{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UBL3","secondaryAccessions":["A8K7C3","D3DSW9","O60659","O60660","Q96B62"],"uniProtkbId":"ASH2L_HUMAN","entryAudit":{"firstPublicDate":"2003-06-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-01","entryVersion":212,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Set1/Ash2 histone methyltransferase complex subunit ASH2"}},"alternativeNames":[{"fullName":{"value":"ASH2-like protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:744"}],"value":"ASH2L"},"synonyms":[{"value":"ASH2L1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12670868"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19131338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19556245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21220120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22266653"}],"value":"Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91X20"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12670868"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14992727"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15199122"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15960975"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16253997"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17355966"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17500065"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17998332"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18838538"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19131338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19556245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21220120"}],"value":"Interacts with HCFC1 (PubMed:12670868). Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7 (PubMed:15199122, PubMed:15960975, PubMed:17500065). Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BACC1, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin (PubMed:14992727, PubMed:15199122, PubMed:15960975, PubMed:17500065). Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (PubMed:16253997, PubMed:17355966, PubMed:17998332, PubMed:18838538). Found in a complex with RBBP5, ASH2L, DPY30, KMT2A, KMT2D and WDR5 (By similarity). Component of a histone methylation complex composed of at least ZNF335, RBBP5, ASH2L and WDR5; the complex may have histone H3-specific methyltransferase activity, however does not have specificity for 'Lys-4' of histone H3 (PubMed:19131338). Within the complex, interacts with ZNF335 (PubMed:19131338). Interacts with RBBP5 (PubMed:19131338, PubMed:19556245, PubMed:21220120). Components of this complex may associate with components of a nuclear receptor-mediated transcription complex to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5 (PubMed:19131338). Within this complex also interacts with CCAR2 and EMSY (PubMed:19131338). Interacts with DPY30 (PubMed:19556245). Interacts with SETD1A and SETD1B (PubMed:17998332)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"O43823","geneName":"AKAP8","intActId":"EBI-1237481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"P10275","geneName":"AR","intActId":"EBI-608057"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"P24863","geneName":"CCNC","intActId":"EBI-395261"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"Q8TAP6","geneName":"CEP76","intActId":"EBI-742887"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"Q9HCK8","geneName":"CHD8","intActId":"EBI-1169146"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"Q9C005","geneName":"DPY30","intActId":"EBI-744973"},"numberOfExperiments":23,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"Q09472","geneName":"EP300","intActId":"EBI-447295"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"O75460-2","geneName":"ERN1","intActId":"EBI-25852368"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"Q0VDC6","geneName":"FKBP1A","intActId":"EBI-10226858"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"P51610","geneName":"HCFC1","intActId":"EBI-396176"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"P54652","geneName":"HSPA2","intActId":"EBI-356991"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"Q14696","geneName":"MESD","intActId":"EBI-6165891"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"Q14686","geneName":"NCOA6","intActId":"EBI-78670"},"numberOfExperiments":16,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"Q6ZW49","geneName":"PAXIP1","intActId":"EBI-743225"},"numberOfExperiments":13,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"Q15291","geneName":"RBBP5","intActId":"EBI-592823"},"numberOfExperiments":40,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3","intActId":"EBI-540797"},"interactantTwo":{"uniProtKBAccession":"P04637","geneName":"TP53","intActId":"EBI-366083"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3-3","intActId":"EBI-16130425"},"interactantTwo":{"uniProtKBAccession":"Q9C005","geneName":"DPY30","intActId":"EBI-744973"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3-3","intActId":"EBI-16130425"},"interactantTwo":{"uniProtKBAccession":"Q03164","geneName":"KMT2A","intActId":"EBI-591370"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3-3","intActId":"EBI-16130425"},"interactantTwo":{"uniProtKBAccession":"Q9UMN6","geneName":"KMT2B","intActId":"EBI-765774"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3-3","intActId":"EBI-16130425"},"interactantTwo":{"uniProtKBAccession":"Q8NEZ4","geneName":"KMT2C","intActId":"EBI-1042997"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3-3","intActId":"EBI-16130425"},"interactantTwo":