{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UBU3","secondaryAccessions":["A8CF34","A8CF38","A8CF42","A8DN29","A8DN30","Q86YP8","Q8TAT9","Q9H3R3"],"uniProtkbId":"GHRL_HUMAN","entryAudit":{"firstPublicDate":"2001-12-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-01","entryVersion":217,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Appetite-regulating hormone"}},"alternativeNames":[{"fullName":{"value":"Growth hormone secretagogue"}},{"fullName":{"value":"Growth hormone-releasing peptide"}},{"fullName":{"value":"Motilin-related peptide"}},{"fullName":{"value":"Protein M46"}}],"contains":[{"recommendedName":{"fullName":{"value":"Ghrelin-27"}}},{"recommendedName":{"fullName":{"value":"Ghrelin-28"},"shortNames":[{"value":"Ghrelin"}]}},{"recommendedName":{"fullName":{"value":"Obestatin"}}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"GHRL"},"synonyms":[{"value":"MTLRP"}],"orfNames":[{"value":"UNQ524/PRO1066"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11306336"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35027551"}],"value":"Precursor of the appetite-regulating peptide ghrelin, including ghrelin-27 and ghrelin-28"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10604470"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11739476"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35027551"}],"value":"Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470, PubMed:35027551). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion (PubMed:11739476). Involved in growth regulation (PubMed:10604470)"}],"commentType":"FUNCTION","molecule":"Ghrelin-27"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10604470"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11306336"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11739476"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35027551"}],"value":"Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470, PubMed:35027551). Octanoylated ghrelin-28 is the most commonly found ghrelin and octanoylation is essential for the activation of the growth hormone secretagogue receptor type 1 (GHSR) (PubMed:11306336, PubMed:35027551). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion (PubMed:11739476). Involved in growth regulation (PubMed:10604470)"}],"commentType":"FUNCTION","molecule":"Ghrelin-28"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9QYH7"}],"value":"May have an appetite-reducing effect resulting in decreased food intake (By similarity). May reduce gastric emptying activity and jejunal motility (By similarity)"}],"commentType":"FUNCTION","molecule":"Obestatin"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9UBU3","intActId":"EBI-10319458"},"interactantTwo":{"uniProtKBAccession":"Q9UMX0","geneName":"UBQLN1","intActId":"EBI-741480"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBU3","intActId":"EBI-10319458"},"interactantTwo":{"uniProtKBAccession":"Q9UMX0-2","geneName":"UBQLN1","intActId":"EBI-10173939"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBU3","intActId":"EBI-10319458"},"interactantTwo":{"uniProtKBAccession":"Q9UHD9","geneName":"UBQLN2","intActId":"EBI-947187"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9EQX0"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"Ghrelin"}],"isoformIds":["Q9UBU3-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"des-Gln14-ghrelin"}],"isoformIds":["Q9UBU3-2"],"sequenceIds":["VSP_003245"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q9UBU3-3"],"sequenceIds":["VSP_041437"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q9UBU3-4"],"sequenceIds":["VSP_041437","VSP_003245"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["Q9UBU3-5"],"sequenceIds":["VSP_041438"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"isoformIds":["Q9UBU3-6"],"sequenceIds":["VSP_047642"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12414809"}],"value":"Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10604470"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18443287"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35027551"}],"value":"O-octanoylated by GOAT/MBOAT4 (PubMed:18443287). O-octanoylation or O-decanoylation is essential for ghrelin activity (PubMed:10604470, PubMed:35027551). The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26 (PubMed:10604470). A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid (PubMed:10604470). Also O-acetylated and O-butyrylated on Ser-26 to minor levels (PubMed:18443287)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9QYH7"}],"value":"Amidation of Leu-98 is essential for obestatin activity"}],"commentType":"PTM"},{"commentType":"MASS SPECTROMETRY","molecule":"Ghrelin-28","method":"Electrospray","molWeight":3398.9,"molWeightError":0.3,"note":"Ghrelin-28-C10, O-decanoylated form.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12414809"}]},{"commentType":"MASS SPECTROMETRY","molecule":"Ghrelin-28","method":"Electrospray","molWeight":3397.2,"molWeightError":0.5,"note":"Ghrelin-28-C10:1, O-decenoylated form.