{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UKN8","secondaryAccessions":["Q5VZJ7"],"uniProtkbId":"TF3C4_HUMAN","entryAudit":{"firstPublicDate":"2004-06-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-11-04","entryVersion":188,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"General transcription factor 3C polypeptide 4"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10523658"}],"value":"2.3.1.48"}]},"alternativeNames":[{"fullName":{"value":"TF3C-delta"}},{"fullName":{"value":"Transcription factor IIIC 90 kDa subunit"},"shortNames":[{"value":"TFIIIC 90 kDa subunit"},{"value":"TFIIIC90"}]},{"fullName":{"value":"Transcription factor IIIC subunit delta"}}]},"genes":[{"geneName":{"value":"GTF3C4"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10523658"}],"value":"Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin (PubMed:10523658). Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3 (PubMed:10523658). May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F (PubMed:10523658). May be localized close to the A box (PubMed:10523658)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45948"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:10731"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:61930"}],"ecNumber":"2.3.1.48","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10523658"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10523658"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17409385"}],"value":"Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9UKN8","intActId":"EBI-1237240"},"interactantTwo":{"uniProtKBAccession":"Q9Y5Q9","geneName":"GTF3C3","intActId":"EBI-1054873"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UKN8","intActId":"EBI-1237240"},"interactantTwo":{"uniProtKBAccession":"Q969F1","geneName":"GTF3C6","intActId":"EBI-6268616"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TFIIIC subunit 4 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAH11619.1","note":"Contaminating sequence. Potential poly-A sequence.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":822,"modifier":"EXACT"}},"description":"General transcription factor 3C polypeptide 4","featureId":"PRO_0000209713"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":608,"modifier":"EXACT"},"end":{"value":663,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"}]},{"type":"Modified residue","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":604,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":611,"modifier":"EXACT"},"end":{"value":611,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":652,"modifier":"EXACT"},"end":{"value":652,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Cross-link","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":629,"modifier":"EXACT"},"end":{"value":629,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Sequence conflict","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"in Ref. 1; AAF05087","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"in Ref. 1; AAF05087","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"in Ref. 1; AAF05087","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"in Ref. 1; AAF05087","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":483,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"in Ref. 1; AAF05087","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":690,"modifier":"EXACT"},"end":{"value":690,"modifier":"EXACT"}},"description":"in Ref. 1; AAF05087","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Beta strand","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Turn","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Turn","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Turn","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLL"}]},{"type":"Helix","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Turn","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":398,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":410,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":428,"modifier":"EXACT"},"end":{"value":431,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Turn","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":438,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":447,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":456,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":468,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":482,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":488,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":509,"modifier":"EXACT"},"end":{"value":514,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":518,"modifier":"EXACT"},"end":{"value":526,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":533,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":537,"modifier":"EXACT"},"end":{"value":550,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":555,"modifier":"EXACT"},"end":{"value":567,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":571,"modifier":"EXACT"},"end":{"value":587,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":664,"modifier":"EXACT"},"end":{"value":695,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":709,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":720,"modifier":"EXACT"},"end":{"value":722,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLJ"}]},{"type":"Helix","location":{"start":{"value":725,"modifier":"EXACT"},"end":{"value":737,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Turn","location":{"start":{"value":748,"modifier":"EXACT"},"end":{"value":751,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":758,"modifier":"EXACT"},"end":{"value":763,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":769,"modifier":"EXACT"},"end":{"value":772,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Turn","location":{"start":{"value":774,"modifier":"EXACT"},"end":{"value":776,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Beta strand","location":{"start":{"value":782,"modifier":"EXACT"},"end":{"value":784,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":796,"modifier":"EXACT"},"end":{"value":798,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Helix","location":{"start":{"value":804,"modifier":"EXACT"},"end":{"value":809,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]},{"type":"Turn","location":{"start":{"value":815,"modifier":"EXACT"},"end":{"value":817,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CLI"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"10523658","citationType":"journal article","authors":["Hsieh Y.