{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UKV8","secondaryAccessions":["Q8TCZ5","Q8WV58","Q96ID1"],"uniProtkbId":"AGO2_HUMAN","entryAudit":{"firstPublicDate":"2000-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-05-05","entryVersion":220,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"}],"value":"Protein argonaute-2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"}],"value":"Argonaute2"},{"value":"hAgo2"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15105377"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23746446"}],"value":"3.1.26.n2"}]},"alternativeNames":[{"fullName":{"value":"Argonaute RISC catalytic component 2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"}],"value":"Eukaryotic translation initiation factor 2C 2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"}],"value":"eIF-2C 2"},{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"}],"value":"eIF2C 2"}]},{"fullName":{"value":"PAZ Piwi domain protein"},"shortNames":[{"value":"PPD"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"}],"value":"Protein slicer"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:3263"}],"value":"AGO2"},"synonyms":[{"value":"EIF2C2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8CJG0"},{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15105377"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15260970"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284456"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15337849"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800637"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16081698"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16142218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16271387"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16289642"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16357216"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16756390"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16936728"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17382880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17507929"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17524464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17531811"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17932509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18048652"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18178619"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18690212"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18771919"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19167051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23746446"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37328606"}],"value":"Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34903581"}],"value":"(Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Endonucleolytic cleavage to 5'-phosphomonoester.","ecNumber":"3.1.26.n2","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15105377"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23746446"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284456"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}},{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284456"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284456"}],"value":"Inhibited by EDTA"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":1.1,"unit":"nM","substrate":"a synthetic 21-nucleotide single-stranded RNA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15105377"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800637"}]}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8CJG0"},{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14508492"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14703574"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14749716"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15337849"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15766526"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15973356"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16081698"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16271387"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16289642"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16357216"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16699599"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16756390"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17382880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17507929"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17531811"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17932509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18178619"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18690212"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19167051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19801630"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20505670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20616046"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21475248"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21981923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22539551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22682761"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22791714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22915799"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23125361"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24726324"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25697406"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26009488"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28546213"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29395067"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37328606"}],"value":"Interacts with DICER1 through its Piwi domain and with TARBP2 during assembly of the RNA-induced silencing complex (RISC) (PubMed:14749716, PubMed:15973356, PubMed:16271387, PubMed:16289642, PubMed:16357216, PubMed:17507929, PubMed:18178619, PubMed:18690212, PubMed:33199684). Together, DICER1, AGO2 and TARBP2 constitute the trimeric RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC). Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Note however that the term RISC has also been used to describe the trimeric RLC/miRLC. The formation of RISC complexes containing siRNAs rather than miRNAs appears to occur independently of DICER1. Interacts with AGO1. Also interacts with DDB1, DDX5, DDX6, DDX20, DHX30, DHX36, DDX47, DHX9, ELAVL, FXR1, GEMIN4, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, PABPC1, PRMT5, P4HA1, P4HB, RBM4, SART3, TNRC6A, TNRC6B, UPF1 and YBX1. Interacts with the P-body components DCP1A and XRN1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with RBM4; the interaction is modulated under stress-induced conditions, occurs under both cell proliferation and differentiation conditions and in an RNA- and phosphorylation-independent manner. Interacts with LIMD1, WTIP and AJUBA. Interacts with TRIM71; the interaction increases in presence of RNA (PubMed:23125361). Interacts with APOBEC3G in an RNA-dependent manner. Interacts with APOBEC3A, APOBEC3C, APOBEC3F and APOBEC3H. Interacts with DICER1, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (PubMed:17507929, PubMed:24726324). Interacts with FMR1 (PubMed:14703574). Interacts with ZFP36 (PubMed:15766526). Found in a complex, composed of AGO2, CHD7 and ARB2A (By similarity). Interacts with RC3H1; the interaction is RNA independent (PubMed:25697406). Interacts with SND1 (PubMed:14508492, PubMed:28546213). Interacts with SYT11 (By similarity). Interacts with CLNK (PubMed:26009488). Interacts with GARRE1 (PubMed:29395067). Interacts with GRB2; this interaction is important for the formation of a ternary complex containing GRB2, AGO2 and DICER1 (PubMed:37328606). Interacts with FAM120A (By similarity)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32213613"}],"value":"(Microbial infection) Interacts with Epstein-Barr virus (EBV) tegument protein BGLF2; this interaction participates in the regulation of cellular miRNA by the virus, leading to enhanced SUMOylation"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30258011"}],"value":"(Microbial infection) Interacts with rotavirus A non-structural protein 5; this interaction probably plays a role in the sequestration of AGO2 in viral factories"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31400113"}],"value":"(Microbial infection) Interacts with human herpesvirus 8 protein MTA/ORF57; this interaction inhibits P-body formation"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q9UL18","geneName":"AGO1","intActId":"EBI-527363"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q9UIV1","geneName":"CNOT7","intActId":"EBI-2105113"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"P26196","geneName":"DDX6","intActId":"EBI-351257"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q96C10","geneName":"DHX58","intActId":"EBI-744193"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q9UPY3","geneName":"DICER1","intActId":"EBI-395506"},"numberOfExperiments":21,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q9UPY3-1","geneName":"DICER1","intActId":"EBI-15569571"},"numberOfExperiments":14,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"G5E9A7","geneName":"DMWD","intActId":"EBI-10976677"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"P00533","geneName":"EGFR","intActId":"EBI-297353"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q13541","geneName":"EIF4EBP1","intActId":"EBI-74090"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"P22607","geneName":"FGFR3","intActId":"EBI-348399"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q02790","geneName":"FKBP4","intActId":"EBI-1047444"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q9BVP2","geneName":"GNL3","intActId":"EBI-641642"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"O15397","geneName":"IPO8","intActId":"EBI-358808"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q9UGP4","geneName":"LIMD1","intActId":"EBI-2652871"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q5S007","geneName":"LRRK2","intActId":"EBI-5323863"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q86UE4","geneName":"MTDH","intActId":"EBI-1046588"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q6IQ23","geneName":"PLEKHA7","intActId":"EBI-2125301"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"O75569","geneName":"PRKRA","intActId":"EBI-713955"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"P04156","geneName":"PRNP","intActId":"EBI-977302"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q15185","geneName":"PTGES3","intActId":"EBI-1049387"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"P63244","geneName":"RACK1","intActId":"EBI-296739"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"P06400","geneName":"RB1","intActId":"EBI-491274"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q7Z699","geneName":"SPRED1","intActId":"EBI-5235340"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q15633","geneName":"TARBP2","intActId":"EBI-978581"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q9UHD2","geneName":"TBK1","intActId":"EBI-356402"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"A7MCY6","geneName":"TBKBP1","intActId":"EBI-359969"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q8NDV7","geneName":"TNRC6A","intActId":"EBI-2269715"},"numberOfExperiments":23,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q9UPQ9","geneName":"TNRC6B","intActId":"EBI-947158"},"numberOfExperiments":14,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q9UPQ9-2","geneName":"TNRC6B","intActId":"EBI-6514011"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q9HCJ0","geneName":"TNRC6C","intActId":"EBI-6507625"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKV8","intActId":"EBI-528269"},"interactantTwo":{"uniProtKBAccession":"Q9HA38","geneName":"ZMAT3","intActId":"EBI-2548480"},"numberOfExperiments":5,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23125361"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23603119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31400113"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33199684"}],"value":"Cytoplasm, P-body","id":"SL-0230"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23125361"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9UKV8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9UKV8-2"],"sequenceIds":["VSP_037001"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18690212"}],"value":"Hydroxylated. 