{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9V7W1","secondaryAccessions":["A0A0B4LGQ7","B7YZR6","Q0E947","Q95TV6","Q9U3X2"],"uniProtkbId":"PIGV_DROME","entryAudit":{"firstPublicDate":"2006-07-25","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-01","entryVersion":143,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Drosophila melanogaster","commonName":"Fruit fly","taxonId":7227,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Diptera","Brachycera","Muscomorpha","Ephydroidea","Drosophilidae","Drosophila","Sophophora"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"GPI mannosyltransferase 2"},"ecNumbers":[{"value":"2.4.1.-"}]},"alternativeNames":[{"fullName":{"value":"GPI mannosyltransferase II"},"shortNames":[{"value":"GPI-MT-II"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"FlyBase","id":"FBgn0265174"}],"value":"PIG-V"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"FlyBase","id":"FBgn0265174"}],"value":"CG44239"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22575127"}],"value":"Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. Required for the GPI-mediated endoplasmic reticulum exit and proper targeting to the cell surface of chp. Required for GPI-mediated membrane attachment of chp, qsm and Cont. Essential for microvillar stability in the rhabdomere"}],"commentType":"FUNCTION"},{"texts":[{"value":"Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22575127"}],"value":"Homozygous lethal"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the PIGV family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11102367"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"22575127"}],"value":"Was originally (PubMed:11102367) named veg. However, more thorough studies (PubMed:22575127) found that the veg phenotype does not map to this protein. It is still not known which gene corresponds to the veg phenotype"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAL13718.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"GPI mannosyltransferase 2","featureId":"PRO_0000246237"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Glycosylation","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Mutagenesis","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"No phenotype; when associated with V-276.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22575127"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"Shows reduced levels of chp and ninaE, small rhabdomeres with severely disorganized microvilli and retinal degeneration; when associated with V-276.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22575127"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"Displays defects in chp trafficking to the membrane and mislocalization of ninaE, Rh3 and Rh4 in photoreceptors. Shows reduced levels of chp and ninaE, small rhabdomeres with severely disorganized microvilli and retinal degeneration; when associated with or without A-63 or L-310. Mild photoreceptor cell and microvillar disorganization; when associated with A-306. No phenotype; when associated with L-62.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22575127"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"Mild photoreceptor cell and microvillar disorganization; when associated with V-276.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22575127"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"Shows reduced levels of chp and ninaE, small rhabdomeres with severely disorganized microvilli and retinal degeneration; when associated with V-276.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22575127"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"in Ref. 1; AAF23239","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"in Ref. 1; AAF23239","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Sequence conflict","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"in Ref. 1; AAF23239 and 6; AAL13718","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}}],"keywords":[{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0328","category":"Molecular function","name":"Glycosyltransferase"},{"id":"KW-0337","category":"Biological process","name":"GPI-anchor biosynthesis"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11102367","citationType":"journal article","authors":["Prokopenko S.N.","He Y.","Lu Y.","Bellen H.J."],"citationCrossReferences":[{"database":"PubMed","id":"11102367"},{"database":"DOI","id":"10.1093/genetics/156.4.1691"}],"title":"Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins.","publicationDate":"2000","journal":"Genetics","firstPage":"1691","lastPage":"1715","volume":"156"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"22575127","citationType":"journal article","authors":["Rosenbaum E.E.","Brehm K.S.","Vasiljevic E.","Gajeski A.","Colley N.J."],"citationCrossReferences":[{"database":"PubMed","id":"22575127"},{"database":"DOI","id":"10.1017/s0952523812000181"}],"title":"Drosophila GPI-mannosyltransferase 2 is required for GPI anchor attachment and surface expression of chaoptin.","publicationDate":"2012","journal":"Vis. Neurosci.","firstPage":"143","lastPage":"156","volume":"29"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","FUNCTION","DISRUPTION PHENOTYPE","MUTAGENESIS OF TRP-62; ASP-63; ALA-276; GLN-306 AND TRP-310"],"referenceComments":[{"value":"CN BW","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"10731132","citationType":"journal article","authors":["Adams M.D.","Celniker S.E.","Holt R.A.","Evans C.A.","Gocayne J.D.","Amanatides P.G.","Scherer S.E.","Li P.W.","Hoskins R.A.","Galle R.F.","George R.A.","Lewis S.E.","Richards S.","Ashburner M.","Henderson S.N.","Sutton G.G.","Wortman J.R.","Yandell M.D.","Zhang Q.","Chen L.X.","Brandon R.C.","Rogers Y.