{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UK61","secondaryAccessions":["A1L3A4","B5ME28","Q9H2F7","Q9UPP7"],"uniProtkbId":"TASOR_HUMAN","entryAudit":{"firstPublicDate":"2007-07-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-05-05","entryVersion":153,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26022416"}],"value":"Protein TASOR"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11149944"}],"value":"CTCL tumor antigen se89-1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18726359"}],"value":"Retinoblastoma-associated protein RAP140"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26022416"}],"value":"Transgene activation suppressor protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26022416"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:30314"}],"value":"TASOR"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:30314"}],"value":"C3orf63"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:30314"}],"value":"FAM208A"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10470851"}],"value":"KIAA1105"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q69ZR9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26022416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28581500"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29211708"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30487602"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32976585"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33009411"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37433650"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39589886"}],"value":"Core component of the HUSH complex, a multiprotein complex that specifically mediates epigenetic repression of mobile genetic elements, such as retroviruses and transposable elements (PubMed:26022416, PubMed:28581500, PubMed:29211708, PubMed:32976585, PubMed:33009411, PubMed:37433650). The HUSH complex represses LINE-1 (L1) retrotransposons that are still capable of transposition (PubMed:29211708, PubMed:32976585). Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex also represses exogenous retroviruses and synthetic transgenes (PubMed:26022416). The HUSH complex also represses expression of latent herpes simplex virus (PubMed:39589886). Mediates silencing of unintegrated retroviral DNA following recruitment by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2, a chromatin remodeler that compacts chromatin (PubMed:26022416, PubMed:28581500). Within the HUSH complex, TASOR acts as the central scaffold which recruits MPHOSPH8 and PPHLN1 to mobile genetic elements and mediates association with SETDB1 and MORC2 (PubMed:32976585, PubMed:33009411, PubMed:39589886). The ability to silence mobile genetic elements plays a crucial role in early embryonic development: it is required to maintain epiblast cell fitness and cell division (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26022416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28581500"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30487602"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32976585"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39013473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39489739"}],"value":"Core component of the HUSH complex, also named HUSH1 complex, composed of TASOR, PPHLN1 and MPHOSPH8 (PubMed:26022416, PubMed:32976585, PubMed:39013473, PubMed:39489739). Interacts with MORC2; recruiting MORC2 to heterochromatic loci (PubMed:28581500). Interacts with ZNF638; leading to recruitment of the HUSH complex to unintegrated retroviral DNA (PubMed:30487602)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9UK61","intActId":"EBI-308354"},"interactantTwo":{"uniProtKBAccession":"Q99549","geneName":"MPHOSPH8","intActId":"EBI-2653928"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26022416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28581500"}],"value":"Localizes to chromatin"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26022416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28581500"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26022416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28581500"}],"value":"Chromosome","id":"SL-0468"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9UK61-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9UK61-2"],"sequenceIds":["VSP_027030","VSP_027032"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q9UK61-3"],"sequenceIds":["VSP_027033","VSP_027034"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q9UK61-4"],"sequenceIds":["VSP_027031"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33009411"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37433650"}],"value":"The TASOR pseudo-PARP domain is essential for the repression of mobile genetic elements"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29891865"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30297740"}],"value":"(Microbial infection) Ubiquitinated following interaction with HIV-2 viral protein Vpx; Vpx promotes interaction and with a DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase, leading to proteasomal degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TASOR family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAG34913.