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12414809"}]},{"commentType":"MASS SPECTROMETRY","molecule":"Ghrelin-28","method":"Electrospray","molWeight":3371.3,"molWeightError":0.1,"note":"Ghrelin-28-C8, O-octanoylated form.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12414809"}]},{"commentType":"MASS SPECTROMETRY","molecule":"Ghrelin-27","method":"Electrospray","molWeight":3243.6,"molWeightError":0.4,"note":"Ghrelin-27-C10, O-decanoylated form.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12414809"}]},{"commentType":"MASS SPECTROMETRY","molecule":"Ghrelin-27","method":"Electrospray","molWeight":3214.6,"molWeightError":0.6,"note":"Ghrelin-27-C8, O-octanoylated form.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12414809"}]},{"commentType":"MASS SPECTROMETRY","molecule":"Ghrelin-27","method":"MALDI","molWeight":3214.0,"molWeightError":0.0,"note":"Ghrelin-27-C8, O-octanoylated form.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18443287"}]},{"commentType":"MASS SPECTROMETRY","molecule":"Ghrelin-28","method":"MALDI","molWeight":3370.0,"molWeightError":0.0,"note":"Ghrelin-28-C8, O-octanoylated form.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18443287"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the motilin family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/327/Ghrelin","ftp":false},{"commentType":"WEB RESOURCE","resourceName":"Protein Spotlight","resourceUrl":"https://www.proteinspotlight.org/back_issues/066","ftp":false,"note":"Gut feelings - Issue 66 of January 2006"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Ghrelin","ftp":false,"note":"Ghrelin entry"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10930375"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15340161"}]},{"type":"Peptide","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Ghrelin-28","featureId":"PRO_0000019202"},{"type":"Peptide","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Ghrelin-27","featureId":"PRO_0000019203"},{"type":"Propeptide","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Removed in mature form","featureId":"PRO_0000019204"},{"type":"Peptide","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Obestatin","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9QYH7"}],"featureId":"PRO_0000045140"},{"type":"Propeptide","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Removed in mature form","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"PRO_0000045141"},{"type":"Region","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Leucine amide","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9QYH7"}]},{"type":"Lipidation","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"O-decanoyl serine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10604470"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12414809"}]},{"type":"Lipidation","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"O-hexanoyl serine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9EQX0"}]},{"type":"Lipidation","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"O-octanoyl serine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10604470"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12414809"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18443287"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17727735"}],"featureId":"VSP_041438","alternativeSequence":{"originalSequence":"MPSPGTVCSLLLLGMLWLDLAMAGSSFLSPEHQRVQQRKESKKPPAKLQPRALAGWLRPEDGGQAEGAEDELEVR","alternativeSequences":["MFTCWWSYLRSTLAAVPGEASRVQ"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"in isoform 3 and isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17727735"}],"featureId":"VSP_041437","alternativeSequence":{"originalSequence":"MPSPGTVCSLLLLGMLWLDLAMAGSSFLSPEHQRVQ","alternativeSequences":["MFTCWWSYLRSTLAAVPGEASRVQ"]}},{"type":"Alternative sequence","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12414809"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17727735"}],"featureId":"VSP_003245","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"in isoform 6","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.6"}],"featureId":"VSP_047642","alternativeSequence":{"originalSequence":"FNAPFDVGIKLSGVQYQQHSQALGKFLQDILWEEAKEAPADK","alternativeSequences":["RPQPTSDRPQALLTSL"]}},{"type":"Natural variant","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"in dbSNP:rs696217","featureCrossReferences":[{"database":"dbSNP","id":"rs696217"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"VAR_050095","alternativeSequence":{"originalSequence":"L","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"in dbSNP:rs4684677","featureCrossReferences":[{"database":"dbSNP","id":"rs4684677"}],"featureId":"VAR_029135","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["L"]}},{"type":"Helix","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7W2Z"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0027","category":"PTM","name":"Amidation"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0372","category":"Molecular