{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UIS9","secondaryAccessions":["A4UTZ0","B4DXJ5","E9PEC5","K7ELI2","K7EQZ4","K7ESN0","O15248","O95241","Q7Z7B5","Q8N4W4","Q9UNZ6","Q9UNZ7","Q9UNZ8","Q9UNZ9"],"uniProtkbId":"MBD1_HUMAN","entryAudit":{"firstPublicDate":"2004-07-19","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-07-19","entryVersion":221,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Methyl-CpG-binding domain protein 1"}},"alternativeNames":[{"fullName":{"value":"CXXC-type zinc finger protein 3"}},{"fullName":{"value":"Methyl-CpG-binding protein MBD1"}},{"fullName":{"value":"Protein containing methyl-CpG-binding domain 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:6916"}],"value":"MBD1"},"synonyms":[{"value":"CXXC3"},{"value":"PCM1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10454587"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10648624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12665582"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12697822"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12711603"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14555760"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14610093"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9207790"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9774669"}],"value":"Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12665582"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12697822"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12711603"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14555760"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14728690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15691849"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16757475"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19666599"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9207790"}],"value":"Interacts with OASL, ATF7IP, ATF7IP2 and BAHD1 (PubMed:12665582, PubMed:14728690, PubMed:15691849, PubMed:16757475, PubMed:19666599). Binds CHAF1A and the SUV39H1-CBX5 complex via the MBD domain (PubMed:12697822, PubMed:12711603). Binds MGP via the TRD domain (PubMed:14555760). May be part of the MeCP1 complex (PubMed:9207790)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9UIS9","intActId":"EBI-867196"},"interactantTwo":{"uniProtKBAccession":"P45973","geneName":"CBX5","intActId":"EBI-78219"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UIS9","intActId":"EBI-867196"},"interactantTwo":{"uniProtKBAccession":"Q13111","geneName":"CHAF1A","intActId":"EBI-1020839"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UIS9","intActId":"EBI-867196"},"interactantTwo":{"uniProtKBAccession":"Q13547","geneName":"HDAC1","intActId":"EBI-301834"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UIS9","intActId":"EBI-867196"},"interactantTwo":{"uniProtKBAccession":"Q92769","geneName":"HDAC2","intActId":"EBI-301821"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UIS9","intActId":"EBI-867196"},"interactantTwo":{"uniProtKBAccession":"O15379","geneName":"HDAC3","intActId":"EBI-607682"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UIS9","intActId":"EBI-867196"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UIS9","intActId":"EBI-867196"},"interactantTwo":{"uniProtKBAccession":"Q99435","geneName":"NELL2","intActId":"EBI-946274"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UIS9","intActId":"EBI-867196"},"interactantTwo":{"uniProtKBAccession":"O75925","geneName":"PIAS1","intActId":"EBI-629434"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UIS9","intActId":"EBI-867196"},"interactantTwo":{"uniProtKBAccession":"Q9Y6X2","geneName":"PIAS3","intActId":"EBI-2803703"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UIS9","intActId":"EBI-867196"},"interactantTwo":{"uniProtKBAccession":"Q15156","geneName":"PML-RAR","intActId":"EBI-867256"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UIS9","intActId":"EBI-867196"},"interactantTwo":{"uniProtKBAccession":"Q15047","geneName":"SETDB1","intActId":"EBI-79691"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UIS9","intActId":"EBI-867196"},"interactantTwo":{"uniProtKBAccession":"P63165","geneName":"SUMO1","intActId":"EBI-80140"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UIS9","intActId":"EBI-867196"},"interactantTwo":{"uniProtKBAccession":"O43463","geneName":"SUV39H1","intActId":"EBI-349968"},"numberOfExperiments":5,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10454587"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10648624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12711603"}],"value":"Nuclear, in a punctate pattern (PubMed:12711603). Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes (PubMed:10454587, PubMed:10648624)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12711603"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14610093"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10454587"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10648624"}],"value":"Nucleus matrix","id":"SL-0181"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10454587"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10648624"}],"value":"Nucleus speckle","id":"SL-0186"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10454587"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10648624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12711603"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14555760"}],"value":"Chromosome","id":"SL-0468"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"MBD1v1"}],"isoformIds":["Q9UIS9-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"MBD1v2"}],"isoformIds":["Q9UIS9-2"],"sequenceIds":["VSP_011065","VSP_011068","VSP_011070"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"synonyms":[{"value":"MBD1v3"}],"isoformIds":["Q9UIS9-4"],"sequenceIds":["VSP_011066","VSP_011068"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"synonyms":[{"value":"PCM1"}],"isoformIds":["Q9UIS9-5"],"sequenceIds":["VSP_011064"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"synonyms":[{"value":"MBD1v6"}],"isoformIds":["Q9UIS9-6"],"sequenceIds":["VSP_011068","VSP_011069","VSP_011071"],"isoformSequenceStatus":"Described"},{"name":{"value":"7"},"isoformIds":["Q9UIS9-7"],"sequenceIds":["VSP_011066"],"isoformSequenceStatus":"Described"},{"name":{"value":"8"},"isoformIds":["Q9UIS9-8"],"sequenceIds":["VSP_011065","VSP_011068"],"isoformSequenceStatus":"Described"},{"name":{"value":"9"},"isoformIds":["Q9UIS9-9"],"sequenceIds":["VSP_042812"],"isoformSequenceStatus":"Described"},{"name":{"value":"10"},"isoformIds":["Q9UIS9-10"],"sequenceIds":["VSP_011064","VSP_054737","VSP_054738"],"isoformSequenceStatus":"Described"},{"name":{"value":"11"},"isoformIds":["Q9UIS9-11"],"sequenceIds":["VSP_054736","VSP_011068","VSP_054739"],"isoformSequenceStatus":"Described"},{"name":{"value":"12"},"isoformIds":["Q9UIS9-12"],"sequenceIds":["VSP_011070"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9207790"}],"value":"Widely expressed"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14728690"}],"value":"Up-regulated by interferon"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10581239"}],"value":"The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29276034"}],"value":"The third CXXC-type zinc