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAI29988.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":1670,"modifier":"EXACT"}},"description":"Protein TASOR","featureId":"PRO_0000295728"},{"type":"Domain","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"TASOR pseudo-PARP","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33009411"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":921,"modifier":"EXACT"},"end":{"value":947,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1532,"modifier":"EXACT"},"end":{"value":1558,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1638,"modifier":"EXACT"},"end":{"value":1670,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":927,"modifier":"EXACT"},"end":{"value":938,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1532,"modifier":"EXACT"},"end":{"value":1545,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1546,"modifier":"EXACT"},"end":{"value":1558,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1659,"modifier":"EXACT"},"end":{"value":1670,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"}]},{"type":"Modified residue","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":633,"modifier":"EXACT"},"end":{"value":633,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":636,"modifier":"EXACT"},"end":{"value":636,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":673,"modifier":"EXACT"},"end":{"value":673,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":800,"modifier":"EXACT"},"end":{"value":800,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":843,"modifier":"EXACT"},"end":{"value":843,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q69ZR9"}]},{"type":"Modified residue","location":{"start":{"value":927,"modifier":"EXACT"},"end":{"value":927,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16964243"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":971,"modifier":"EXACT"},"end":{"value":971,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":979,"modifier":"EXACT"},"end":{"value":979,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":982,"modifier":"EXACT"},"end":{"value":982,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":1049,"modifier":"EXACT"},"end":{"value":1049,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1103,"modifier":"EXACT"},"end":{"value":1103,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":1552,"modifier":"EXACT"},"end":{"value":1552,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Cross-link","location":{"start":{"value":586,"modifier":"EXACT"},"end":{"value":586,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":823,"modifier":"EXACT"},"end":{"value":823,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":832,"modifier":"EXACT"},"end":{"value":832,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":872,"modifier":"EXACT"},"end":{"value":872,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18726359"}],"featureId":"VSP_027030","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":921,"modifier":"EXACT"},"end":{"value":981,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11149944"}],"featureId":"VSP_027031","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":942,"modifier":"EXACT"},"end":{"value":982,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18726359"}],"featureId":"VSP_027032","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1495,"modifier":"EXACT"},"end":{"value":1512,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_027033","alternativeSequence":{"originalSequence":"ALLENDEKDEEDMSLDSG","alternativeSequences":["DAVLTLTPLELGVGISQH"]}},{"type":"Alternative sequence","location":{"start":{"value":1513,"modifier":"EXACT"},"end":{"value":1670,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_027034","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"in dbSNP:rs958755","featureCrossReferences":[{"database":"dbSNP","id":"rs958755"}],"featureId":"VAR_059595","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":831,"modifier":"EXACT"},"end":{"value":831,"modifier":"EXACT"}},"description":"in dbSNP:rs17056999","featureCrossReferences":[{"database":"dbSNP","id":"rs17056999"}],"featureId":"VAR_033350","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":998,"modifier":"EXACT"},"end":{"value":998,"modifier":"EXACT"}},"description":"in dbSNP:rs2291498","featureCrossReferences":[{"database":"dbSNP","id":"rs2291498"}],"featureId":"VAR_055092","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":1046,"modifier":"EXACT"},"end":{"value":1046,"modifier":"EXACT"}},"description":"in dbSNP:rs9835332","featureCrossReferences":[{"database":"dbSNP","id":"rs9835332"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10470851"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11149944"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18726359"}],"featureId":"VAR_033351","alternativeSequence":{"originalSequence":"T","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":1435,"modifier":"EXACT"},"end":{"value":1435,"modifier":"EXACT"}},"description":"in