","Collins C.A.","Lohmann K.","van de Warrenburg B.P.","Burmeister M."],"citationCrossReferences":[{"database":"PubMed","id":"29604224"},{"database":"DOI","id":"10.1002/ana.25220"}],"title":"Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects.","publicationDate":"2018","journal":"Ann. Neurol.","firstPage":"1075","lastPage":"1088","volume":"83"},"referencePositions":["DISRUPTION PHENOTYPE"]},{"referenceNumber":4,"citation":{"id":"29307555","citationType":"journal article","authors":["Anding A.L.","Wang C.","Chang T.K.","Sliter D.A.","Powers C.M.","Hofmann K.","Youle R.J.","Baehrecke E.H."],"citationCrossReferences":[{"database":"PubMed","id":"29307555"},{"database":"DOI","id":"10.1016/j.cub.2017.11.064"}],"title":"Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance.","publicationDate":"2018","journal":"Curr. Biol.","firstPage":"287","lastPage":"295","volume":"28"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DOMAIN","DISRUPTION PHENOTYPE","MUTAGENESIS OF PHE-2308"],"evidences":[{"evidenceCode":"ECO:0000305"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AE014296","properties":[{"key":"ProteinId","value":"AAF49887.3"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_729825.2","properties":[{"key":"NucleotideSequenceId","value":"NM_168512.4"}]},{"database":"SMR","id":"Q9VU08","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9VU08","properties":[{"key":"Number of interactors","value":"1031"}]},{"database":"IntAct","id":"Q9VU08","properties":[{"key":"Interactions","value":"7"}]},{"database":"STRING","id":"7227.FBpp0271898","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9VU08","properties":[{"key":"glycosylation","value":"3 sites, 1 O-linked glycan (2 sites)"}]},{"database":"PaxDb","id":"7227-FBpp0271898","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9VU08","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"FBtr0273390","properties":[{"key":"ProteinId","value":"FBpp0271898"},{"key":"GeneId","value":"FBgn0052113"}]},{"database":"GeneID","id":"39448","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dme:Dmel_CG32113","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"CG32113-RB","properties":[{"key":"OrganismName","value":"d. melanogaster"}]},{"database":"AGR","id":"FB:FBgn0052113","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"55187","properties":[{"key":"Description","value":"-"}]},{"database":"FlyBase","id":"FBgn0052113","properties":[{"key":"GeneName","value":"Vps13D"}]},{"database":"VEuPathDB","id":"VectorBase:FBgn0052113","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1796","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_000131_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9VU08","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"IEFVMDQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"272810at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9VU08","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q9VU08","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"39448","properties":[{"key":"hits","value":"0 hits in 1 CRISPR screen"}]},{"database":"GenomeRNAi","id":"39448","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9VU08","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000803","properties":[{"key":"Component","value":"Chromosome 3L"}]},{"database":"Bgee","id":"FBgn0052113","properties":[{"key":"ExpressionPatterns","value":"Expressed in indirect flight muscle cell (Drosophila) in body wall and 127 other cell types or