4-hydroxylation appears to enhance protein stability but is not required for miRNA-binding or endonuclease activity"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33184234"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33184237"}],"value":"Ubiquitinated on surface-exposed lysines by a SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 during target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). Ubiquitination by the SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 leads to its subsequent degradation, thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). ZSWIM8 recognizes and binds AGO2 when it is engaged with a TDMD target (PubMed:33184237)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28114302"}],"value":"Phosphorylated. A phosphorylation cycle of C-terminal serine cluster (Ser-824-Ser-834) regulates the release of target mRNAs. Target-binding leads to phosphorylation of these residues by CSNK1A1, which reduces the affinity of AGO2 for mRNA and enables target release. The ANKRD52-PPP6C phosphatase complex dephosphorylates the residues, which primes AGO2 for binding a new target"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23603119"}],"value":"Phosphorylation at Ser-387 by AKT3; leads to up-regulate translational repression of microRNA target and down-regulate endonucleolytic cleavage"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Lessel-Kreienkamp syndrome","diseaseAccession":"DI-06006","acronym":"LESKRES","description":"An autosomal dominant disorder characterized by global developmental delay, intellectual disability of variable degree, and speech and language delay apparent from infancy or early childhood. Behavioral disorders are observed in most patients. Additional variable features include seizures, hypotonia, gait abnormalities, visual and cardiac defects, and non-specific facial dysmorphism.","diseaseCrossReference":{"database":"MIM","id":"619149"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33199684"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"}],"value":"Belongs to the argonaute family. Ago subfamily"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH07633.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAL76093.1","note":"cDNA contains a duplication of an internal sequence at the 5' end.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":859,"modifier":"EXACT"}},"description":"Protein argonaute-2","featureId":"PRO_0000194057"},{"type":"Domain","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"PAZ","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00142"}]},{"type":"Domain","location":{"start":{"value":517,"modifier":"EXACT"},"end":{"value":818,"modifier":"EXACT"}},"description":"Piwi","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"Interaction with guide RNA"},{"type":"Region","location":{"start":{"value":524,"modifier":"EXACT"},"end":{"value":566,"modifier":"EXACT"}},"description":"Interaction with guide RNA"},{"type":"Region","location":{"start":{"value":587,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"Interaction with GW182 family members","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":650,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"Interaction with GW182 family members","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":709,"modifier":"EXACT"},"end":{"value":710,"modifier":"EXACT"}},"description":"Interaction with guide RNA"},{"type":"Region","location":{"start":{"value":753,"modifier":"EXACT"},"end":{"value":761,"modifier":"EXACT"}},"description":"Interaction with guide RNA"},{"type":"Region","location":{"start":{"value":790,"modifier":"EXACT"},"end":{"value":812,"modifier":"EXACT"}},"description":"Interaction with guide RNA"},{"type":"Compositional bias","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":597,"modifier":"EXACT"},"end":{"value":597,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240"}},{"type":"Binding site","location":{"start":{"value":669,"modifier":"EXACT"},"end":{"value":669,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240"}},{"type":"Binding site","location":{"start":{"value":807,"modifier":"EXACT"},"end":{"value":807,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240"}},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"3'-nitrotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8CJG0"},{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"}]},{"type":"Modified residue","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23603119"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":700,"modifier":"EXACT"},"end":{"value":700,"modifier":"EXACT"}},"description":"4-hydroxyproline","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18690212"}]},{"type":"Modified residue","location":{"start":{"value":824,"modifier":"EXACT"},"end":{"value":824,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28114302"}]},{"type":"Modified residue","location":{"start":{"value":828,"modifier":"EXACT"},"end":{"value":828,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28114302"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":831,"modifier":"EXACT"},"end":{"value":831,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28114302"}]},{"type":"Modified residue","location":{"start":{"value":834,"modifier":"EXACT"},"end":{"value":834,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28114302"}]},{"type":"Alternative sequence","location":{"start":{"value":724,"modifier":"EXACT"},"end":{"value":757,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_037001","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"in LESKRES; impairs shRNA-mediated silencing. Does not affect targeting to P-bodies. Increases binding to mRNA targets. Does not affect interaction with DICER1. Decreased phosphorylation of the C-terminal serine cluster. Does not affect phosphorylation of Ser-387; dbSNP:rs2073179658","featureCrossReferences":[{"database":"dbSNP","id":"rs2073179658"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33199684"}],"featureId":"VAR_085417","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"in LESKRES; impairs shRNA-mediated silencing. Does not affect targeting to P-bodies. Increases binding to mRNA targets. Does not affect interaction with DICER1. Decreased phosphorylation of the C-terminal serine cluster. Does not affect phosphorylation of Ser-387","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33199684"}],"featureId":"VAR_085418","alternativeSequence":{"originalSequence":"G","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"in LESKRES; dbSNP:rs2132941125","featureCrossReferences":[{"database":"dbSNP","id":"rs2132941125"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33199684"}],"featureId":"VAR_085419","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"in LESKRES; impairs shRNA-mediated silencing. Does not affect targeting to P-bodies. Increases binding to mRNA targets. Does not affect interaction with DICER1. Does not affect phosphorylation of the C-terminal serine cluster. Does not affect phosphorylation of Ser-387","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33199684"}],"featureId":"VAR_085420","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"in LESKRES; dbSNP:rs2073092496","featureCrossReferences":[{"database":"dbSNP","id":"rs2073092496"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33199684"}],"featureId":"VAR_085421","alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"in LESKRES; impairs shRNA-mediated silencing. Does not affect targeting to P-bodies. Increases binding to mRNA targets. Does not affect interaction with DICER1. Decreased phosphorylation of the C-terminal serine cluster. Does not affect phosphorylation of Ser-387; dbSNP:rs2073092234","featureCrossReferences":[{"database":"dbSNP","id":"rs2073092234"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33199684"}],"featureId":"VAR_085422","alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"in LESKRES; impairs shRNA-mediated silencing. Decreased phosphorylation of the C-terminal serine cluster. Increased binding to mRNA targets","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33199684"}],"featureId":"VAR_085423","alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":573,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"in LESKRES","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33199684"}],"featureId":"VAR_085424","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":733,"modifier":"EXACT"},"end":{"value":733,"modifier":"EXACT"}},"description":"in LESKRES; complete loss of function. Changes in the subcellular location pattern. Diffuse location into the cytoplasm. Does not bind mRNA. Abolishes interaction with DICER1. Abolishes phosphorylation of the C-terminal serine cluster. Does not affect phosphorylation of Ser-387; dbSNP:rs2072681689","featureCrossReferences":[{"database":"dbSNP","id":"rs2072681689"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33199684"}],"featureId":"VAR_085425","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":751,"modifier":"EXACT"},"end":{"value":751,"modifier":"EXACT"}},"description":"in LESKRES; dbSNP:rs2072680461","featureCrossReferences":[{"database":"dbSNP","id":"rs2072680461"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33199684"}],"featureId":"VAR_085426","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":760,"modifier":"EXACT"},"end":{"value":760,"modifier":"EXACT"}},"description":"in LESKRES; impairs shRNA-mediated silencing. Does not affect targeting to P-bodies. Increases binding to mRNA targets. Does not affect interaction with DICER1. Decreased phosphorylation of a C-terminal serine cluster. Does not affect phosphorylation of Ser-387","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33199684"}],"featureId":"VAR_085427","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"No effect.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284456"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["W"]}},{"type":"Mutagenesis","location":{"start":{"value":470,"modifier":"EXACT"},"end":{"value":470,"modifier":"EXACT"}},"description":"No effect on miRNA-binding or target mRNA cleavage. Abrogates binding to the 7-methylguanosine cap of mRNA and prevents inhibition of translation. Abolishes interaction with TNRC6C; when associated with V-505.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17524464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21981923"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":470,"modifier":"EXACT"},"end":{"value":470,"modifier":"EXACT"}},"description":"No effect on binding to the 7-methylguanosine cap of mRNA or inhibition of translation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17524464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21981923"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["W"]}},{"type":"Mutagenesis","location":{"start":{"value":505,"modifier":"EXACT"},"end":{"value":505,"modifier":"EXACT"}},"description":"No effect on miRNA-binding or target mRNA cleavage. Abrogates binding to the 7-methylguanosine cap of mRNA and prevents inhibition of translation and abolishes interaction with TNRC6C; when associated with V-470.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17524464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21981923"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":505,"modifier":"EXACT"},"end":{"value":505,"modifier":"EXACT"}},"description":"No effect on binding to the 7-methylguanosine cap of mRNA or inhibition of translation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17524464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21981923"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["W"]}},{"type":"Mutagenesis","location":{"start":{"value":533,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"Impairs RNA cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800629"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":545,"modifier":"EXACT"},"end":{"value":545,"modifier":"EXACT"}},"description":"Impairs RNA cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800629"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":570,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"Impairs RNA cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800629"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":597,"modifier":"EXACT"},"end":{"value":597,"modifier":"EXACT"}},"description":"Abrogates RNA cleavage but does not affect binding to siRNA or translational repression.