{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9ULX7","secondaryAccessions":["Q5TB24","Q8NCF4"],"uniProtkbId":"CAH14_HUMAN","entryAudit":{"firstPublicDate":"2000-12-01","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2000-05-01","entryVersion":197,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Carbonic anhydrase 14"},"ecNumbers":[{"value":"4.2.1.1"}]},"alternativeNames":[{"fullName":{"value":"Carbonate dehydratase XIV"}},{"fullName":{"value":"Carbonic anhydrase XIV"},"shortNames":[{"value":"CA-XIV"}]}],"flag":"Precursor"},"genes":[{"geneName":{"value":"CA14"},"orfNames":[{"value":"UNQ690/PRO1335"}]}],"comments":[{"texts":[{"value":"Reversible hydration of carbon dioxide"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hydrogencarbonate + H(+) = CO2 + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10748"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:17544"}],"ecNumber":"4.2.1.1"}},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24374484"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16686544"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16807956"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17127057"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17314045"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17705204"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18618712"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19186056"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19206230"}],"value":"Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt)"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":7.9,"unit":"mM","substrate":"CO(2)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18618712"}]}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"value":"High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the alpha-carbonic anhydrase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"Carbonic anhydrase 14","featureId":"PRO_0000004251"},{"type":"Topological domain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Alpha-carbonic anhydrase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01134"}]},{"type":"Active site","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Proton donor/acceptor","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00918"}]},{"type":"Binding site","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24374484"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24374484"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24374484"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00918"}],"ligand":{"name":"substrate"}},{"type":"Modified residue","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Glycosylation","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24374484"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24374484"}]},{"type":"Sequence conflict","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"in Ref. 3; BAC11191","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Beta strand","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Helix","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Helix","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Helix","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Helix","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Helix","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Turn","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Helix","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Helix","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Helix","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Helix","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Helix","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Helix","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]},{"type":"Beta strand","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJF"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"10512682","citationType":"journal article","authors":["Fujikawa-Adachi K.","Nishimori I.","Taguchi T.","Onishi S."],"citationCrossReferences":[{"database":"PubMed","id":"10512682"},{"database":"DOI","id":"10.1006/geno.1999.5938"}],"title":"Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1.","publicationDate":"1999","journal":"Genomics","firstPage":"74","lastPage":"81","volume":"61"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"12975309","citationType":"journal article","authors":["Clark H.F.","Gurney A.L.","Abaya E.","Baker K.","Baldwin D.T.","Brush J.","Chen J.","Chow B.","Chui C.","Crowley C.","Currell B.","Deuel B.","Dowd P.","Eaton D.","Foster J.S.","Grimaldi C.","Gu Q.","Hass P.E.","Heldens S.","Huang A.","Kim H.S.","Klimowski L.","Jin Y.","Johnson S.","Lee J.","Lewis L.","Liao D.","Mark M.R.","Robbie E.","Sanchez C.","Schoenfeld J.","Seshagiri S.","Simmons L.","Singh J.","Smith V.","Stinson J.","Vagts A.","Vandlen R.L.","Watanabe C.","Wieand D.","Woods K.","Xie M.