function","name":"Hormone"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"10604470","citationType":"journal article","authors":["Kojima M.","Hosoda H.","Date Y.","Nakazato M.","Matsuo H.","Kangawa K."],"citationCrossReferences":[{"database":"PubMed","id":"10604470"},{"database":"DOI","id":"10.1038/45230"}],"title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach.","publicationDate":"1999","journal":"Nature","firstPage":"656","lastPage":"660","volume":"402"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","ACYLATION AT SER-26"],"referenceComments":[{"value":"Stomach","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"10930375","citationType":"journal article","authors":["Tomasetto C.","Karam S.M.","Ribieras S.","Masson R.","Lefebvre O.","Staub A.","Alexander G.","Chenard M.-P.","Rio M.-C."],"citationCrossReferences":[{"database":"PubMed","id":"10930375"},{"database":"DOI","id":"10.1053/gast.2000.9371"}],"title":"Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide.","publicationDate":"2000","journal":"Gastroenterology","firstPage":"395","lastPage":"405","volume":"119"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","PROTEIN SEQUENCE OF 24-33"],"referenceComments":[{"value":"Stomach","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-39OCQJ934TJS4","citationType":"journal article","authors":["Wajnrajch M.P.","Ten I.S.","Gertner J.M.","Leibel R.L."],"title":"Genomic organization of the human Ghrelin gene.","publicationDate":"2000","journal":"J. Endocr. Genet.","firstPage":"231","lastPage":"233","volume":"1"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"12414809","citationType":"journal article","authors":["Hosoda H.","Kojima M.","Mizushima T.","Shimizu S.","Kangawa K."],"citationCrossReferences":[{"database":"PubMed","id":"12414809"},{"database":"DOI","id":"10.1074/jbc.m205366200"}],"title":"Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"64","lastPage":"70","volume":"278"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)","TISSUE SPECIFICITY","ACYLATION AT SER-26","MASS SPECTROMETRY"],"referenceComments":[{"value":"Stomach","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"17727735","citationType":"journal article","authors":["Seim I.","Collet C.","Herington A.C.","Chopin L.K."],"citationCrossReferences":[{"database":"PubMed","id":"17727735"},{"database":"DOI","id":"10.1186/1471-2164-8-298"}],"title":"Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"298","lastPage":"298","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5)"],"referenceComments":[{"value":"Heart","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Placenta","type":"TISSUE"},{"value":"Stomach","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"CI-2CSEIJ9E1GKQU","citationType":"submission","authors":["Jeffery P.L.","Herington A.C.","Chopin L.K."],"title":"Identification and expression pattern of an exon 3-deleted proghrelin variant in the prostate.","publicationDate":"NOV-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6)"]},{"referenceNumber":7,"citation":{"id":"12975309","citationType":"journal article","authors":["Clark H.F.","Gurney A.L.","Abaya E.","Baker K.","Baldwin D.T.","Brush J.","Chen J.","Chow B.","Chui C.","Crowley C.","Currell B.","Deuel B.","Dowd P.","Eaton D.","Foster J.S.","Grimaldi C.","Gu Q.","Hass P.E.","Heldens S.","Huang A.","Kim H.S.","Klimowski L.","Jin Y.","Johnson S.","Lee J.","Lewis L.","Liao D.","Mark M.R.","Robbie E.","Sanchez C.","Schoenfeld J.","Seshagiri S.","Simmons L.","Singh J.","Smith V.","Stinson J.","Vagts A.","Vandlen R.L.","Watanabe C.","Wieand D.","Woods K.","Xie M.-H.","Yansura D.G.","Yi S.","Yu G.","Yuan J.","Zhang M.","Zhang Z.","Goddard A.D.","Wood W.I.","Godowski P.J.","Gray A.M."],"citationCrossReferences":[{"database":"PubMed","id":"12975309"},{"database":"DOI","id":"10.1101/gr.1293003"}],"title":"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.","publicationDate":"2003","journal":"Genome Res.","firstPage":"2265","lastPage":"2270","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":8,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.-S.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":9,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":10,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)","VARIANT MET-72"],"referenceComments":[{"value":"Blood","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"15340161","citationType":"journal article","authors":["Zhang Z.","Henzel W.J."],"citationCrossReferences":[{"database":"PubMed","id":"15340161"},{"database":"DOI","id":"10.1110/ps.04682504"}],"title":"Signal peptide prediction based on analysis of experimentally verified cleavage sites.","publicationDate":"2004","journal":"Protein Sci.","firstPage":"2819","lastPage":"2824","volume":"13"},"referencePositions":["PROTEIN SEQUENCE OF 24-38"]},{"referenceNumber":12,"citation":{"id":"11739476","citationType":"journal article","authors":["Wren A.M.","Seal