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During spermatogenesis, also regulates distal elongation of the basal-body and their docking (anchoring) to the plasma membrane and as a consequence, regulates the initiation and proper elongation of axonemal microtubules (PubMed:31821146). Within the complex, required to recruit or stabilize Cby at the distal basal body of cilia to promote DZIP1-mediated early ciliary membrane formation and initiate TZ assembly (PubMed:31821146, PubMed:33370260). May also act with Dzip1 to restrict Cep290 localization to the proximal part of the TZ (PubMed:31821146). May also be involved in recruitment or stabilization of Mks1 at the TZ (PubMed:31821146)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31821146"}],"value":"Component of a ciliary transition zone (TZ)-localized complex composed of DZIP1, Fam92 and Cby (PubMed:31821146). 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Localizes at the centriolar distal ends of early spermatocytes and in elongating spermatids, when the TZ migrates away from the basal body, localizes at the ring centriole (PubMed:31821146)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31821146"}],"value":"Cytoplasm, cytoskeleton, cilium basal body","id":"SL-0087"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31821146"}],"value":"In neurons of the second and third antennal segments, expressed at the tip of the dendrites"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31821146"}],"value":"Viable but displays adherent transition zone (TZ) assembly in sensory neurons and spermatocytes (PubMed:31821146). Consequently, adults display phenotypes associated with ciliary dysfunction and disorganization, such as reduced geotaxis response and decreased male fertility (PubMed:31821146). Some mutants also display, reduced scolopidia cilia number, deformed axonemes, excess accumulation of material beneath the ciliary membrane and deformation of the ciliary membrane (PubMed:31821146). In spermatocytes, some centrioles are undocked and display irregular distal ends or microtubules extending from the distal ends (PubMed:31821146). Dzip expression is slightly reduced and in spermatocytes, Mks1 is lost or reduced at the cilliary transition zone and Cby is completely lost at the tip of the centrioles (PubMed:31821146)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CIBAR family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"CBY1-interacting BAR domain-containing protein homolog","featureId":"PRO_0000452642"},{"type":"Region","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"Acidic 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