-H.","Yansura D.G.","Yi S.","Yu G.","Yuan J.","Zhang M.","Zhang Z.","Goddard A.D.","Wood W.I.","Godowski P.J.","Gray A.M."],"citationCrossReferences":[{"database":"PubMed","id":"12975309"},{"database":"DOI","id":"10.1101/gr.1293003"}],"title":"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.","publicationDate":"2003","journal":"Genome Res.","firstPage":"2265","lastPage":"2270","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":4,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":5,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"16807956","citationType":"journal article","authors":["Temperini C.","Scozzafava A.","Vullo D.","Supuran C.T."],"citationCrossReferences":[{"database":"PubMed","id":"16807956"},{"database":"DOI","id":"10.1002/chem.200600159"}],"title":"Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.","publicationDate":"2006","journal":"Chemistry","firstPage":"7057","lastPage":"7066","volume":"12"},"referencePositions":["ACTIVITY REGULATION"]},{"referenceNumber":8,"citation":{"id":"16686544","citationType":"journal article","authors":["Temperini C.","Scozzafava A.","Vullo D.","Supuran C.T."],"citationCrossReferences":[{"database":"PubMed","id":"16686544"},{"database":"DOI","id":"10.1021/jm0603320"}],"title":"Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.","publicationDate":"2006","journal":"J. Med. Chem.","firstPage":"3019","lastPage":"3027","volume":"49"},"referencePositions":["ACTIVITY REGULATION"]},{"referenceNumber":9,"citation":{"id":"17705204","citationType":"journal article","authors":["Koehler K.","Hillebrecht A.","Schulze Wischeler J.","Innocenti A.","Heine A.","Supuran C.T.","Klebe G."],"citationCrossReferences":[{"database":"PubMed","id":"17705204"},{"database":"DOI","id":"10.1002/anie.200701189"}],"title":"Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.","publicationDate":"2007","journal":"Angew. Chem. Int. Ed. Engl.","firstPage":"7697","lastPage":"7699","volume":"46"},"referencePositions":["ACTIVITY REGULATION"]},{"referenceNumber":10,"citation":{"id":"17127057","citationType":"journal article","authors":["Temperini C.","Innocenti A.","Scozzafava A.","Mastrolorenzo A.","Supuran C.T."],"citationCrossReferences":[{"database":"PubMed","id":"17127057"},{"database":"DOI","id":"10.1016/j.bmcl.2006.11.027"}],"title":"Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.","publicationDate":"2007","journal":"Bioorg. Med. Chem. Lett.","firstPage":"628","lastPage":"635","volume":"17"},"referencePositions":["ACTIVITY REGULATION"]},{"referenceNumber":11,"citation":{"id":"17314045","citationType":"journal article","authors":["Temperini C.","Innocenti A.","Guerri A.","Scozzafava A.","Rusconi S.","Supuran C.T."],"citationCrossReferences":[{"database":"PubMed","id":"17314045"},{"database":"DOI","id":"10.1016/j.bmcl.2007.01.113"}],"title":"Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.","publicationDate":"2007","journal":"Bioorg. Med. Chem. Lett.","firstPage":"2210","lastPage":"2215","volume":"17"},"referencePositions":["ACTIVITY REGULATION"]},{"referenceNumber":12,"citation":{"id":"19186056","citationType":"journal article","authors":["Crocetti L.","Maresca A.","Temperini C.","Hall R.A.","Scozzafava A.","Muehlschlegel F.A.","Supuran C.T."],"citationCrossReferences":[{"database":"PubMed","id":"19186056"},{"database":"DOI","id":"10.1016/j.bmcl.2009.01.038"}],"title":"A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.","publicationDate":"2009","journal":"Bioorg. Med. Chem. Lett.","firstPage":"1371","lastPage":"1375","volume":"19"},"referencePositions":["ACTIVITY REGULATION"]},{"referenceNumber":13,"citation":{"id":"19206230","citationType":"journal article","authors":["Maresca A.","Temperini C.","Vu H.","Pham N.B.","Poulsen S.-A.","Scozzafava A.","Quinn R.J.","Supuran C.T."],"citationCrossReferences":[{"database":"PubMed","id":"19206230"},{"database":"DOI","id":"10.1021/ja809683v"}],"title":"Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.","publicationDate":"2009","journal":"J. Am. Chem. Soc.","firstPage":"3057","lastPage":"3062","volume":"131"},"referencePositions":["ACTIVITY REGULATION"]},{"referenceNumber":14,"citation":{"id":"18618712","citationType":"journal article","authors":["Di Fiore A.","Monti S.M.","Hilvo M.","Parkkila S.","Romano V.","Scaloni A.","Pedone C.","Scozzafava A.","Supuran C.T.","De Simone G."],"citationCrossReferences":[{"database":"PubMed","id":"18618712"},{"database":"DOI","id":"10.1002/prot.22144"}],"title":"Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.","publicationDate":"2009","journal":"Proteins","firstPage":"164","lastPage":"175","volume":"74"},"referencePositions":["BIOPHYSICOCHEMICAL PROPERTIES","ACTIVITY REGULATION"]},{"referenceNumber":15,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":16,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"24374484","citationType":"journal article","authors":["Alterio V.","Pan P.","Parkkila S.","Buonanno M.","Supuran C.T.","Monti S.M.","De Simone G."],"citationCrossReferences":[{"database":"PubMed","id":"24374484"},{"database":"DOI","id":"10.1002/bip.22456"}],"title":"The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors.","publicationDate":"2014","journal":"Biopolymers","firstPage":"769","lastPage":"778","volume":"101"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 16-290","ZINC-BINDING SITES","GLYCOSYLATION AT ASN-213","DISULFIDE BOND"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB025904","properties":[{"key":"ProteinId","value":"BAA85002.