{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9VFS5","secondaryAccessions":["Q8MSX6"],"uniProtkbId":"PP4R3_DROME","entryAudit":{"firstPublicDate":"2008-12-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-05-05","entryVersion":165,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Drosophila melanogaster","commonName":"Fruit fly","taxonId":7227,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Diptera","Brachycera","Muscomorpha","Ephydroidea","Drosophilidae","Drosophila","Sophophora"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Serine/threonine-protein phosphatase 4 regulatory subunit 3"},"shortNames":[{"value":"PP4R3"}]},"alternativeNames":[{"fullName":{"value":"Protein falafel"}}]},"genes":[{"geneName":{"value":"flfl"},"orfNames":[{"value":"CG9351"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16085932"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18487071"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19204120"}],"value":"Regulatory subunit of serine/threonine-protein phosphatase 4. The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro). May be involved in DNA damage repair. Key mediator specific for the localization of mira and associated cell fate determinants during both interphase and mitosis. Nuclear Flfl is required to exclude mira/pros from the nucleus when inefficiently bound to the cytoskeleton/cortex, whereas cytosolic or membrane-associated flfl is required for the cortical association and asymmetric localization of mira/pros/brat/stau at metaphase and anaphase"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19204120"}],"value":"Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Probably part of a PP4 PPP4C-PPP4R2-PPP4R3 complex containing Pp4-19C, PPP4R2r and flfl. Interacts with mira"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Predominantly nuclear during interphase/prophase and cytoplasmic after nuclear envelope breakdown"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19204120"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19204120"}],"value":"Membrane","id":"SL-0162"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19204120"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"B"},"isoformIds":["Q9VFS5-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"D"},"isoformIds":["Q9VFS5-2"],"sequenceIds":["VSP_037302"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19204120"}],"value":"Expressed in neuroblasts"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16085932"}],"value":"Mutant larvae exhibit hypersensitivity to the anticancer drug cisplatin"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SMEK family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":980,"modifier":"EXACT"}},"description":"Serine/threonine-protein phosphatase 4 regulatory subunit 3","featureId":"PRO_0000355974"},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"WH1"},{"type":"Region","location":{"start":{"value":640,"modifier":"EXACT"},"end":{"value":668,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":695,"modifier":"EXACT"},"end":{"value":861,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":885,"modifier":"EXACT"},"end":{"value":980,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":695,"modifier":"EXACT"},"end":{"value":708,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":709,"modifier":"EXACT"},"end":{"value":749,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":757,"modifier":"EXACT"},"end":{"value":789,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":803,"modifier":"EXACT"},"end":{"value":859,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":885,"modifier":"EXACT"},"end":{"value":926,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":929,"modifier":"EXACT"},"end":{"value":939,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":940,"modifier":"EXACT"},"end":{"value":951,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":953,"modifier":"EXACT"},"end":{"value":968,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":651,"modifier":"EXACT"},"end":{"value":657,"modifier":"EXACT"}},"description":"in isoform D","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12537569"}],"featureId":"VSP_037302","alternativeSequence":{}},{"type":"Beta strand","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WSF"}]},{"type":"Beta strand","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WSF"}]},{"type":"Helix","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WSF"}]},{"type":"Beta strand","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WSF"}]},{"type":"Turn","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WSF"}]},{"type":"Beta strand","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WSF"}]},{"type":"Beta