{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9V9K7","secondaryAccessions":["A4UZ50","Q53XG1","Q8SWW6","Q95TJ0"],"uniProtkbId":"SRRT_DROME","entryAudit":{"firstPublicDate":"2002-01-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-08-02","entryVersion":164,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Drosophila melanogaster","commonName":"Fruit fly","taxonId":7227,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Diptera","Brachycera","Muscomorpha","Ephydroidea","Drosophilidae","Drosophila","Sophophora"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Serrate RNA effector molecule homolog"}},"alternativeNames":[{"fullName":{"value":"Arsenite-resistance protein 2 homolog"}}]},"genes":[{"geneName":{"value":"Ars2"},"orfNames":[{"value":"CG7843"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19632183"}],"value":"Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19632183"}],"value":"Interacts with cbp20, Dcr-2 and pasha"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19632183"}],"value":"Lethality"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the ARS2 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAL13972.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAM11365.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAM11365.1","note":"Contaminating sequence. Potential poly-A sequence.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":943,"modifier":"EXACT"}},"description":"Serrate RNA effector molecule homolog","featureId":"PRO_0000220968"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":493,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":637,"modifier":"EXACT"},"end":{"value":662,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":851,"modifier":"EXACT"},"end":{"value":886,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":456,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":493,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":653,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18327897"}]},{"type":"Modified residue","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18327897"}]},{"type":"Modified residue","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18327897"}]},{"type":"Modified residue","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18327897"}]},{"type":"Modified residue","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18327897"}]},{"type":"Modified residue","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17372656"}]},{"type":"Modified residue","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18327897"}]},{"type":"Modified residue","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18327897"}]},{"type":"Modified residue","location":{"start":{"value":426,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17372656"}]},{"type":"Modified residue","location":{"start":{"value":640,"modifier":"EXACT"},"end":{"value":640,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18327897"}]},{"type":"Modified residue","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":642,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18327897"}]}],"keywords":[{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0943","category":"Biological process","name":"RNA-mediated gene silencing"}],"references":[{"referenceNumber":1,"citation":{"id":"10731132","citationType":"journal article","authors":["Adams M.D.","Celniker S.E.","Holt R.A.","Evans C.A.","Gocayne J.D.","Amanatides P.G.","Scherer S.E.","Li P.W.","Hoskins R.A.","Galle R.F.","George R.A.","Lewis S.E.","Richards S.","Ashburner M.","Henderson S.N.","Sutton G.G.","Wortman J.R.","Yandell M.D.","Zhang Q.","Chen L.X.","Brandon R.C.","Rogers Y.-H.C.","Blazej R.G.","Champe M.","Pfeiffer B.D.","Wan K.H.","Doyle C.","Baxter E.G.","Helt G.","Nelson C.R.","Miklos G.L.G.","Abril J.F.","Agbayani A.","An H.-J.","Andrews-Pfannkoch C.","Baldwin D.","Ballew R.M.","Basu A.","Baxendale J.","Bayraktaroglu L.","Beasley E.M.","Beeson K.Y.","Benos P.V.","Berman B.P.","Bhandari D.","Bolshakov S.","Borkova D.","Botchan M.R.","Bouck J.","Brokstein P.","Brottier P.","Burtis K.C.","Busam D.A.","Butler H.","Cadieu E.","Center A.","Chandra I.","Cherry J.M.","Cawley S.","Dahlke C.","Davenport L.B.","Davies P.","de Pablos B.","Delcher A.","Deng Z.","Mays A.D.","Dew I.","Dietz S.M.","Dodson K.","Doup L.E.","Downes M.","Dugan-Rocha S.","Dunkov B.C.","Dunn P.","Durbin K.J.","Evangelista C.C.","Ferraz C.","Ferriera S.","Fleischmann W.","Fosler C.","Gabrielian A.E.","Garg N.S.","Gelbart W.M.","Glasser K.","Glodek A.","Gong F.","Gorrell J.H.","Gu Z.","Guan P.","Harris M.","Harris N.L.","Harvey D.A.","Heiman T.J.","Hernandez J.R.","Houck J.","Hostin D.","Houston K.A.","Howland T.J.","Wei M.