{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9VF87","secondaryAccessions":["Q6NP16","Q8MR06"],"uniProtkbId":"CYFIP_DROME","entryAudit":{"firstPublicDate":"2007-03-06","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-01","entryVersion":155,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Drosophila melanogaster","commonName":"Fruit fly","taxonId":7227,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Diptera","Brachycera","Muscomorpha","Ephydroidea","Drosophilidae","Drosophila","Sophophora"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11438699"}],"value":"Cytoplasmic FMR1-interacting protein"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.2"}],"value":"Specifically Rac1-associated protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11438699"}],"value":"Cyfip"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAF55173.1"},{"evidenceCode":"ECO:0000312","source":"FlyBase","id":"FBgn0038320"}],"value":"Sra-1"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"FlyBase","id":"FBgn0038320"}],"value":"CG4931"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12818175"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14588242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15269173"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385157"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32200800"}],"value":"Plays a role in guidance and morphology of central and peripheral axons and in synaptic morphology. Also required for formation of cell membrane protrusions and for bristle development (PubMed:12818175, PubMed:14588242, PubMed:15269173, PubMed:15385157). Plays a role in regulating mitochondrial activity, energy metabolism and membrane potential which maintains normal gamma-aminobutyric acid (GABA) signaling and ensures normal social behavior (PubMed:32200800)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12818175"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15269173"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385157"}],"value":"Interacts with Fmr1 and Rac1. Component of the WAVE complex composed of Hem/Kette, Scar/Wave and Cyfip where it binds through its C-terminus directly to Hem"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9VF87","intActId":"EBI-116862"},"interactantTwo":{"uniProtKBAccession":"Q24150","geneName":"Nap1","intActId":"EBI-603430"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12818175"}],"value":"Accumulates in central axons and motor neuron terminals"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12818175"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12818175"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15269173"}],"value":"In the embryo, expressed mainly in the gut and in the developing central nervous system where high levels of expression are found in the CNS neuropile. Expression in the gut diminishes as development proceeds (at protein level). In the adult, expressed specifically in the nervous system"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12818175"}],"value":"Expressed throughout the life cycle with no major peaks of expression. In the embryo, uniquitously and highly expressed at precellular and cellular blastoderm stages"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12818175"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14588242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15269173"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32200800"}],"value":"Flies display pupal lethality with defects in axon growth, branching and pathfinding, synaptic length and organization of the neuromuscular junction. They also display defects in cell morphology with cells exhibiting a starfish-like shape with multiple slender cell extensions and loss of actin filaments at the cell periphery (PubMed:12818175, PubMed:14588242, PubMed:15269173). RNAi-mediated knockdown in gamma-aminobutyric acid (GABA)ergic neurons, or specifically in the anterior paired lateral (APL) neurons or in the antennal lobe local interneurons (LNs), results in feeding-dependent socialization defects (PubMed:32200800)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Belongs to the CYFIP family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAM52715.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1291,"modifier":"EXACT"}},"description":"Cytoplasmic FMR1-interacting protein","featureId":"PRO_0000279714"},{"type":"Region","location":{"start":{"value":1270,"modifier":"EXACT"},"end":{"value":1291,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1271,"modifier":"EXACT"},"end":{"value":1291,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11438699","citationType":"journal article","authors":["Schenck A.","Bardoni B.","Moro A.","Bagni C.","Mandel J.