{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UK17","secondaryAccessions":["O60576","O60577","Q14D71","Q5T0M0","Q9UH85","Q9UH86","Q9UK16"],"uniProtkbId":"KCND3_HUMAN","entryAudit":{"firstPublicDate":"2003-11-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-03-07","entryVersion":214,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"A-type voltage-gated potassium channel KCND3"}},"alternativeNames":[{"fullName":{"value":"Potassium voltage-gated channel subfamily D member 3"}},{"fullName":{"value":"Voltage-gated potassium channel subunit Kv4.3"}}]},"genes":[{"geneName":{"value":"KCND3"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62897"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10200233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17187064"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21349352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22457051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23280837"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23280838"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34997220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9843794"}],"value":"Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (PubMed:10200233, PubMed:17187064, PubMed:21349352, PubMed:22457051, PubMed:23280837, PubMed:23280838, PubMed:34997220, PubMed:9843794). In cardiomyocytes, may generate the transient outward potassium current I(To) (By similarity). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation (PubMed:10200233, PubMed:17187064, PubMed:21349352, PubMed:22457051, PubMed:23280837, PubMed:23280838, PubMed:34997220, PubMed:9843794). Channel properties are modulated by interactions with regulatory subunits (PubMed:17187064, PubMed:34997220). Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation (PubMed:17187064, PubMed:34997220). Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics (PubMed:34997220)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"K(+)(in) = K(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29463"},{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10200233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17187064"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21349352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22457051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23280837"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23280838"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34997220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9843794"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62897"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0V1"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12297301"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14980207"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17187064"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19213956"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34997220"}],"value":"Homotetramer (PubMed:17187064, PubMed:34997220). Heterotetramer with KCND2 (By similarity). Associates with the regulatory subunits KCNIP3 and KCNIP4 (By similarity). Interacts with KCNE1, KCNE2, SCN1B and KCNAB1 and DLG1 (PubMed:12297301, PubMed:19213956). Component of heteromultimeric potassium channels. Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Interacts with KCNIP1; each KCNIP1 monomer interacts with two adjacent KCND3 subunits, through both the N-terminal inactivation ball of a KCND3 subunit and a C-terminal helix from the adjacent KCND3 subunit, clamping them together; this interaction stabilizes the tetrameric form and modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation (PubMed:14980207, PubMed:17187064, PubMed:34997220). Interacts with DPP6; this interaction modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation (PubMed:34997220). Interacts with KCNIP2; each KCNIP2 monomer interacts with two adjacent KCND3 subunits, through both the N-terminal inactivation ball of a KCND3 subunit and a C-terminal helix from the adjacent KCND3 subunit, clamping them together; this interaction modulates the channel gating kinetics (PubMed:12297301, PubMed:34997220)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9UK17","intActId":"EBI-9825212"},"interactantTwo":{"uniProtKBAccession":"Q9NZI2","geneName":"KCNIP1","intActId":"EBI-2120635"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62897"}],"value":"Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23280837"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23280838"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62897"}],"value":"Cell membrane, sarcolemma","id":"SL-0238"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62897"}],"value":"Cell projection, dendrite","id":"SL-0283"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"KCND3L"},{"value":"Long"}],"isoformIds":["Q9UK17-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"KCND3S"},{"value":"Short"}],"isoformIds":["Q9UK17-2"],"sequenceIds":["VSP_008826"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10200233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10729221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9843794"}],"value":"Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus (PubMed:10200233, PubMed:10729221, PubMed:9843794). Detected at lower levels in liver, skeletal muscle, kidney and pancreas (PubMed:10200233, PubMed:10729221)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14980207"}],"value":"Two N-terminal domains regulate binding to and modulation by KCNIP1"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62897"}],"value":"Regulated through phosphorylation at Ser-569 by CaMK2D"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Spinocerebellar ataxia 19","diseaseAccession":"DI-03932","acronym":"SCA19","description":"A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA19 is a relatively mild, cerebellar ataxic syndrome with cognitive impairment, pyramidal tract involvement, tremor and peripheral neuropathy, and mild atrophy of the cerebellar hemispheres and vermis.","diseaseCrossReference":{"database":"MIM","id":"607346"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23280837"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23280838"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28895081"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Brugada syndrome 9","diseaseAccession":"DI-04444","acronym":"BRGDA9","description":"A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. 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