dbSNP:rs2291498","featureCrossReferences":[{"database":"dbSNP","id":"rs2291498"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11149944"}],"featureId":"VAR_033352","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":941,"modifier":"EXACT"},"end":{"value":941,"modifier":"EXACT"}},"description":"in Ref. 6; BAA83057","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":1129,"modifier":"EXACT"},"end":{"value":1129,"modifier":"EXACT"}},"description":"in Ref. 1; AAD55098","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":1135,"modifier":"EXACT"},"end":{"value":1135,"modifier":"EXACT"}},"description":"in Ref. 1; AAD55098","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Beta strand","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Helix","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Helix","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Beta strand","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Helix","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Helix","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Beta strand","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Turn","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Helix","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Turn","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Beta strand","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Beta strand","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Helix","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Beta strand","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Beta strand","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Helix","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Beta strand","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Helix","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Helix","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Beta strand","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Helix","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Helix","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Beta strand","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Beta strand","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Beta strand","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TL1"}]},{"type":"Helix","location":{"start":{"value":1016,"modifier":"EXACT"},"end":{"value":1038,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6SWG"}]},{"type":"Helix","location":{"start":{"value":1047,"modifier":"EXACT"},"end":{"value":1050,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6SWG"}]},{"type":"Helix","location":{"start":{"value":1075,"modifier":"EXACT"},"end":{"value":1091,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6SWG"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"18726359","citationType":"journal article","authors":["Li Q.","Wen H.","Ao S."],"citationCrossReferences":[{"database":"PubMed","id":"18726359"},{"database":"DOI","id":"10.1007/bf02882285"}],"title":"Identification and cloning of the cDNA of a Rb-associated protein RAP140a.","publicationDate":"2000","journal":"Sci. China, Ser. C, Life Sci.","firstPage":"637","lastPage":"647","volume":"43"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)","VARIANT ARG-1046"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.-S.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-598 (ISOFORM 1)"],"referenceComments":[{"value":"Cerebellum","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 376-1670 (ISOFORM 3)"]},{"referenceNumber":5,"citation":{"id":"11149944","citationType":"journal article","authors":["Eichmueller S.","Usener D.","Dummer R.","Stein A.","Thiel D.","Schadendorf D."],"citationCrossReferences":[{"database":"PubMed","id":"11149944"},{"database":"DOI","id":"10.1073/pnas.98.2.629"}],"title":"Serological detection of cutaneous T-cell lymphoma-associated antigens.","publicationDate":"2001","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"629","lastPage":"634","volume":"98"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 523-1274 (ISOFORM 4)","VARIANTS ARG-1046 AND VAL-1435"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"10470851","citationType":"journal article","authors":["Kikuno R.","Nagase T.","Ishikawa K.","Hirosawa M.","Miyajima N.","Tanaka A.","Kotani H.","Nomura N.