{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UNZ5","secondaryAccessions":["B2R4J9"],"uniProtkbId":"L10K_HUMAN","entryAudit":{"firstPublicDate":"2001-11-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-01","entryVersion":150,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Leydig cell tumor 10 kDa protein homolog"}}},"genes":[{"geneName":{"value":"C19orf53"},"orfNames":[{"value":"HSPC023"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"May have a potential role in hypercalcemia of malignancy"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the UPF0390 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Leydig cell tumor 10 kDa protein homolog","featureId":"PRO_0000084343"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Natural variant","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"in dbSNP:rs10104","featureCrossReferences":[{"database":"dbSNP","id":"rs10104"}],"featureId":"VAR_053783","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Helix","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8INE"}]},{"type":"Helix","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8FLB"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11042152","citationType":"journal article","authors":["Zhang Q.-H.","Ye M.","Wu X.-Y.","Ren S.-X.","Zhao M.","Zhao C.-J.","Fu G.","Shen Y.","Fan H.-Y.","Lu G.","Zhong M.","Xu X.-R.","Han Z.-G.","Zhang J.-W.","Tao J.","Huang Q.-H.","Zhou J.","Hu G.-X.","Gu J.","Chen S.-J.","Chen Z."],"citationCrossReferences":[{"database":"PubMed","id":"11042152"},{"database":"DOI","id":"10.1101/gr.140200"}],"title":"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.","publicationDate":"2000","journal":"Genome Res.","firstPage":"1546","lastPage":"1560","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Umbilical cord blood","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Tongue","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF078852","properties":[{"key":"ProteinId","value":"AAD44484.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK311855","properties":[{"key":"ProteinId","value":"BAG34796.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471106","properties":[{"key":"ProteinId","value":"EAW84372.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC015465","properties":[{"key":"ProteinId","value":"AAH15465.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS12298.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_054766.1","properties":[{"key":"NucleotideSequenceId","value":"NM_014047.3"}]},{"database":"PDB","id":"8FLA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.63 A"},{"key":"Chains","value":"VB=1-99"}]},{"database":"PDB","id":"8FLB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"VB=1-99"}]},{"database":"PDB","id":"8FLC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.76 A"},{"key":"Chains","value":"VB=1-99"}]},{"database":"PDB","id":"8IDT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"T=1-99"}]},{"database":"PDB","id":"8IDY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"T=1-99"}]},{"database":"PDB","id":"8INE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"T=1-99"}]},{"database":"PDB","id":"8INF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"T=1-99"}]},{"database":"PDBsum","id":"8FLA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FLB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FLC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8IDT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8IDY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8INE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8INF","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29272","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29273","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29274","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35370","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35371","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35596","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35597","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"118798","properties":[{"key":"Interactions","value":"35"}]},{"database":"DIP","id":"DIP-61980N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9UNZ5","properties":[{"key":"Number of interactors","value":"295"}]},{"database":"IntAct","id":"Q9UNZ5","properties":[{"key":"Interactions","value":"14"}]},{"database":"MINT","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000465432","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9UNZ5","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"C19orf53","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"17369716","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000465432","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"85350","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"71794","properties":[{"key":"antibodies","value":"35 antibodies from 10 providers"}]},{"database":"DNASU","id":"28974","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000588234.6","properties":[{"key":"ProteinId","value":"ENSP00000465432.1"},{"key":"GeneId","value":"ENSG00000104979.10"}]},{"database":"GeneID","id":"28974","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:28974","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000588234.6","properties":[{"key":"ProteinId","value":"ENSP00000465432.1"},{"key":"RefSeqNucleotideId","value":"NM_014047.3"},{"key":"RefSeqProteinId","value":"NP_054766.1"}]},{"database":"UCSC","id":"uc002mxg.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:24991","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA147358407","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"28974","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"C19orf53","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:24991","properties":[{"key":"GeneName","value":"C19orf53"}]},{"database":"HPA","id":"ENSG00000104979","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"620685","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000104979","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000104979","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S8BT","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000011740","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_182392_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"IEHETAM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5239630at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9UNZ5","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000104979","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"28974","properties":[{"key":"hits","value":"527 hits in 1136 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"C19orf53","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"28974","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9UNZ5","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q9UNZ5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"RNAct","id":"Q9UNZ5","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000104979","properties":[{"key":"ExpressionPatterns","value":"Expressed in hindlimb stylopod muscle and 201 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9UNZ5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"InterPro","id":"IPR019034","properties":[{"key":"EntryName","value":"UPF0390"}]},{"database":"PANTHER","id":"PTHR16967","properties":[{"key":"EntryName","value":"LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16967:SF1","properties":[{"key":"EntryName","value":"LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09495","properties":[{"key":"EntryName","value":"DUF2462"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAQGQRKFQAHKPAKSKTAAAASEKNRGPRKGGRVIAPKKARVVQQQKLKKNLEVGIRKKIEHDVVMKASSSLPKKLALLKAPAKKKGAAAATSSKTPS","length":99,"molWeight":10577,"crc64":"A5FDF26764BED659","md5":"1CE73A8CB71E9F6188E0CA46D98932DE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":1,"Natural variant":1,"Helix":2},"uniParcId":"UPI000012E181"}}