L.J.","Cohen M.A.","Brynes A.E.","Frost G.S.","Murphy K.G.","Dhillo W.S.","Ghatei M.A.","Bloom S.R."],"citationCrossReferences":[{"database":"PubMed","id":"11739476"},{"database":"DOI","id":"10.1210/jcem.86.12.8111"}],"title":"Ghrelin enhances appetite and increases food intake in humans.","publicationDate":"2001","journal":"J. Clin. Endocrinol. Metab.","firstPage":"5992","lastPage":"5992","volume":"86"},"referencePositions":["FUNCTION"]},{"referenceNumber":13,"citation":{"id":"18443287","citationType":"journal article","authors":["Gutierrez J.A.","Solenberg P.J.","Perkins D.R.","Willency J.A.","Knierman M.D.","Jin Z.","Witcher D.R.","Luo S.","Onyia J.E.","Hale J.E."],"citationCrossReferences":[{"database":"PubMed","id":"18443287"},{"database":"DOI","id":"10.1073/pnas.0800708105"}],"title":"Ghrelin octanoylation mediated by an orphan lipid transferase.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"6320","lastPage":"6325","volume":"105"},"referencePositions":["MASS SPECTROMETRY","ACYLATION AT SER-26"],"referenceComments":[{"value":"Thyroid carcinoma","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"11306336","citationType":"journal article","authors":["Kojima M.","Hosoda H.","Matsuo H.","Kangawa K."],"citationCrossReferences":[{"database":"PubMed","id":"11306336"},{"database":"DOI","id":"10.1016/s1043-2760(00)00362-3"}],"title":"Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.","publicationDate":"2001","journal":"Trends Endocrinol. Metab.","firstPage":"118","lastPage":"122","volume":"12"},"referencePositions":["REVIEW"]},{"referenceNumber":15,"citation":{"id":"35027551","citationType":"journal article","authors":["Qin J.","Cai Y.","Xu Z.","Ming Q.","Ji S.Y.","Wu C.","Zhang H.","Mao C.","Shen D.D.","Hirata K.","Ma Y.","Yan W.","Zhang Y.","Shao Z."],"citationCrossReferences":[{"database":"PubMed","id":"35027551"},{"database":"DOI","id":"10.1038/s41467-022-27975-9"}],"title":"Molecular mechanism of agonism and inverse agonism in ghrelin receptor.","publicationDate":"2022","journal":"Nat. Commun.","firstPage":"300","lastPage":"300","volume":"13"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS) OF 24-39","FUNCTION","OCTANOYLATION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7W2Z"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB029434","properties":[{"key":"ProteinId","value":"BAA89371.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ252278","properties":[{"key":"ProteinId","value":"CAB65733.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF296558","properties":[{"key":"ProteinId","value":"AAG10300.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"EU072086","properties":[{"key":"ProteinId","value":"ABV55189.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF549569","properties":[{"key":"ProteinId","value":"ABQ40357.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF549571","properties":[{"key":"ProteinId","value":"ABQ40358.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF549572","properties":[{"key":"ProteinId","value":"ABQ40359.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF549573","properties":[{"key":"ProteinId","value":"ABQ40360.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF549574","properties":[{"key":"ProteinId","value":"ABQ40361.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF549575","properties":[{"key":"ProteinId","value":"ABQ40362.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EU072083","properties":[{"key":"ProteinId","value":"ABV55186.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EU072084","properties":[{"key":"ProteinId","value":"ABV55187.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EU072085","properties":[{"key":"ProteinId","value":"ABV55188.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EU072087","properties":[{"key":"ProteinId","value":"ABV55190.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY184207","properties":[{"key":"ProteinId","value":"AAO27351.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY359053","properties":[{"key":"ProteinId","value":"AAQ89412.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC022384","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471055","properties":[{"key":"ProteinId","value":"EAW64074.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471055","properties":[{"key":"ProteinId","value":"EAW64075.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC025791","properties":[{"key":"ProteinId","value":"AAH25791.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB035700","properties":[{"key":"ProteinId","value":"BAB19045.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS33700.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBU3-1"},{"database":"CCDS","id":"CCDS46747.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBU3-5"},{"database":"CCDS","id":"CCDS46748.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBU3-3"},{"database":"CCDS","id":"CCDS46749.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBU3-4"},{"database":"CCDS","id":"CCDS46750.