{"uniProtKBAccession":"O14686","geneName":"KMT2D","intActId":"EBI-996065"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3-3","intActId":"EBI-16130425"},"interactantTwo":{"uniProtKBAccession":"Q15291","geneName":"RBBP5","intActId":"EBI-592823"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3-3","intActId":"EBI-16130425"},"interactantTwo":{"uniProtKBAccession":"O15047","geneName":"SETD1A","intActId":"EBI-540779"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBL3-3","intActId":"EBI-16130425"},"interactantTwo":{"uniProtKBAccession":"Q9UPS6-2","geneName":"SETD1B","intActId":"EBI-16197836"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17355966"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"ASH2L1"}],"isoformIds":["Q9UBL3-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"ASH2L2"}],"isoformIds":["Q9UBL3-2"],"sequenceIds":["VSP_007577","VSP_007578"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q9UBL3-3"],"sequenceIds":["VSP_007577"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10393421"}],"value":"Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21285357"}],"value":"Both monomethylated and dimethylated on arginine residues in the C-terminus. Arg-296 is the major site. Methylation is not required for nuclear localization, nor for MLL complex integrity or maintenance of global histone H3K4me3 levels"}],"commentType":"PTM"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/44404/ASH2L","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":628,"modifier":"EXACT"}},"description":"Set1/Ash2 histone methyltransferase complex subunit ASH2","featureId":"PRO_0000064697"},{"type":"Domain","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":583,"modifier":"EXACT"}},"description":"B30.2/SPRY","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00548"}]},{"type":"Zinc finger","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"PHD-type; atypical","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21660059"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"DNA-binding","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21660059"}]},{"type":"Region","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":628,"modifier":"EXACT"}},"description":"Interaction with RBBP5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21220120"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21660059"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3RSN"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21660059"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3RSN"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21660059"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3RSN"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21660059"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3RSN"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Modified residue","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine; by PRMT1 and PRMT5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21285357"}]},{"type":"Modified residue","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11466562"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_007577","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":541,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11466562"}],"featureId":"VSP_007578","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":478,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"in dbSNP:rs34167006","featureCrossReferences":[{"database":"dbSNP","id":"rs34167006"}],"featureId":"VAR_050679","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Abolishes methylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21285357"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Mutagenesis","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Slightly decreased methylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21285357"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in Ref. 1; AAC13564","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"in Ref. 1; AAC13564","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"in Ref. 1; AAC13563","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"in Ref. 1; AAC13564","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Sequence conflict","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"in Ref. 1; AAC13564","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"in Ref. 1; AAC13564","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Beta strand","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Turn","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Beta strand","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Helix","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Beta strand","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Turn","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Beta strand","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Helix","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Helix","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Helix","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Helix","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Helix","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Helix","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Helix","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Turn","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Beta strand","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Helix","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Beta