finger mediates binding to DNA containing unmethylated CpG dinucleotides"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14555760"}],"value":"The transcriptional repression domain (TRD) is involved in transcription repression and in protein interactions"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16757475"}],"value":"Sumoylated, sumoylation may increase interaction with ATF7IP"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15327775"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17066076"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30849389"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31612521"}],"value":"Was reported to recruit SETDB1 during DNA replication, to form a S phase-specific complex that would facilitate methylation of H3 'Lys-9' during replication-coupled chromatin assembly and vould be at least composed of the CAF-1 subunit CHAF1A, MBD1 and SETDB1 (PubMed:15327775). The interaction with SETDB1 was also reported to be inhibited by sumoylation at Lys-499 and Lys-538 (PubMed:17066076). However, these papers have been retracted because some data, results and conclusions are not reliable (PubMed:30849389, PubMed:31612521)"}],"commentType":"CAUTION"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"Methyl-CpG-binding domain protein 1","featureId":"PRO_0000096258"},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"MBD","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10581239"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11371345"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.36"}]},{"type":"Zinc finger","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"CXXC-type 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26354109"}]},{"type":"Zinc finger","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"CXXC-type 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}]},{"type":"Zinc finger","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"CXXC-type 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29276034"}]},{"type":"Region","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":520,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":592,"modifier":"EXACT"}},"description":"Transcriptional repression domain (TRD)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14555760"}]},{"type":"Motif","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":417,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":426,"modifier":"EXACT"},"end":{"value":439,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29276034"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5W9Q"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29276034"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5W9Q"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29276034"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5W9Q"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":350,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29276034"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5W9Q"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"6"}},{"type":"Binding site","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29276034"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5W9Q"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"6"}},{"type":"Binding site","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29276034"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5W9Q"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"6"}},{"type":"Binding site","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29276034"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5W9Q"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"6"}},{"type":"Binding site","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29276034"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5W9Q"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Modified residue","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":399,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Cross-link","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":440,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":499,"modifier":"EXACT"},"end":{"value":499,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":538,"modifier":"EXACT"},"end":{"value":538,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25772364"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":558,"modifier":"EXACT"},"end":{"value":558,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"in isoform 5 and isoform 10","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9207790"}],"featureId":"VSP_011064","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"in isoform 9","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_042812","alternativeSequence":{"originalSequence":"R","alternativeSequences":["RHLAHRLRRRHQRCQRRTPLAVAPPT"]}},{"type":"Alternative sequence","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 8","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10454587"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.5"}],"featureId":"VSP_011065","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"in isoform 11","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_054736","alternativeSequence":{"originalSequence":"LQPYTNRRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAM","alternativeSequences":["L"]}},{"type":"Alternative sequence","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"in isoform 4 and isoform 7","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10454587"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_011066","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"in isoform 10","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_054737","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":483,"modifier":"EXACT"},"end":{"value":528,"modifier":"EXACT"}},"description":"in isoform 2, isoform 4, isoform 6, isoform 8 and isoform 11","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10454587"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.5"}],"featureId":"VSP_011068","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":573,"modifier":"EXACT"},"end":{"value":596,"modifier":"EXACT"}},"description":"in isoform 6","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_011069","alternativeSequence":{"originalSequence":"ITEIFSLGGTRFRDTAVWLPRSKD","alternativeSequences":["EPTTQPQYSGNFDNDLYEIYLIDI"]}},{"type":"Alternative sequence","location":{"start":{"value":593,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 12","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10454587"}],"featureId":"VSP_011070","alternativeSequence":{"originalSequence":"RSKDLKKPGARKQ","alternativeSequences":["SLQGRHSGREDGCKVWETEDTVEPTSTSWNPRGWPGTHVSLSPPPASMMWVSCRRSWCPSSQS"]}},{"type":"Alternative sequence","location":{"start":{"value":594,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"in isoform 10","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_054738","alternativeSequence":{"originalSequence":"SKDLKKPGARKQ","alternativeSequences":["YYHLALDWKCNCGYHLCCRSVLVP"]}},{"type":"Alternative sequence","location":{"start":{"value":594,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"in isoform 