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284456"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800637"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18771919"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":633,"modifier":"EXACT"},"end":{"value":633,"modifier":"EXACT"}},"description":"No effect.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284456"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":633,"modifier":"EXACT"},"end":{"value":633,"modifier":"EXACT"}},"description":"Abrogates RNA cleavage. Binds siRNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284456"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":634,"modifier":"EXACT"},"end":{"value":634,"modifier":"EXACT"}},"description":"Abrogates RNA cleavage. Binds siRNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284456"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["P","A"]}},{"type":"Mutagenesis","location":{"start":{"value":669,"modifier":"EXACT"},"end":{"value":669,"modifier":"EXACT"}},"description":"Abrogates RNA cleavage but does not affect binding to siRNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284456"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800637"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16357216"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":673,"modifier":"EXACT"},"end":{"value":673,"modifier":"EXACT"}},"description":"Impairs RNA cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800637"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23746446"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":673,"modifier":"EXACT"},"end":{"value":673,"modifier":"EXACT"}},"description":"No effect on RNA cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800637"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23746446"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":676,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"Impairs RNA cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23746446"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A","I","M","R","Y"]}},{"type":"Mutagenesis","location":{"start":{"value":676,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"Abrogates RNA cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23746446"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":682,"modifier":"EXACT"},"end":{"value":682,"modifier":"EXACT"}},"description":"No effect.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284456"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Mutagenesis","location":{"start":{"value":683,"modifier":"EXACT"},"end":{"value":683,"modifier":"EXACT"}},"description":"No effect on RNA cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800637"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":700,"modifier":"EXACT"},"end":{"value":700,"modifier":"EXACT"}},"description":"Reduced protein stability.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18690212"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":704,"modifier":"EXACT"},"end":{"value":704,"modifier":"EXACT"}},"description":"No effect.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284456"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["Y"]}},{"type":"Mutagenesis","location":{"start":{"value":744,"modifier":"EXACT"},"end":{"value":744,"modifier":"EXACT"}},"description":"No effect.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15284456"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["Y"]}},{"type":"Mutagenesis","location":{"start":{"value":807,"modifier":"EXACT"},"end":{"value":807,"modifier":"EXACT"}},"description":"Abrogates RNA cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800637"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23746446"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["A","R"]}},{"type":"Sequence conflict","location":{"start":{"value":564,"modifier":"EXACT"},"end":{"value":564,"modifier":"EXACT"}},"description":"in Ref. 5; AAF13034","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["W"]}},{"type":"Sequence conflict","location":{"start":{"value":589,"modifier":"EXACT"},"end":{"value":589,"modifier":"EXACT"}},"description":"in Ref. 5; AAF13034","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":617,"modifier":"EXACT"},"end":{"value":617,"modifier":"EXACT"}},"description":"in Ref. 5; AAF13034","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":637,"modifier":"EXACT"},"end":{"value":637,"modifier":"EXACT"}},"description":"in Ref. 3; AAL76093","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Helix","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5T7B"}]},{"type":"Beta strand","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D6J"}]},{"type":"Beta strand","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Turn","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Turn","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4W5N"}]},{"type":"Beta strand","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D6J"}]},{"type":"Beta strand","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4E"}]},{"type":"Helix","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KI3"}]},{"type":"Beta strand","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Turn","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6RA4"}]},{"type":"Beta strand","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4F3T"}]},{"type":"Beta strand","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6RA4"}]},{"type":"Helix","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6RA4"}]},{"type":"Beta strand","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6RA4"}]},{"type":"Beta strand","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4OLB"}]},{"type":"Helix","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9K6P"}]},{"type":"Beta strand","location":{"start":{"value":406,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":417,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Turn","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9K6P"}]},{"type":"Helix","location":{"start":{"value":441,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3LUC"}]},{"type":"Helix","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":455,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BF2"}]},{"type":"Turn","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BF2"}]},{"type":"Helix","location":{"start":{"value":464,"modifier":"EXACT"},"end":{"value":480,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BF2"}]},{"type":"Beta strand","location":{"start":{"value":490,"modifier":"EXACT"},"end":{"value":494,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BF2"}]},{"type":"Helix","location":{"start":{"value":498,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BF2"}]},{"type":"Helix","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BF2"}]},{"type":"Beta strand","location":{"start":{"value":517,"modifier":"EXACT"},"end":{"value":522,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BF2"}]},{"type":"Helix","location":{"start":{"value":528,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BF2"}]},{"type":"Helix","location":{"start":{"value":534,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BF2"}]},{"type":"Beta strand","location":{"start":{"value":544,"modifier":"EXACT"},"end":{"value":548,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BF2"}]},{"type":"Helix","location":{"start":{"value":550,"modifier":"EXACT"},"end":{"value":553,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BF2"}]},{"type":"Helix","location":{"start":{"value":557,"modifier":"EXACT"},"end":{"value":571,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BF2"}]},{"type":"Helix","location":{"start":{"value":580,"modifier":"EXACT"},"end":{"value":582,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":585,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":591,"modifier":"EXACT"},"end":{"value":599,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":600,"modifier":"EXACT"},"end":{"value":602,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Turn","location":{"start":{"value":603,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KI6"}]},{"type":"Beta strand","location":{"start":{"value":606,"modifier":"EXACT"},"end":{"value":608,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9K6Q"}]},{"type":"Beta strand","location":{"start":{"value":610,"modifier":"EXACT"},"end":{"value":617,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":619,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":633,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":657,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":662,"modifier":"EXACT"},"end":{"value":669,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":673,"modifier":"EXACT"},"end":{"value":675,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":676,"modifier":"EXACT"},"end":{"value":694,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":701,"modifier":"EXACT"},"end":{"value":709,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":710,"modifier":"EXACT"},"end":{"value":712,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4W5Q"}]},{"type":"Beta strand","location":{"start":{"value":715,"modifier":"EXACT"},"end":{"value":719,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":720,"modifier":"EXACT"},"end":{"value":722,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Turn","location":{"start":{"value":725,"modifier":"EXACT"},"end":{"value":728,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":734,"modifier":"EXACT"},"end":{"value":736,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":738,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":743,"modifier":"EXACT"},"end":{"value":745,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":747,"modifier":"EXACT"},"end":{"value":751,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":757,"modifier":"EXACT"},"end":{"value":759,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CBD"}]},{"type":"Beta strand","location":{"start":{"value":763,"modifier":"EXACT"},"end":{"value":770,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":776,"modifier":"EXACT"},"end":{"value":786,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":793,"modifier":"EXACT"},"end":{"value":795,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KI6"}]},{"type":"Helix","location":{"start":{"value":801,"modifier":"EXACT"},"end":{"value":816,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Turn","location":{"start":{"value":817,"modifier":"EXACT"},"end":{"value":820,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Beta strand","location":{"start":{"value":822,"modifier":"EXACT"},"end":{"value":826,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9K6R"}]},{"type":"Helix","location":{"start":{"value":831,"modifier":"EXACT"},"end":{"value":834,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9K6R"}]},{"type":"Helix","location":{"start":{"value":837,"modifier":"EXACT"},"end":{"value":846,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Helix","location":{"start":{"value":847,"modifier":"EXACT"},"end":{"value":849,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]},{"type":"Turn","location":{"start":{"value":850,"modifier":"EXACT"},"end":{"value":854,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4Z4D"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0379","category":"PTM","name":"Hydroxylation"},{"id":"KW-0991","category":"Disease","name":"Intellectual disability"},{"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"id":"KW-0464","category":"Ligand","name":"Manganese"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0944","category":"PTM","name":"Nitration"},{"id":"KW-0540","category":"Molecular function","name":"Nuclease"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0687","category":"Molecular function","name":"Ribonucleoprotein"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0943","category":"Biological process","name":"RNA-mediated gene silencing"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0810","category":"Biological process","name":"Translation regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L. III","Engels R.","Gloeckner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.J.