-H.","Ibegwam C.","Jalali M.","Kalush F.","Karpen G.H.","Ke Z.","Kennison J.A.","Ketchum K.A.","Kimmel B.E.","Kodira C.D.","Kraft C.L.","Kravitz S.","Kulp D.","Lai Z.","Lasko P.","Lei Y.","Levitsky A.A.","Li J.H.","Li Z.","Liang Y.","Lin X.","Liu X.","Mattei B.","McIntosh T.C.","McLeod M.P.","McPherson D.","Merkulov G.","Milshina N.V.","Mobarry C.","Morris J.","Moshrefi A.","Mount S.M.","Moy M.","Murphy B.","Murphy L.","Muzny D.M.","Nelson D.L.","Nelson D.R.","Nelson K.A.","Nixon K.","Nusskern D.R.","Pacleb J.M.","Palazzolo M.","Pittman G.S.","Pan S.","Pollard J.","Puri V.","Reese M.G.","Reinert K.","Remington K.","Saunders R.D.C.","Scheeler F.","Shen H.","Shue B.C.","Siden-Kiamos I.","Simpson M.","Skupski M.P.","Smith T.J.","Spier E.","Spradling A.C.","Stapleton M.","Strong R.","Sun E.","Svirskas R.","Tector C.","Turner R.","Venter E.","Wang A.H.","Wang X.","Wang Z.-Y.","Wassarman D.A.","Weinstock G.M.","Weissenbach J.","Williams S.M.","Woodage T.","Worley K.C.","Wu D.","Yang S.","Yao Q.A.","Ye J.","Yeh R.-F.","Zaveri J.S.","Zhan M.","Zhang G.","Zhao Q.","Zheng L.","Zheng X.H.","Zhong F.N.","Zhong W.","Zhou X.","Zhu S.C.","Zhu X.","Smith H.O.","Gibbs R.A.","Myers E.W.","Rubin G.M.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"10731132"},{"database":"DOI","id":"10.1126/science.287.5461.2185"}],"title":"The genome sequence of Drosophila melanogaster.","publicationDate":"2000","journal":"Science","firstPage":"2185","lastPage":"2195","volume":"287"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"12537572","citationType":"journal article","authors":["Misra S.","Crosby M.A.","Mungall C.J.","Matthews B.B.","Campbell K.S.","Hradecky P.","Huang Y.","Kaminker J.S.","Millburn G.H.","Prochnik S.E.","Smith C.D.","Tupy J.L.","Whitfield E.J.","Bayraktaroglu L.","Berman B.P.","Bettencourt B.R.","Celniker S.E.","de Grey A.D.N.J.","Drysdale R.A.","Harris N.L.","Richter J.","Russo S.","Schroeder A.J.","Shu S.Q.","Stapleton M.","Yamada C.","Ashburner M.","Gelbart W.M.","Rubin G.M.","Lewis S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537572"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0083"}],"title":"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0083.1","lastPage":"RESEARCH0083.22","volume":"3"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"12537569","citationType":"journal article","authors":["Stapleton M.","Carlson J.W.","Brokstein P.","Yu C.","Champe M.","George R.A.","Guarin H.","Kronmiller B.","Pacleb J.M.","Park S.","Wan K.H.","Rubin G.M.","Celniker S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537569"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0080"}],"title":"A Drosophila full-length cDNA resource.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0080.1","lastPage":"RESEARCH0080.8","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"},{"value":"Embryo","type":"TISSUE"},{"value":"Larva","type":"TISSUE"},{"value":"Pupae","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"CI-BJAFQQMADFKKU","citationType":"submission","authors":["Stapleton M.","Carlson J.W.","Chavez C.","Frise E.","George R.A.","Pacleb J.M.","Park S.","Wan K.H.","Yu C.","Rubin G.M.","Celniker S.E."],"publicationDate":"JAN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"},{"value":"Embryo","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"17372656","citationType":"journal article","authors":["Bodenmiller B.","Mueller L.N.","Pedrioli P.G.A.","Pflieger D.","Juenger M.A.","Eng J.K.","Aebersold R.","Tao W.A."],"citationCrossReferences":[{"database":"PubMed","id":"17372656"},{"database":"DOI","id":"10.1039/b617545g"}],"title":"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells.","publicationDate":"2007","journal":"Mol. Biosyst.","firstPage":"275","lastPage":"286","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326 AND SER-426","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":6,"citation":{"id":"18327897","citationType":"journal article","authors":["Zhai B.","Villen J.","Beausoleil S.A.","Mintseris J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18327897"},{"database":"DOI","id":"10.1021/pr700696a"}],"title":"Phosphoproteome analysis of Drosophila melanogaster embryos.