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"10470851"},{"database":"DOI","id":"10.1093/dnares/6.3.197"}],"title":"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.","publicationDate":"1999","journal":"DNA Res.","firstPage":"197","lastPage":"205","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 941-1274 (ISOFORM 1)","VARIANT ARG-1046"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-927","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"16964243","citationType":"journal article","authors":["Beausoleil S.A.","Villen J.","Gerber S.A.","Rush J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"16964243"},{"database":"DOI","id":"10.1038/nbt1240"}],"title":"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.","publicationDate":"2006","journal":"Nat. Biotechnol.","firstPage":"1285","lastPage":"1292","volume":"24"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-927","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":12,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-633; SER-636; SER-927 AND SER-979","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-633; SER-636; SER-927; THR-982 AND SER-1103","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-927 AND SER-1103","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":15,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344; SER-673; SER-800; SER-927; SER-971; SER-979; THR-1049; SER-1103 AND SER-1552","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-927 AND SER-1103","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"26022416","citationType":"journal article","authors":["Tchasovnikarova I.A.","Timms R.T.","Matheson N.J.","Wals K.","Antrobus R.","Goettgens B.","Dougan G.","Dawson M.A.","Lehner P.J."],"citationCrossReferences":[{"database":"PubMed","id":"26022416"},{"database":"DOI","id":"10.1126/science.aaa7227"}],"title":"Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.","publicationDate":"2015","journal":"Science","firstPage":"1481","lastPage":"1485","volume":"348"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","IDENTIFICATION IN THE HUSH COMPLEX"]},{"referenceNumber":18,"citation":{"id":"28581500","citationType":"journal article","authors":["Tchasovnikarova I.A.","Timms R.T.","Douse C.H.","Roberts R.C.","Dougan G.","Kingston R.E.","Modis Y.","Lehner P.J."],"citationCrossReferences":[{"database":"PubMed","id":"28581500"},{"database":"DOI","id":"10.1038/ng.3878"}],"title":"Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.","publicationDate":"2017","journal":"Nat. Genet.","firstPage":"1035","lastPage":"1044","volume":"49"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH MORC2"]},{"referenceNumber":19,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-586; LYS-823; LYS-832 AND LYS-872","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":20,"citation":{"id":"29211708","citationType":"journal article","authors":["Liu N.","Lee C.H.","Swigut T.","Grow E.","Gu B.","Bassik M.C.","Wysocka J."],"citationCrossReferences":[{"database":"PubMed","id":"29211708"},{"database":"DOI","id":"10.1038/nature25179"}],"title":"Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators.","publicationDate":"2018","journal":"Nature","firstPage":"228","lastPage":"232","volume":"553"},"referencePositions":["FUNCTION"]},{"referenceNumber":21,"citation":{"id":"30487602","citationType":"journal article","authors":["Zhu Y.","Wang G.Z.","Cingoez O.","Goff S.P."],"citationCrossReferences":[{"database":"PubMed","id":"30487602"},{"database":"DOI","id":"10.1038/s41586-018-0750-6"}],"title":"NP220 mediates silencing of unintegrated retroviral DNA.","publicationDate":"2018","journal":"Nature","firstPage":"278","lastPage":"282","volume":"564"},"referencePositions":["FUNCTION","INTERACTION WITH ZNF638"]},{"referenceNumber":22,"citation":{"id":"29891865","citationType":"journal article","authors":["Chougui G.","Munir-Matloob S.","Matkovic R.","Martin M.M.","Morel M.","Lahouassa H.","Leduc M.","Ramirez B.C.","Etienne L.","Margottin-Goguet F."],"citationCrossReferences":[{"database":"PubMed","id":"29891865"},{"database":"DOI","id":"10.1038/s41564-018-0179-6"}],"title":"HIV-2/SIV viral protein X counteracts HUSH repressor complex.","publicationDate":"2018","journal":"Nat. Microbiol.","firstPage":"891","lastPage":"897","volume":"3"},"referencePositions":["UBIQUITINATION (MICROBIAL INFECTION)"]},{"referenceNumber":23,"citation":{"id":"30297740","citationType":"journal article","authors":["Yurkovetskiy L.","Guney M.H.","Kim K.","Goh S.L.","McCauley S.","Dauphin A.","Diehl W.E.","Luban J."],"citationCrossReferences":[{"database":"PubMed","id":"30297740"},{"database":"DOI","id":"10.1038/s41564-018-0256-x"}],"title":"Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex.","publicationDate":"2018","journal":"Nat. Microbiol.","firstPage":"1354","lastPage":"1361","volume":"3"},"referencePositions":["UBIQUITINATION (MICROBIAL INFECTION)"]},{"referenceNumber":24,"citation":{"id":"37433650","citationType":"journal article","authors":["Schoepp T.","Prigozhin D.M.","Douse C.","Kaji K.","Cook A.G.","O'Carroll D."],"citationCrossReferences":[{"database":"PubMed","id":"37433650"},{"database":"DOI","id":"10.1261/rna.079693.123"}],"title":"The DUF3715 domain has a conserved role in RNA-directed transposon silencing.","publicationDate":"2023","journal":"RNA","firstPage":"1471","lastPage":"1480","volume":"29"},"referencePositions":["FUNCTION","DOMAIN"]},{"referenceNumber":25,"citation":{"id":"39013473","citationType":"journal article","authors":["Danac J.M.C.","Matthews R.E.","Gungi A.","Qin C.","Parsons H.","Antrobus R.","Timms R.T.","Tchasovnikarova