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBU3-2"},{"database":"PIR","id":"A59316","properties":[{"key":"EntryName","value":"A59316"}]},{"database":"RefSeq","id":"NP_001128413.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001134941.3"}],"isoformId":"Q9UBU3-2"},{"database":"RefSeq","id":"NP_001128416.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001134944.2"}],"isoformId":"Q9UBU3-3"},{"database":"RefSeq","id":"NP_001128417.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001134945.2"}],"isoformId":"Q9UBU3-4"},{"database":"RefSeq","id":"NP_001128418.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001134946.2"}],"isoformId":"Q9UBU3-5"},{"database":"RefSeq","id":"NP_001289750.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001302821.2"}],"isoformId":"Q9UBU3-1"},{"database":"RefSeq","id":"NP_001289751.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001302822.2"}],"isoformId":"Q9UBU3-1"},{"database":"RefSeq","id":"NP_001289752.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001302823.2"}],"isoformId":"Q9UBU3-2"},{"database":"RefSeq","id":"NP_001289753.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001302824.2"}],"isoformId":"Q9UBU3-1"},{"database":"RefSeq","id":"NP_001289754.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001302825.2"}],"isoformId":"Q9UBU3-1"},{"database":"RefSeq","id":"NP_057446.1","properties":[{"key":"NucleotideSequenceId","value":"NM_016362.5"}],"isoformId":"Q9UBU3-1"},{"database":"PDB","id":"6H3E","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=24-41"}]},{"database":"PDB","id":"7F9Y","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"C=24-51"}]},{"database":"PDB","id":"7NA7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"L=24-35"}]},{"database":"PDB","id":"7W2Z","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"L=24-39"}]},{"database":"PDBsum","id":"6H3E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7F9Y","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7NA7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7W2Z","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-24267","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31500","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32268","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"119706","properties":[{"key":"Interactions","value":"18"}]},{"database":"FunCoup","id":"Q9UBU3","properties":[{"key":"Number of interactors","value":"596"}]},{"database":"IntAct","id":"Q9UBU3","properties":[{"key":"Interactions","value":"13"}]},{"database":"NDEx","id":"IQUERY-CP-GHRL","properties":[{"key":"Evidences","value":"6 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000335074","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1921664","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"GHRL","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"17865471","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000335074","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"84065","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBU3-1"},{"database":"ProteomicsDB","id":"84066","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBU3-2"},{"database":"ProteomicsDB","id":"84067","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBU3-3"},{"database":"ProteomicsDB","id":"84068","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBU3-4"},{"database":"ProteomicsDB","id":"84069","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBU3-5"},{"database":"ABCD","id":"Q9UBU3","properties":[{"key":"antibodies","value":"20 sequenced antibodies"}]},{"database":"Antibodypedia","id":"2526","properties":[{"key":"antibodies","value":"932 antibodies from 44 providers"}]},{"database":"DNASU","id":"51738","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000287656.11","properties":[{"key":"ProteinId","value":"ENSP00000287656.7"},{"key":"GeneId","value":"ENSG00000157017.17"}],"isoformId":"Q9UBU3-2"},{"database":"Ensembl","id":"ENST00000335542.13","properties":[{"key":"ProteinId","value":"ENSP00000335074.8"},{"key":"GeneId","value":"ENSG00000157017.17"}],"isoformId":"Q9UBU3-1"},{"database":"Ensembl","id":"ENST00000422159.5","properties":[{"key":"ProteinId","value":"ENSP00000405464.1"},{"key":"GeneId","value":"ENSG00000157017.17"}],"isoformId":"Q9UBU3-6"},{"database":"Ensembl","id":"ENST00000429122.1","properties":[{"key":"ProteinId","value":"ENSP00000414819.1"},{"key":"GeneId","value":"ENSG00000157017.17"}],"isoformId":"Q9UBU3-1"},{"database":"Ensembl","id":"ENST00000430179.5","properties":[{"key":"ProteinId","value":"ENSP00000399922.1"},{"key":"GeneId","value":"ENSG00000157017.17"}],"isoformId":"Q9UBU3-2"},{"database":"Ensembl","id":"ENST00000437422.6","properties":[{"key":"ProteinId","value":"ENSP00000416768.2"},{"key":"GeneId","value":"ENSG00000157017.17"}],"isoformId":"Q9UBU3-3"},{"database":"Ensembl","id":"ENST00000439975.6","properties":[{"key":"ProteinId","value":"ENSP00000403725.2"},{"key":"GeneId","value":"ENSG00000157017.17"}],"isoformId":"Q9UBU3-5"},{"database