-L."],"citationCrossReferences":[{"database":"PubMed","id":"11438699"},{"database":"DOI","id":"10.1073/pnas.151231598"}],"title":"A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.","publicationDate":"2001","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"8844","lastPage":"8849","volume":"98"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAG61254.1"}]},{"referenceNumber":2,"citation":{"id":"CI-30JUSQ5TGTM77","citationType":"submission","authors":["Langmann C.","Harden N."],"title":"DSra-1 is an effector for DRac1 during Drosophila embryogenesis.","publicationDate":"APR-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"evidences":[{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAK31584.1"}]},{"referenceNumber":3,"citation":{"id":"10731132","citationType":"journal article","authors":["Adams M.D.","Celniker S.E.","Holt R.A.","Evans C.A.","Gocayne J.D.","Amanatides P.G.","Scherer S.E.","Li P.W.","Hoskins R.A.","Galle R.F.","George R.A.","Lewis S.E.","Richards S.","Ashburner M.","Henderson S.N.","Sutton G.G.","Wortman J.R.","Yandell M.D.","Zhang Q.","Chen L.X.","Brandon R.C.","Rogers Y.-H.C.","Blazej R.G.","Champe M.","Pfeiffer B.D.","Wan K.H.","Doyle C.","Baxter E.G.","Helt G.","Nelson C.R.","Miklos G.L.G.","Abril J.F.","Agbayani A.","An H.-J.","Andrews-Pfannkoch C.","Baldwin D.","Ballew R.M.","Basu A.","Baxendale J.","Bayraktaroglu L.","Beasley E.M.","Beeson K.Y.","Benos P.V.","Berman B.P.","Bhandari D.","Bolshakov S.","Borkova D.","Botchan M.R.","Bouck J.","Brokstein P.","Brottier P.","Burtis K.C.","Busam D.A.","Butler H.","Cadieu E.","Center A.","Chandra I.","Cherry J.M.","Cawley S.","Dahlke C.","Davenport L.B.","Davies P.","de Pablos B.","Delcher A.","Deng Z.","Mays A.D.","Dew I.","Dietz S.M.","Dodson K.","Doup L.E.","Downes M.","Dugan-Rocha S.","Dunkov B.C.","Dunn P.","Durbin K.J.","Evangelista C.C.","Ferraz C.","Ferriera S.","Fleischmann W.","Fosler C.","Gabrielian A.E.","Garg N.S.","Gelbart W.M.","Glasser K.","Glodek A.","Gong F.","Gorrell J.H.","Gu Z.","Guan P.","Harris M.","Harris N.L.","Harvey D.A.","Heiman T.J.","Hernandez J.R.","Houck J.","Hostin D.","Houston K.A.","Howland T.J.","Wei M.-H.","Ibegwam C.","Jalali M.","Kalush F.","Karpen G.H.","Ke Z.","Kennison J.A.","Ketchum K.A.","Kimmel B.E.","Kodira C.D.","Kraft C.L.","Kravitz S.","Kulp D.","Lai Z.","Lasko P.","Lei Y.","Levitsky A.A.","Li J.H.","Li Z.","Liang Y.","Lin X.","Liu X.","Mattei B.","McIntosh T.C.","McLeod M.P.","McPherson D.","Merkulov G.","Milshina N.V.","Mobarry C.","Morris J.","Moshrefi A.","Mount S.M.","Moy M.","Murphy B.","Murphy L.","Muzny D.M.","Nelson D.L.","Nelson D.R.","Nelson K.A.","Nixon K.","Nusskern D.R.","Pacleb J.M.","Palazzolo M.","Pittman G.S.","Pan S.","Pollard J.","Puri V.","Reese M.G.","Reinert K.","Remington K.","Saunders R.D.C.","Scheeler F.","Shen H.","Shue B.C.","Siden-Kiamos I.","Simpson M.","Skupski M.P.","Smith T.J.","Spier E.","Spradling A.C.","Stapleton M.","Strong R.","Sun E.","Svirskas R.","Tector C.","Turner R.","Venter E.","Wang A.H.","Wang X.","Wang Z.-Y.","Wassarman D.A.","Weinstock G.M.","Weissenbach J.","Williams S.M.","Woodage T.","Worley K.C.","Wu D.","Yang S.","Yao Q.A.","Ye J.","Yeh R.-F.","Zaveri J.S.","Zhan M.","Zhang G.","Zhao Q.","Zheng L.","Zheng X.H.","Zhong F.N.","Zhong W.","Zhou X.","Zhu S.C.","Zhu X.","Smith H.O.","Gibbs R.A.","Myers E.W.","Rubin G.M.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"10731132"},{"database":"DOI","id":"10.1126/science.287.5461.2185"}],"title":"The genome sequence of Drosophila melanogaster.","publicationDate":"2000","journal":"Science","firstPage":"2185","lastPage":"2195","volume":"287"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAF55173.1"}],"value":"Berkeley","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAF55173.1"}]},{"referenceNumber":4,"citation":{"id":"12537572","citationType":"journal article","authors":["Misra S.","Crosby M.A.","Mungall C.J.","Matthews B.B.","Campbell K.S.","Hradecky P.","Huang Y.","Kaminker J.S.","Millburn G.H.","Prochnik S.E.","Smith C.D.","Tupy J.L.","Whitfield E.J.","Bayraktaroglu L.","Berman B.P.","Bettencourt B.R.","Celniker S.E.","de Grey A.D.N.J.","Drysdale R.A.","Harris N.L.","Richter J.","Russo S.","Schroeder A.J.","Shu S.Q.","Stapleton M.","Yamada C.","Ashburner M.","Gelbart W.M.","Rubin G.M.","Lewis