strand","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Helix","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3RSN"}]},{"type":"Helix","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TOJ"}]},{"type":"Beta strand","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TOJ"}]},{"type":"Beta strand","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":398,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":457,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Turn","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":465,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":469,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":472,"modifier":"EXACT"},"end":{"value":474,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":545,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":548,"modifier":"EXACT"},"end":{"value":556,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Helix","location":{"start":{"value":557,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4X8N"}]},{"type":"Beta strand","location":{"start":{"value":562,"modifier":"EXACT"},"end":{"value":571,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":573,"modifier":"EXACT"},"end":{"value":577,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":579,"modifier":"EXACT"},"end":{"value":581,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TOJ"}]},{"type":"Beta strand","location":{"start":{"value":587,"modifier":"EXACT"},"end":{"value":589,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4X8P"}]},{"type":"Helix","location":{"start":{"value":594,"modifier":"EXACT"},"end":{"value":597,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5F6L"}]},{"type":"Beta strand","location":{"start":{"value":599,"modifier":"EXACT"},"end":{"value":602,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TOJ"}]},{"type":"Helix","location":{"start":{"value":603,"modifier":"EXACT"},"end":{"value":615,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4RIQ"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"},"sequence":"Q9UBL3-2"},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"},"sequence":"Q9UBL3-3"},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"11466562","citationType":"journal article","authors":["Wang J.","Zhou Y.","Yin B.","Du G.","Huang X.","Li G.","Shen Y.","Yuan J.","Qiang B."],"citationCrossReferences":[{"database":"PubMed","id":"11466562"},{"database":"DOI","id":"10.1007/s001090100222"}],"title":"ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines.","publicationDate":"2001","journal":"J. Mol. Med.","firstPage":"399","lastPage":"405","volume":"79"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"10393421","citationType":"journal article","authors":["Ikegawa S.","Isomura M.","Koshizuka Y.","Nakamura Y."],"citationCrossReferences":[{"database":"PubMed","id":"10393421"},{"database":"DOI","id":"10.1159/000015248"}],"title":"Cloning and characterization of ASH2L and ash2l, human and mouse homologs of the Drosophila ash2 gene.","publicationDate":"1999","journal":"Cytogenet. Cell Genet.","firstPage":"167","lastPage":"172","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)","TISSUE SPECIFICITY"]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)"]},{"referenceNumber":4,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)"],"referenceComments":[{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"12670868","citationType":"journal article","authors":["Wysocka J.","Myers M.P.","Laherty C.D.","Eisenman R.N.","Herr W."],"citationCrossReferences":[{"database":"PubMed","id":"12670868"},{"database":"DOI","id":"10.1101/gad.252103"}],"title":"Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.","publicationDate":"2003","journal":"Genes Dev.","firstPage":"896","lastPage":"911","volume":"17"},"referencePositions":["FUNCTION","INTERACTION WITH HCFC1"]},{"referenceNumber":7,"citation":{"id":"14992727","citationType":"journal article","authors":["Hughes C.M.","Rozenblatt-Rosen O.","Milne T.A.","Copeland T.D.","Levine S.S.","Lee J.C.","Hayes D.N.","Shanmugam K.S.","Bhattacharjee A.","Biondi C.A.","Kay G.F.","Hayward N.K.","Hess J.L.","Meyerson M."],"citationCrossReferences":[{"database":"PubMed","id":"14992727"},{"database":"DOI","id":"10.1016/s1097-2765(04)00081-4"}],"title":"Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.","publicationDate":"2004","journal":"Mol. Cell","firstPage":"587","lastPage":"597","volume":"13"},"referencePositions":["IDENTIFICATION IN THE MEN1-ASSOCIATED HISTONE METHYLTRANSFERASE COMPLEX"]},{"referenceNumber":8,"citation":{"id":"15199122","citationType":"journal article","authors":["Yokoyama A.","Wang Z.","Wysocka J.","Sanyal M.","Aufiero D.J.","Kitabayashi I.","Herr W.","Cleary M.L."],"citationCrossReferences":[{"database":"PubMed","id":"15199122"},{"database":"DOI","id":"10.1128/mcb.24.13.5639-5649.2004"}],"title":"Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.","publicationDate":"2004","journal":"Mol. Cell. Biol.","firstPage":"5639","lastPage":"5649","volume":"24"},"referencePositions":["IDENTIFICATION IN THE MLL-LIKE COMPLEX"]},{"referenceNumber":9,"citation":{"id":"15960975","citationType":"journal article","authors":["Dou Y.","Milne T.A.","Tackett A.J.","Smith E.R.","Fukuda A.","Wysocka J.","Allis C.D.","Chait B.T.","Hess J.L.","Roeder R.G."],"citationCrossReferences":[{"database":"PubMed","id":"15960975"},{"database":"DOI","id":"10.1016/j.cell.2005.04.031"}],"title":"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.","publicationDate":"2005","journal":"Cell","firstPage":"873","lastPage":"885","volume":"121"},"referencePositions":["IDENTIFICATION IN THE MLL1/MLL COMPLEX"]},{"referenceNumber":10,"citation":{"id":"16253997","citationType":"journal article","authors":["Lee J.