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 239-859 (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Eye","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"11914277","citationType":"journal article","authors":["Mourelatos Z.","Dostie J.","Paushkin S.","Sharma A.","Charroux B.","Abel L.","Rappsilber J.","Mann M.","Dreyfuss G."],"citationCrossReferences":[{"database":"PubMed","id":"11914277"},{"database":"DOI","id":"10.1101/gad.974702"}],"title":"miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs.","publicationDate":"2002","journal":"Genes Dev.","firstPage":"720","lastPage":"728","volume":"16"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 47-859 (ISOFORM 1)"]},{"referenceNumber":4,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 275-859 (ISOFORM 1)"]},{"referenceNumber":5,"citation":{"id":"10534406","citationType":"journal article","authors":["Koesters R.","Adams V.","Betts D.","Moos R.","Schmid M.","Siermann A.","Hassam S.","Weitz S.","Lichter P.","Heitz P.U.","von Knebel Doeberitz M.","Briner J."],"citationCrossReferences":[{"database":"PubMed","id":"10534406"},{"database":"DOI","id":"10.1006/geno.1999.5951"}],"title":"Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression.","publicationDate":"1999","journal":"Genomics","firstPage":"210","lastPage":"218","volume":"61"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 483-859 (ISOFORM 1)"]},{"referenceNumber":6,"citation":{"id":"14508492","citationType":"journal article","authors":["Caudy A.A.","Ketting R.F.","Hammond S.M.","Denli A.M.","Bathoorn A.M.","Tops B.B.","Silva J.M.","Myers M.M.","Hannon G.J.","Plasterk R.H."],"citationCrossReferences":[{"database":"PubMed","id":"14508492"},{"database":"DOI","id":"10.1038/nature01956"}],"title":"A micrococcal nuclease homologue in RNAi effector complexes.","publicationDate":"2003","journal":"Nature","firstPage":"411","lastPage":"414","volume":"425"},"referencePositions":["INTERACTION WITH SND1"]},{"referenceNumber":7,"citation":{"id":"14749716","citationType":"journal article","authors":["Tahbaz N.","Kolb F.A.","Zhang H.","Jaronczyk K.","Filipowicz W.","Hobman T.C."],"citationCrossReferences":[{"database":"PubMed","id":"14749716"},{"database":"DOI","id":"10.1038/sj.embor.7400070"}],"title":"Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer.","publicationDate":"2004","journal":"EMBO Rep.","firstPage":"189","lastPage":"194","volume":"5"},"referencePositions":["INTERACTION WITH DICER1"]},{"referenceNumber":8,"citation":{"id":"15105377","citationType":"journal article","authors":["Martinez J.","Tuschl T."],"citationCrossReferences":[{"database":"PubMed","id":"15105377"},{"database":"DOI","id":"10.1101/gad.1187904"}],"title":"RISC is a 5' phosphomonoester-producing RNA endonuclease.","publicationDate":"2004","journal":"Genes Dev.","firstPage":"975","lastPage":"980","volume":"18"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","BIOPHYSICOCHEMICAL PROPERTIES"]},{"referenceNumber":9,"citation":{"id":"15260970","citationType":"journal article","authors":["Meister G.","Landthaler M.","Patkaniowska A.","Dorsett Y.","Teng G.","Tuschl T."],"citationCrossReferences":[{"database":"PubMed","id":"15260970"},{"database":"DOI","id":"10.1016/j.molcel.2004.07.007"}],"title":"Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.","publicationDate":"2004","journal":"Mol. Cell","firstPage":"185","lastPage":"197","volume":"15"},"referencePositions":["FUNCTION"]},{"referenceNumber":10,"citation":{"id":"14703574","citationType":"journal article","authors":["Jin P.","Zarnescu D.C.","Ceman S.","Nakamoto M.","Mowrey J.","Jongens T.A.","Nelson D.L.","Moses K.","Warren S.T."],"citationCrossReferences":[{"database":"PubMed","id":"14703574"},{"database":"DOI","id":"10.1038/nn1174"}],"title":"Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway.","publicationDate":"2004","journal":"Nat. Neurosci.","firstPage":"113","lastPage":"117","volume":"7"},"referencePositions":["INTERACTION WITH FMR1"]},{"referenceNumber":11,"citation":{"id":"15337849","citationType":"journal article","authors":["Pillai R.S.","Artus C.G.","Filipowicz W."],"citationCrossReferences":[{"database":"PubMed","id":"15337849"},{"database":"DOI","id":"10.1261/rna.7131604"}],"title":"Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis.","publicationDate":"2004","journal":"RNA","firstPage":"1518","lastPage":"1525","volume":"10"},"referencePositions":["FUNCTION","INTERACTION WITH GEMIN4"]},{"referenceNumber":12,"citation":{"id":"15284456","citationType":"journal article","authors":["Liu J.","Carmell M.A.","Rivas F.V.","Marsden C.G.","Thomson J.M.","Song J.-J.","Hammond S.M.","Joshua-Tor L.","Hannon G.J."],"citationCrossReferences":[{"database":"PubMed","id":"15284456"},{"database":"DOI","id":"10.1126/science.1102513"}],"title":"Argonaute2 is the catalytic engine of mammalian RNAi.","publicationDate":"2004","journal":"Science","firstPage":"1437","lastPage":"1441","volume":"305"},"referencePositions":["FUNCTION","ACTIVITY REGULATION","MUTAGENESIS OF LEU-140; ASP-597; GLN-633; HIS-634; ASP-669; HIS-682; PHE-704 AND THR-744","COFACTOR"]},{"referenceNumber":13,"citation":{"id":"15766526","citationType":"journal article","authors":["Jing Q.","Huang S.","Guth S.","Zarubin T.","Motoyama A.","Chen J.","Di Padova F.","Lin S.C.","Gram H.","Han J."],"citationCrossReferences":[{"database":"PubMed","id":"15766526"},{"database":"DOI","id":"10.1016/j.cell.2004.12.038"}],"title":"Involvement of microRNA in AU-rich element-mediated mRNA instability.","publicationDate":"2005","journal":"Cell","firstPage":"623","lastPage":"634","volume":"120"},"referencePositions":["INTERACTION WITH ZFP36"]},{"referenceNumber":14,"citation":{"id":"16271387","citationType":"journal article","authors":["Gregory R.I.","Chendrimada T.P.","Cooch N.","Shiekhattar R."],"citationCrossReferences":[{"database":"PubMed","id":"16271387"},{"database":"DOI","id":"10.1016/j.cell.2005.10.022"}],"title":"Human RISC couples microRNA biogenesis and posttranscriptional gene silencing.","publicationDate":"2005","journal":"Cell","firstPage":"631","lastPage":"640","volume":"123"},"referencePositions":["FUNCTION","INTERACTION WITH DICER1 AND TARBP2"]},{"referenceNumber":15,"citation":{"id":"16289642","citationType":"journal article","authors":["Meister G.","Landthaler M.","Peters L.","Chen P.Y.","Urlaub H.","Luehrmann R.","Tuschl T."],"citationCrossReferences":[{"database":"PubMed","id":"16289642"},{"database":"DOI","id":"10.1016/j.cub.2005.10.048"}],"title":"Identification of novel argonaute-associated proteins.","publicationDate":"2005","journal":"Curr. Biol.","firstPage":"2149","lastPage":"2155","volume":"15"},"referencePositions":["FUNCTION","INTERACTION WITH DDX20; DICER1; GEMIN4; MOV10; PRMT5 AND TNRC6B","SUBCELLULAR LOCATION"]},{"referenceNumber":16,"citation":{"id":"16142218","citationType":"journal article","authors":["Haase A.D.","Jaskiewicz L.","Zhang H.","Laine S.","Sack R.","Gatignol A.","Filipowicz W."],"citationCrossReferences":[{"database":"PubMed","id":"16142218"},{"database":"DOI","id":"10.1038/sj.embor.7400509"}],"title":"TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing.","publicationDate":"2005","journal":"EMBO Rep.","firstPage":"961","lastPage":"967","volume":"6"},"referencePositions":["FUNCTION"]},{"referenceNumber":17,"citation":{"id":"16357216","citationType":"journal article","authors":["Maniataki E.","Mourelatos Z."],"citationCrossReferences":[{"database":"PubMed","id":"16357216"},{"database":"DOI","id":"10.1101/gad.1384005"}],"title":"A human, ATP-independent, RISC assembly machine fueled by pre-miRNA.","publicationDate":"2005","journal":"Genes Dev.","firstPage":"2979","lastPage":"2990","volume":"19"},"referencePositions":["FUNCTION","INTERACTION WITH DICER1 AND TARBP2","MUTAGENESIS OF ASP-669"]},{"referenceNumber":18,"citation":{"id":"15800629","citationType":"journal article","authors":["Ma J.-B.","Yuan Y.-R.","Meister G.","Pei Y.","Tuschl T.","Patel D.J."],"citationCrossReferences":[{"database":"PubMed","id":"15800629"},{"database":"DOI","id":"10.1038/nature03514"}],"title":"Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein.","publicationDate":"2005","journal":"Nature","firstPage":"666","lastPage":"670","volume":"434"},"referencePositions":["MUTAGENESIS OF LYS-533; GLN-545 AND LYS-570"]},{"referenceNumber":19,"citation":{"id":"15973356","citationType":"journal article","authors":["Chendrimada T.P.","Gregory R.I.","Kumaraswamy E.","Norman J.","Cooch N.","Nishikura K.","Shiekhattar R."],"citationCrossReferences":[{"database":"PubMed","id":"15973356"},{"database":"DOI","id":"10.1038/nature03868"}],"title":"TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing.","publicationDate":"2005","journal":"Nature","firstPage":"740","lastPage":"744","volume":"436"},"referencePositions":["INTERACTION WITH DICER1 AND TARBP2"]},{"referenceNumber":20,"citation":{"id":"15908945","citationType":"journal article","authors":["Sen G.L.","Blau H.M."],"citationCrossReferences":[{"database":"PubMed","id":"15908945"},{"database":"DOI","id":"10.1038/ncb1265"}],"title":"Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies.","publicationDate":"2005","journal":"Nat. Cell Biol.","firstPage":"633","lastPage":"636","volume":"7"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":21,"citation":{"id":"15800637","citationType":"journal article","authors":["Rivas F.V.","Tolia N.H.","Song J.-J.","Aragon J.P.","Liu J.","Hannon G.J.","Joshua-Tor L."],"citationCrossReferences":[{"database":"PubMed","id":"15800637"},{"database":"DOI","id":"10.1038/nsmb918"}],"title":"Purified Argonaute2 and an siRNA form recombinant human RISC.","publicationDate":"2005","journal":"Nat. Struct. Mol. Biol.","firstPage":"340","lastPage":"349","volume":"12"},"referencePositions":["FUNCTION","BIOPHYSICOCHEMICAL PROPERTIES","MUTAGENESIS OF ASP-597; ASP-669; GLU-673; GLU-683 AND HIS-807"]},{"referenceNumber":22,"citation":{"id":"16081698","citationType":"journal article","authors":["Pillai R.S.","Bhattacharyya S.N.","Artus C.G.","Zoller T.","Cougot N.","Basyuk E.","Bertrand E.","Filipowicz W."],"citationCrossReferences":[{"database":"PubMed","id":"16081698"},{"database":"DOI","id":"10.1126/science.1115079"}],"title":"Inhibition of translational initiation by Let-7 MicroRNA in human cells.","publicationDate":"2005","journal":"Science","firstPage":"1573","lastPage":"1576","volume":"309"},"referencePositions":["FUNCTION","INTERACTION WITH DCP1A AND XRN1","SUBCELLULAR LOCATION"]},{"referenceNumber":23,"citation":{"id":"16936728","citationType":"journal article","authors":["Janowski B.A.","Huffman K.E.","Schwartz J.C.","Ram R.","Nordsell R.","Shames D.S.","Minna J.D.","Corey D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16936728"},{"database":"DOI","id":"10.1038/nsmb1140"}],"title":"Involvement of AGO1 and AGO2 in mammalian transcriptional silencing.","publicationDate":"2006","journal":"Nat. Struct. Mol. Biol.","firstPage":"787","lastPage":"792","volume":"13"},"referencePositions":["FUNCTION"]},{"referenceNumber":24,"citation":{"id":"16756390","citationType":"journal article","authors":["Chu C.