I.A."],"citationCrossReferences":[{"database":"PubMed","id":"39013473"},{"database":"DOI","id":"10.1016/j.molcel.2024.06.020"}],"title":"Competition between two HUSH complexes orchestrates the immune response to retroelement invasion.","publicationDate":"2024","journal":"Mol. Cell","firstPage":"2870","lastPage":"2881","volume":"84"},"referencePositions":["IDENTIFICATION IN THE HUSH COMPLEX"]},{"referenceNumber":26,"citation":{"id":"39489739","citationType":"journal article","authors":["Jensvold Z.D.","Flood J.R.","Christenson A.E.","Lewis P.W."],"citationCrossReferences":[{"database":"PubMed","id":"39489739"},{"database":"DOI","id":"10.1038/s41467-024-53761-w"}],"title":"Interplay between two paralogous human silencing hub (HuSH) complexes in regulating LINE-1 element silencing.","publicationDate":"2024","journal":"Nat. Commun.","firstPage":"9492","lastPage":"9492","volume":"15"},"referencePositions":["IDENTIFICATION IN THE HUSH COMPLEX"]},{"referenceNumber":27,"citation":{"id":"39589886","citationType":"journal article","authors":["Roubille S.","Escure T.","Juillard F.","Corpet A.","Neplaz R.","Binda O.","Seurre C.","Gonin M.","Bloor S.","Cohen C.","Texier P.","Haigh O.","Pascual O.","Ganor Y.","Magdinier F.","Labetoulle M.","Lehner P.J.","Lomonte P."],"citationCrossReferences":[{"database":"PubMed","id":"39589886"},{"database":"DOI","id":"10.1073/pnas.2412258121"}],"title":"The HUSH epigenetic repressor complex silences PML nuclear body-associated HSV-1 quiescent genomes.","publicationDate":"2024","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2412258121","lastPage":"e2412258121","volume":"121"},"referencePositions":["FUNCTION"]},{"referenceNumber":28,"citation":{"id":"33009411","citationType":"journal article","authors":["Douse C.H.","Tchasovnikarova I.A.","Timms R.T.","Protasio A.V.","Seczynska M.","Prigozhin D.M.","Albecka A.","Wagstaff J.","Williamson J.C.","Freund S.M.V.","Lehner P.J.","Modis Y."],"citationCrossReferences":[{"database":"PubMed","id":"33009411"},{"database":"DOI","id":"10.1038/s41467-020-18761-6"}],"title":"TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.","publicationDate":"2020","journal":"Nat. Commun.","firstPage":"4940","lastPage":"4940","volume":"11"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) OF 110-332","FUNCTION","DOMAIN"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TL1"}]},{"referenceNumber":29,"citation":{"id":"32976585","citationType":"journal article","authors":["Prigozhin D.M.","Douse C.H.","Farleigh L.E.","Albecka A.","Tchasovnikarova I.A.","Timms R.T.","Oda S.I.","Adolf F.","Freund S.M.V.","Maslen S.","Lehner P.J.","Modis Y."],"citationCrossReferences":[{"database":"PubMed","id":"32976585"},{"database":"DOI","id":"10.1093/nar/gkaa785"}],"title":"Periphilin self-association underpins epigenetic silencing by the HUSH complex.","publicationDate":"2020","journal":"Nucleic Acids Res.","firstPage":"10313","lastPage":"10328","volume":"48"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 1013-1095 IN COMPLEX WITH PPHLN1","FUNCTION","IDENTIFICATION IN THE HUSH COMPLEX"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6SWG"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF180425","properties":[{"key":"ProteinId","value":"AAD55098.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC099781","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK094486","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC129987","properties":[{"key":"ProteinId","value":"AAI29988.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF273053","properties":[{"key":"ProteinId","value":"AAG34913.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB029028","properties":[{"key":"ProteinId","value":"BAA83057.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS2877.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UK61-2"},{"database":"CCDS","id":"CCDS46853.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UK61-3"},{"database":"CCDS","id":"CCDS87094.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UK61-4"},{"database":"CCDS","id":"CCDS93292.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UK61-1"},{"database":"RefSeq","id":"NP_001106207.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001112736.2"}],"isoformId":"Q9UK61-3"},{"database":"RefSeq","id":"NP_001350869.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001363940.1"}],"isoformId":"Q9UK61-4"},{"database":"RefSeq","id":"NP_001352564.