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"1675","lastPage":"1682","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-79; SER-81; THR-300; SER-303; SER-309; SER-349; SER-352; SER-640 AND SER-642","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Embryo","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"19632183","citationType":"journal article","authors":["Sabin L.R.","Zhou R.","Gruber J.J.","Lukinova N.","Bambina S.","Berman A.","Lau C.-K.","Thompson C.B.","Cherry S."],"citationCrossReferences":[{"database":"PubMed","id":"19632183"},{"database":"DOI","id":"10.1016/j.cell.2009.04.045"}],"title":"Ars2 regulates both miRNA- and siRNA- dependent silencing and suppresses RNA virus infection in Drosophila.","publicationDate":"2009","journal":"Cell","firstPage":"340","lastPage":"351","volume":"138"},"referencePositions":["FUNCTION","INTERACTION WITH PASHA; CBP20 AND DCR-2","DISRUPTION PHENOTYPE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AE013599","properties":[{"key":"ProteinId","value":"AAF57281.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AE013599","properties":[{"key":"ProteinId","value":"AAM68343.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AE013599","properties":[{"key":"ProteinId","value":"AAM68344.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY058743","properties":[{"key":"ProteinId","value":"AAL13972.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY095037","properties":[{"key":"ProteinId","value":"AAM11365.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT011368","properties":[{"key":"ProteinId","value":"AAR96160.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_610203.2","properties":[{"key":"NucleotideSequenceId","value":"NM_136359.3"}]},{"database":"RefSeq","id":"NP_724453.1","properties":[{"key":"NucleotideSequenceId","value":"NM_165458.2"}]},{"database":"RefSeq","id":"NP_724454.1","properties":[{"key":"NucleotideSequenceId","value":"NM_165459.2"}]},{"database":"AlphaFoldDB","id":"Q9V9K7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9V9K7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"61443","properties":[{"key":"Interactions","value":"17"}]},{"database":"DIP","id":"DIP-24057N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9V9K7","properties":[{"key":"Number of interactors","value":"2473"}]},{"database":"IntAct","id":"Q9V9K7","properties":[{"key":"Interactions","value":"61"}]},{"database":"STRING","id":"7227.FBpp0085356","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q9V9K7","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"7227-FBpp0085356","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9V9K7","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"35539","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"FBtr0086018","properties":[{"key":"ProteinId","value":"FBpp0085354"},{"key":"GeneId","value":"FBgn0033062"}]},{"database":"EnsemblMetazoa","id":"FBtr0086020","properties":[{"key":"ProteinId","value":"FBpp0085356"},{"key":"GeneId","value":"FBgn0033062"}]},{"database":"EnsemblMetazoa","id":"FBtr0086021","properties":[{"key":"ProteinId","value":"FBpp0085357"},{"key":"GeneId","value":"FBgn0033062"}]},{"database":"GeneID","id":"35539","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dme:Dmel_CG7843","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"CG7843-RA","properties":[{"key":"OrganismName","value":"d. melanogaster"}]},{"database":"AGR","id":"FB:FBgn0033062","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"35539","properties":[{"key":"Description","value":"-"}]},{"database":"FlyBase","id":"FBgn0033062","properties":[{"key":"GeneName","value":"Ars2"}]},{"database":"VEuPathDB","id":"VectorBase:FBgn0033062","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2295","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_008560_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9V9K7","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GARDEWS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"342064at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9V9K7","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-DME-6807505","properties":[{"key":"PathwayName","value":"RNA polymerase II transcribes snRNA genes"}]},{"database":"Reactome","id":"R-DME-72163","properties":[{"key":"PathwayName","value":"mRNA Splicing - Major Pathway"}]},{"database":"Reactome","id":"R-DME-9770562","properties":[{"key":"PathwayName","value":"mRNA Polyadenylation"}]},{"database":"Reactome","id":"R-DME-9930044","properties":[{"key":"PathwayName","value":"Nuclear RNA decay"}]},{"database":"SignaLink","id":"Q9V9K7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"35539","properties":[{"key":"hits","value":"1 hit