11","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_054739","alternativeSequence":{"originalSequence":"SKDLKKPGARKQ","alternativeSequences":["AGTREGKMDVKCGRPRTQWSPRARAGTHEDGLEPMSVSHHLQLR"]}},{"type":"Alternative sequence","location":{"start":{"value":597,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"in isoform 6","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_011071","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":401,"modifier":"EXACT"},"end":{"value":401,"modifier":"EXACT"}},"description":"in dbSNP:rs125555","featureCrossReferences":[{"database":"dbSNP","id":"rs125555"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10441743"}],"featureId":"VAR_019513","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Abolishes binding to methylated DNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10581239"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11371345"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A","K"]}},{"type":"Mutagenesis","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"Strongly reduces binding to methylated DNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10581239"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11371345"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"No loss of binding to methylated DNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11371345"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Mutagenesis","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Strongly reduces binding to methylated DNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10581239"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11371345"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Strongly reduces binding to methylated DNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10581239"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11371345"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A","F"]}},{"type":"Mutagenesis","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Abolishes binding to methylated DNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10581239"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11371345"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A","K"]}},{"type":"Mutagenesis","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Reduces binding to methylated DNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10581239"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11371345"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Strongly reduces binding to methylated DNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11371345"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"No loss of binding to methylated DNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10581239"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11371345"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Disrupts tertiary structure and abolishes DNA binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10581239"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"Strongly reduces binding to methylated DNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11371345"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":576,"modifier":"EXACT"},"end":{"value":576,"modifier":"EXACT"}},"description":"Abolishes interaction with ATF7IP and subsequent transcription repression activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15691849"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"in Ref. 5; ABP02056","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"in Ref. 5; ABP02056","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Sequence conflict","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"in Ref. 1; CAA71735 and 3; AAD51442/AAD51443","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"MD","alternativeSequences":["NG"]}},{"type":"Sequence conflict","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"in Ref. 1; CAA71735","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["M"]}},{"type":"Beta strand","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IG4"}]},{"type":"Turn","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6D1T"}]},{"type":"Beta strand","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6D1T"}]},{"type":"Turn","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6D1T"}]},{"type":"Beta strand","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6D1T"}]},{"type":"Beta strand","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1D9N"}]},{"type":"Helix","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6D1T"}]},{"type":"Beta strand","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IG4"}]},{"type":"Turn","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6D1T"}]},{"type":"Beta strand","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4D4W"}]},{"type":"Helix","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4D4W"}]},{"type":"Helix","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4D4W"}]},{"type":"Beta strand","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5W9Q"}]},{"type":"Helix","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5W9Q"}]},{"type":"Beta strand","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5W9Q"}]},{"type":"Helix","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5W9Q"}]},{"type":"Helix","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":362,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5W9Q"}]},{"type":"Helix","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5W9Q"}]},{"type":"Turn","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5W9Q"}]},{"type":"Helix","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5W9Q"}]},{"type":"Sequence conflict","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"},"sequence":"Q9UIS9-7"},"description":"in Ref. 3; AAD51444","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"9207790","citationType":"journal article","authors":["Cross S.H.","Meehan R.R.","Nan X.","Bird A."],"citationCrossReferences":[{"database":"PubMed","id":"9207790"},{"database":"DOI","id":"10.1038/ng0797-256"}],"title":"A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins.","publicationDate":"1997","journal":"Nat. Genet.","firstPage":"256","lastPage":"259","volume":"16"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)","FUNCTION","INTERACTION WITH THE MECP1 COMPLEX","TISSUE SPECIFICITY"]},{"referenceNumber":2,"citation":{"id":"10441743","citationType":"journal article","authors":["Hendrich B.","Abbott C.","McQueen H.","Chambers D.","Cross S.H.","Bird A."],"citationCrossReferences":[{"database":"PubMed","id":"10441743"},{"database":"DOI","id":"10.1007/s003359901112"}],"title":"Genomic structure and chromosomal mapping of the murine and human mbd1, mbd2, mbd3, and mbd4 genes.","publicationDate":"1999","journal":"Mamm. Genome","firstPage":"906","lastPage":"912","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT ALA-401"]},{"referenceNumber":3,"citation":{"id":"10454587","citationType":"journal article","authors":["Fujita N.","Takebayashi S.","Okumura K.","Kudo S.","Chiba T.","Saya H.","Nakao M."],"citationCrossReferences":[{"database":"PubMed","id":"10454587"},{"database":"DOI","id":"10.1128/mcb.19.9.6415"}],"title":"Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms.","publicationDate":"1999","journal":"Mol. Cell. Biol.","firstPage":"6415","lastPage":"6426","volume":"19"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 4 AND 7)","FUNCTION","SUBCELLULAR LOCATION"],"referenceComments":[{"value":"Fibroblast","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"14728690","citationType":"journal article","authors":["Andersen J.B.","Strandbygaard D.J.","Hartmann R.","Justesen J."],"citationCrossReferences":[{"database":"PubMed","id":"14728690"},{"database":"DOI","id":"10.1046/j.1432-1033.2003.03966.x"}],"title":"Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1.","publicationDate":"2004","journal":"Eur. J. Biochem.","firstPage":"628","lastPage":"636","volume":"271"},"referencePositions":["NUCLEOTIDE SEQUENCE (ISOFORM 6)","INDUCTION BY INTERFERON","INTERACTION WITH OASL"],"referenceComments":[{"value":"Leukocyte","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"CI-8TCQ63MVV6DR4","citationType":"submission","authors":["Laget S.M.","Xu S.