strand","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WSF"}]},{"type":"Turn","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WSF"}]},{"type":"Beta strand","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WSF"}]},{"type":"Beta strand","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WSF"}]},{"type":"Helix","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WSF"}]},{"type":"Beta strand","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WSF"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10731132","citationType":"journal article","authors":["Adams M.D.","Celniker S.E.","Holt R.A.","Evans C.A.","Gocayne J.D.","Amanatides P.G.","Scherer S.E.","Li P.W.","Hoskins R.A.","Galle R.F.","George R.A.","Lewis S.E.","Richards S.","Ashburner M.","Henderson S.N.","Sutton G.G.","Wortman J.R.","Yandell M.D.","Zhang Q.","Chen L.X.","Brandon R.C.","Rogers Y.-H.C.","Blazej R.G.","Champe M.","Pfeiffer B.D.","Wan K.H.","Doyle C.","Baxter E.G.","Helt G.","Nelson C.R.","Miklos G.L.G.","Abril J.F.","Agbayani A.","An H.-J.","Andrews-Pfannkoch C.","Baldwin D.","Ballew R.M.","Basu A.","Baxendale J.","Bayraktaroglu L.","Beasley E.M.","Beeson K.Y.","Benos P.V.","Berman B.P.","Bhandari D.","Bolshakov S.","Borkova D.","Botchan M.R.","Bouck J.","Brokstein P.","Brottier P.","Burtis K.C.","Busam D.A.","Butler H.","Cadieu E.","Center A.","Chandra I.","Cherry J.M.","Cawley S.","Dahlke C.","Davenport L.B.","Davies P.","de Pablos B.","Delcher A.","Deng Z.","Mays A.D.","Dew I.","Dietz S.M.","Dodson K.","Doup L.E.","Downes M.","Dugan-Rocha S.","Dunkov B.C.","Dunn P.","Durbin K.J.","Evangelista C.C.","Ferraz C.","Ferriera S.","Fleischmann W.","Fosler C.","Gabrielian A.E.","Garg N.S.","Gelbart W.M.","Glasser K.","Glodek A.","Gong F.","Gorrell J.H.","Gu Z.","Guan P.","Harris M.","Harris N.L.","Harvey D.A.","Heiman T.J.","Hernandez J.R.","Houck J.","Hostin D.","Houston K.A.","Howland T.J.","Wei M.-H.","Ibegwam C.","Jalali M.","Kalush F.","Karpen G.H.","Ke Z.","Kennison J.A.","Ketchum K.A.","Kimmel B.E.","Kodira C.D.","Kraft C.L.","Kravitz S.","Kulp D.","Lai Z.","Lasko P.","Lei Y.","Levitsky A.A.","Li J.H.","Li Z.","Liang Y.","Lin X.","Liu X.","Mattei B.","McIntosh T.C.","McLeod M.P.","McPherson D.","Merkulov G.","Milshina N.V.","Mobarry C.","Morris J.","Moshrefi A.","Mount S.M.","Moy M.","Murphy B.","Murphy L.","Muzny D.M.","Nelson D.L.","Nelson D.R.","Nelson K.A.","Nixon K.","Nusskern D.R.","Pacleb J.M.","Palazzolo M.","Pittman G.S.","Pan S.","Pollard J.","Puri V.","Reese M.G.","Reinert K.","Remington K.","Saunders R.D.C.","Scheeler F.","Shen H.","Shue B.C.","Siden-Kiamos I.","Simpson M.","Skupski M.P.","Smith T.J.","Spier E.","Spradling A.C.","Stapleton M.","Strong R.","Sun E.","Svirskas R.","Tector C.","Turner R.","Venter E.","Wang A.H.","Wang X.","Wang Z.-Y.","Wassarman D.A.","Weinstock G.M.","Weissenbach J.","Williams S.M.","Woodage T.","Worley K.C.","Wu D.","Yang S.","Yao Q.A.","Ye J.","Yeh R.-F.","Zaveri J.S.","Zhan M.","Zhang G.","Zhao Q.","Zheng L.","Zheng X.H.","Zhong F.N.","Zhong W.","Zhou X.","Zhu S.C.","Zhu X.","Smith H.O.","Gibbs R.A.","Myers E.W.","Rubin G.M.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"10731132"},{"database":"DOI","id":"10.1126/science.287.5461.2185"}],"title":"The genome sequence of Drosophila melanogaster.","publicationDate":"2000","journal":"Science","firstPage":"2185","lastPage":"2195","volume":"287"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"12537572","citationType":"journal article","authors":["Misra S.","Crosby M.A.","Mungall C.J.","Matthews B.B.","Campbell K.S.","Hradecky P.","Huang Y.","Kaminker J.S.","Millburn G.H.","Prochnik S.E.","Smith C.D.","Tupy J.L.","Whitfield E.J.","Bayraktaroglu L.","Berman B.P.","Bettencourt B.R.","Celniker S.E.","de Grey A.D.N.J.","Drysdale R.A.","Harris N.L.","Richter J.","Russo S.","Schroeder A.J.","Shu S.Q.","Stapleton M.","Yamada C.","Ashburner M.","Gelbart W.M.","Rubin G.M.","Lewis S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537572"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0083"}],"title":"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0083.1","lastPage":"RESEARCH0083.22","volume":"3"},"referencePositions":["GENOME REANNOTATION","ALTERNATIVE SPLICING"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"12537569","citationType":"journal article","authors":["Stapleton M.","Carlson J.W.","Brokstein P.","Yu C.","Champe M.","George R.A.","Guarin H.","Kronmiller B.","Pacleb J.M.","Park S.","Wan K.H.","Rubin G.M.","Celniker S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537569"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0080"}],"title":"A Drosophila full-length cDNA resource.