-J.","Kundu T.K.","Wang Z.","Kovelman R.","Roeder R.G."],"citationCrossReferences":[{"database":"PubMed","id":"10523658"},{"database":"DOI","id":"10.1128/mcb.19.11.7697"}],"title":"The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity.","publicationDate":"1999","journal":"Mol. Cell. Biol.","firstPage":"7697","lastPage":"7704","volume":"19"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","PROTEIN SEQUENCE OF 139-156; 170-179; 614-626 AND 643-659","FUNCTION","CATALYTIC ACTIVITY","INTERACTION WITH GTF3C1; GTF3C2; GTF3C5; BRF1; POLR3C AND POLR3F"]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.S.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.R.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.I.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.M.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Placenta","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"17409385","citationType":"journal article","authors":["Dumay-Odelot H.","Marck C.","Durrieu-Gaillard S.","Lefebvre O.","Jourdain S.","Prochazkova M.","Pflieger A.","Teichmann M."],"citationCrossReferences":[{"database":"PubMed","id":"17409385"},{"database":"DOI","id":"10.1074/jbc.m611542200"}],"title":"Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC.","publicationDate":"2007","journal":"J. Biol. Chem.","firstPage":"17179","lastPage":"17189","volume":"282"},"referencePositions":["IDENTIFICATION IN TFIIIC COMPLEX","INTERACTION WITH GTF3C6"]},{"referenceNumber":6,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-611","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-611","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-611","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-611","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":12,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-611","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-604; SER-611 AND SER-652","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-225 AND LYS-629","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF142328","properties":[{"key":"ProteinId","value":"AAF05087.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL160165","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471090","properties":[{"key":"ProteinId","value":"EAW88011.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC011619","properties":[{"key":"ProteinId","value":"AAH11619.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC094774","properties":[{"key":"ProteinId","value":"AAH94774.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC104755","properties":[{"key":"ProteinId","value":"AAI04756.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC112245","properties":[{"key":"ProteinId","value":"AAI12246.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS6953.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_036336.2","properties":[{"key":"NucleotideSequenceId","value":"NM_012204.4"}]},{"database":"PDB","id":"8CLI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"B=1-822"}]},{"database":"PDB","id":"8CLJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"B/G=1-822"}]},{"database":"PDB","id":"8CLL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"B/G=1-822"}]},{"database":"PDBsum","id":"8CLI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CLJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CLL","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16713","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16714","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16717","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"114738","properties":[{"key":"Interactions","value":"215"}]},{"database":"ComplexPortal","id":"CPX-2373","properties":[{"key":"EntryName","value":"General transcription factor TFIIIC complex"}]},{"database":"CORUM","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9UKN8","properties":[{"key":"Number of interactors","value":"3404"}]},{"database":"IntAct","id":"Q9UKN8","properties":[{"key":"Interactions","value":"84"}]},{"database":"MINT","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-GTF3C4","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000361219","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5724603","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9UKN8","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"GTF3C4","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"212276467","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000361219","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"84826","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31705","properties":[{"key":"antibodies","value":"215 antibodies from 28 providers"}]},{"database":"DNASU","id":"9329","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000372146.5","properties":[{"key":"ProteinId","value":"ENSP00000361219.4"},{"key":"GeneId","value":"ENSG00000125484.13"}]},{"database":"GeneID","id":"9329","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:9329","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000372146.5","properties":[{"key":"ProteinId","value":"ENSP00000361219.4"},{"key":"RefSeqNucleotideId","value":"NM_012204.4"},{"key":"RefSeqProteinId","value":"NP_036336.2"}]},{"database":"UCSC","id":"uc010mzv.