-Y."],"title":"New splice variant of the methyl-CpG binding protein 1 (MBD1).","publicationDate":"MAR-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8)"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9)"]},{"referenceNumber":7,"citation":{"id":"16177791","citationType":"journal article","authors":["Nusbaum C.","Zody M.C.","Borowsky M.L.","Kamal M.","Kodira C.D.","Taylor T.D.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Abouelleil A.","Allen N.R.","Anderson S.","Bloom T.","Bugalter B.","Butler J.","Cook A.","DeCaprio D.","Engels R.","Garber M.","Gnirke A.","Hafez N.","Hall J.L.","Norman C.H.","Itoh T.","Jaffe D.B.","Kuroki Y.","Lehoczky J.","Lui A.","Macdonald P.","Mauceli E.","Mikkelsen T.S.","Naylor J.W.","Nicol R.","Nguyen C.","Noguchi H.","O'Leary S.B.","Piqani B.","Smith C.L.","Talamas J.A.","Topham K.","Totoki Y.","Toyoda A.","Wain H.M.","Young S.K.","Zeng Q.","Zimmer A.R.","Fujiyama A.","Hattori M.","Birren B.W.","Sakaki Y.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16177791"},{"database":"DOI","id":"10.1038/nature03983"}],"title":"DNA sequence and analysis of human chromosome 18.","publicationDate":"2005","journal":"Nature","firstPage":"551","lastPage":"555","volume":"437"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)"],"referenceComments":[{"value":"Prostate","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"9774669","citationType":"journal article","authors":["Hendrich B.","Bird A."],"citationCrossReferences":[{"database":"PubMed","id":"9774669"},{"database":"DOI","id":"10.1128/mcb.18.11.6538"}],"title":"Identification and characterization of a family of mammalian methyl-CpG binding proteins.","publicationDate":"1998","journal":"Mol. Cell. Biol.","firstPage":"6538","lastPage":"6547","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 169-220","FUNCTION"]},{"referenceNumber":10,"citation":{"id":"10648624","citationType":"journal article","authors":["Ng H.-H.","Jeppesen P.","Bird A."],"citationCrossReferences":[{"database":"PubMed","id":"10648624"},{"database":"DOI","id":"10.1128/mcb.20.4.1394-1406.2000"}],"title":"Active repression of methylated genes by the chromosomal protein MBD1.","publicationDate":"2000","journal":"Mol. Cell. Biol.","firstPage":"1394","lastPage":"1406","volume":"20"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":11,"citation":{"id":"12711603","citationType":"journal article","authors":["Fujita N.","Watanabe S.","Ichimura T.","Tsuruzoe S.","Shinkai Y.","Tachibana M.","Chiba T.","Nakao M."],"citationCrossReferences":[{"database":"PubMed","id":"12711603"},{"database":"DOI","id":"10.1074/jbc.m302283200"}],"title":"Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"24132","lastPage":"24138","volume":"278"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH THE SUV39H1-CBX5 COMPLEX"]},{"referenceNumber":12,"citation":{"id":"12665582","citationType":"journal article","authors":["Fujita N.","Watanabe S.","Ichimura T.","Ohkuma Y.","Chiba T.","Saya H.","Nakao M."],"citationCrossReferences":[{"database":"PubMed","id":"12665582"},{"database":"DOI","id":"10.1128/mcb.23.8.2834-2843.2003"}],"title":"MCAF mediates MBD1-dependent transcriptional repression.","publicationDate":"2003","journal":"Mol. Cell. Biol.","firstPage":"2834","lastPage":"2843","volume":"23"},"referencePositions":["FUNCTION","INTERACTION WITH ATF7IP"]},{"referenceNumber":13,"citation":{"id":"12697822","citationType":"journal article","authors":["Reese B.E.","Bachman K.E.","Baylin S.B.","Rountree M.R."],"citationCrossReferences":[{"database":"PubMed","id":"12697822"},{"database":"DOI","id":"10.1128/mcb.23.9.3226-3236.2003"}],"title":"The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1.","publicationDate":"2003","journal":"Mol. Cell. Biol.","firstPage":"3226","lastPage":"3236","volume":"23"},"referencePositions":["FUNCTION","INTERACTION WITH CHAF1A"]},{"referenceNumber":14,"citation":{"id":"14610093","citationType":"journal article","authors":["Ghoshal K.","Majumder S.","Datta J.","Motiwala T.","Bai S.","Sharma S.M.","Frankel W.","Jacob S.T."],"citationCrossReferences":[{"database":"PubMed","id":"14610093"},{"database":"DOI","id":"10.1074/jbc.m309393200"}],"title":"Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"6783","lastPage":"6793","volume":"279"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":15,"citation":{"id":"15327775","citationType":"journal article","authors":["Sarraf S.A.","Stancheva I."],"citationCrossReferences":[{"database":"PubMed","id":"15327775"},{"database":"DOI","id":"10.1016/j.molcel.2004.06.043"}],"title":"Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly.","publicationDate":"2004","journal":"Mol. Cell","firstPage":"595","lastPage":"605","volume":"15"},"referencePositions":["RETRACTED PAPER"]},{"referenceNumber":16,"citation":{"id":"30849389","citationType":"journal article","authors":["Sarraf S.A.","Stancheva I."],"citationCrossReferences":[{"database":"PubMed","id":"30849389"},{"database":"DOI","id":"10.1016/j.molcel.2019.02.023"}],"title":"Retraction Notice to: Methyl-CpG Binding Protein MBD1 Couples Histone H3 Methylation at Lysine 9 by SETDB1 to DNA Replication and Chromatin Assembly.","publicationDate":"2019","journal":"Mol. Cell","firstPage":"1084","lastPage":"1084","volume":"73"},"referencePositions":["RETRACTION NOTICE OF PUBMED:15327775"]},{"referenceNumber":17,"citation":{"id":"15691849","citationType":"journal article","authors":["Ichimura T.","Watanabe S.","Sakamoto Y.","Aoto T.","Fujita N.","Nakao M."],"citationCrossReferences":[{"database":"PubMed","id":"15691849"},{"database":"DOI","id":"10.1074/jbc.m413654200"}],"title":"Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins.","publicationDate":"2005","journal":"J. Biol. Chem.","firstPage":"13928","lastPage":"13935","volume":"280"},"referencePositions":["INTERACTION WITH ATF7IP AND ATF7IP2","MUTAGENESIS OF ILE-576"]},{"referenceNumber":18,"citation":{"id":"17066076","citationType":"journal article","authors":["Lyst M.J.","Nan X.","Stancheva I."],"citationCrossReferences":[{"database":"PubMed","id":"17066076"},{"database":"DOI","id":"10.1038/sj.emboj.7601404"}],"title":"Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins.","publicationDate":"2006","journal":"EMBO J.","firstPage":"5317","lastPage":"5328","volume":"25"},"referencePositions":["RETRACTED PAPER"]},{"referenceNumber":19,"citation":{"id":"31612521","citationType":"journal article","authors":["Lyst M.J.","Nan X.","Stancheva