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY358689","properties":[{"key":"ProteinId","value":"AAQ89052.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK074765","properties":[{"key":"ProteinId","value":"BAC11191.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT020054","properties":[{"key":"ProteinId","value":"AAV38857.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL138795","properties":[{"key":"ProteinId","value":"CAI22810.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC034412","properties":[{"key":"ProteinId","value":"AAH34412.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS947.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_036245.1","properties":[{"key":"NucleotideSequenceId","value":"NM_012113.3"}]},{"database":"PDB","id":"4LU3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=16-290"}]},{"database":"PDB","id":"5CJF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.83 A"},{"key":"Chains","value":"A=16-291"}]},{"database":"PDBsum","id":"4LU3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CJF","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"117162","properties":[{"key":"Interactions","value":"77"}]},{"database":"FunCoup","id":"Q9ULX7","properties":[{"key":"Number of interactors","value":"275"}]},{"database":"IntAct","id":"Q9ULX7","properties":[{"key":"Interactions","value":"63"}]},{"database":"STRING","id":"9606.ENSP00000358107","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3510","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB08782","properties":[{"key":"GenericName","value":"4-(2-AMINOETHYL)BENZENESULFONAMIDE"}]},{"database":"DrugBank","id":"DB00819","properties":[{"key":"GenericName","value":"Acetazolamide"}]},{"database":"DrugBank","id":"DB07050","properties":[{"key":"GenericName","value":"Benzolamide"}]},{"database":"DrugBank","id":"DB00562","properties":[{"key":"GenericName","value":"Benzthiazide"}]},{"database":"DrugBank","id":"DB03854","properties":[{"key":"GenericName","value":"Cadaverine"}]},{"database":"DrugBank","id":"DB19764","properties":[{"key":"GenericName","value":"Carzenide"}]},{"database":"DrugBank","id":"DB14086","properties":[{"key":"GenericName","value":"Cianidanol"}]},{"database":"DrugBank","id":"DB04665","properties":[{"key":"GenericName","value":"Coumarin"}]},{"database":"DrugBank","id":"DB11672","properties":[{"key":"GenericName","value":"Curcumin"}]},{"database":"DrugBank","id":"DB00606","properties":[{"key":"GenericName","value":"Cyclothiazide"}]},{"database":"DrugBank","id":"DB08846","properties":[{"key":"GenericName","value":"Ellagic acid"}]},{"database":"DrugBank","id":"DB07767","properties":[{"key":"GenericName","value":"Ferulic acid"}]},{"database":"DrugBank","id":"DB03260","properties":[{"key":"GenericName","value":"Hexamethylene diamine"}]},{"database":"DrugBank","id":"DB08165","properties":[{"key":"GenericName","value":"indane-5-sulfonamide"}]},{"database":"DrugBank","id":"DB06795","properties":[{"key":"GenericName","value":"Mafenide"}]},{"database":"DrugBank","id":"DB14144","properties":[{"key":"GenericName","value":"p-Aminophenol"}]},{"database":"DrugBank","id":"DB04066","properties":[{"key":"GenericName","value":"p-Coumaric acid"}]},{"database":"DrugBank","id":"DB03255","properties":[{"key":"GenericName","value":"Phenol"}]},{"database":"DrugBank","id":"DB11085","properties":[{"key":"GenericName","value":"Resorcinol"}]},{"database":"DrugBank","id":"DB00127","properties":[{"key":"GenericName","value":"Spermine"}]},{"database":"DrugBank","id":"DB06824","properties":[{"key":"GenericName","value":"Triethylenetetramine"}]},{"database":"DrugBank","id":"DB00909","properties":[{"key":"GenericName","value":"Zonisamide"}]},{"database":"DrugCentral","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"2598","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q9ULX7","properties":[{"key":"glycosylation","value":"1 site, No reported glycans"}]},{"database":"GlyGen","id":"Q9ULX7","properties":[{"key":"glycosylation","value":"1 site, 1 N-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CA14","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"8928036","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000358107","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"85149","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"2374","properties":[{"key":"antibodies","value":"200 