-H.C.","Blazej R.G.","Champe M.","Pfeiffer B.D.","Wan K.H.","Doyle C.","Baxter E.G.","Helt G.","Nelson C.R.","Miklos G.L.G.","Abril J.F.","Agbayani A.","An H.-J.","Andrews-Pfannkoch C.","Baldwin D.","Ballew R.M.","Basu A.","Baxendale J.","Bayraktaroglu L.","Beasley E.M.","Beeson K.Y.","Benos P.V.","Berman B.P.","Bhandari D.","Bolshakov S.","Borkova D.","Botchan M.R.","Bouck J.","Brokstein P.","Brottier P.","Burtis K.C.","Busam D.A.","Butler H.","Cadieu E.","Center A.","Chandra I.","Cherry J.M.","Cawley S.","Dahlke C.","Davenport L.B.","Davies P.","de Pablos B.","Delcher A.","Deng Z.","Mays A.D.","Dew I.","Dietz S.M.","Dodson K.","Doup L.E.","Downes M.","Dugan-Rocha S.","Dunkov B.C.","Dunn P.","Durbin K.J.","Evangelista C.C.","Ferraz C.","Ferriera S.","Fleischmann W.","Fosler C.","Gabrielian A.E.","Garg N.S.","Gelbart W.M.","Glasser K.","Glodek A.","Gong F.","Gorrell J.H.","Gu Z.","Guan P.","Harris M.","Harris N.L.","Harvey D.A.","Heiman T.J.","Hernandez J.R.","Houck J.","Hostin D.","Houston K.A.","Howland T.J.","Wei M.-H.","Ibegwam C.","Jalali M.","Kalush F.","Karpen G.H.","Ke Z.","Kennison J.A.","Ketchum K.A.","Kimmel B.E.","Kodira C.D.","Kraft C.L.","Kravitz S.","Kulp D.","Lai Z.","Lasko P.","Lei Y.","Levitsky A.A.","Li J.H.","Li Z.","Liang Y.","Lin X.","Liu X.","Mattei B.","McIntosh T.C.","McLeod M.P.","McPherson D.","Merkulov G.","Milshina N.V.","Mobarry C.","Morris J.","Moshrefi A.","Mount S.M.","Moy M.","Murphy B.","Murphy L.","Muzny D.M.","Nelson D.L.","Nelson D.R.","Nelson K.A.","Nixon K.","Nusskern D.R.","Pacleb J.M.","Palazzolo M.","Pittman G.S.","Pan S.","Pollard J.","Puri V.","Reese M.G.","Reinert K.","Remington K.","Saunders R.D.C.","Scheeler F.","Shen H.","Shue B.C.","Siden-Kiamos I.","Simpson M.","Skupski M.P.","Smith T.J.","Spier E.","Spradling A.C.","Stapleton M.","Strong R.","Sun E.","Svirskas R.","Tector C.","Turner R.","Venter E.","Wang A.H.","Wang X.","Wang Z.-Y.","Wassarman D.A.","Weinstock G.M.","Weissenbach J.","Williams S.M.","Woodage T.","Worley K.C.","Wu D.","Yang S.","Yao Q.A.","Ye J.","Yeh R.-F.","Zaveri J.S.","Zhan M.","Zhang G.","Zhao Q.","Zheng L.","Zheng X.H.","Zhong F.N.","Zhong W.","Zhou X.","Zhu S.C.","Zhu X.","Smith H.O.","Gibbs R.A.","Myers E.W.","Rubin G.M.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"10731132"},{"database":"DOI","id":"10.1126/science.287.5461.2185"}],"title":"The genome sequence of Drosophila melanogaster.","publicationDate":"2000","journal":"Science","firstPage":"2185","lastPage":"2195","volume":"287"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"12537572","citationType":"journal article","authors":["Misra S.","Crosby M.A.","Mungall C.J.","Matthews B.B.","Campbell K.S.","Hradecky P.","Huang Y.","Kaminker J.S.","Millburn G.H.","Prochnik S.E.","Smith C.D.","Tupy J.L.","Whitfield E.J.","Bayraktaroglu L.","Berman B.P.","Bettencourt B.R.","Celniker S.E.","de Grey A.D.N.J.","Drysdale R.A.","Harris N.L.","Richter J.","Russo S.","Schroeder A.J.","Shu S.Q.","Stapleton M.","Yamada C.","Ashburner M.","Gelbart W.M.","Rubin G.M.","Lewis S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537572"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0083"}],"title":"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0083.1","lastPage":"RESEARCH0083.22","volume":"3"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-BJAF7TF0PNAEV","citationType":"submission","authors":["Stapleton M.","Carlson J.W.","Chavez C.","Frise E.","George R.A.","Pacleb J.M.","Park S.","Wan K.H.","Yu C.","Rubin G.M.","Celniker S.E."],"publicationDate":"OCT-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"},{"value":"Embryo","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"12537569","citationType":"journal article","authors":["Stapleton M.","Carlson J.W.","Brokstein P.","Yu C.","Champe M.","George R.A.","Guarin H.","Kronmiller B.","Pacleb J.M.","Park S.","Wan K.H.","Rubin G.M.","Celniker S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537569"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0080"}],"title":"A Drosophila full-length cDNA resource.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0080.1","lastPage":"RESEARCH0080.8","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-449"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"},{"value":"Ovary","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF211892","properties":[{"key":"ProteinId","value":"AAF23239.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AE013599","properties":[{"key":"ProteinId","value":"AHN56304.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AE013599","properties":[{"key":"ProteinId","value":"AHN56305.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AE013599","properties":[{"key":"ProteinId","value":"AHN56306.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BT016020","properties":[{"key":"ProteinId","value":"AAV36905.