I."],"citationCrossReferences":[{"database":"PubMed","id":"31612521"},{"database":"DOI","id":"10.15252/embj.2019103220"}],"title":"Retraction: Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins.","publicationDate":"2019","journal":"EMBO J.","firstPage":"e103220","lastPage":"e103220","volume":"38"},"referencePositions":["RETRACTION NOTICE OF PUBMED:17066076"]},{"referenceNumber":20,"citation":{"id":"16757475","citationType":"journal article","authors":["Uchimura Y.","Ichimura T.","Uwada J.","Tachibana T.","Sugahara S.","Nakao M.","Saitoh H."],"citationCrossReferences":[{"database":"PubMed","id":"16757475"},{"database":"DOI","id":"10.1074/jbc.m602280200"}],"title":"Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation.","publicationDate":"2006","journal":"J. Biol. Chem.","firstPage":"23180","lastPage":"23190","volume":"281"},"referencePositions":["SUMOYLATION","INTERACTION WITH ATF7IP"]},{"referenceNumber":21,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":22,"citation":{"id":"19666599","citationType":"journal article","authors":["Bierne H.","Tham T.N.","Batsche E.","Dumay A.","Leguillou M.","Kerneis-Golsteyn S.","Regnault B.","Seeler J.S.","Muchardt C.","Feunteun J.","Cossart P."],"citationCrossReferences":[{"database":"PubMed","id":"19666599"},{"database":"DOI","id":"10.1073/pnas.0901259106"}],"title":"Human BAHD1 promotes heterochromatic gene silencing.","publicationDate":"2009","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"13826","lastPage":"13831","volume":"106"},"referencePositions":["INTERACTION WITH BAHD1"]},{"referenceNumber":23,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":25,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":26,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":27,"citation":{"id":"25218447","citationType":"journal article","authors":["Hendriks I.A.","D'Souza R.C.","Yang B.","Verlaan-de Vries M.","Mann M.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25218447"},{"database":"DOI","id":"10.1038/nsmb.2890"}],"title":"Uncovering global SUMOylation signaling networks in a site-specific manner.","publicationDate":"2014","journal":"Nat. Struct. Mol. Biol.","firstPage":"927","lastPage":"936","volume":"21"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-538","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":28,"citation":{"id":"25772364","citationType":"journal article","authors":["Hendriks I.A.","Treffers L.W.","Verlaan-de Vries M.","Olsen J.V.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25772364"},{"database":"DOI","id":"10.1016/j.celrep.2015.02.033"}],"title":"SUMO-2 orchestrates chromatin modifiers in response to DNA damage.","publicationDate":"2015","journal":"Cell Rep.","firstPage":"1778","lastPage":"1791","volume":"10"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-538","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":29,"citation":{"id":"25755297","citationType":"journal article","authors":["Xiao Z.","Chang J.G.","Hendriks I.A.","Sigurdsson J.O.","Olsen J.V.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25755297"},{"database":"DOI","id":"10.1074/mcp.o114.044792"}],"title":"System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.","publicationDate":"2015","journal":"Mol. Cell. Proteomics","firstPage":"1419","lastPage":"1434","volume":"14"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-277 AND LYS-422","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":30,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-117; LYS-277; LYS-422; LYS-440; LYS-499; LYS-538 AND LYS-558","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":31,"citation":{"id":"10581239","citationType":"journal article","authors":["Ohki I.","Shimotake N.","Fujita N.","Nakao M.","Shirakawa M."],"citationCrossReferences":[{"database":"PubMed","id":"10581239"},{"database":"DOI","id":"10.1093/emboj/18.23.6653"}],"title":"Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1.","publicationDate":"1999","journal":"EMBO J.","firstPage":"6653","lastPage":"6661","volume":"18"},"referencePositions":["STRUCTURE BY NMR OF 1-75 IN COMPLEX WITH METHYLATED DNA","MUTAGENESIS OF ARG-22; ARG-30; ASP-32; TYR-34; ARG-44; SER-45; TYR-52 AND PHE-64"]},{"referenceNumber":32,"citation":{"id":"11371345","citationType":"journal article","authors":["Ohki I.","Shimotake N.","Fujita N.","Jee J.","Ikegami T.","Nakao M.","Shirakawa M."],"citationCrossReferences":[{"database":"PubMed","id":"11371345"},{"database":"DOI","id":"10.1016/s0092-8674(01)00324-5"}],"title":"Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA.","publicationDate":"2001","journal":"Cell","firstPage":"487","lastPage":"497","volume":"105"},"referencePositions":["STRUCTURE BY NMR OF 1-75 IN COMPLEX WITH METHYLATED DNA","DOMAIN MBD","MUTAGENESIS OF ARG-22; ARG-30; ASP-32; TYR-34; ARG-44; SER-45; LYS-46; TYR-52 AND LYS-65"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1IG4"}]},{"referenceNumber":33,"citation":{"id":"14555760","citationType":"journal article","authors":["Watanabe S.","Ichimura T.","Fujita N.","Tsuruzoe S.","Ohki I.","Shirakawa M.","Kawasuji M.","Nakao M."],"citationCrossReferences":[{"database":"PubMed","id":"14555760"},{"database":"DOI","id":"10.1073/pnas.2131819100"}],"title":"Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin.","publicationDate":"2003","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12859","lastPage":"12864","volume":"100"},"referencePositions":["STRUCTURE BY NMR OF 1-75 IN COMPLEX WITH METHYLATED DNA","FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH MPG","DOMAIN TRD"]},{"referenceNumber":34,"citation":{"id":"26354109","citationType":"journal article","authors":["Thomson R.","Smith B.O."],"citationCrossReferences":[{"database":"PubMed","id":"26354109"},{"database":"DOI","id":"10.1007/s10858-015-9986-8"}],"title":"Solution structure of human MBD1 CXXC1.","publicationDate":"2015","journal":"J. Biomol. NMR","firstPage":"309","lastPage":"314","volume":"63"},"referencePositions":["STRUCTURE BY NMR OF 167-222","DOMAIN CXXC-TYPE 1 ZINC-FINGER"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4D4W"}]},{"referenceNumber":35,"citation":{"id":"29276034","citationType":"journal article","authors":["Xu C.","Liu K.","Lei M.","Yang A.","Li Y.","Hughes T.R.","Min J."],"citationCrossReferences":[{"database":"PubMed","id":"29276034"},{"database":"DOI","id":"10.1016/j.str.2017.11.022"}],"title":"DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.","publicationDate":"2018","journal":"Structure","firstPage":"85","lastPage":"95.e3","volume":"26"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 330-388 IN COMPLEX WITH CPG DNA","DOMAIN CXXC-TYPE 3 ZINC-FINGER","ZINC-BINDING"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5W9Q"}]},{"referenceNumber":36,"citation":{"id":"CI-B0T40SF06S665","citationType":"submission","authoringGroup":["Structural genomics consortium (SGC)"],"title":"Complex of MBD1-MBD and methylated DNA.","publicationDate":"APR-2018","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 1-77 IN COMPLEX WITH METHYLATED DNA","DOMAIN MBD"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6D1T"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Y10746","properties":[{"key":"ProteinId","value":"CAA71735.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF120981","properties":[{"key":"ProteinId","value":"AAD50371.