antibodies from 30 providers"}]},{"database":"DNASU","id":"23632","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000369111.9","properties":[{"key":"ProteinId","value":"ENSP00000358107.3"},{"key":"GeneId","value":"ENSG00000118298.13"}]},{"database":"Ensembl","id":"ENST00000647854.1","properties":[{"key":"ProteinId","value":"ENSP00000498013.1"},{"key":"GeneId","value":"ENSG00000118298.13"}]},{"database":"GeneID","id":"23632","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:23632","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000369111.9","properties":[{"key":"ProteinId","value":"ENSP00000358107.3"},{"key":"RefSeqNucleotideId","value":"NM_012113.3"},{"key":"RefSeqProteinId","value":"NP_036245.1"}]},{"database":"UCSC","id":"uc001etx.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:1372","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA25988","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"23632","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"23632","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CA14","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1372","properties":[{"key":"GeneName","value":"CA14"}]},{"database":"HPA","id":"ENSG00000118298","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (brain, choroid plexus, retina, tongue)"}]},{"database":"MIM","id":"604832","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000118298","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000118298","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0382","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000156893","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_039326_1_2_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GYDQPST","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"429145at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9ULX7","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"4.2.1.1","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1475029","properties":[{"key":"PathwayName","value":"Reversible hydration of carbon dioxide"}]},{"database":"SABIO-RK","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000118298","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"23632","properties":[{"key":"hits","value":"12 hits in 1161 CRISPR screens"}]},{"database":"ChiTaRS","id":"CA14","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"CA14","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"23632","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9ULX7","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:Q9ULX7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"Q9ULX7","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000118298","properties":[{"key":"ExpressionPatterns","value":"Expressed in pigmented layer of retina and 137 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9ULX7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10512682"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0004089","properties":[{"key":"GoTerm","value":"F:carbonate dehydratase activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd03126","properties":[{"key":"EntryName","value":"alpha_CA_XII_XIV"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.200.10:FF:000003","properties":[{"key":"EntryName","value":"Carbonic anhydrase 12"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.200.10","properties":[{"key":"EntryName","value":"Alpha carbonic anhydrase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001148","properties":[{"key":"EntryName","value":"CA_dom"}]},{"database":"InterPro","id":"IPR036398","properties":[{"key":"EntryName","value":"CA_dom_sf"}]},{"database":"InterPro","id":"IPR023561","properties":[{"key":"EntryName","value":"Carbonic_anhydrase_a-class"}]},{"database":"PANTHER","id":"PTHR18952","properties":[{"key":"EntryName","value":"CARBONIC ANHYDRASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18952:SF84","properties":[{"key":"EntryName","value":"CARBONIC ANHYDRASE 14"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00194","properties":[{"key":"EntryName","value":"Carb_anhydrase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01057","properties":[{"key":"EntryName","value":"Carb_anhydrase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51069","properties":[{"key":"EntryName","value":"Carbonic anhydrase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51144","properties":[{"key":"EntryName","value":"ALPHA_CA_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA","length":337,"molWeight":37668,"crc64":"6E101C44EA70A700","md5":"EA6D68BEA7162795592C56EBC3680B33"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"ACTIVITY REGULATION":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":1,"Active site":1,"Binding site":4,"Modified residue":1,"Glycosylation":1,"Disulfide bond":1,"Sequence conflict":1,"Beta strand":16,"Helix":11,"Turn":1},"uniParcId":"UPI00000389EA"}}