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY058489","properties":[{"key":"ProteinId","value":"AAL13718.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001286508.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001299579.1"}]},{"database":"RefSeq","id":"NP_001286509.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001299580.1"}]},{"database":"RefSeq","id":"NP_001286510.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001299581.1"}]},{"database":"AlphaFoldDB","id":"Q9V7W1","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9V7W1","properties":[{"key":"Number of interactors","value":"567"}]},{"database":"STRING","id":"7227.FBpp0308218","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q9V7W1","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q9V7W1","properties":[{"key":"glycosylation","value":"2 sites"}]},{"database":"PaxDb","id":"7227-FBpp0308218","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9V7W1","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"19835383","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"FBtr0339071","properties":[{"key":"ProteinId","value":"FBpp0308217"},{"key":"GeneId","value":"FBgn0265174"}]},{"database":"EnsemblMetazoa","id":"FBtr0339072","properties":[{"key":"ProteinId","value":"FBpp0308218"},{"key":"GeneId","value":"FBgn0265174"}]},{"database":"EnsemblMetazoa","id":"FBtr0339073","properties":[{"key":"ProteinId","value":"FBpp0308219"},{"key":"GeneId","value":"FBgn0265174"}]},{"database":"GeneID","id":"19835383","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dme:Dmel_CG44239","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"CG6657-RA","properties":[{"key":"OrganismName","value":"d. melanogaster"}]},{"database":"AGR","id":"FB:FBgn0265174","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"19835383","properties":[{"key":"Description","value":"-"}]},{"database":"FlyBase","id":"FBgn0265174","properties":[{"key":"GeneName","value":"PIG-V"}]},{"database":"VEuPathDB","id":"VectorBase:FBgn0265174","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2647","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_029048_3_2_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9V7W1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GALFIWC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10252502at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9V7W1","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-DME-162710","properties":[{"key":"PathwayName","value":"Synthesis of glycosylphosphatidylinositol (GPI)"}]},{"database":"UniPathway","id":"UPA00196","properties":[{"key":"RectionId","value":"-"}]},{"database":"BioGRID-ORCS","id":"19835383","properties":[{"key":"hits","value":"0 hits in 1 CRISPR screen"}]},{"database":"GenomeRNAi","id":"19835383","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9V7W1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000803","properties":[{"key":"Component","value":"Chromosome 2R"}]},{"database":"Bgee","id":"FBgn0265174","properties":[{"key":"ExpressionPatterns","value":"Expressed in oviduct (Drosophila) and 81 other cell types or tissues"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0031501","properties":[{"key":"GoTerm","value":"C:mannosyltransferase complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0120563","properties":[{"key":"GoTerm","value":"F:dol-P-Man:Man(1)GlcN-acyl-PI alpha-1,6-mannosyltransferase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0000030","properties":[{"key":"GoTerm","value":"F:mannosyltransferase activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006506","properties":[{"key":"GoTerm","value":"P:GPI anchor biosynthetic process"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22575127"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23250212"}]},{"database":"GO","id":"GO:0045313","properties":[{"key":"GoTerm","value":"P:rhabdomere membrane biogenesis"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23250212"}]},{"database":"InterPro","id":"IPR007315","properties":[{"key":"EntryName","value":"PIG-V/Gpi18"}]},{"database":"PANTHER","id":"PTHR12468","properties":[{"key":"EntryName","value":"GPI MANNOSYLTRANSFERASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12468:SF2","properties":[{"key":"EntryName","value":"GPI MANNOSYLTRANSFERASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04188","properties":[{"key":"EntryName","value":"Mannosyl_trans2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTEKVTKLALASRLIVLLVQLVANGALPEHKPDVFRMPVSSDQNASWIDKVIKRCLGGLRHWDGEYFLHIAENLYSYENTLAFYPLYPVVVRHVGQAVEAIGISLSQESILLVVAVALNFWLFCESANLLFQLTQVLFNDLNKSWNAALIYCFNPATIFFTAAYSETFFAYSSLHLMLECSKPTGSFRYLRLGTALAACLLCRSNGLITLGYPLYFFGRQLLLKNKEPNTCMQLTQMTLTILGAIGILHTYYFYIYRLYCLPNTRPNHPQHIVDYAVERKYLLSGQGSEGSPWCQYTLPFPYTYVQSHYWDVGFLRYYKWKQLPNFLLALPMLSFMHWHCYDYMQHLAKAVWAKLTPSGFKELIRDHTTFPFVLHAAILTLVCTVYVHIQVSTRLLASATPVFYWFAADHMPKTLAQLKLRSKAGALFVWCTTYSLVGTVLFSNNYPWT","length":449,"molWeight":51544,"crc64":"8B3145FC9B766D83","md5":"702262B909AD9DE29CDE1818DA7C8D31"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1,"CAUTION":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Topological domain":9,"Transmembrane":8,"Glycosylation":2,"Mutagenesis":5,"Sequence conflict":3},"uniParcId":"UPI0000081530"}}