-Y.","Rana T.M."],"citationCrossReferences":[{"database":"PubMed","id":"16756390"},{"database":"DOI","id":"10.1371/journal.pbio.0040210"}],"title":"Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.","publicationDate":"2006","journal":"PLoS Biol.","firstPage":"E210","lastPage":"E210","volume":"4"},"referencePositions":["FUNCTION","INTERACTION WITH DDX6 AND AGO1","SUBCELLULAR LOCATION"]},{"referenceNumber":25,"citation":{"id":"16699599","citationType":"journal article","authors":["Wichroski M.J.","Robb G.B.","Rana T.M."],"citationCrossReferences":[{"database":"PubMed","id":"16699599"},{"database":"DOI","id":"10.1371/journal.ppat.0020041"}],"title":"Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.","publicationDate":"2006","journal":"PLoS Pathog.","firstPage":"E41","lastPage":"E41","volume":"2"},"referencePositions":["INTERACTION WITH APOBEC3G"]},{"referenceNumber":26,"citation":{"id":"17382880","citationType":"journal article","authors":["Vasudevan S.","Steitz J.A."],"citationCrossReferences":[{"database":"PubMed","id":"17382880"},{"database":"DOI","id":"10.1016/j.cell.2007.01.038"}],"title":"AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.","publicationDate":"2007","journal":"Cell","firstPage":"1105","lastPage":"1118","volume":"128"},"referencePositions":["FUNCTION","INTERACTION WITH FXR1","SUBCELLULAR LOCATION"]},{"referenceNumber":27,"citation":{"id":"17524464","citationType":"journal article","authors":["Kiriakidou M.","Tan G.S.","Lamprinaki S.","De Planell-Saguer M.","Nelson P.T.","Mourelatos Z."],"citationCrossReferences":[{"database":"PubMed","id":"17524464"},{"database":"DOI","id":"10.1016/j.cell.2007.05.016"}],"title":"An mRNA m7G cap binding-like motif within human Ago2 represses translation.","publicationDate":"2007","journal":"Cell","firstPage":"1141","lastPage":"1151","volume":"129"},"referencePositions":["FUNCTION","MUTAGENESIS OF PHE-470 AND PHE-505"]},{"referenceNumber":28,"citation":{"id":"17932509","citationType":"journal article","authors":["Hoeck J.","Weinmann L.","Ender C.","Ruedel S.","Kremmer E.","Raabe M.","Urlaub H.","Meister G."],"citationCrossReferences":[{"database":"PubMed","id":"17932509"},{"database":"DOI","id":"10.1038/sj.embor.7401088"}],"title":"Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.","publicationDate":"2007","journal":"EMBO Rep.","firstPage":"1052","lastPage":"1060","volume":"8"},"referencePositions":["FUNCTION","ASSOCIATION WITH POLYSOMES AND MNRP","INTERACTION WITH DDB1; DDX5; DHX30; DHX36; DDX47; ELAVL1; HNRNPF; IGF2BP1; ILF3; MATR3; PABPC1; RBM4; SART3; UPF1 AND YBX1"]},{"referenceNumber":29,"citation":{"id":"17531811","citationType":"journal article","authors":["Robb G.B.","Rana T.M."],"citationCrossReferences":[{"database":"PubMed","id":"17531811"},{"database":"DOI","id":"10.1016/j.molcel.2007.04.016"}],"title":"RNA helicase A interacts with RISC in human cells and functions in RISC loading.","publicationDate":"2007","journal":"Mol. Cell","firstPage":"523","lastPage":"537","volume":"26"},"referencePositions":["FUNCTION","INTERACTION WITH DHX9"]},{"referenceNumber":30,"citation":{"id":"17507929","citationType":"journal article","authors":["Chendrimada T.P.","Finn K.J.","Ji X.","Baillat D.","Gregory R.I.","Liebhaber S.A.","Pasquinelli A.E.","Shiekhattar R."],"citationCrossReferences":[{"database":"PubMed","id":"17507929"},{"database":"DOI","id":"10.1038/nature05841"}],"title":"MicroRNA silencing through RISC recruitment of eIF6.","publicationDate":"2007","journal":"Nature","firstPage":"823","lastPage":"828","volume":"447"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY","FUNCTION","INTERACTION WITH DICER1; EIF6; MOV10; RPL7A AND TARBP2","ASSOCIATION WITH THE 60S RIBOSOME"]},{"referenceNumber":31,"citation":{"id":"18048652","citationType":"journal article","authors":["Vasudevan S.","Tong Y.","Steitz J.A."],"citationCrossReferences":[{"database":"PubMed","id":"18048652"},{"database":"DOI","id":"10.1126/science.1149460"}],"title":"Switching from repression to activation: microRNAs can up-regulate translation.","publicationDate":"2007","journal":"Science","firstPage":"1931","lastPage":"1934","volume":"318"},"referencePositions":["FUNCTION"]},{"referenceNumber":32,"citation":{"id":"18771919","citationType":"journal article","authors":["Wu L.","Fan J.","Belasco J.G."],"citationCrossReferences":[{"database":"PubMed","id":"18771919"},{"database":"DOI","id":"10.1016/j.cub.2008.07.072"}],"title":"Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.","publicationDate":"2008","journal":"Curr. Biol.","firstPage":"1327","lastPage":"1332","volume":"18"},"referencePositions":["FUNCTION","MUTAGENESIS OF ASP-597"]},{"referenceNumber":33,"citation":{"id":"18690212","citationType":"journal article","authors":["Qi H.H.","Ongusaha P.P.","Myllyharju J.","Cheng D.","Pakkanen O.","Shi Y.","Lee S.W.","Peng J.","Shi Y."],"citationCrossReferences":[{"database":"PubMed","id":"18690212"},{"database":"DOI","id":"10.1038/nature07186"}],"title":"Prolyl 4-hydroxylation regulates Argonaute 2 stability.","publicationDate":"2008","journal":"Nature","firstPage":"421","lastPage":"424","volume":"455"},"referencePositions":["FUNCTION","INTERACTION WITH DICER1; P4HA1; P4HB; TNRC6A AND TNRC6B","SUBCELLULAR LOCATION","HYDROXYLATION AT PRO-700","MUTAGENESIS OF PRO-700"]},{"referenceNumber":34,"citation":{"id":"18178619","citationType":"journal article","authors":["MacRae I.J.","Ma E.","Zhou M.","Robinson C.V.","Doudna J.A."],"citationCrossReferences":[{"database":"PubMed","id":"18178619"},{"database":"DOI","id":"10.1073/pnas.0710869105"}],"title":"In vitro reconstitution of the human RISC-loading complex.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"512","lastPage":"517","volume":"105"},"referencePositions":["FUNCTION","INTERACTION WITH DICER1 AND TARBP2"]},{"referenceNumber":35,"citation":{"id":"19167051","citationType":"journal article","authors":["Weinmann L.","Hoeck J.","Ivacevic T.","Ohrt T.","Muetze J.","Schwille P.","Kremmer E.","Benes V.","Urlaub H.","Meister G."],"citationCrossReferences":[{"database":"PubMed","id":"19167051"},{"database":"DOI","id":"10.1016/j.cell.2008.12.023"}],"title":"Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.","publicationDate":"2009","journal":"Cell","firstPage":"496","lastPage":"507","volume":"136"},"referencePositions":["FUNCTION","INTERACTION WITH IMP8","SUBCELLULAR LOCATION"]},{"referenceNumber":36,"citation":{"id":"19801630","citationType":"journal article","authors":["Lin J.C.","Tarn W.Y."],"citationCrossReferences":[{"database":"PubMed","id":"19801630"},{"database":"DOI","id":"10.1074/jbc.m109.032946"}],"title":"RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"34658","lastPage":"34665","volume":"284"},"referencePositions":["INTERACTION WITH RBM4"]},{"referenceNumber":37,"citation":{"id":"20616046","citationType":"journal article","authors":["James V.","Zhang Y.","Foxler D.E.","de Moor C.H.","Kong Y.W.","Webb T.M.","Self T.J.","Feng Y.","Lagos D.","Chu C.Y.","Rana T.M.","Morley S.J.","Longmore G.D.","Bushell M.","Sharp T.V."],"citationCrossReferences":[{"database":"PubMed","id":"20616046"},{"database":"DOI","id":"10.1073/pnas.0914987107"}],"title":"LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.","publicationDate":"2010","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12499","lastPage":"12504","volume":"107"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH LIMD1; WTIP AND AJUBA"]},{"referenceNumber":38,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":39,"citation":{"id":"21981923","citationType":"journal article","authors":["Braun J.E.","Huntzinger E.","Fauser M.","Izaurralde E."],"citationCrossReferences":[{"database":"PubMed","id":"21981923"},{"database":"DOI","id":"10.1016/j.molcel.2011.09.007"}],"title":"GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.","publicationDate":"2011","journal":"Mol. Cell","firstPage":"120","lastPage":"133","volume":"44"},"referencePositions":["INTERACTION WITH TNRC6C","MUTAGENESIS OF PHE-470 AND PHE-505"]},{"referenceNumber":40,"citation":{"id":"22791714","citationType":"journal article","authors":["Liu C.","Zhang X.","Huang F.","Yang B.","Li J.","Liu B.","Luo H.","Zhang P.","Zhang H."],"citationCrossReferences":[{"database":"PubMed","id":"22791714"},{"database":"DOI","id":"10.1074/jbc.m112.354001"}],"title":"APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10.","publicationDate":"2012","journal":"J. Biol. Chem.","firstPage":"29373","lastPage":"29383","volume":"287"},"referencePositions":["INTERACTION WITH MOV10"]},{"referenceNumber":41,"citation":{"id":"22915799","citationType":"journal article","authors":["Phalora P.K.","Sherer N.M.","Wolinsky S.M.","Swanson C.M.","Malim M.H."],"citationCrossReferences":[{"database":"PubMed","id":"22915799"},{"database":"DOI","id":"10.1128/jvi.00595-12"}],"title":"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.","publicationDate":"2012","journal":"J. Virol.","firstPage":"11712","lastPage":"11724","volume":"86"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH APOBEC3A; APOBEC3C; APOBEC3F; APOBEC3G AND APOBEC3H"]},{"referenceNumber":42,"citation":{"id":"23746446","citationType":"journal article","authors":["Faehnle C.R.","Elkayam E.","Haase A.D.","Hannon G.J.","Joshua-Tor L."],"citationCrossReferences":[{"database":"PubMed","id":"23746446"},{"database":"DOI","id":"10.1016/j.celrep.2013.05.033"}],"title":"The making of a slicer: activation of human Argonaute-1.","publicationDate":"2013","journal":"Cell Rep.","firstPage":"1901","lastPage":"1909","volume":"3"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","MUTAGENESIS OF GLU-673; PHE-676 AND HIS-807"]},{"referenceNumber":43,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387 AND SER-828","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":44,"citation":{"id":"23603119","citationType":"journal article","authors":["Horman S.R.","Janas M.M.","Litterst C.","Wang B.","MacRae I.J.","Sever M.J.","Morrissey D.V.","Graves P.","Luo B.","Umesalma S.","Qi H.H.","Miraglia L.J.","Novina C.D.","Orth A.P."],"citationCrossReferences":[{"database":"PubMed","id":"23603119"},{"database":"DOI","id":"10.1016/j.molcel.2013.03.015"}],"title":"Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets.","publicationDate":"2013","journal":"Mol. Cell","firstPage":"356","lastPage":"367","volume":"50"},"referencePositions":["PHOSPHORYLATION AT SER-387","SUBCELLULAR LOCATION"]},{"referenceNumber":45,"citation":{"id":"23125361","citationType":"journal article","authors":["Loedige I.","Gaidatzis D.","Sack R.","Meister G.","Filipowicz W."],"citationCrossReferences":[{"database":"PubMed","id":"23125361"},{"database":"DOI","id":"10.1093/nar/gks1032"}],"title":"The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.","publicationDate":"2013","journal":"Nucleic Acids Res.","firstPage":"518","lastPage":"532","volume":"41"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH TRIM71"]},{"referenceNumber":46,"citation":{"id":"24726324","citationType":"journal article","authors":["Gregersen L.H.","Schueler M.","Munschauer M.","Mastrobuoni G.","Chen W.","Kempa S.","Dieterich C.","Landthaler M."],"citationCrossReferences":[{"database":"PubMed","id":"24726324"},{"database":"DOI","id":"10.1016/j.molcel.2014.03.017"}],"title":"MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.","publicationDate":"2014","journal":"Mol. Cell","firstPage":"573","lastPage":"585","volume":"54"},"referencePositions":["INTERACTION WITH MOV10"]},{"referenceNumber":47,"citation":{"id":"26009488","citationType":"journal article","authors":["Xu M.","Cai C.","Sun X.","Chen W.","Li Q.","Zhou H."],"citationCrossReferences":[{"database":"PubMed","id":"26009488"},{"database":"DOI","id":"10.1016/j.bbrc.2015.05.046"}],"title":"Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.","publicationDate":"2015","journal":"Biochem. Biophys. Res. Commun.","firstPage":"275","lastPage":"279","volume":"463"},"referencePositions":["INTERACTION WITH CLNK"]},{"referenceNumber":48,"citation":{"id":"25697406","citationType":"journal article","authors":["Srivastava M.","Duan G.","Kershaw N.J.","Athanasopoulos V.","Yeo J.H.","Ose T.","Hu D.","Brown S.H.","Jergic S.","Patel H.R.","Pratama A.","Richards S.","Verma A.","Jones E.Y.","Heissmeyer V.","Preiss T.","Dixon N.E.","Chong M.M.","Babon J.J.","Vinuesa C.G."],"citationCrossReferences":[{"database":"PubMed","id":"25697406"},{"database":"DOI","id":"10.1038/ncomms7253"}],"title":"Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.","publicationDate":"2015","journal":"Nat. Commun.","firstPage":"6253","lastPage":"6253","volume":"6"},"referencePositions":["INTERACTION WITH RC3H1"]},{"referenceNumber":49,"citation":{"id":"28114302","citationType":"journal article","authors":["Golden R.J.","Chen B.","Li T.","Braun J.","Manjunath H.","Chen X.","Wu J.","Schmid V.","Chang T.C.","Kopp F.","Ramirez-Martinez A.","Tagliabracci V.S.","Chen Z.J.","Xie Y.","Mendell J.T."],"citationCrossReferences":[{"database":"PubMed","id":"28114302"},{"database":"DOI","id":"10.1038/nature21025"}],"title":"An Argonaute phosphorylation cycle promotes microRNA-mediated silencing.","publicationDate":"2017","journal":"Nature","firstPage":"197","lastPage":"202","volume":"542"},"referencePositions":["PHOSPHORYLATION AT SER-824; SER-828; SER-831 AND SER-834"]},{"referenceNumber":50,"citation":{"id":"28546213","citationType":"journal article","authors":["Elbarbary R.A.","Miyoshi K.","Myers J.R.","Du P.","Ashton J.M.","Tian B.","Maquat L.E."],"citationCrossReferences":[{"database":"PubMed","id":"28546213"},{"database":"DOI","id":"10.1126/science.aai9372"}],"title":"Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition.","publicationDate":"2017","journal":"Science","firstPage":"859","lastPage":"862","volume":"356"},"referencePositions":["INTERACTION WITH SND1"]},{"referenceNumber":51,"citation":{"id":"29395067","citationType":"journal article","authors":["Youn J.Y.","Dunham W.H.","Hong S.J.","Knight J.D.R.","Bashkurov M.","Chen G.I.","Bagci H.","Rathod B.","MacLeod G.","Eng S.W.M.","Angers S.","Morris Q.","Fabian M.","Cote J.F.","Gingras