tissues"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29307555"}]},{"database":"GO","id":"GO:0010008","properties":[{"key":"GoTerm","value":"C:endosome membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005764","properties":[{"key":"GoTerm","value":"C:lysosome"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29307555"}]},{"database":"GO","id":"GO:0005741","properties":[{"key":"GoTerm","value":"C:mitochondrial outer membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0070530","properties":[{"key":"GoTerm","value":"F:K63-linked polyubiquitin modification-dependent protein binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29307555"}]},{"database":"GO","id":"GO:0120014","properties":[{"key":"GoTerm","value":"F:phospholipid transfer activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0043130","properties":[{"key":"GoTerm","value":"F:ubiquitin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29307555"}]},{"database":"GO","id":"GO:0120009","properties":[{"key":"GoTerm","value":"P:intermembrane lipid transfer"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016236","properties":[{"key":"GoTerm","value":"P:macroautophagy"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007005","properties":[{"key":"GoTerm","value":"P:mitochondrion organization"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29307555"}]},{"database":"GO","id":"GO:0000423","properties":[{"key":"GoTerm","value":"P:mitophagy"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29307555"}]},{"database":"GO","id":"GO:0061709","properties":[{"key":"GoTerm","value":"P:reticulophagy"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"37633267"}]},{"database":"CDD","id":"cd23453","properties":[{"key":"EntryName","value":"beta-trefoil_Ricin_VPS13D"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd14306","properties":[{"key":"EntryName","value":"UBA_VP13D"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR041969","properties":[{"key":"EntryName","value":"VP13D_UBA"}]},{"database":"InterPro","id":"IPR026847","properties":[{"key":"EntryName","value":"VPS13"}]},{"database":"InterPro","id":"IPR056747","properties":[{"key":"EntryName","value":"VPS13-like_M"}]},{"database":"InterPro","id":"IPR026854","properties":[{"key":"EntryName","value":"VPS13_N"}]},{"database":"InterPro","id":"IPR009543","properties":[{"key":"EntryName","value":"VPS13_VAB"}]},{"database":"PANTHER","id":"PTHR16166:SF141","properties":[{"key":"EntryName","value":"INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16166","properties":[{"key":"EntryName","value":"VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25033","properties":[{"key":"EntryName","value":"VPS13_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12624","properties":[{"key":"EntryName","value":"VPS13_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25036","properties":[{"key":"EntryName","value":"VPS13_VAB"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLRDLITWVLNTYLGKYLENLNSAQLSVALLSGEVELENIPIRKDALRSFNLPVEVTAGSIRKIKLQIPVRQFRTSPWCISIEGLFCIICPKNLDNWDYEKEKLQDLEYKLAVLDTAEAGWRSEKGKQMESYYFSSYNNWLKYGTNMATNIIDNIELKISDVHFRFEDIVDTGKSKICTGIKIGSLTAQSCDCDWTNGSYKMNNNEMNYKLVELKELSVYWDLLHEDIKCQSYSNQEILEKMHSTCELRSHNFIIKPICATARWKRDKCQQVIRTKDKPRVSCELLVPEVVIDISKVQRLQMLDKLSEIRQVKEVRQYRLKRPTCTVESNPIAWWKYATICHGFDFKKNEEKWLMLKENLRYMLLYKSIILNPNENLSAADKEFKAYIESDRKISDLTIMRRICFEKVFTKGFAFESQNEQGKNMLFHWFPNWMGWYANSPSTPNNEQDESLKHLEDDILVALENSLQNSSDLKSDAVFGHFSIKLLKGLVILQTEDKLNDGRNKSMEMQFNNFSAYLQLSPQLTSYTVGISLQEVYLIDKTSSDTMHNYLIKPQTGNTATPNQLVKNAALQEDILFQLQYENCNHLRFQLNIKSKGLDLIYNEDAIQWLLDFLADSNSFKYSPRNRVAKKTDFMKNWNEMFSGNEVNRKIWMFEIEIFAPRIIFLENYKVSNSLMVLLDFGKLEMRKMEVKRVIPVIESAVTENTSDDDETYLTPCSTPPASEKSGSESPTLLENPKTESFLNKNVQLEYVLHNKIYDKYLINFTNLQVLVCKYEERWQACLKTSSNFHLIDKFNINLTLEQRNIFTVDPEYPSFMLFGTCPTILIHGNEELINNCCNIMKPIIKASKEMENIYRGGNTIYASERIKNLAEDDRSRVVIEFVMDQLVIEMQSTERSIAELQIIGARAGLTKEPHETNISMSVHGLLLVDAIQSFGPDFELLVASHRHVGMDSLSGSLKHSAIVSPTSPGSPNFFDRATSPHMITKAVQNIKMGDRSTEFCDDEDSTALISVDIKIVPPNESNSMQLHTTSITFNSLDIIANQDTIIEILNFAKRTLLAQNIFPSESPESPKEATEAPVDVVDQVDHKSHNEIFFDFFRLNILLLYTIKRDKFNVGRKVGTVTLTEAKINASFQSDLSIIGSLGGIQVIDITSEAFCHPRILSVGRDQILRASDTNKQTVLSQLSNEIYSNNYNEETKSDESDAISFQSHWSDKTTCTFQMRMASASYTHCPRFLRDVNACITYFKRSLREFATSIGNKATDMAKEFVQQVRAVEQIGPVYPQRNRQDNWLDIIISSPIIILPISNTSTNVLIANLGKISCSNAVKCDSDEFNESYTIEIKNTYVYSLNIDEGEYSFNVHPAKNKDAIPILHDTAITLQLYAGYSDDNDEDKQLNRFSIKGSMVEALKVSLNRKQYELLLESIRYATNFSNEVLNESDELDQNGDIEPTANIDAESIISTTIQFSVPVFQINLQNEYHNDLINLTFKNFNVKHISKGFDKDVEVVLKSVLMEDLKSDLTSPFRNMVTSVDLEQKIKKNEMTSSSCPDLPSYCNSLKNRSSSVPSCFYNHMQVKVFGGDQKYTSSNKNELGKKKESQTLVIYKSHTGRSAQNGKLEQTSSIQFNCLNLAICVERWYTIFDFFGLVSVDNVNEKYPEEMKLVEKHIDKVCSKLKVSIRSFNFTLIRNESLLSRVNVSNAVFMILQDPYSKIVEGCLGSVSVNDLTKYGNIYKQKFLTSGTEALNFVYKKKLVDLEALNTLDTDSTLRINMSAVHYIHTKRFSTELHVFVKDLLQLQTPVIRKLKKHGSEQNMRPSKMKLVIQADSPVIVLPSSYNRNEVIIAYLGQFSLKNSFHFASDNNIISKMSATPSKDEILDVMRIDLVNINLFSGERSSMKAKADQEKDRIIIADMNFLRLGQPFFNESCFLHLQLERNLSADAHRVCPDISVQGTFSKLSGIINIQQYKLIRSFLNNNIGEQTDDIYMNYHNNSCTSIERLSTINLMPKNEVSKIVSILISIRILLEDVSLLLALNTSQSAAIEPLACIHFLKSTLEIDLFSDGSQDIDLISSNILIVDERNESDKSNENVFKNILEPSKKEVRIENSVQVEVHCRKKATFSKYTIMLNNMRVFALLSFLDQLKSYLQEDSPAPVVNNAANQIAQKPQIDTSISTEYVVNITDSEIIFAEECSRLDSNAIILKSTTVICYKPNSNIVPLSLDINHLEIFSCTLDAEEESALSIIDPFTLIIELRSNCLNILIQKHLNIRLSYVDVKLFSRMARLLPTQTSRPKNVISKADSDLEKAAPLVAMGFEISDCLYAMQINNWRINDAAIWLSQQKQNTYRNPALEMKTAVVDASLISVFIIDDCMDADVPLLEVSLSKFLLNFTFQTQDPNPKETNIRHYSLGNIDTEVSVNYYNRRLSGWEPVAETWESNLNWKYTKGHLDNKKRFEIGISSKQMLKLNVTSTFIELFHMVLKNWTNDFNDNGAKNFRQRSPFIPFALQNLSGTPLLFKPIYAPLGDLTRSDLQQVELIKNWYSVQPNETKTFDFSQKSKLRHVHSHQLNLHQIFVQIHGWTLIGPISVDKVGMFFRTTKLDSQFLTKSRIVFDISLIGSAQKLIKVKSSLGVINKLDRNVFLKMTLKGTHSDGLSSISVIKPNDELSVPLKFIDASLYVAHNTSESDAYEDTGFSNEEILWKACGKDDTRQLLAGYDTNKSILYTFVNISREIYHCKEQNLPGHKITLLPPLKINNMLCCDLMFKIHEHATGRINSSESVNIYNVNICQPLNLSITLDNFQLSGQLKIPVSHRGVIEPKLKLIDIQKRELHVRVSIQSVPGKGMELYISAPVWIINKTGLPLIYKQEGTSHTAAGQFEEHETARQVAPLMFSFSDQEGSPALVLRLGKAYGSNNMWCKSFSTHKDLADRDLRAENTKGSYAIGISVRRGRGLYACTTFVTLSPRFHLHNRSGYKLEFMQLCDIVNYDRPDPRKIISAPVDCNFAFHWPNWDQEQIICVRIPEIECCCWSKGIPIKDVQSLYINVRNEWGEMFFLRLEIISKDATFILLFTDARTLPPPIRIDNCSEVVINFSQLRSKPVWITPVRPQSSLSYVMDDPLGQQILLMEAPGGNMIEFPINNKNNIKKTLTYTNFIYIAFQGTFERSNEEENTHRQLVLGVRGKKVVIVEKNSGDRSQLWLMNSNGQLEHEGSTPPIQTNDANAVRLVLDLEKAPNPMEFTNLVVRTPNKQRVTTQTWRFENGRLMCHANMCVQSRFGESGLKPNYEAVVGRTENRASSSKQIPIGQHIVAQKLRPGSGQLELSTKMDGPISTIEICDIKIKQNSVFLTPDLLWMHASLNNRQITDKGKVSFVHEYLINVELVKGIGISIIARKPCEEIMFISLDHINCDIVQSALENSLDLNIAYIQIDNQLLDAVSPIALHTQTSNDLEETQNAVVLKLKMLPSPNKNAIIFKYLTLDLKPSTASLEEKLILKVASFLGYGKINRQNLSVQYQFENTDDKPFLQDMKRYYFENLSIGATQVRLSAFTSSKLPVELHETKKALGLTLIKFEDALIELDRYSDKLHFETMDVYRKELKKHYINQVKWHAAAILGSVDFLGNPLGFANDLSEGVSGLIFEGSVKSLVKNVTHGISNSTAKLTETLSDSLGKVVLDDHDNETRQRILELQSNTSGGHLAAGLKGLGFGLLGGVTSIVRHTYDGATSDGVPGFLSGLGKGLVGTVTKPIIGVLDLASETASAVRETSRDSHRNAPERKRLPRCVTGAPGGLLPLYSNRQSKGQQYLYLINQKNFSEKIISYEPNLWSDKEARLRLLVSTEYVRIFSLSDANPTIMFECHVSEILSCHPVVTNAGTTPTTSSRASASHYIEISTNLPKITRPRIRCRSEECAEAASRCINYAKSVFDEREHAVL","length":3919,"molWeight":445040,"crc64":"B2F6CD3B6373005F","md5":"88B4F417FE20CD1D311EC50B256D8E29"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DOMAIN":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Mutagenesis":1},"uniParcId":"UPI0001914953"}}