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001365635.2"}],"isoformId":"Q9UK61-1"},{"database":"RefSeq","id":"NP_056039.2","properties":[{"key":"NucleotideSequenceId","value":"NM_015224.3"}],"isoformId":"Q9UK61-2"},{"database":"PDB","id":"6SWG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.51 A"},{"key":"Chains","value":"C=1013-1095"}]},{"database":"PDB","id":"6TL1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.03 A"},{"key":"Chains","value":"A/B=110-332"}]},{"database":"PDBsum","id":"6SWG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TL1","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"116873","properties":[{"key":"Interactions","value":"124"}]},{"database":"ComplexPortal","id":"CPX-2348","properties":[{"key":"EntryName","value":"HUSH epigenetic repressor complex"}]},{"database":"CORUM","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-56150N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9UK61","properties":[{"key":"Number of interactors","value":"2937"}]},{"database":"IntAct","id":"Q9UK61","properties":[{"key":"Interactions","value":"79"}]},{"database":"MINT","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"MUSIC2-C5190-TASOR","properties":[{"key":"Evidences","value":"Osteosarcoma (U2OS) cell map - DNA replication and repair system (48 proteins)"}]},{"database":"STRING","id":"9606.ENSP00000347845","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q9UK61","properties":[{"key":"glycosylation","value":"3 sites, 2 glycans"}]},{"database":"GlyGen","id":"Q9UK61","properties":[{"key":"glycosylation","value":"6 sites, 2 O-linked glycans (6 sites)"}]},{"database":"iPTMnet","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"FAM208A","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"229462994","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000347845","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"84729","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UK61-1"},{"database":"ProteomicsDB","id":"84730","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UK61-2"},{"database":"ProteomicsDB","id":"84731","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UK61-3"},{"database":"ProteomicsDB","id":"84732","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UK61-4"},{"database":"Pumba","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1875","properties":[{"key":"antibodies","value":"30 antibodies from 14 providers"}]},{"database":"DNASU","id":"23272","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000355628.9","properties":[{"key":"ProteinId","value":"ENSP00000347845.5"},{"key":"GeneId","value":"ENSG00000163946.15"}],"isoformId":"Q9UK61-4"},{"database":"Ensembl","id":"ENST00000431842.6","properties":[{"key":"ProteinId","value":"ENSP00000399410.2"},{"key":"GeneId","value":"ENSG00000163946.15"}],"isoformId":"Q9UK61-2"},{"database":"Ensembl","id":"ENST00000493960.6","properties":[{"key":"ProteinId","value":"ENSP00000417509.2"},{"key":"GeneId","value":"ENSG00000163946.15"}],"isoformId":"Q9UK61-3"},{"database":"Ensembl","id":"ENST00000683822.1","properties":[{"key":"ProteinId","value":"ENSP00000508241.1"},{"key":"GeneId","value":"ENSG00000163946.15"}],"isoformId":"Q9UK61-1"},{"database":"GeneID","id":"23272","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:23272","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000683822.1","properties":[{"key":"ProteinId","value":"ENSP00000508241.1"},{"key":"RefSeqNucleotideId","value":"NM_001365635.2"},{"key":"RefSeqProteinId","value":"NP_001352564.1"}]},{"database":"UCSC","id":"uc003dic.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9UK61-1"},{"database":"AGR","id":"HGNC:30314","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA128395774","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"23272","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"23272","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"TASOR","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:30314","properties":[{"key":"GeneName","value":"TASOR"}]},{"database":"HPA","id":"ENSG00000163946","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"616493","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000163946","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000163946","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QUY9","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00530000063735","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_004573_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MRQKHEY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5960959at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9UK61","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9843970","properties":[{"key":"PathwayName","value":"Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"}]},{"database":"SignaLink","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000163946","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"23272","properties":[{"key":"hits","value":"29 hits in 1168 CRISPR screens"}]},{"database":"ChiTaRS","id":"FAM208A","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"23272","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9UK61","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9UK61","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"RNAct","id":"Q9UK61","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000163946","properties":[{"key":"ExpressionPatterns","value":"Expressed in secondary oocyte and 208 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9UK61","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26022416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28581500"}]},{"database":"GO","id":"GO:0000792","properties":[{"key":"GoTerm","value":"C:heterochromatin"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28581500"}]},{"database":"GO","id":"GO:0140283","properties":[{"key":"GoTerm","value":"C:HUSH complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26022416"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"39013473"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"39489739"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26022416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28581500"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29211708"}]},{"database":"GO","id":"GO:0030674","properties":[{"key":"GoTerm","value":"F:protein-macromolecule adaptor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33009411"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22658674"}]},{"database":"GO","id":"GO:0008595","properties":[{"key":"GoTerm","value":"P:anterior/posterior axis specification, embryo"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0140719","properties":[{"key":"GoTerm","value":"P:constitutive heterochromatin formation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28581500"}]},{"database":"GO","id":"GO:0060809","properties":[{"key":"GoTerm","value":"P:mesodermal to mesenchymal transition involved in gastrulation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045814","properties":[{"key":"GoTerm","value":"P:negative regulation of gene expression, epigenetic"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26022416"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33009411"}]},{"database":"GO","id":"GO:0097355","properties":[{"key":"GoTerm","value":"P:protein localization to heterochromatin"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28581500"}]},{"database":"GO","id":"GO:0141005","properties":[{"key":"GoTerm","value":"P:transposable element silencing by heterochromatin formation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29211708"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33009411"}]},{"database":"CDD","id":"cd22569","properties":[{"key":"EntryName","value":"TASOR_PBD"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR056242","properties":[{"key":"EntryName","value":"PIN_TASOR"}]},{"database":"InterPro","id":"IPR046432","properties":[{"key":"EntryName","value":"TASOR"}]},{"database":"InterPro","id":"IPR056243","properties":[{"key":"EntryName","value":"TASOR_ab_dom"}]},{"database":"InterPro","id":"IPR022188","properties":[{"key":"EntryName","value":"TASOR_DUF3715"}]},{"database":"PANTHER","id":"PTHR16207:SF1","properties":[{"key":"EntryName","value":"PROTEIN TASOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16207","properties":[{"key":"EntryName","value":"SET DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12509","properties":[{"key":"EntryName","value":"DUF3715"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24630","properties":[{"key":"EntryName","value":"PIN_TASOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23314","properties":[{"key":"EntryName","value":"TASOR_alpha-beta"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MATAVETEACQPTDASWESGGGGDDEMKQALPELESSQQNGGGGGLNIAEPSGGAGREENAGAEAAQSLSHEQPQDSSEAGAAALPRGPEEPERPVRRSFQIPRKSREKKALFQPLTPGSREFEDVVNILHSSYLEPTSVTNFNYRRACLVHNELLEKEFTEKRRELKFDGRLDKELSESYAFLMVDRYQVQTICEKGLHVGQSKITILGSPSMGVYLSRYADLLQANPLDTGAMGDVVIFKIMKGKIKSIYDPMGVKSLESMLNKSALDPTPKHECHVSKNANRITSLLAYRAYELTQYYFYEYGFDELRRRPRHVCPYAVVSFTYKDDIQTPKFVPSSRSNSFNTDRNIDKYNYTLWKGQLLNKGKLLCYISLRSATRAFLPIKLPEKLDVETVMSIDHLKQKIPPALFYKETYLGPNEVLKNGMYCSLYEVVEKTRIGSNMESLLQKLDREKLVLVKPLGDRGYLFLLSPYQMVPPYEYQTAKSRVLHALFLFQEPRSIVTSQKGSTNAAPQERHESMPDVLKIAQFLQFSLIQCRKEFKNISAINFHSVVEKYVSEFFKRGFGSGKREFIMFPYDSRLDDKKFLYSAPRNKSHIDTCLHAYIFRPEVYQLPICKLKELFEENRKLQQFSPLSDYEGQEEEMNGTKMKFGKRNNSRGEAIISGKQRSSHSLDYDKDRVKELINLIQCRKKSVGGDSDTEDMRSKTVLKRKLEDLPENMRKLAKTSNLSENCHLYEESPQPIGSLGHDADLRRQQQDTCNSGIADIHRLFNWLSETLANARHSDASLTDTVNKALGLSTDDAYEELRQKHEYELNSTPDKKDYEQPTCAKVENAQFKGTQSLLLEVDATSKYSVAISTSEVGTDHKLHLKEDPNLISVNNFEDCSLCPSVPIEHGFRRQQSKSNNVEETEIHWKLIPITGGNARSPEDQLGKHGEKQTPGMKSPEEQLVCVPPQEAFPNDPRVINRQRSSDYQFPSSPFTDTLKGTTEDDVLTGQVEEQCVPAAEAEPPAVSETTERTVLGEYNLFSRKIEEILKQKNVSYVSTVSTPIFSTQEKMKRLSEFIYSKTSKAGVQEFVDGLHEKLNTIIIKASAKGGNLPPVSPNDSGAKIASNPLERHVIPVSSSDFNNKHLLEPLCSDPLKDTNSDEQHSTSALTEVEMNQPQHATELMVTSDHIVPGDMAREPVEETTKSPSDVNISAQPALSNFISQLEPEVFNSLVKIMKDVQKNTVKFYIHEEEESVLCKEIKEYLIKLGNTECHPEQFLERRSKLDKLLIIIQNEDIAGFIHKIPGLVTLKKLPCVSFAGVDSLDDVKNHTYNELFVSGGFIVSDESILNPEVVTVENLKNFLTFLEELSTPEGKWQWKVHCKFQKKLKELGRLNAKALSLLTLLNVYQKKHLVEILSYHNCDSQTRNAPELDCLIRLQAQNIQQRHIVFLTEKNIKMLSSYTDNGIVVATAEDFMQNFKNLVGYHNSITEENLPQLGANENLESQSALLENDEKDEEDMSLDSGDEISHIEVCSNFHSEIWEKETKGSRGTDQKKNTQIELQSSPDVQNSLLEDKTYLDSEERTSIDIVCSEGENSNSTEQDSYSNFQVYHSQLNMSHQFSHFNVLTHQTFLGTPYALSSSQSQENENYFLSAYTESLDRDKSPPPLSWGKSDSSRPYSQEK","length":1670,"molWeight":189032,"crc64":"A8BE5ED05A96C897","md5":"9EF19DBF061ABE261DF6A78EF1EA817A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"DOMAIN":1,"PTM":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Domain":1,"Region":4,"Compositional bias":5,"Modified residue":14,"Cross-link":4,"Alternative sequence":5,"Natural variant":5,"Sequence conflict":3,"Beta strand":12,"Helix":14,"Turn":2},"uniParcId":"UPI00019B21E8"}}