in 1 CRISPR screen"}]},{"database":"GenomeRNAi","id":"35539","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9V9K7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000803","properties":[{"key":"Component","value":"Chromosome 2R"}]},{"database":"Bgee","id":"FBgn0033062","properties":[{"key":"ExpressionPatterns","value":"Expressed in male accessory gland secondary cell (Drosophila) in male reproductive gland and 273 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9V9K7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0071013","properties":[{"key":"GoTerm","value":"C:catalytic step 2 spliceosome"},{"key":"GoEvidenceType","value":"HDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"18981222"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"40991927"}]},{"database":"GO","id":"GO:0071011","properties":[{"key":"GoTerm","value":"C:precatalytic spliceosome"},{"key":"GoEvidenceType","value":"HDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"18981222"}]},{"database":"GO","id":"GO:0030674","properties":[{"key":"GoTerm","value":"F:protein-macromolecule adaptor activity"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"40991927"}]},{"database":"GO","id":"GO:0050829","properties":[{"key":"GoTerm","value":"P:defense response to Gram-negative bacterium"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19046341"}]},{"database":"GO","id":"GO:0000398","properties":[{"key":"GoTerm","value":"P:mRNA splicing, via spliceosome"},{"key":"GoEvidenceType","value":"IC:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18981222"}]},{"database":"GO","id":"GO:0045071","properties":[{"key":"GoTerm","value":"P:negative regulation of viral genome replication"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19632183"}]},{"database":"GO","id":"GO:0071027","properties":[{"key":"GoTerm","value":"P:nuclear RNA surveillance"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"40991927"}]},{"database":"GO","id":"GO:0031053","properties":[{"key":"GoTerm","value":"P:primary miRNA processing"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19632183"}]},{"database":"GO","id":"GO:0035194","properties":[{"key":"GoTerm","value":"P:regulatory ncRNA-mediated post-transcriptional gene silencing"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19632183"}]},{"database":"GO","id":"GO:0030422","properties":[{"key":"GoTerm","value":"P:siRNA processing"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19632183"}]},{"database":"InterPro","id":"IPR063856","properties":[{"key":"EntryName","value":"RRM_SRRT"}]},{"database":"InterPro","id":"IPR039727","properties":[{"key":"EntryName","value":"SE/Ars2"}]},{"database":"InterPro","id":"IPR007042","properties":[{"key":"EntryName","value":"SERRATE/Ars2_C"}]},{"database":"InterPro","id":"IPR021933","properties":[{"key":"EntryName","value":"SERRATE/Ars2_N"}]},{"database":"PANTHER","id":"PTHR13165","properties":[{"key":"EntryName","value":"ARSENITE-RESISTANCE PROTEIN 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13165:SF0","properties":[{"key":"EntryName","value":"SERRATE RNA EFFECTOR MOLECULE HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04959","properties":[{"key":"EntryName","value":"ARS2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF28978","properties":[{"key":"EntryName","value":"RRM_SRRT"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12066","properties":[{"key":"EntryName","value":"SERRATE_Ars2_N"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGDSDDEYDRKRRDKFRGERESYRTERRDDRRPVGGSAGARDEWAERNPFRGGASAGGGGARHRPDYSDYRGPGARPRYGSPVRDLPPAKRMRPDWGDGDVRANPRFGGYDPYLMQAWNDHYQSMHSAYSHGGHAPPVRESIGGGGGDTLTQPAMLNLKQFLDTQDENISDSEVMRKYTEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVKRSEEQRGFLQRRTDVFMELLENGTIGSVKVDSSQADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQPRALHRTSSIFLRNLAPSITRSEIEAVCNRFSGYLRVAIADPLVERRWYRRGWITFMRDVNIKEICWGLNNQRLRDCEMGAIVNRDLSRRVRPANGITAHKQVVRSDIKLCAKIALNLDEKFRLWAEGPKDDSNSARANESSENGSGSTYGFNSQNPVLQNITDYLIEEASAEEEELLGLTGENKDTEGEPIERDEQLISVLDRLVLYLRIVHSVDYYNHCEYPYEDEMPNRCGIIHARGPPPVRVTNNDVQEYIKIYESKLQQFLTKTVPLSDEEIKNLGAKDAETEVEKFVQANTQELAKDKWLCPLSGKKFKGPEFIRKHIFNKHEEKVDEVRKEVQYFNNYLRDPKRPQLPEHPGTSKRPESESARGGGGGYRPPMYPPFSAMPYGFGPPMMGGGRGGRNFPPARRELPLEHQRRLIGYHDLDAPANSDMFD","length":943,"molWeight":107222,"crc64":"0C1AF09E02E8AB0B","md5":"3B6BBD4218C237B461AE34670535446E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1,"SEQUENCE CAUTION":3},"countByFeatureType":{"Chain":1,"Region":4,"Compositional bias":9,"Modified residue":11},"uniParcId":"UPI0000124937"}}