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF120980","properties":[{"key":"ProteinId","value":"AAD50371.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF078830","properties":[{"key":"ProteinId","value":"AAD51442.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF078831","properties":[{"key":"ProteinId","value":"AAD51443.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF078832","properties":[{"key":"ProteinId","value":"AAD51444.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF078833","properties":[{"key":"ProteinId","value":"AAD51445.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF488685","properties":[{"key":"ProteinId","value":"ABP02056.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK302004","properties":[{"key":"ProteinId","value":"BAG63407.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC090246","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC033242","properties":[{"key":"ProteinId","value":"AAH33242.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ564845","properties":[{"key":"ProteinId","value":"CAD92308.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF072241","properties":[{"key":"ProteinId","value":"AAC68870.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS11941.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-4"},{"database":"CCDS","id":"CCDS11942.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-7"},{"database":"CCDS","id":"CCDS11943.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-1"},{"database":"CCDS","id":"CCDS11944.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-5"},{"database":"CCDS","id":"CCDS32832.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-2"},{"database":"CCDS","id":"CCDS56071.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-8"},{"database":"CCDS","id":"CCDS56072.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-6"},{"database":"CCDS","id":"CCDS56073.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-9"},{"database":"CCDS","id":"CCDS59318.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-10"},{"database":"CCDS","id":"CCDS59319.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-11"},{"database":"CCDS","id":"CCDS59320.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-12"},{"database":"RefSeq","id":"NP_001191065.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001204136.2"}],"isoformId":"Q9UIS9-12"},{"database":"RefSeq","id":"NP_001191066.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001204137.2"}],"isoformId":"Q9UIS9-9"},{"database":"RefSeq","id":"NP_001191067.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001204138.2"}]},{"database":"RefSeq","id":"NP_001191068.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001204139.2"}],"isoformId":"Q9UIS9-1"},{"database":"RefSeq","id":"NP_001191069.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001204140.2"}]},{"database":"RefSeq","id":"NP_001191070.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001204141.2"}],"isoformId":"Q9UIS9-10"},{"database":"RefSeq","id":"NP_001191071.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001204142.2"}],"isoformId":"Q9UIS9-6"},{"database":"RefSeq","id":"NP_001191072.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001204143.2"}],"isoformId":"Q9UIS9-11"},{"database":"RefSeq","id":"NP_001191080.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001204151.3"}],"isoformId":"Q9UIS9-8"},{"database":"RefSeq","id":"NP_001375067.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001388138.1"}],"isoformId":"Q9UIS9-1"},{"database":"RefSeq","id":"NP_001375069.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001388140.1"}],"isoformId":"Q9UIS9-9"},{"database":"RefSeq","id":"NP_001375073.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001388144.1"}],"isoformId":"Q9UIS9-11"},{"database":"RefSeq","id":"NP_001386815.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001399886.1"}],"isoformId":"Q9UIS9-9"},{"database":"RefSeq","id":"NP_001386826.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001399897.1"}],"isoformId":"Q9UIS9-1"},{"database":"RefSeq","id":"NP_001386827.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001399898.1"}],"isoformId":"Q9UIS9-1"},{"database":"RefSeq","id":"NP_001386870.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001399941.1"}],"isoformId":"Q9UIS9-7"},{"database":"RefSeq","id":"NP_001386871.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001399942.1"}],"isoformId":"Q9UIS9-7"},{"database":"RefSeq","id":"NP_001386886.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001399957.1"}],"isoformId":"Q9UIS9-4"},{"database":"RefSeq","id":"NP_002375.1","properties":[{"key":"NucleotideSequenceId","value":"NM_002384.3"}],"isoformId":"Q9UIS9-4"},{"database":"RefSeq","id":"NP_056669.2","properties":[{"key":"NucleotideSequenceId","value":"NM_015844.3"}],"isoformId":"Q9UIS9-7"},{"database":"RefSeq","id":"NP_056670.2","properties":[{"key":"NucleotideSequenceId","value":"NM_015845.4"}],"isoformId":"Q9UIS9-2"},{"database":"RefSeq","id":"NP_056671.2","properties":[{"key":"NucleotideSequenceId","value":"NM_015846.4"}],"isoformId":"Q9UIS9-1"},{"database":"RefSeq","id":"NP_056723.2","properties":[{"key":"NucleotideSequenceId","value":"NM_015847.4"}],"isoformId":"Q9UIS9-5"},{"database":"RefSeq","id":"XP_005258328.1","properties":[{"key":"NucleotideSequenceId","value":"XM_005258271.4"}],"isoformId":"Q9UIS9-1"},{"database":"RefSeq","id":"XP_016881259.1","properties":[{"key":"NucleotideSequenceId","value":"XM_017025770.3"}],"isoformId":"Q9UIS9-7"},{"database":"RefSeq","id":"XP_016881265.1","properties":[{"key":"NucleotideSequenceId","value":"XM_017025776.3"}],"isoformId":"Q9UIS9-4"},{"database":"RefSeq","id":"XP_054174603.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054318628.1"}],"isoformId":"Q9UIS9-1"},{"database":"RefSeq","id":"XP_054174613.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054318638.1"}],"isoformId":"Q9UIS9-7"},{"database":"RefSeq","id":"XP_054174616.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054318641.1"}],"isoformId":"Q9UIS9-4"},{"database":"PDB","id":"1D9N","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-75"}]},{"database":"PDB","id":"1IG4","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-75"}]},{"database":"PDB","id":"4D4W","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=167-222"}]},{"database":"PDB","id":"5W9Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=330-388"}]},{"database":"PDB","id":"6D1T","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"A=1-77"}]},{"database":"PDBsum","id":"1D9N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1IG4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4D4W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5W9Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6D1T","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"110322","properties":[{"key":"Interactions","value":"80"}]},{"database":"CORUM","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9UIS9","properties":[{"key":"Number of