A.C."],"citationCrossReferences":[{"database":"PubMed","id":"29395067"},{"database":"DOI","id":"10.1016/j.molcel.2017.12.020"}],"title":"High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.","publicationDate":"2018","journal":"Mol. Cell","firstPage":"517.e11","lastPage":"532.e11","volume":"69"},"referencePositions":["INTERACTION WITH GARRE1"]},{"referenceNumber":52,"citation":{"id":"30258011","citationType":"journal article","authors":["Dhillon P.","Rao C.D."],"citationCrossReferences":[{"database":"PubMed","id":"30258011"},{"database":"DOI","id":"10.1128/jvi.01363-18"}],"title":"Rotavirus Induces Formation of Remodeled Stress Granules and P Bodies and Their Sequestration in Viroplasms To Promote Progeny Virus Production.","publicationDate":"2018","journal":"J. Virol.","firstPage":"0","lastPage":"0","volume":"92"},"referencePositions":["INTERACTION WITH ROTAVIRUS A NON-STRUCTURAL PROTEIN 5 (MICROBIAL INFECTION)"]},{"referenceNumber":53,"citation":{"id":"31400113","citationType":"journal article","authors":["Sharma N.R.","Majerciak V.","Kruhlak M.J.","Yu L.","Kang J.G.","Yang A.","Gu S.","Fritzler M.J.","Zheng Z.M."],"citationCrossReferences":[{"database":"PubMed","id":"31400113"},{"database":"DOI","id":"10.1093/nar/gkz683"}],"title":"KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.","publicationDate":"2019","journal":"Nucleic Acids Res.","firstPage":"9368","lastPage":"9385","volume":"47"},"referencePositions":["INTERACTION WITH HUMAN HERPES VIRUS 8 PROTEIN KTA/ORF57 (MICROBIAL INFECTION)","SUBCELLULAR LOCATION"]},{"referenceNumber":54,"citation":{"id":"33184234","citationType":"journal article","authors":["Han J.","LaVigne C.A.","Jones B.T.","Zhang H.","Gillett F.","Mendell J.T."],"citationCrossReferences":[{"database":"PubMed","id":"33184234"},{"database":"DOI","id":"10.1126/science.abc9546"}],"title":"A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming.","publicationDate":"2020","journal":"Science","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["UBIQUITINATION"]},{"referenceNumber":55,"citation":{"id":"33184237","citationType":"journal article","authors":["Shi C.Y.","Kingston E.R.","Kleaveland B.","Lin D.H.","Stubna M.W.","Bartel D.P."],"citationCrossReferences":[{"database":"PubMed","id":"33184237"},{"database":"DOI","id":"10.1126/science.abc9359"}],"title":"The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation.","publicationDate":"2020","journal":"Science","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["UBIQUITINATION"]},{"referenceNumber":56,"citation":{"id":"33199684","citationType":"journal article","authors":["Lessel D.","Zeitler D.M.","Reijnders M.R.F.","Kazantsev A.","Hassani Nia F.","Bartholomaeus A.","Martens V.","Bruckmann A.","Graus V.","McConkie-Rosell A.","McDonald M.","Lozic B.","Tan E.S.","Gerkes E.","Johannsen J.","Denecke J.","Telegrafi A.","Zonneveld-Huijssoon E.","Lemmink H.H.","Cham B.W.M.","Kovacevic T.","Ramsdell L.","Foss K.","Le Duc D.","Mitter D.","Syrbe S.","Merkenschlager A.","Sinnema M.","Panis B.","Lazier J.","Osmond M.","Hartley T.","Mortreux J.","Busa T.","Missirian C.","Prasun P.","Luettgen S.","Mannucci I.","Lessel I.","Schob C.","Kindler S.","Pappas J.","Rabin R.","Willemsen M.","Gardeitchik T.","Loehner K.","Rump P.","Dias K.R.","Evans C.A.","Andrews P.I.","Roscioli T.","Brunner H.G.","Chijiwa C.","Lewis M.E.S.","Jamra R.A.","Dyment D.A.","Boycott K.M.","Stegmann A.P.A.","Kubisch C.","Tan E.C.","Mirzaa G.M.","McWalter K.","Kleefstra T.","Pfundt R.","Ignatova Z.","Meister G.","Kreienkamp H.J."],"citationCrossReferences":[{"database":"PubMed","id":"33199684"},{"database":"DOI","id":"10.1038/s41467-020-19572-5"}],"title":"Germline AGO2 mutations impair RNA interference and human neurological development.","publicationDate":"2020","journal":"Nat. Commun.","firstPage":"5797","lastPage":"5797","volume":"11"},"referencePositions":["INVOLVEMENT IN LESKRES","VARIANTS LESKRES CYS-201; VAL-201; GLN-203; MET-357; THR-364; PRO-367; SER-573; ARG-733; TYR-751 AND ARG-760","CHARACTERIZATION OF VARIANTS LESKRES PRO-192; CYS-201; VAL-201; GLN-203; MET-357; THR-364; PRO-367; SER-573; ARG-733; TYR-751 AND ARG-760","SUBCELLULAR LOCATION","PHOSPHORYLATION AT SER-387","INTERACTION WITH DICER1"]},{"referenceNumber":57,"citation":{"id":"32213613","citationType":"journal article","authors":["Liu X.","Sadaoka T.","Krogmann T.","Cohen J.I."],"citationCrossReferences":[{"database":"PubMed","id":"32213613"},{"database":"DOI","id":"10.1128/jvi.00258-20"}],"title":"Epstein-Barr Virus (EBV) Tegument Protein BGLF2 Suppresses Type I Interferon Signaling To Promote EBV Reactivation.","publicationDate":"2020","journal":"J. Virol.","firstPage":"0","lastPage":"0","volume":"94"},"referencePositions":["INTERACTION WITH EPSTEIN-BARR VIRUS TEGUMENT PROTEIN BGLF2 (MICROBIAL INFECTION)"]},{"referenceNumber":58,"citation":{"id":"34903581","citationType":"journal article","authors":["Pawlica P.","Yario T.A.","White S.","Wang J.","Moss W.N.","Hui P.","Vinetz J.M.","Steitz J.A."],"citationCrossReferences":[{"database":"PubMed","id":"34903581"},{"database":"DOI","id":"10.1073/pnas.2116668118"}],"title":"SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes.","publicationDate":"2021","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"0","lastPage":"0","volume":"118"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)"]},{"referenceNumber":59,"citation":{"id":"37328606","citationType":"journal article","authors":["Stainthorp A.K.","Lin C.C.","Wang D.","Medhi R.","Ahmed Z.","Suen K.M.","Miska E.A.","Whitehouse A.","Ladbury J.E."],"citationCrossReferences":[{"database":"PubMed","id":"37328606"},{"database":"DOI","id":"10.1038/s41598-023-36996-3"}],"title":"Regulation of microRNA expression by the adaptor protein GRB2.","publicationDate":"2023","journal":"Sci. Rep.","firstPage":"9784","lastPage":"9784","volume":"13"},"referencePositions":["FUNCTION","INTERACTION WITH GRB2"]},{"referenceNumber":60,"citation":{"id":"20505670","citationType":"journal article","authors":["Frank F.","Sonenberg N.","Nagar B."],"citationCrossReferences":[{"database":"PubMed","id":"20505670"},{"database":"DOI","id":"10.1038/nature09039"}],"title":"Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.","publicationDate":"2010","journal":"Nature","firstPage":"818","lastPage":"822","volume":"465"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.69 ANGSTROMS) OF 439-575 IN COMPLEX WITH AMP; CMP; GMP AND PHOSPHATE"]},{"referenceNumber":61,"citation":{"id":"21475248","citationType":"journal article","authors":["Frank F.","Fabian M.R.","Stepinski J.","Jemielity J.","Darzynkiewicz E.","Sonenberg N.","Nagar B."],"citationCrossReferences":[{"database":"PubMed","id":"21475248"},{"database":"DOI","id":"10.1038/embor.2011.48"}],"title":"Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.","publicationDate":"2011","journal":"EMBO Rep.","firstPage":"415","lastPage":"420","volume":"12"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 439-575 IN COMPLEX WITH 7-MGTPG AND ATP"]},{"referenceNumber":62,"citation":{"id":"22682761","citationType":"journal article","authors":["Elkayam E.","Kuhn C.D.","Tocilj A.","Haase A.D.","Greene E.M.","Hannon G.J.","Joshua-Tor L."],"citationCrossReferences":[{"database":"PubMed","id":"22682761"},{"database":"DOI","id":"10.1016/j.cell.2012.05.017"}],"title":"The structure of human argonaute-2 in complex with miR-20a.","publicationDate":"2012","journal":"Cell","firstPage":"100","lastPage":"110","volume":"150"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEX WITH MIRNA-20A","GUIDE RNA-BINDING"]},{"referenceNumber":63,"citation":{"id":"22539551","citationType":"journal article","authors":["Schirle N.T.","MacRae I.J."],"citationCrossReferences":[{"database":"PubMed","id":"22539551"},{"database":"DOI","id":"10.1126/science.1221551"}],"title":"The crystal structure of human Argonaute2.","publicationDate":"2012","journal":"Science","firstPage":"1037","lastPage":"1040","volume":"336"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH RNA AND L-TRYPTOPHAN","GUIDE RNA-BINDING"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC067931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC107375","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC007633","properties":[{"key":"ProteinId","value":"AAH07633.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC018727","properties":[{"key":"ProteinId","value":"AAH18727.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC125214","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY077717","properties":[{"key":"ProteinId","value":"AAL76093.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT007229","properties":[{"key":"ProteinId","value":"AAP35893.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF121255","properties":[{"key":"ProteinId","value":"AAF13034.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS55279.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UKV8-2"},{"database":"CCDS","id":"CCDS6380.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UKV8-1"},{"database":"RefSeq","id":"NP_001158095.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001164623.3"}],"isoformId":"Q9UKV8-2"},{"database":"RefSeq","id":"NP_036286.2","properties":[{"key":"NucleotideSequenceId","value":"NM_012154.5"}],"isoformId":"Q9UKV8-1"},{"database":"PDB","id":"3LUC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.69 A"},{"key":"Chains","value":"A/B/C=439-575"}]},{"database":"PDB","id":"3LUD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C=439-575"}]},{"database":"PDB","id":"3LUG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B/C=439-575"}]},{"database":"PDB","id":"3LUH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C=439-575"}]},{"database":"PDB","id":"3LUJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C=439-575"}]},{"database":"PDB","id":"3LUK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B/C=439-575"}]},{"database":"PDB","id":"3QX8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C=439-575"}]},{"database":"PDB","id":"3QX9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C=439-575"}]},{"database":"PDB","id":"4F3T","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4OLA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4OLB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4W5N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4W5O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4W5Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4W5R","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4W5T","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4Z4C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4Z4D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4Z4E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4Z4F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4Z4G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4Z4H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"4Z4I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"5JS1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"5JS2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"5KI6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"5T7B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.53 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"5WEA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.12 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"6CBD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"6MDZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"A/B=1-859"}]},{"database":"PDB","id":"6MFN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"6MFR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"A/B=1-859"}]},{"database":"PDB","id":"6N4O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"6NIT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"A/B=1-859"}]},{"database":"PDB","id":"6RA4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=222-355"}]},{"database":"PDB","id":"7C6B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B/C=440-578"}]},{"database":"PDB","id":"7D7U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C=440-578"}]},{"database":"PDB","id":"7KI3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/D=1-859"}]},{"database":"PDB","id":"8D6J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"8D71","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"8THQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.41 A"},{"key":"Chains","value":"A/B=227-352"}]},{"database":"PDB","id":"9BEZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C=440-575"}]},{"database":"PDB","id":"9BF0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.78 