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Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10369681"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10978333"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11714801"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17646674"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20676092"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34155405"}],"value":"Homodimer. Heterodimer with other IKAROS family members. Interacts with IKZF4 and IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"O94929","geneName":"ABLIM3","intActId":"EBI-351267"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"O94929-2","geneName":"ABLIM3","intActId":"EBI-11961672"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q9NX04","geneName":"AIRIM","intActId":"EBI-8643161"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"A0A0S2Z4Y8","geneName":"AKAP10","intActId":"EBI-16428921"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q99996-2","geneName":"AKAP9","intActId":"EBI-9641546"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q49AR9","geneName":"ANKS1A","intActId":"EBI-11954519"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"P29972","geneName":"AQP1","intActId":"EBI-745213"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q15052","geneName":"ARHGEF6","intActId":"EBI-1642523"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q9H6L4","geneName":"ARMC7","intActId":"EBI-742909"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q8N8Y2","geneName":"ATP6V0D2","intActId":"EBI-3923949"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q8N5M1","geneName":"ATPAF2","intActId":"EBI-1166928"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"O75934","geneName":"BCAS2","intActId":"EBI-1050106"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"P51451","geneName":"BLK","intActId":"EBI-2105445"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q9H2G9","geneName":"BLZF1","intActId":"EBI-2548012"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q13895","geneName":"BYSL","intActId":"EBI-358049"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q53TS8","geneName":"C2CD6","intActId":"EBI-739879"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q9NP86","geneName":"CABP5","intActId":"EBI-10311131"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q9H257-2","geneName":"CARD9","intActId":"EBI-11530605"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q8NEC5","geneName":"CATSPER1","intActId":"EBI-744545"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q68D86","geneName":"CCDC102B","intActId":"EBI-10171570"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q8N4L8","geneName":"CCDC24","intActId":"EBI-1104933"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q2TAC2-2","geneName":"CCDC57","intActId":"EBI-10961624"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKT9","intActId":"EBI-747204"},"interactantTwo":{"uniProtKBAccession":"Q8TD31-3","geneName":"CCHCR1","intActId":"EBI-101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