S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537572"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0083"}],"title":"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0083.1","lastPage":"RESEARCH0083.22","volume":"3"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAF55173.1"}]},{"referenceNumber":5,"citation":{"id":"CI-D92FP7GSOOE33","citationType":"submission","authors":["Stapleton M.","Brokstein P.","Hong L.","Agbayani A.","Carlson J.W.","Champe M.","Chavez C.","Dorsett V.","Dresnek D.","Farfan D.","Frise E.","George R.A.","Gonzalez M.","Guarin H.","Kronmiller B.","Li P.W.","Liao G.","Miranda A.","Mungall C.J.","Nunoo J.","Pacleb J.M.","Paragas V.","Park S.","Patel S.","Phouanenavong S.","Wan K.H.","Yu C.","Lewis S.E.","Rubin G.M.","Celniker S.E."],"publicationDate":"DEC-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1152"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAR82782.1"}],"value":"Berkeley","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAR82782.1"}],"value":"Embryo","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAK31584.1"}]},{"referenceNumber":6,"citation":{"id":"12537569","citationType":"journal article","authors":["Stapleton M.","Carlson J.W.","Brokstein P.","Yu C.","Champe M.","George R.A.","Guarin H.","Kronmiller B.","Pacleb J.M.","Park S.","Wan K.H.","Rubin G.M.","Celniker S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537569"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0080"}],"title":"A Drosophila full-length cDNA resource.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0080.1","lastPage":"RESEARCH0080.8","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 156-1291"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAM52715.1"}],"value":"Berkeley","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAM52715.1"}],"value":"Embryo","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAM52715.1"}]},{"referenceNumber":7,"citation":{"id":"14588242","citationType":"journal article","authors":["Kunda P.","Craig G.","Dominguez V.","Baum B."],"citationCrossReferences":[{"database":"PubMed","id":"14588242"},{"database":"DOI","id":"10.1016/j.cub.2003.10.005"}],"title":"Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions.","publicationDate":"2003","journal":"Curr. Biol.","firstPage":"1867","lastPage":"1875","volume":"13"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":8,"citation":{"id":"12818175","citationType":"journal article","authors":["Schenck A.","Bardoni B.","Langmann C.","Harden N.","Mandel J.-L.","Giangrande A."],"citationCrossReferences":[{"database":"PubMed","id":"12818175"},{"database":"DOI","id":"10.1016/s0896-6273(03)00354-4"}],"title":"CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.","publicationDate":"2003","journal":"Neuron","firstPage":"887","lastPage":"898","volume":"38"},"referencePositions":["FUNCTION","INTERACTION WITH FMR1 AND RAC1","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE","DISRUPTION PHENOTYPE"],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":9,"citation":{"id":"15385157","citationType":"journal article","authors":["Schenck A.","Qurashi A.","Carrera P.","Bardoni B.","Diebold C.","Schejter E.","Mandel J.-L.","Giangrande A."],"citationCrossReferences":[{"database":"PubMed","id":"15385157"},{"database":"DOI","id":"10.1016/j.ydbio.2004.07.009"}],"title":"WAVE/SCAR, a multifunctional complex coordinating different aspects of neuronal connectivity.","publicationDate":"2004","journal":"Dev. Biol.","firstPage":"260","lastPage":"270","volume":"274"},"referencePositions":["FUNCTION","COMPONENT OF WAVE COMPLEX"],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":10,"citation":{"id":"15269173","citationType":"journal article","authors":["Bogdan S.","Grewe O.","Strunk M.","Mertens A.","Klaembt C."],"citationCrossReferences":[{"database":"PubMed","id":"15269173"},{"database":"DOI","id":"10.1242/dev.01274"}],"title":"Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila.","publicationDate":"2004","journal":"Development","firstPage":"3981","lastPage":"3989","volume":"131"},"referencePositions":["FUNCTION","INTERACTION WITH HEM","TISSUE SPECIFICITY","DISRUPTION PHENOTYPE"],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":11,"citation":{"id":"32200800","citationType":"journal article","authors":["Kanellopoulos A.K.","Mariano V.","Spinazzi M.","Woo Y.J.","McLean C.","Pech U.","Li K.W.","Armstrong J.D.","Giangrande A.","Callaerts P.","Smit A.B.","Abrahams B.S.","Fiala A.","Achsel T.","Bagni C."],"citationCrossReferences":[{"database":"PubMed","id":"32200800"},{"database":"DOI","id":"10.1016/j.cell.2020.02.044"}],"title":"Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits.","publicationDate":"2020","journal":"Cell","firstPage":"1178","lastPage":"1197.e20","volume":"180"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY017343","properties":[{"key":"ProteinId","value":"AAG61254.