A"},{"key":"Chains","value":"A/B/C=442-575"}]},{"database":"PDB","id":"9BF2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A/B/C=440-575"}]},{"database":"PDB","id":"9CMP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A=2-859"}]},{"database":"PDB","id":"9DHX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"9K6P","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"9K6Q","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"9K6R","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=20-859"}]},{"database":"PDB","id":"9K6S","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"9K6T","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"9LMZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C=440-574"}]},{"database":"PDB","id":"9LSN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B/C=440-574"}]},{"database":"PDB","id":"9LSO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.13 A"},{"key":"Chains","value":"A/B/C=440-574"}]},{"database":"PDB","id":"9OBD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.02 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"9OBE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-859"}]},{"database":"PDB","id":"9W5I","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.63 A"},{"key":"Chains","value":"D=1-859"}]},{"database":"PDBsum","id":"3LUC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3LUD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3LUG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3LUH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3LUJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3LUK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3QX8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3QX9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4F3T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4OLA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4OLB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4W5N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4W5O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4W5Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4W5R","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4W5T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4Z4C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4Z4D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4Z4E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4Z4F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4Z4G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4Z4H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4Z4I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JS1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JS2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5KI6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5T7B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5WEA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CBD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MDZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MFN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MFR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6N4O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6NIT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RA4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7C6B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7D7U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KI3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8D6J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8D71","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8THQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BEZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BF0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BF2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9CMP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9DHX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9K6P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9K6Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9K6R","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9K6S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9K6T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9LMZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9LSN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9LSO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OBD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OBE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9W5I","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-45752","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-46888","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54352","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62131","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62132","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62133","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62134","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62135","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-65663","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"118041","properties":[{"key":"Interactions","value":"2021"}]},{"database":"ComplexPortal","id":"CPX-8623","properties":[{"key":"EntryName","value":"miRNA RISC complex, TNRC6A variant"}]},{"database":"ComplexPortal","id":"CPX-8624","properties":[{"key":"EntryName","value":"miRNA RISC complex, TNRC6B variant"}]},{"database":"ComplexPortal","id":"CPX-8625","properties":[{"key":"EntryName","value":"miRNA RISC complex, TNRC6C variant"}]},{"database":"CORUM","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-29194N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9UKV8","properties":[{"key":"Number of interactors","value":"2179"}]},{"database":"IntAct","id":"Q9UKV8","properties":[{"key":"Interactions","value":"250"}]},{"database":"MINT","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-AGO2","properties":[{"key":"Evidences","value":"5 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000220592","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4680043","properties":[{"key":"Description","value":"-"}]},{"database":"DrugCentral","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9UKV8","properties":[{"key":"glycosylation","value":"2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"AGO2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"229463006","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000220592","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"84894","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UKV8-1"},{"database":"ProteomicsDB","id":"84895","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UKV8-2"},{"database":"Pumba","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"27626","properties":[{"key":"antibodies","value":"369 antibodies from 43 providers"}]},{"database":"DNASU","id":"27161","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000220592.10","properties":[{"key":"ProteinId","value":"ENSP00000220592.5"},{"key":"GeneId","value":"ENSG00000123908.12"}],"isoformId":"Q9UKV8-1"},{"database":"Ensembl","id":"ENST00000519980.5","properties":[{"key":"ProteinId","value":"ENSP00000430176.1"},{"key":"GeneId","value":"ENSG00000123908.12"}],"isoformId":"Q9UKV8-2"},{"database":"GeneID","id":"27161","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:27161","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000220592.10","properties":[{"key":"ProteinId","value":"ENSP00000220592.5"},{"key":"RefSeqNucleotideId","value":"NM_012154.5"},{"key":"RefSeqProteinId","value":"NP_036286.2"}]},{"database":"UCSC","id":"uc003yvm.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9UKV8-1"},{"database":"AGR","id":"HGNC:3263","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA27694","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"27161","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"27161","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"AGO2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3263","properties":[{"key":"GeneName","value":"AGO2"}]},{"database":"HPA","id":"ENSG00000123908","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"AGO2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"606229","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"619149","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000123908","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"528084","properties":[{"key":"Disease","value":"Non-specific syndromic intellectual disability"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000123908","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1041","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155239","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_004544_4_3_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CFAQQQH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10252740at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9UKV8","properties":[{"key":"Number of GO annotations","value":"9 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-165159","properties":[{"key":"PathwayName","value":"MTOR signalling"}]},{"database":"Reactome","id":"R-HSA-1912408","properties":[{"key":"PathwayName","value":"Pre-NOTCH Transcription and Translation"}]},{"database":"Reactome","id":"R-HSA-203927","properties":[{"key":"PathwayName","value":"MicroRNA (miRNA) biogenesis"}]},{"database":"Reactome","id":"R-HSA-4086398","properties":[{"key":"PathwayName","value":"Ca2+ pathway"}]},{"database":"Reactome","id":"R-HSA-426486","properties":[{"key":"PathwayName","value":"Small interfering RNA (siRNA) biogenesis"}]},{"database":"Reactome","id":"R-HSA-426496","properties":[{"key":"PathwayName","value":"Post-transcriptional silencing by small RNAs"}]},{"database":"Reactome","id":"R-HSA-5578749","properties":[{"key":"PathwayName","value":"Transcriptional regulation by small RNAs"}]},{"database":"Reactome","id":"R-HSA-5628897","properties":[{"key":"PathwayName","value":"TP53 Regulates Metabolic Genes"}]},{"database":"Reactome","id":"R-HSA-5687128","properties":[{"key":"PathwayName","value":"MAPK6/MAPK4 signaling"}]},{"database":"Reactome","id":"R-HSA-8934593","properties":[{"key":"PathwayName","value":"Regulation of RUNX1 Expression and Activity"}]},{"database":"Reactome","id":"R-HSA-8943723","properties":[{"key":"PathwayName","value":"Regulation of PTEN mRNA translation"}]},{"database":"Reactome","id":"R-HSA-8948700","properties":[{"key":"PathwayName","value":"Competing endogenous RNAs (ceRNAs) regulate PTEN translation"}]},{"database":"Reactome","id":"R-HSA-8986944","properties":[{"key":"PathwayName","value":"Transcriptional Regulation by MECP2"}]},{"database":"Reactome","id":"R-HSA-9018519","properties":[{"key":"PathwayName","value":"Estrogen-dependent gene expression"}]},{"database":"Reactome","id":"R-HSA-9022692","properties":[{"key":"PathwayName","value":"Regulation of MECP2 expression and activity"}]},{"database":"Reactome","id":"R-HSA-9029569","properties":[{"key":"PathwayName","value":"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"}]},{"database":"Reactome","id":"R-HSA-9725371","properties":[{"key":"PathwayName","value":"Nuclear events stimulated by ALK signaling in cancer"}]},{"database":"Reactome","id":"R-HSA-9759811","properties":[{"key":"PathwayName","value":"Regulation of CDH11 mRNA translation by microRNAs"}]},{"database":"Reactome","id":"R-HSA-9764562","properties":[{"key":"PathwayName","value":"Regulation of CDH1 mRNA translation by microRNAs"}]},{"database":"Reactome","id":"R-HSA-9768778","properties":[{"key":"PathwayName","value":"Regulation of NPAS4 mRNA translation"}]},{"database":"Reactome","id":"R-HSA-9820841","properties":[{"key":"PathwayName","value":"M-decay: degradation of maternal mRNAs by maternally stored factors"}]},{"database":"Reactome","id":"R-HSA-9824594","properties":[{"key":"PathwayName","value":"Regulation of MITF-M-dependent genes involved in apoptosis"}]},{"database":"Reactome","id":"R-HSA-9839394","properties":[{"key":"PathwayName","value":"TGFBR3 expression"}]},{"database":"Reactome","id":"R-HSA-9909620","properties":[{"key":"PathwayName","value":"Regulation of PD-L1(CD274) translation"}]},{"database":"SignaLink","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000123908","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"27161","properties":[{"key":"hits","value":"49 hits in 1163 CRISPR