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:4667","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA29055","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"9329","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"9329","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"GTF3C4","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:4667","properties":[{"key":"GeneName","value":"GTF3C4"}]},{"database":"HPA","id":"ENSG00000125484","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"604892","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000125484","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000125484","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QTDJ","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000011873","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_018536_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NGHVWLR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6021743at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9UKN8","properties":[{"key":"Number of GO annotations","value":"1 GO annotation based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.3.1.48","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-749476","properties":[{"key":"PathwayName","value":"RNA Polymerase III Abortive And Retractive Initiation"}]},{"database":"Reactome","id":"R-HSA-76061","properties":[{"key":"PathwayName","value":"RNA Polymerase III Transcription Initiation From Type 1 Promoter"}]},{"database":"Reactome","id":"R-HSA-76066","properties":[{"key":"PathwayName","value":"RNA Polymerase III Transcription Initiation From Type 2 Promoter"}]},{"database":"SignaLink","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000125484","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"9329","properties":[{"key":"hits","value":"550 hits in 1193 CRISPR screens"}]},{"database":"ChiTaRS","id":"GTF3C4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"GTF3C4","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"9329","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9UKN8","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q9UKN8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"RNAct","id":"Q9UKN8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000125484","properties":[{"key":"ExpressionPatterns","value":"Expressed in primordial germ cell in gonad and 179 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9UKN8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17409385"}]},{"database":"GO","id":"GO:0000127","properties":[{"key":"GoTerm","value":"C:transcription factor TFIIIC complex"},{"key":"GoEvidenceType","value":"IDA:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17409385"}]},{"database":"GO","id":"GO:0036408","properties":[{"key":"GoTerm","value":"F:histone H3K14 acetyltransferase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10523658"}]},{"database":"GO","id":"GO:0061733","properties":[{"key":"GoTerm","value":"F:protein-lysine-acetyltransferase activity"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10523658"}]},{"database":"GO","id":"GO:0000995","properties":[{"key":"GoTerm","value":"F:RNA polymerase III general transcription initiation factor activity"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17409385"}]},{"database":"GO","id":"GO:0042791","properties":[{"key":"GoTerm","value":"P:5S class rRNA transcription by RNA polymerase III"},{"key":"GoEvidenceType","value":"IC:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17409385"}]},{"database":"GO","id":"GO:0006383","properties":[{"key":"GoTerm","value":"P:transcription by RNA polymerase III"},{"key":"GoEvidenceType","value":"IC:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17409385"}]},{"database":"GO","id":"GO:0006384","properties":[{"key":"GoTerm","value":"P:transcription initiation at RNA polymerase III promoter"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17409835"}]},{"database":"GO","id":"GO:0042797","properties":[{"key":"GoTerm","value":"P:tRNA transcription by RNA polymerase III"},{"key":"GoEvidenceType","value":"IC:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17409385"}]},{"database":"InterPro","id":"IPR045803","properties":[{"key":"EntryName","value":"DUF5921"}]},{"database":"InterPro","id":"IPR044230","properties":[{"key":"EntryName","value":"GTF3C4"}]},{"database":"InterPro","id":"IPR024761","properties":[{"key":"EntryName","value":"TFIIIC_delta_N"}]},{"database":"InterPro","id":"IPR024764","properties":[{"key":"EntryName","value":"TFIIIC_Znf"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"PANTHER","id":"PTHR15496:SF2","properties":[{"key":"EntryName","value":"GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15496","properties":[{"key":"EntryName","value":"GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19336","properties":[{"key":"EntryName","value":"DUF5921"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12657","properties":[{"key":"EntryName","value":"TFIIIC_delta"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12660","properties":[{"key":"EntryName","value":"zf-TFIIIC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNTADQARVGPADDGPAPSGEEEGEGGGEAGGKEPAADAAPGPSAAFRLMVTRREPAVKLQYAVSGLEPLAWSEDHRVSVSTARSIAVLELICDVHNPGQDLVIHRTSVPAPLNSCLLKVGSKTEVAECKEKFAASKDPTVSQTFMLDRVFNPEGKALPPMRGFKYTSWSPMGCDANGRCLLAALTMDNRLTIQANLNRLQWVQLVDLTEIYGERLYETSYRLSKNEAPEGNLGDFAEFQRRHSMQTPVRMEWSGICTTQQVKHNNECRDVGSVLLAVLFENGNIAVWQFQLPFVGKESISSCNTIESGITSPSVLFWWEYEHNNRKMSGLIVGSAFGPIKILPVNLKAVKGYFTLRQPVILWKEMDQLPVHSIKCVPLYHPYQKCSCSLVVAARGSYVFWCLLLISKAGLNVHNSHVTGLHSLPIVSMTADKQNGTVYTCSSDGKVRQLIPIFTDVALKFEHQLIKLSDVFGSVRTHGIAVSPCGAYLAIITTEGMINGLHPVNKNYQVQFVTLKTFEEAAAQLLESSVQNLFKQVDLIDLVRWKILKDKHIPQFLQEALEKKIESSGVTYFWRFKLFLLRILYQSMQKTPSEALWKPTHEDSKILLVDSPGMGNADDEQQEEGTSSKQVVKQGLQERSKEGDVEEPTDDSLPTTGDAGGREPMEEKLLEIQGKIEAVEMHLTREHMKRVLGEVYLHTWITENTSIPTRGLCNFLMSDEEYDDRTARVLIGHISKKMNKQTFPEHCSLCKEILPFTDRKQAVCSNGHIWLRCFLTYQSCQSLIYRRCLLHDSIARHPAPEDPDWIKRLLQSPCPFCDSPVF","length":822,"molWeight":91982,"crc64":"2546A1E7D87F563C","md5":"20C314FEE0DC332C84C957201CFB60A1"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":2,"Modified residue":5,"Cross-link":2,"Sequence conflict":6,"Beta strand":36,"Helix":17,"Turn":8},"uniParcId":"UPI000013CBAB"}}