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The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity (PubMed:32966759). The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:23097424). Plays a role as a regulator of spermatogenesis (PubMed:19357193). Crucial regulator of the mitotic cell cycle and development (PubMed:15737938, PubMed:19357193). Required for the correct dynein-dynactin perinuclear localization important for nucleus-centrosome coupling that occur upon meiotic progression of primary spermatocytes (PubMed:19357193, PubMed:23904267). Plays a role in sperm motility and fertility (PubMed:19357193). May have a role in the PNG/PLU/GNU pathway (PubMed:15737938)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23097424"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31530651"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32966759"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37995689"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39032490"}],"value":"Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13, IntS14 and IntS15 (PubMed:23097424, PubMed:31530651, PubMed:32966759, PubMed:37995689, PubMed:39032490). The core complex associates with protein phosphatase 2A subunits mts/PP2A and Pp2A-29B, to form the Integrator-PP2A (INTAC) complex (PubMed:32966759, PubMed:37995689)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19357193"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23904267"}],"value":"Colocalizes with dynein-dynactin on the nuclear surface at the meiotic G2/prophase transition in primary spermatocytes (PubMed:19357193). Nuclear location is required for recruitment of dynein motors to nuclear envelope at G2/M (PubMed:23904267)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19357193"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23097424"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39032490"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19357193"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23097424"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9799434"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19357193"}],"value":"Cytoplasm, perinuclear region","id":"SL-0198"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9799434"}],"value":"Expressed in nurse cells at stages 9-10 of oogenesis and exported to the oocyte. Also expressed in the follicle cells surrounding the oocyte"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9799434"}],"value":"Expressed both maternally and zygotically. Expressed in the nucleus during the G2 phase of primary spermatocytes at stages S3-S4. Distributed between the nucleus and the cytoplasm in G2 phase of primary spermatocytes at stage S5. Localized in the cytoplasm in G2 phase of primary spermatocytes at stage S6. Remains dispersed throughout the cell until the completion of meiosis when it becomes restricted from nuclei of onion-stage spermatides"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15737938"}],"value":"Phosphorylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15737938"}],"value":"Results in almost complete steril males. Mature sperm formed in small amounts in testes are immotile or weakly motile; seminal vesicles are largely empty. Primary spermatocytes appeared normal (Cysts of 16 cells); however, spermatids show irregularities in nuclear size and number. Spermatocytes I exhibit failure of nucleus-centrosome coupling that normally occur upon meiotic phase entry; those that progress through meiotic divisions exhibit defects in spindle assembly and chromosome segregation. When injected into Xenopus embryos, causes developmental arrest with gastrulation defects and defective cell cycles resulting in polyploid nuclei. RNAi injection into HeLa cells or Drosophila syncytial embryos causes mitotic cell cycle, giving rise to multinucleated polyploidy cells"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Integrator subunit 13 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAA90969.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAA90969.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous termination","sequence":"AAA90971.1","note":"Truncated C-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAA90971.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":689,"modifier":"EXACT"}},"description":"Protein asunder","featureId":"PRO_0000385342"},{"type":"Region","location":{"start":{"value":592,"modifier":"EXACT"},"end":{"value":619,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":665,"modifier":"EXACT"},"end":{"value":689,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":521,"modifier":"EXACT"},"end":{"value":550,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Motif","location":{"start":{"value":613,"modifier":"EXACT"},"end":{"value":619,"modifier":"EXACT"}},"description":"Nuclear localization signal (NLS)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23904267"}]},{"type":"Compositional bias","location":{"start":{"value":599,"modifier":"EXACT"},"end":{"value":614,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Mutagenesis","location":{"start":{"value":617,"modifier":"EXACT"},"end":{"value":619,"modifier":"EXACT"}},"description":"Loss of nuclear location. 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