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0080.1","lastPage":"RESEARCH0080.8","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D)"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"},{"value":"Embryo","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"16085932","citationType":"journal article","authors":["Gingras A.-C.","Caballero M.","Zarske M.","Sanchez A.","Hazbun T.R.","Fields S.","Sonenberg N.","Hafen E.","Raught B.","Aebersold R."],"citationCrossReferences":[{"database":"PubMed","id":"16085932"},{"database":"DOI","id":"10.1074/mcp.m500231-mcp200"}],"title":"A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.","publicationDate":"2005","journal":"Mol. Cell. Proteomics","firstPage":"1725","lastPage":"1740","volume":"4"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]},{"referenceNumber":5,"citation":{"id":"19204120","citationType":"journal article","authors":["Sousa-Nunes R.","Chia W.","Somers W.G."],"citationCrossReferences":[{"database":"PubMed","id":"19204120"},{"database":"DOI","id":"10.1101/gad.1723609"}],"title":"Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions.","publicationDate":"2009","journal":"Genes Dev.","firstPage":"359","lastPage":"372","volume":"23"},"referencePositions":["FUNCTION","SUBUNIT","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":6,"citation":{"id":"18487071","citationType":"journal article","authors":["Martin-Granados C.","Philp A.","Oxenham S.K.","Prescott A.R.","Cohen P.T.W."],"citationCrossReferences":[{"database":"PubMed","id":"18487071"},{"database":"DOI","id":"10.1016/j.biocel.2008.03.021"}],"title":"Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases.","publicationDate":"2008","journal":"Int. J. Biochem. Cell Biol.","firstPage":"2315","lastPage":"2332","volume":"40"},"referencePositions":["PROBABLE COMPONENT OF A COMPLEX WITH PP4-19C AND PPP4R2R","FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AE014297","properties":[{"key":"ProteinId","value":"AAF54974.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AE014297","properties":[{"key":"ProteinId","value":"AAN13587.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY118508","properties":[{"key":"ProteinId","value":"AAM49877.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_650304.2","properties":[{"key":"NucleotideSequenceId","value":"NM_142047.4"}],"isoformId":"Q9VFS5-2"},{"database":"RefSeq","id":"NP_731849.2","properties":[{"key":"NucleotideSequenceId","value":"NM_169548.3"}],"isoformId":"Q9VFS5-1"},{"database":"RefSeq","id":"NP_731850.2","properties":[{"key":"NucleotideSequenceId","value":"NM_169549.2"}],"isoformId":"Q9VFS5-1"},{"database":"PDB","id":"4WSF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=2-123"}]},{"database":"PDBsum","id":"4WSF","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9VFS5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9VFS5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"66755","properties":[{"key":"Interactions","value":"12"}]},{"database":"FunCoup","id":"Q9VFS5","properties":[{"key":"Number of interactors","value":"2664"}]},{"database":"IntAct","id":"Q9VFS5","properties":[{"key":"Interactions","value":"2"}]},{"database":"STRING","id":"7227.FBpp0311112","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9VFS5","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"PaxDb","id":"7227-FBpp0311112","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9VFS5","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"41675","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"FBtr0082817","properties":[{"key":"ProteinId","value":"FBpp0082285"},{"key":"GeneId","value":"FBgn0024555"}]},{"database":"EnsemblMetazoa","id":"FBtr0344783","properties":[{"key":"ProteinId","value":"FBpp0311112"},{"key":"GeneId","value":"FBgn0024555"}]},{"database":"GeneID","id":"41675","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dme:Dmel_CG9351","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"CG9351-RB","properties":[{"key":"OrganismName","value":"d. melanogaster"}],"isoformId":"Q9VFS5-1"},{"database":"UCSC","id":"CG9351-RD","properties":[{"key":"OrganismName","value":"d. melanogaster"}]},{"database":"AGR","id":"FB:FBgn0024555","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"41675","properties":[{"key":"Description","value":"-"}]},{"database":"FlyBase","id":"FBgn0024555","properties":[{"key":"GeneName","value":"flfl"}]},{"database":"VEuPathDB","id":"VectorBase:FBgn0024555","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2175","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"Q9VFS5","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ALMTHNN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"27483at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9VFS5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"41675","properties":[{"key":"hits","value":"0 