":"Ensembl","id":"ENST00000449238.6","properties":[{"key":"ProteinId","value":"ENSP00000388145.2"},{"key":"GeneId","value":"ENSG00000157017.17"}],"isoformId":"Q9UBU3-4"},{"database":"Ensembl","id":"ENST00000457360.5","properties":[{"key":"ProteinId","value":"ENSP00000391406.1"},{"key":"GeneId","value":"ENSG00000157017.17"}],"isoformId":"Q9UBU3-1"},{"database":"Ensembl","id":"ENST00000910666.1","properties":[{"key":"ProteinId","value":"ENSP00000580725.1"},{"key":"GeneId","value":"ENSG00000157017.17"}],"isoformId":"Q9UBU3-1"},{"database":"Ensembl","id":"ENST00000910668.1","properties":[{"key":"ProteinId","value":"ENSP00000580727.1"},{"key":"GeneId","value":"ENSG00000157017.17"}],"isoformId":"Q9UBU3-1"},{"database":"Ensembl","id":"ENST00000910670.1","properties":[{"key":"ProteinId","value":"ENSP00000580728.1"},{"key":"GeneId","value":"ENSG00000157017.17"}],"isoformId":"Q9UBU3-1"},{"database":"Ensembl","id":"ENST00000910671.1","properties":[{"key":"ProteinId","value":"ENSP00000580730.1"},{"key":"GeneId","value":"ENSG00000157017.17"}],"isoformId":"Q9UBU3-1"},{"database":"GeneID","id":"51738","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:51738","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000335542.13","properties":[{"key":"ProteinId","value":"ENSP00000335074.8"},{"key":"RefSeqNucleotideId","value":"NM_016362.5"},{"key":"RefSeqProteinId","value":"NP_057446.1"}]},{"database":"UCSC","id":"uc003bvj.2","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9UBU3-1"},{"database":"AGR","id":"HGNC:18129","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA142671740","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"51738","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"51738","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"GHRL","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:18129","properties":[{"key":"GeneName","value":"GHRL"}]},{"database":"HPA","id":"ENSG00000157017","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (stomach)"}]},{"database":"MalaCards","id":"GHRL","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"605353","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000157017","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157017","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SFY3","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000004064","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_168380_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QYQQYGR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9896247at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9UBU3","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-375276","properties":[{"key":"PathwayName","value":"Peptide ligand-binding receptors"}],"isoformId":"Q9UBU3-1"},{"database":"Reactome","id":"R-HSA-416476","properties":[{"key":"PathwayName","value":"G alpha (q) signalling events"}],"isoformId":"Q9UBU3-1"},{"database":"Reactome","id":"R-HSA-422085","properties":[{"key":"PathwayName","value":"Synthesis, secretion, and deacylation of Ghrelin"}]},{"database":"SignaLink","id":"Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000157017","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"51738","properties":[{"key":"hits","value":"15 hits in 1142 CRISPR screens"}]},{"database":"GeneWiki","id":"Ghrelin","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"51738","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9UBU3","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9UBU3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"RNAct","id":"Q9UBU3","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000157017","properties":[{"key":"ExpressionPatterns","value":"Expressed in cardia of stomach and 125 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9UBU3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17113048"}]},{"database":"GO","id":"GO:0005788","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15039149"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15531532"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17392603"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0099013","properties":[{"key":"GoTerm","value":"C:neuronal dense core vesicle lumen"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0098794","properties":[{"key":"GoTerm","value":"C:postsynapse"},{"key":"GoEvidenceType","value":"IEA:GOC"}]},{"database":"GO","id":"GO:0098685","properties":[{"key":"GoTerm","value":"C:Schaffer collateral - CA1 synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034774","properties":[{"key":"GoTerm","value":"C:secretory granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0031768","properties":[{"key":"GoTerm","value":"F:ghrelin receptor binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0016608","properties":[{"key":"GoTerm","value":"F:growth hormone-releasing hormone activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11739476"}]},{"database":"GO","id":"GO:0030296","properties":[{"key":"GoTerm","value":"F:protein