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY029211","properties":[{"key":"ProteinId","value":"AAK31584.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AE014297","properties":[{"key":"ProteinId","value":"AAF55173.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BT011115","properties":[{"key":"ProteinId","value":"AAR82782.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY122203","properties":[{"key":"ProteinId","value":"AAM52715.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_650447.1","properties":[{"key":"NucleotideSequenceId","value":"NM_142190.3"}]},{"database":"AlphaFoldDB","id":"Q9VF87","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9VF87","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"66924","properties":[{"key":"Interactions","value":"13"}]},{"database":"ComplexPortal","id":"CPX-2972","properties":[{"key":"EntryName","value":"WAVE regulatory complex"}]},{"database":"DIP","id":"DIP-33370N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9VF87","properties":[{"key":"Number of interactors","value":"1604"}]},{"database":"IntAct","id":"Q9VF87","properties":[{"key":"Interactions","value":"8"}]},{"database":"MINT","id":"Q9VF87","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"7227.FBpp0082541","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"7227-FBpp0082541","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9VF87","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"FBtr0083085","properties":[{"key":"ProteinId","value":"FBpp0082541"},{"key":"GeneId","value":"FBgn0038320"}]},{"database":"GeneID","id":"41861","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dme:Dmel_CG4931","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"FB:FBgn0038320","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"41861","properties":[{"key":"Description","value":"-"}]},{"database":"FlyBase","id":"FBgn0038320","properties":[{"key":"GeneName","value":"Cyfip"}]},{"database":"VEuPathDB","id":"VectorBase:FBgn0038320","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3534","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_002688_2_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9VF87","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DQPNRVE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10265867at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9VF87","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-DME-2029482","properties":[{"key":"PathwayName","value":"Regulation of actin dynamics for phagocytic cup formation"}]},{"database":"Reactome","id":"R-DME-4420097","properties":[{"key":"PathwayName","value":"VEGFA-VEGFR2 Pathway"}]},{"database":"Reactome","id":"R-DME-5663213","properties":[{"key":"PathwayName","value":"RHO GTPases Activate WASPs and WAVEs"}]},{"database":"Reactome","id":"R-DME-6798695","properties":[{"key":"PathwayName","value":"Neutrophil degranulation"}]},{"database":"Reactome","id":"R-DME-9013149","properties":[{"key":"PathwayName","value":"RAC1 GTPase cycle"}]},{"database":"Reactome","id":"R-DME-9013423","properties":[{"key":"PathwayName","value":"RAC3 GTPase cycle"}]},{"database":"SignaLink","id":"Q9VF87","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"41861","properties":[{"key":"hits","value":"0 hits in 3 CRISPR screens"}]},{"database":"GenomeRNAi","id":"41861","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9VF87","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000803","properties":[{"key":"Component","value":"Chromosome 3R"}]},{"database":"Bgee","id":"FBgn0038320","properties":[{"key":"ExpressionPatterns","value":"Expressed in embryonic/larval hemocyte (Drosophila) and 68 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9VF87","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0045177","properties":[{"key":"GoTerm","value":"C:apical part of cell"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21884694"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21884694"}]},{"database":"GO","id":"GO:0043005","properties":[{"key":"GoTerm","value":"C:neuron projection"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031209","properties":[{"key":"GoTerm","value":"C:SCAR complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15385157"}]},{"database":"GO","id":"GO:0045202","properties":[{"key":"GoTerm","value":"C:synapse"},{"key":"GoEvidenceType","value":"ISS:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"11438699"}]},{"database":"GO","id":"GO:0000340","properties":[{"key":"GoTerm","value":"F:RNA 