{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UMN6","secondaryAccessions":["O15022","O95836","Q96GP2","Q96IP3","Q9UK25","Q9Y668","Q9Y669"],"uniProtkbId":"KMT2B_HUMAN","entryAudit":{"firstPublicDate":"2000-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-01","entryVersion":239,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Histone-lysine N-methyltransferase 2B"},"shortNames":[{"value":"Lysine N-methyltransferase 2B"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"}],"value":"2.1.1.364"}]},"alternativeNames":[{"fullName":{"value":"Myeloid/lymphoid or mixed-lineage leukemia protein 4"}},{"fullName":{"value":"Trithorax homolog 2"}},{"fullName":{"value":"WW domain-binding protein 7"},"shortNames":[{"value":"WBP-7"}]}]},"genes":[{"geneName":{"value":"KMT2B"},"synonyms":[{"value":"HRX2"},{"value":"KIAA0304"},{"value":"MLL2"},{"value":"MLL4"},{"value":"TRX2"},{"value":"WBP7"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O08550"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17707229"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24081332"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"}],"value":"Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60264"},{"database":"Rhea","id":"RHEA-COMP:15543"},{"database":"Rhea","id":"RHEA-COMP:15547"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:61929"}],"ecNumber":"2.1.1.364","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60265"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24081332"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25561738"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60268"},{"database":"Rhea","id":"RHEA-COMP:15540"},{"database":"Rhea","id":"RHEA-COMP:15543"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:61929"},{"database":"ChEBI","id":"CHEBI:61976"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60269"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25561738"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14992727"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17707229"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17825402"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18840606"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22266653"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22327296"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22665483"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23508102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25561738"}],"value":"Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4, ASH2L, RBBP5, WDR5, DPY30, MEN1; the complex interacts with POLR2A and POLR2B via MEN1 (PubMed:14992727, PubMed:23508102). Interacts with NFE2 (PubMed:17707229). Interacts with KDM6B (PubMed:17825402). Interacts (via WIN motif) with WDR5 (PubMed:18840606, PubMed:22266653, PubMed:22665483). Interacts (via MBM motif) with MEN1 (PubMed:22327296). 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