tyrosine kinase activator activity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15350694"}]},{"database":"GO","id":"GO:0008154","properties":[{"key":"GoTerm","value":"P:actin polymerization or depolymerization"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15232612"}]},{"database":"GO","id":"GO:0008343","properties":[{"key":"GoTerm","value":"P:adult feeding behavior"},{"key":"GoEvidenceType","value":"ISS:HGNC-UCL"}]},{"database":"GO","id":"GO:0051216","properties":[{"key":"GoTerm","value":"P:cartilage development"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15576457"}]},{"database":"GO","id":"GO:0043400","properties":[{"key":"GoTerm","value":"P:cortisol secretion"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17201814"}]},{"database":"GO","id":"GO:0046697","properties":[{"key":"GoTerm","value":"P:decidualization"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17494105"}]},{"database":"GO","id":"GO:0016358","properties":[{"key":"GoTerm","value":"P:dendrite development"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16491079"}]},{"database":"GO","id":"GO:0007186","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"10604470"}]},{"database":"GO","id":"GO:0001696","properties":[{"key":"GoTerm","value":"P:gastric acid secretion"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006006","properties":[{"key":"GoTerm","value":"P:glucose metabolic process"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17392603"}]},{"database":"GO","id":"GO:0030252","properties":[{"key":"GoTerm","value":"P:growth hormone secretion"},{"key":"GoEvidenceType","value":"TAS:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"16511605"}]},{"database":"GO","id":"GO:0009755","properties":[{"key":"GoTerm","value":"P:hormone-mediated signaling pathway"},{"key":"GoEvidenceType","value":"TAS:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"16511605"}]},{"database":"GO","id":"GO:0016525","properties":[{"key":"GoTerm","value":"P:negative regulation of angiogenesis"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15572208"}]},{"database":"GO","id":"GO:0043066","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15158140"}]},{"database":"GO","id":"GO:0042322","properties":[{"key":"GoTerm","value":"P:negative regulation of circadian sleep/wake cycle, REM sleep"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18329818"}]},{"database":"GO","id":"GO:0001937","properties":[{"key":"GoTerm","value":"P:negative regulation of endothelial cell proliferation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15572208"}]},{"database":"GO","id":"GO:0050728","properties":[{"key":"GoTerm","value":"P:negative regulation of inflammatory response"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15232612"}]},{"database":"GO","id":"GO:0032691","properties":[{"key":"GoTerm","value":"P:negative regulation of interleukin-1 beta production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15232612"}]},{"database":"GO","id":"GO:0032715","properties":[{"key":"GoTerm","value":"P:negative regulation of interleukin-6 production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15232612"}]},{"database":"GO","id":"GO:0032720","properties":[{"key":"GoTerm","value":"P:negative regulation of tumor necrosis factor production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15232612"}]},{"database":"GO","id":"GO:1904179","properties":[{"key":"GoTerm","value":"P:positive regulation of adipose tissue development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032100","properties":[{"key":"GoTerm","value":"P:positive regulation of appetite"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11739476"}]},{"database":"GO","id":"GO:1903012","properties":[{"key":"GoTerm","value":"P:positive regulation of bone development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0046010","properties":[{"key":"GoTerm","value":"P:positive regulation of circadian sleep/wake cycle, non-REM sleep"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18329818"}]},{"database":"GO","id":"GO:0120162","properties":[{"key":"GoTerm","value":"P:positive regulation of cold-induced thermogenesis"},{"key":"GoEvidenceType","value":"ISS:YuBioLab"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"19666521"}]},{"database":"GO","id":"GO:0051461","properties":[{"key":"GoTerm","value":"P:positive regulation of corticotropin secretion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12566947"}]},{"database":"GO","id":"GO:0051464","properties":[{"key":"GoTerm","value":"P:positive regulation of cortisol secretion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12566947"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18329818"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1904000","properties":[{"key":"GoTerm","value":"P:positive regulation of eating behavior"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1904346","properties":[{"key":"GoTerm","value":"P:positive regulation of gastric mucosal blood