interactors","value":"3326"}]},{"database":"IntAct","id":"Q9UIS9","properties":[{"key":"Interactions","value":"56"}]},{"database":"MINT","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000468785","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9UIS9","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"MBD1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"50401200","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000468785","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"84560","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-1"},{"database":"ProteomicsDB","id":"84561","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-2"},{"database":"ProteomicsDB","id":"84562","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-4"},{"database":"ProteomicsDB","id":"84563","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-5"},{"database":"ProteomicsDB","id":"84564","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-6"},{"database":"ProteomicsDB","id":"84565","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-7"},{"database":"ProteomicsDB","id":"84566","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-8"},{"database":"ProteomicsDB","id":"84567","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UIS9-9"},{"database":"Pumba","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3959","properties":[{"key":"antibodies","value":"449 antibodies from 36 providers"}]},{"database":"CPTC","id":"Q9UIS9","properties":[{"key":"antibodies","value":"3 antibodies"}]},{"database":"DNASU","id":"4152","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000269468.10","properties":[{"key":"ProteinId","value":"ENSP00000269468.5"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-1"},{"database":"Ensembl","id":"ENST00000269471.9","properties":[{"key":"ProteinId","value":"ENSP00000269471.5"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-2"},{"database":"Ensembl","id":"ENST00000339998.10","properties":[{"key":"ProteinId","value":"ENSP00000339546.5"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-6"},{"database":"Ensembl","id":"ENST00000347968.7","properties":[{"key":"ProteinId","value":"ENSP00000285102.5"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-7"},{"database":"Ensembl","id":"ENST00000353909.7","properties":[{"key":"ProteinId","value":"ENSP00000269469.5"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-5"},{"database":"Ensembl","id":"ENST00000382948.9","properties":[{"key":"ProteinId","value":"ENSP00000372407.5"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-1"},{"database":"Ensembl","id":"ENST00000398488.5","properties":[{"key":"ProteinId","value":"ENSP00000381502.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-4"},{"database":"Ensembl","id":"ENST00000398493.5","properties":[{"key":"ProteinId","value":"ENSP00000381506.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-7"},{"database":"Ensembl","id":"ENST00000457839.6","properties":[{"key":"ProteinId","value":"ENSP00000405268.2"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-9"},{"database":"Ensembl","id":"ENST00000585595.5","properties":[{"key":"ProteinId","value":"ENSP00000468430.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-9"},{"database":"Ensembl","id":"ENST00000585672.5","properties":[{"key":"ProteinId","value":"ENSP00000466092.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-10"},{"database":"Ensembl","id":"ENST00000587605.5","properties":[{"key":"ProteinId","value":"ENSP00000468042.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-11"},{"database":"Ensembl","id":"ENST00000588937.5","properties":[{"key":"ProteinId","value":"ENSP00000467763.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-2"},{"database":"Ensembl","id":"ENST00000590208.5","properties":[{"key":"ProteinId","value":"ENSP00000468785.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-12"},{"database":"Ensembl","id":"ENST00000591416.5","properties":[{"key":"ProteinId","value":"ENSP00000467017.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-1"},{"database":"Ensembl","id":"ENST00000591535.5","properties":[{"key":"ProteinId","value":"ENSP00000465923.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-8"},{"database":"Ensembl","id":"ENST00000865888.1","properties":[{"key":"ProteinId","value":"ENSP00000535947.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-1"},{"database":"Ensembl","id":"ENST00000865889.1","properties":[{"key":"ProteinId","value":"ENSP00000535948.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-9"},{"database":"Ensembl","id":"ENST00000865895.1","properties":[{"key":"ProteinId","value":"ENSP00000535954.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-1"},{"database":"Ensembl","id":"ENST00000865900.1","properties":[{"key":"ProteinId","value":"ENSP00000535959.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-1"},{"database":"Ensembl","id":"ENST00000865907.1","properties":[{"key":"ProteinId","value":"ENSP00000535966.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-1"},{"database":"Ensembl","id":"ENST00000865913.1","properties":[{"key":"ProteinId","value":"ENSP00000535972.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-9"},{"database":"Ensembl","id":"ENST00000865916.1","properties":[{"key":"ProteinId","value":"ENSP00000535975.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-1"},{"database":"Ensembl","id":"ENST00000865918.1","properties":[{"key":"ProteinId","value":"ENSP00000535977.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-1"},{"database":"Ensembl","id":"ENST00000865924.1","properties":[{"key":"ProteinId","value":"ENSP00000535983.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-1"},{"database":"Ensembl","id":"ENST00000919205.1","properties":[{"key":"ProteinId","value":"ENSP00000589264.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-9"},{"database":"Ensembl","id":"ENST00000919207.1","properties":[{"key":"ProteinId","value":"ENSP00000589266.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-9"},{"database":"Ensembl","id":"ENST00000919216.1","properties":[{"key":"ProteinId","value":"ENSP00000589275.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-5"},{"database":"Ensembl","id":"ENST00000919220.1","properties":[{"key":"ProteinId","value":"ENSP00000589279.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-9"},{"database":"Ensembl","id":"ENST00000950610.1","properties":[{"key":"ProteinId","value":"ENSP00000620669.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-7"},{"database":"Ensembl","id":"ENST00000950621.1","properties":[{"key":"ProteinId","value":"ENSP00000620680.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-1"},{"database":"Ensembl","id":"ENST00000950630.1","properties":[{"key":"ProteinId","value":"ENSP00000620689.1"},{"key":"GeneId","value":"ENSG00000141644.20"}],"isoformId":"Q9UIS9-1"},{"database":"GeneID","id":"4152","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:4152","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000269468.10","properties":[{"key":"ProteinId","value":"ENSP00000269468.5"},{"key":"RefSeqNucleotideId","value":"NM_015846.4"},{"key":"RefSeqProteinId","value":"NP_056671.2"}]},{"database":"UCSC","id":"uc002leg.