screens"}]},{"database":"CD-CODE","id":"232F8A39","properties":[{"key":"EntryName","value":"P-body"}]},{"database":"CD-CODE","id":"278829DE","properties":[{"key":"EntryName","value":"Chromatoid body"}]},{"database":"CD-CODE","id":"804901D1","properties":[{"key":"EntryName","value":"Nuclear speckle"}]},{"database":"CD-CODE","id":"9DBB3093","properties":[{"key":"EntryName","value":"GW-body"}]},{"database":"CD-CODE","id":"C5843A5F","properties":[{"key":"EntryName","value":"miRISC condensate"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"CD-CODE","id":"F85A2E29","properties":[{"key":"EntryName","value":"IMP1 RNP granule"}]},{"database":"ChiTaRS","id":"AGO2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"EIF2C2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"27161","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9UKV8","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9UKV8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"RNAct","id":"Q9UKV8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000123908","properties":[{"key":"ExpressionPatterns","value":"Expressed in colonic epithelium and 198 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9UKV8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17932509"}]},{"database":"GO","id":"GO:0036464","properties":[{"key":"GoTerm","value":"C:cytoplasmic ribonucleoprotein granule"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0030425","properties":[{"key":"GoTerm","value":"C:dendrite"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28159509"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IDA:SynGO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29735530"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23985560"}]},{"database":"GO","id":"GO:0000932","properties":[{"key":"GoTerm","value":"C:P-body"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22915799"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23125361"}]},{"database":"GO","id":"GO:0098794","properties":[{"key":"GoTerm","value":"C:postsynapse"},{"key":"GoEvidenceType","value":"IDA:SynGO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29735530"}]},{"database":"GO","id":"GO:0016442","properties":[{"key":"GoTerm","value":"C:RISC complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17531811"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17671087"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17932509"}]},{"database":"GO","id":"GO:0070578","properties":[{"key":"GoTerm","value":"C:RISC-loading complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15973356"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17531811"}]},{"database":"GO","id":"GO:0001046","properties":[{"key":"GoTerm","value":"F:core promoter sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25336585"}]},{"database":"GO","id":"GO:0003725","properties":[{"key":"GoTerm","value":"F:double-stranded RNA binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19966796"}]},{"database":"GO","id":"GO:0090624","properties":[{"key":"GoTerm","value":"F:endoribonuclease activity, cleaving miRNA-paired mRNA"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15260970"}]},{"database":"GO","id":"GO:0070551","properties":[{"key":"GoTerm","value":"F:endoribonuclease activity, cleaving siRNA-paired mRNA"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17524464"}]},{"database":"GO","id":"GO:0035198","properties":[{"key":"GoTerm","value":"F:miRNA binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15260970"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19966796"}]},{"database":"GO","id":"GO:0035925","properties":[{"key":"GoTerm","value":"F:mRNA 3'-UTR AU-rich region binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17382880"}]},{"database":"GO","id":"GO:0098808","properties":[{"key":"GoTerm","value":"F:mRNA cap binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17524464"}]},{"database":"GO","id":"GO:0000340","properties":[{"key":"GoTerm","value":"F:RNA 7-methylguanosine cap binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17524464"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22658674"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22681889"}]},{"database":"GO","id":"GO:0004521","properties":[{"key":"GoTerm","value":"F:RNA endonuclease activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18178619"}]},{"database":"GO","id":"GO:0000993","properties":[{"key":"GoTerm","value":"F:RNA polymerase II complex binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25336585"}]},{"database":"GO","id":"GO:0003727","properties":[{"key":"GoTerm","value":"F:single-stranded RNA binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19966796"}]},{"database":"GO","id":"GO:0035197","properties":[{"key":"GoTerm","value":"F:siRNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17495927"}]},{"database":"GO","id":"GO:0003743","properties":[{"key":"GoTerm","value":"F:translation initiation factor activity"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10534406"}]},{"database":"GO","id":"GO:0035196","properties":[{"key":"GoTerm","value":"P:miRNA processing"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19966796"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23661684"}]},{"database":"GO","id":"GO:0035278","properties":[{"key":"GoTerm","value":"P:miRNA-mediated gene silencing by inhibition of translation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17671087"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19801630"}]},{"database":"GO","id":"GO:0035279","properties":[{"key":"GoTerm","value":"P:miRNA-mediated gene silencing by mRNA destabilization"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17524464"}]},{"database":"GO","id":"GO:0042985","properties":[{"key":"GoTerm","value":"P:negative regulation of amyloid precursor protein biosynthetic process"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0045947","properties":[{"key":"GoTerm","value":"P:negative regulation of translational initiation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17524464"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19801630"}]},{"database":"GO","id":"GO:0033962","properties":[{"key":"GoTerm","value":"P:P-body assembly"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31400113"}]},{"database":"GO","id":"GO:0045766","properties":[{"key":"GoTerm","value":"P:positive regulation of angiogenesis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27208409"}]},{"database":"GO","id":"GO:1900153","properties":[{"key":"GoTerm","value":"P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060213","properties":[{"key":"GoTerm","value":"P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25336585"}]},{"database":"GO","id":"GO:0045727","properties":[{"key":"GoTerm","value":"P:positive regulation of translation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17382880"}]},{"database":"GO","id":"GO:1901165","properties":[{"key":"GoTerm","value":"P:positive regulation of trophoblast cell migration"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27208409"}]},{"database":"GO","id":"GO:0031054","properties":[{"key":"GoTerm","value":"P:pre-miRNA processing"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17671087"}]},{"database":"GO","id":"GO:0090128","properties":[{"key":"GoTerm","value":"P:regulation of synapse maturation"},{"key":"GoEvidenceType","value":"IDA:SynGO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29735530"}]},{"database":"GO","id":"GO:0031047","properties":[{"key":"GoTerm","value":"P:regulatory ncRNA-mediated gene silencing"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0035194","properties":[{"key":"GoTerm","value":"P:regulatory ncRNA-mediated post-transcriptional gene silencing"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0070922","properties":[{"key":"GoTerm","value":"P:RISC complex assembly"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19701182"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19966796"}]},{"database":"GO","id":"GO:0090625","properties":[{"key":"GoTerm","value":"P:siRNA-mediated gene silencing by mRNA destabilization"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15260970"}]},{"database":"GO","id":"GO:0006412","properties":[{"key":"GoTerm","value":"P:translation"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10534406"}]},{"database":"CDD","id":"cd02846","properties":[{"key":"EntryName","value":"PAZ_argonaute_like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd04657","properties":[{"key":"EntryName","value":"Piwi_ago-like"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP00736","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"2.170.260.10:FF:000001","properties":[{"key":"EntryName","value":"Protein argonaute-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.10:FF:000001","properties":[{"key":"EntryName","value":"Protein argonaute-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.2300:FF:000005","properties":[{"key":"EntryName","value":"Protein argonaute-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.170.260.10","properties":[{"key":"EntryName","value":"paz domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.10","properties":[{"key":"EntryName","value":"Ribonuclease H-like superfamily/Ribonuclease H"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_03031","properties":[{"key":"EntryName","value":"AGO2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR028602","properties":[{"key":"EntryName","value":"AGO2"}]},{"database":"InterPro","id":"IPR014811","properties":[{"key":"EntryName","value":"ArgoL1"}]},{"database":"InterPro","id":"IPR032472","properties":[{"key":"EntryName","value":"ArgoL2"}]},{"database":"InterPro","id":"IPR032473","properties":[{"key":"EntryName","value":"Argonaute_Mid_dom"}]},{"database":"InterPro","id":"IPR032474","properties":[{"key":"EntryName","value":"Argonaute_N"}]},{"database":"InterPro","id":"IPR003100","properties":[{"key":"EntryName","value":"PAZ_dom"}]},{"database":"InterPro","id":"IPR036085","properties":[{"key":"EntryName","value":"PAZ_dom_sf"}]},{"database":"InterPro","id":"IPR003165","properties":[{"key":"EntryName","value":"Piwi"}]},{"database":"InterPro","id":"IPR045246","properties":[{"key":"EntryName","value":"Piwi_ago-like"}]},{"database":"InterPro","id":"IPR012337","properties":[{"key":"EntryName","value":"RNaseH-like_sf"}]},{"database":"InterPro","id":"IPR036397","properties":[{"key":"EntryName","value":"RNaseH_sf"}]},{"database":"PANTHER","id":"PTHR22891","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08699","properties":[{"key":"EntryName","value":"ArgoL1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16488","properties":[{"key":"EntryName","value":"ArgoL2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16487","properties":[{"key":"EntryName","value":"ArgoMid"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16486","properties":[{"key":"EntryName","value":"ArgoN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02170","properties":[{"key":"EntryName","value":"PAZ"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02171","properties":[{"key":"EntryName","value":"Piwi"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01163","properties":[{"key":"EntryName","value":"DUF1785"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00949","properties":[{"key":"EntryName","value":"PAZ"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00950","properties":[{"key":"EntryName","value":"Piwi"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF101690","properties":[{"key":"EntryName","value":"PAZ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53098","properties":[{"key":"EntryName","value":"Ribonuclease H-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50821","properties":[{"key":"EntryName","value":"PAZ"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50822","properties":[{"key":"EntryName","value":"PIWI"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA","length":859,"molWeight":97208,"crc64":"5C8552C43FC81345","md5":"F2BD911377C3ED8B88D8D87913F05479"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"ACTIVITY REGULATION":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"SUBUNIT":4,"INTERACTION":31,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"DOMAIN":1,"PTM":4,"DISEASE":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Domain":2,"Region":8,"Compositional bias":1,"Binding site":3,"Modified residue":7,"Alternative sequence":1,"Natural variant":11,"Mutagenesis":23,"Sequence conflict":4,"Helix":40,"Beta strand":47,"Turn":9},"uniParcId":"UPI0000168652"}}