hits in 3 CRISPR screens"}]},{"database":"EvolutionaryTrace","id":"Q9VFS5","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"41675","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9VFS5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000803","properties":[{"key":"Component","value":"Chromosome 3R"}]},{"database":"Bgee","id":"FBgn0024555","properties":[{"key":"ExpressionPatterns","value":"Expressed in wing disc and 267 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9VFS5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000775","properties":[{"key":"GoTerm","value":"C:chromosome, centromeric region"},{"key":"GoEvidenceType","value":"IPI:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"25562660"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19204120"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19204120"}]},{"database":"GO","id":"GO:0030289","properties":[{"key":"GoTerm","value":"C:protein phosphatase 4 complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18487071"}]},{"database":"GO","id":"GO:0072542","properties":[{"key":"GoTerm","value":"F:protein phosphatase activator activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0055059","properties":[{"key":"GoTerm","value":"P:asymmetric neuroblast division"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19204120"}]},{"database":"GO","id":"GO:0045175","properties":[{"key":"GoTerm","value":"P:basal protein localization"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19204120"}]},{"database":"GO","id":"GO:0006974","properties":[{"key":"GoTerm","value":"P:DNA damage response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006281","properties":[{"key":"GoTerm","value":"P:DNA repair"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16085932"}]},{"database":"GO","id":"GO:0061060","properties":[{"key":"GoTerm","value":"P:negative regulation of peptidoglycan recognition protein signaling pathway"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"34452932"}]},{"database":"GO","id":"GO:2000779","properties":[{"key":"GoTerm","value":"P:regulation of double-strand break repair"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"FunFam","id":"2.30.29.30:FF:000051","properties":[{"key":"EntryName","value":"Serine/threonine-protein phosphatase 4 regulatory subunit 3B"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016024","properties":[{"key":"EntryName","value":"ARM-type_fold"}]},{"database":"InterPro","id":"IPR055236","properties":[{"key":"EntryName","value":"EVH1_PP4R3"}]},{"database":"InterPro","id":"IPR006887","properties":[{"key":"EntryName","value":"P4R3-like_central_dom"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR051137","properties":[{"key":"EntryName","value":"PP4R3-like"}]},{"database":"PANTHER","id":"PTHR23318","properties":[{"key":"EntryName","value":"ATP SYNTHASE GAMMA-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23318:SF0","properties":[{"key":"EntryName","value":"SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22972","properties":[{"key":"EntryName","value":"EVH1_PP4R3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04802","properties":[{"key":"EntryName","value":"PP4R3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48371","properties":[{"key":"EntryName","value":"ARM repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTDTRRRVKLYALNAERQWDDRGTGHVSSTYVERLKGISLLVRAESDGSLLLESKIQPDTAYQKQQDTLIVWSEGDNFDLALSFQEKAGCDEIWEKICQVQGKDPSVEITQDIVEESEDERFEDMSDTAPPIELPPCELSRLEDISETIQSCLSTPLRKEKLSMALESESYIKKLLNLFHVCEDLDNTEGLHHLFEIFKNIFLLNKNALFEIMFADDTIFDVVGCLEYDPSVSQPKKHRQYLKQLAKFREAVPIKNLDLLAKIHQTFRVQYIQDIILPTPSVFVEDNMLNTLSSFIFFNKVEIVTMIQDDERYLLDVFAVLTDPTTGDAKRRDTVLFLKEFCNYAQNLQPQGKDSFYKTLTCLGILQALELTLVMNDKKTKSASIDILTAIVEFSPLVVRNYTLNQANRPEVERMLLNIAIEQMLNDSEPELGIAVQLMGIVKILLEPENMLTEKGDFLNFFYKYSVQTLVAPVILNTIGDRPQNEDYQTAQLLGIVLDILSFCVEHHSYHIKNFLLQKDLLKRILVLMKSTHTFLVLGALRLLRKIIALKDEFYNRHIVKCNLFAPVVDAFIRNNGRYNLLESAILELFEFIKLEDIRTLCVYFVENFSKIFDEIEYVQTFKYLKNRYDQYQDRLKDRDKMENRTDGGLPIIRSGGRFRRDQRQMEEEEEMWFNEEDDFTEEIDTYNNVMKSVSEKNGPQTQNQQKSSPPHSTSPHSGLLGSLSTTASSTATSATSGAPVASGSSSPEAISADEQTQAAVHLAAAALQHHQQQQQQQQQNPFQQQTQPEIAELQQQLSSVEAPQSQELELSQSAAASASPTSSSSSLEASTSSSSASSSSSSSSSSSPPGSSAAASLCDSATVAAVAASQFLSTIATAMAASVTAAAATNSSPSISPAPAVSSPDIENADAQLPPSDDASSPASGEQDANSTEGTSSEADKTTAKKGLVDYESDSGEDDYEEDEYSEGPQAQKRARQA","length":980,"molWeight":109295,"crc64":"ACD1835AB3CF3481","md5":"3305117FDF4C1D028F91749A56B3D5AD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":3,"Compositional bias":8,"Alternative sequence":1,"Beta strand":8,"Helix":2,"Turn":2},"uniParcId":"UPI00001E2108"}}