7-methylguanosine cap binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031267","properties":[{"key":"GoTerm","value":"F:small GTPase binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007411","properties":[{"key":"GoTerm","value":"P:axon guidance"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12818175"}]},{"database":"GO","id":"GO:0033627","properties":[{"key":"GoTerm","value":"P:cell adhesion mediated by integrin"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20937809"}]},{"database":"GO","id":"GO:0030031","properties":[{"key":"GoTerm","value":"P:cell projection assembly"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"14588242"}]},{"database":"GO","id":"GO:0060269","properties":[{"key":"GoTerm","value":"P:centripetally migrating follicle cell migration"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26903538"}]},{"database":"GO","id":"GO:0022416","properties":[{"key":"GoTerm","value":"P:chaeta development"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15269173"}]},{"database":"GO","id":"GO:0001745","properties":[{"key":"GoTerm","value":"P:compound eye morphogenesis"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21884694"}]},{"database":"GO","id":"GO:0030866","properties":[{"key":"GoTerm","value":"P:cortical actin cytoskeleton organization"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"14588242"}]},{"database":"GO","id":"GO:0051491","properties":[{"key":"GoTerm","value":"P:positive regulation of filopodium assembly"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26903538"}]},{"database":"GO","id":"GO:0030833","properties":[{"key":"GoTerm","value":"P:regulation of actin filament polymerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0034315","properties":[{"key":"GoTerm","value":"P:regulation of Arp2/3 complex-mediated actin nucleation"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24439376"}]},{"database":"GO","id":"GO:0008360","properties":[{"key":"GoTerm","value":"P:regulation of cell shape"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"14588242"}]},{"database":"GO","id":"GO:0050807","properties":[{"key":"GoTerm","value":"P:regulation of synapse organization"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12818175"}]},{"database":"GO","id":"GO:0006417","properties":[{"key":"GoTerm","value":"P:regulation of translation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR009828","properties":[{"key":"EntryName","value":"CYRIA/CYRIB_Rac1-bd"}]},{"database":"InterPro","id":"IPR008081","properties":[{"key":"EntryName","value":"Cytoplasmic_FMR1-int"}]},{"database":"PANTHER","id":"PTHR12195","properties":[{"key":"EntryName","value":"CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07159","properties":[{"key":"EntryName","value":"CYRIA-B_Rac1-bd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05994","properties":[{"key":"EntryName","value":"FragX_IP"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF008153","properties":[{"key":"EntryName","value":"FMR1_interacting"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01698","properties":[{"key":"EntryName","value":"CYTOFMRPINTP"}]}],"sequence":{"value":"MTEKITLADALSNVEVLDELSLPDEQPCIEAQPCSIIYKANFDTNFEDRNGFVTGIAKYIEEATTHANLNVLLDEGQKHAVMLYTWRCCSRAIPQPKSNEQPNRVEIYEKTVEVLAPEVNKLLNFMYFQRKAIEAFSGEVKRLCHAEKRKDFVSEAYLLTLGKFINMFAVLDELKNMKSSVKNDYSTYRRAAQFLKVMSDSHTLQESQNLSMFLATQNKIRDTVKDTLEKIVGYEDLLSDVVNICVHMFETKMYLTPEEKHMLVKVMGFGLFLMDSDACNINKLDQKKKIRLDRIDRIFKNLEVVPLFGDMQIAPFNYIKRSKHFDSSKWPLSSSNAISPQADLMVHLPQIREDHVKYISELARYTNEVTTTVKENPSDAENRITADLALRGLQLLSEWTSVVTELYSWKLLHPTDHHQNKECPVEAEEYERATRYNYTSEEKFALIEVIAMIKGLQVLMARIETVLCEAIRRNIYSELQDFVQLSLREPLRKAVKNKKDLIRSIIMSVRETSADWQKGYEPTDDPVAKGKKDPDGGFRIQVPRLNVGPSSTQLYMVRTMLESLIADKSGGKRTLRKDIDGNCLLQIDTFHKTSFYWSYLLNFSDTLQKCCDLSQLWYREFYLEMTMGRKVNKCLVRHQHNEECKDLITMEKRIQFPIEMSMPWILTDHILQTKEPSMMEFVLYPLDLYNDSAYYALTVFRKQFLYDEVEAEVNLCFDQFVYKLSEQIFAHYKQLAGSIFLDKRFRLECEVLGFNFQSYPRNNRYETLLKQRHVQLLGRSIDLNKLITQRINANMHKSIELAISRFEGNDITGIVELEGLLEANRICHKLLSKYLALDNFDGMVKEANHNVLAPYGRITLHVFVELNYDFLVNYCYNAATNRFIRTKVNLSSSQAIQREKPPQMSHYYLWGSKQLNAAYSTQYGQYTGFVGSPHFHAMCRLLGYQGIAVVMDIILKDIVKPLIQGSLLQFTKTLMIAMPKSCKLPRCEYGSPGVLSYYQAHLTDIVQYPDAKTELFQSFREFGNSIIFCLLIEQALSQEEVCDLLHAALFQNIFPRPFCKENEKPEAKQKRLEAQFANLQIVSNVEKIGTAKQAMIAREGDLLTRERLCCGLSIFEVILNRVKSYLDDPVWCGPPPANGIIHVDECSEFHRLWSALQFVYCIPVRGTEYTIEELFGEGLNWAGCVMIVLLGQQRRFEALDFCYHILRVQRVDGKDEDVKGIQLKRMVDRIRRFQVLNSQIFSILNKYLKGGDGEGSNVEHVRCFPPPQHPSVISSSSHYQDPQKLRQSINN","length":1291,"molWeight":149261,"crc64":"F3E4254BAD41015B","md5":"5C90F1E5A6F09DEE362B94ED515793E2"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000007536A"}}