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9UIS9-1"},{"database":"AGR","id":"HGNC:6916","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA30659","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4152","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"4152","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"MBD1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:6916","properties":[{"key":"GeneName","value":"MBD1"}]},{"database":"HPA","id":"ENSG00000141644","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"MBD1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"156535","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000141644","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000141644","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QQE9","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000183005","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_031386_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RTDCGRC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10072024at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9UIS9","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-3899300","properties":[{"key":"PathwayName","value":"SUMOylation of transcription cofactors"}]},{"database":"SignaLink","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000141644","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"4152","properties":[{"key":"hits","value":"14 hits in 1184 CRISPR screens"}]},{"database":"ChiTaRS","id":"MBD1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"MBD1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"4152","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9UIS9","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9UIS9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 18"}]},{"database":"RNAct","id":"Q9UIS9","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000141644","properties":[{"key":"ExpressionPatterns","value":"Expressed in left testis and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9UIS9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10454587"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10648624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12711603"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14555760"}]},{"database":"GO","id":"GO:0016363","properties":[{"key":"GoTerm","value":"C:nuclear matrix"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10454587"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10648624"}]},{"database":"GO","id":"GO:0016607","properties":[{"key":"GoTerm","value":"C:nuclear speck"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10454587"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10648624"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12711603"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14610093"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9774669"}]},{"database":"GO","id":"GO:0010385","properties":[{"key":"GoTerm","value":"F:double-stranded methylated DNA binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11371345"}]},{"database":"GO","id":"GO:0008327","properties":[{"key":"GoTerm","value":"F:methyl-CpG binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25284789"}]},{"database":"GO","id":"GO:0045322","properties":[{"key":"GoTerm","value":"F:unmethylated CpG binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29276034"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29276034"}]},{"database":"GO","id":"GO:0006346","properties":[{"key":"GoTerm","value":"P:DNA methylation-dependent constitutive heterochromatin formation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048712","properties":[{"key":"GoTerm","value":"P:negative regulation of astrocyte differentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045892","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10454587"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030182","properties":[{"key":"GoTerm","value":"P:neuron differentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1903925","properties":[{"key":"GoTerm","value":"P:response to bisphenol A"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042220","properties":[{"key":"GoTerm","value":"P:response to cocaine"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032355","properties":[{"key":"GoTerm","value":"P:response to estradiol"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031667","properties":[{"key":"GoTerm","value":"P:response to nutrient levels"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009410","properties":[{"key":"GoTerm","value":"P:response to xenobiotic stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006366","properties":[{"key":"GoTerm","value":"P:transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9774669"}]},{"database":"GO","id":"GO:0003229","properties":[{"key":"GoTerm","value":"P:ventricular cardiac muscle tissue development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd01396","properties":[{"key":"EntryName","value":"MeCP2_MBD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.890.10:FF:000001","properties":[{"key":"EntryName","value":"methyl-CpG-binding domain protein 1 isoform X7"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.890.10","properties":[{"key":"EntryName","value":"Methyl-cpg-binding Protein 2, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00332","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR016177","properties":[{"key":"EntryName","value":"DNA-bd_dom_sf"}]},{"database":"InterPro","id":"IPR001739","properties":[{"key":"EntryName","value":"Methyl_CpG_DNA-bd"}]},{"database":"InterPro","id":"IPR002857","properties":[{"key":"EntryName","value":"Znf_CXXC"}]},{"database":"PANTHER","id":"PTHR12396","properties":[{"key":"EntryName","value":"METHYL-CPG BINDING PROTEIN, MBD"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12396:SF57","properties":[{"key":"EntryName","value":"METHYL-CPG-BINDING DOMAIN PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01429","properties":[{"key":"EntryName","value":"MBD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02008","properties":[{"key":"EntryName","value":"zf-CXXC"},{"key":"MatchStatus","value":"3"}]},{"database":"SMART","id":"SM00391","properties":[{"key":"EntryName","value":"MBD"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54171","properties":[{"key":"EntryName","value":"DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50982","properties":[{"key":"EntryName","value":"MBD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51058","properties":[{"key":"EntryName","value":"ZF_CXXC"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLTLFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADTDTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECAACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHCPICLRPPRPGLRRQWKCVQRRCLRGKHARRKGGCDSKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESEDGAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTDLVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAVLTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITEIFSLGGTRFRDTAVWLPRSKDLKKPGARKQ","length":605,"molWeight":66607,"crc64":"665732782CC6A32A","md5":"AAA89C25815F4B754D4C97DC42CE7FEA"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":13,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":11,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":3,"PTM":1,"CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":1,"Zinc finger":3,"Region":5,"Motif":1,"Compositional bias":5,"Binding site":24,"Modified residue":3,"Cross-link":7,"Alternative sequence":12,"Natural variant":1,"Mutagenesis":12,"Sequence conflict":5,"Beta strand":8,"Turn":4,"Helix":8},"uniParcId":"UPI000013D836"}}