{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UQD0","secondaryAccessions":["B9VWG8","O95788","Q9NYX2","Q9UPB2"],"uniProtkbId":"SCN8A_HUMAN","entryAudit":{"firstPublicDate":"2003-08-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-01","entryVersion":210,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAA78033.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Sodium channel protein type 8 subunit alpha"}},"alternativeNames":[{"fullName":{"value":"Sodium channel protein type VIII subunit alpha"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19136557"}],"value":"Voltage-gated sodium channel subunit alpha Nav1.6"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:10596"}],"value":"SCN8A"},"synonyms":[{"value":"MED"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24874546"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25239001"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25725044"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26900580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29726066"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33245860"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36696443"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36823201"}],"value":"Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient (PubMed:24874546, PubMed:25239001, PubMed:25725044, PubMed:26900580, PubMed:29726066, PubMed:33245860, PubMed:36696443, PubMed:36823201). Contributes to neuronal excitability by regulating action potential threshold and propagation (PubMed:24874546, PubMed:25239001, PubMed:25725044, PubMed:26900580, PubMed:29726066, PubMed:33245860, PubMed:36696443, PubMed:36823201)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19136557"}],"value":"More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement"}],"commentType":"FUNCTION","molecule":"Isoform 5"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Na(+)(in) = Na(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34963"},{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29726066"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36696443"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36823201"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36823201"}],"value":"Inhibited by tetrodotoxin and, more weakly, by its metabolite 4,9-ah-tetrodotoxin"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9WTU3"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15282281"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24497506"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26900580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28428547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33245860"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36696443"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36823201"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37117223"}],"value":"The voltage-sensitive sodium channel consists of an ion-conducting pore-forming alpha subunit regulated by one or more beta-1 (SCN1B), beta-2 (SCN2B), beta-3 (SCN3B) and/or beta-4 (SCN4B) subunits. Beta-1 (SCN1B) and beta-3 (SCN3B) are non-covalently associated with alpha, while beta-2 (SCN2B) and beta-4 (SCN4B) are covalently linked by disulfide bonds (PubMed:36696443, PubMed:36823201). Interacts with NEDD4 and NEDD4L (By similarity). Interacts with FGF13 (PubMed:15282281, PubMed:33245860). Interacts with FGF14, GBG3, GBB2 and SCN1B (PubMed:26900580). Interacts with TMEM233 (PubMed:37117223). Interacts with the conotoxin GVIIJ (PubMed:24497506). Interacts with the spider beta/delta-theraphotoxin-Pre1a (PubMed:28428547). Interacts with CALM1; the interaction modulates the inactivation rate of SCN8A (By 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in the hippocampus with increased expression in epileptic tissue compared to normal adjacent tissue (at protein level) (PubMed:28842554)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19136557"}],"value":"Expressed in non-neuronal tissues, such as monocytes/macrophages"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform 5"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28842554"}],"value":"Up-regulated in the hippocampus after epilepsy"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). 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