circulation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0060399","properties":[{"key":"GoTerm","value":"P:positive regulation of growth hormone receptor signaling pathway"},{"key":"GoEvidenceType","value":"IC:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"12566947"}]},{"database":"GO","id":"GO:0060124","properties":[{"key":"GoTerm","value":"P:positive regulation of growth hormone secretion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12566947"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18329818"}]},{"database":"GO","id":"GO:0040010","properties":[{"key":"GoTerm","value":"P:positive regulation of growth rate"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032024","properties":[{"key":"GoTerm","value":"P:positive regulation of insulin secretion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0035774","properties":[{"key":"GoTerm","value":"P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043410","properties":[{"key":"GoTerm","value":"P:positive regulation of MAPK cascade"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15350694"}]},{"database":"GO","id":"GO:0040018","properties":[{"key":"GoTerm","value":"P:positive regulation of multicellular organism growth"},{"key":"GoEvidenceType","value":"IC:HGNC-UCL"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16511605"}]},{"database":"GO","id":"GO:0120058","properties":[{"key":"GoTerm","value":"P:positive regulation of small intestinal transit"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1904349","properties":[{"key":"GoTerm","value":"P:positive regulation of small intestine smooth muscle contraction"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1903672","properties":[{"key":"GoTerm","value":"P:positive regulation of sprouting angiogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0051965","properties":[{"key":"GoTerm","value":"P:positive regulation of synapse assembly"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16491079"}]},{"database":"GO","id":"GO:1905564","properties":[{"key":"GoTerm","value":"P:positive regulation of vascular endothelial cell proliferation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0099170","properties":[{"key":"GoTerm","value":"P:postsynaptic modulation of chemical synaptic transmission"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042127","properties":[{"key":"GoTerm","value":"P:regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15564328"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16394173"}]},{"database":"GO","id":"GO:1905333","properties":[{"key":"GoTerm","value":"P:regulation of gastric motility"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0099175","properties":[{"key":"GoTerm","value":"P:regulation of postsynapse organization"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032095","properties":[{"key":"GoTerm","value":"P:regulation of response to food"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0051969","properties":[{"key":"GoTerm","value":"P:regulation of transmission of nerve impulse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0051602","properties":[{"key":"GoTerm","value":"P:response to electrical stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043627","properties":[{"key":"GoTerm","value":"P:response to estrogen"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15292338"}]},{"database":"GO","id":"GO:0009725","properties":[{"key":"GoTerm","value":"P:response to hormone"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15232612"}]},{"database":"InterPro","id":"IPR006737","properties":[{"key":"EntryName","value":"Motilin_assoc"}]},{"database":"InterPro","id":"IPR006738","properties":[{"key":"EntryName","value":"Motilin_ghrelin"}]},{"database":"InterPro","id":"IPR005441","properties":[{"key":"EntryName","value":"Preproghrelin"}]},{"database":"PANTHER","id":"PTHR14122:SF1","properties":[{"key":"EntryName","value":"APPETITE-REGULATING HORMONE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14122","properties":[{"key":"EntryName","value":"GHRELIN PRECURSOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04643","properties":[{"key":"EntryName","value":"Motilin_assoc"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04644","properties":[{"key":"EntryName","value":"Motilin_ghrelin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01624","properties":[{"key":"EntryName","value":"GHRELIN"}]}],"sequence":{"value":"MPSPGTVCSLLLLGMLWLDLAMAGSSFLSPEHQRVQQRKESKKPPAKLQPRALAGWLRPEDGGQAEGAEDELEVRFNAPFDVGIKLSGVQYQQHSQALGKFLQDILWEEAKEAPADK","length":117,"molWeight":12911,"crc64":"39C0572EBECA2755","md5":"118B6FC89151764BBF6031976C630A82"},"extraAttributes":{"countByCommentType":{"FUNCTION":4,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":6,"TISSUE SPECIFICITY":1,"PTM":2,"MASS SPECTROMETRY":7,"SIMILARITY":1,"WEB RESOURCE":3},"countByFeatureType":{"Signal":1,"Peptide":3,"Propeptide":2,"Region":1,"Compositional bias":1,"Modified residue":1,"Lipidation":3,"Alternative sequence":4,"Natural variant":2,"Helix":1},"uniParcId":"UPI00000362D3"}}