-H.","Skalnik D.G."],"citationCrossReferences":[{"database":"PubMed","id":"16253997"},{"database":"DOI","id":"10.1074/jbc.m508312200"}],"title":"CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.","publicationDate":"2005","journal":"J. Biol. Chem.","firstPage":"41725","lastPage":"41731","volume":"280"},"referencePositions":["IDENTIFICATION IN THE SET1 COMPLEX"]},{"referenceNumber":11,"citation":{"id":"17355966","citationType":"journal article","authors":["Lee J.-H.","Tate C.M.","You J.-S.","Skalnik D.G."],"citationCrossReferences":[{"database":"PubMed","id":"17355966"},{"database":"DOI","id":"10.1074/jbc.m609809200"}],"title":"Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.","publicationDate":"2007","journal":"J. Biol. Chem.","firstPage":"13419","lastPage":"13428","volume":"282"},"referencePositions":["SUBCELLULAR LOCATION","IDENTIFICATION IN THE SET1 COMPLEX"]},{"referenceNumber":12,"citation":{"id":"17500065","citationType":"journal article","authors":["Cho Y.-W.","Hong T.","Hong S.","Guo H.","Yu H.","Kim D.","Guszczynski T.","Dressler G.R.","Copeland T.D.","Kalkum M.","Ge K."],"citationCrossReferences":[{"database":"PubMed","id":"17500065"},{"database":"DOI","id":"10.1074/jbc.m701574200"}],"title":"PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.","publicationDate":"2007","journal":"J. Biol. Chem.","firstPage":"20395","lastPage":"20406","volume":"282"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY","IDENTIFICATION IN THE MLL2/3 COMPLEX"]},{"referenceNumber":13,"citation":{"id":"17998332","citationType":"journal article","authors":["Lee J.H.","Skalnik D.G."],"citationCrossReferences":[{"database":"PubMed","id":"17998332"},{"database":"DOI","id":"10.1128/mcb.01356-07"}],"title":"Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.","publicationDate":"2008","journal":"Mol. Cell. Biol.","firstPage":"609","lastPage":"618","volume":"28"},"referencePositions":["IDENTIFICATION IN SET1 COMPLEX","INTERACTION WITH SETD1A AND SETD1B"]},{"referenceNumber":14,"citation":{"id":"18838538","citationType":"journal article","authors":["Wu M.","Wang P.F.","Lee J.S.","Martin-Brown S.","Florens L.","Washburn M.","Shilatifard A."],"citationCrossReferences":[{"database":"PubMed","id":"18838538"},{"database":"DOI","id":"10.1128/mcb.00976-08"}],"title":"Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.","publicationDate":"2008","journal":"Mol. Cell. Biol.","firstPage":"7337","lastPage":"7344","volume":"28"},"referencePositions":["IDENTIFICATION IN SET1 COMPLEX"]},{"referenceNumber":15,"citation":{"id":"19131338","citationType":"journal article","authors":["Garapaty S.","Xu C.F.","Trojer P.","Mahajan M.A.","Neubert T.A.","Samuels H.H."],"citationCrossReferences":[{"database":"PubMed","id":"19131338"},{"database":"DOI","id":"10.1074/jbc.m805872200"}],"title":"Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"7542","lastPage":"7552","volume":"284"},"referencePositions":["FUNCTION","IDENTIFICATION IN A HISTONE METHYLATION COMPLEX","INTERACTION WITH ZNF335; CCAR2; RBBP5 AND EMSY"]},{"referenceNumber":16,"citation":{"id":"19556245","citationType":"journal article","authors":["Patel A.","Dharmarajan V.","Vought V.E.","Cosgrove M.S."],"citationCrossReferences":[{"database":"PubMed","id":"19556245"},{"database":"DOI","id":"10.1074/jbc.m109.014498"}],"title":"On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"24242","lastPage":"24256","volume":"284"},"referencePositions":["FUNCTION","CHARACTERIZATION OF THE MLL1/MLL COMPLEX","INTERACTION WITH DPY30 AND RBBP5"]},{"referenceNumber":17,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":19,"citation":{"id":"21285357","citationType":"journal article","authors":["Butler J.S.","Zurita-Lopez C.I.","Clarke S.G.","Bedford M.T.","Dent S.Y."],"citationCrossReferences":[{"database":"PubMed","id":"21285357"},{"database":"DOI","id":"10.1074/jbc.m110.202416"}],"title":"Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes.","publicationDate":"2011","journal":"J. Biol. Chem.","firstPage":"12234","lastPage":"12244","volume":"286"},"referencePositions":["METHYLATION AT ARG-296 BY PRMT1 AND PRMT5","MUTAGENESIS OF ARG-296 AND ARG-300"]},{"referenceNumber":20,"citation":{"id":"21220120","citationType":"journal article","authors":["Avdic V.","Zhang P.","Lanouette S.","Groulx A.","Tremblay V.","Brunzelle J.","Couture J.F."],"citationCrossReferences":[{"database":"PubMed","id":"21220120"},{"database":"DOI","id":"10.1016/j.str.2010.09.022"}],"title":"Structural and biochemical insights into MLL1 core complex assembly.","publicationDate":"2011","journal":"Structure","firstPage":"101","lastPage":"108","volume":"19"},"referencePositions":["FUNCTION","INTERACTION WITH RBBP5"]},{"referenceNumber":21,"citation":{"id":"22266653","citationType":"journal article","authors":["Zhang P.","Lee H.","Brunzelle J.S.","Couture J.F."],"citationCrossReferences":[{"database":"PubMed","id":"22266653"},{"database":"DOI","id":"10.1093/nar/gkr1235"}],"title":"The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.","publicationDate":"2012","journal":"Nucleic Acids Res.","firstPage":"4237","lastPage":"4246","volume":"40"},"referencePositions":["FUNCTION"]},{"referenceNumber":22,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 (ISOFORMS 2 AND 3)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":23,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"21660059","citationType":"journal article","authors":["Chen Y.","Wan B.","Wang K.C.","Cao F.","Yang Y.","Protacio A.","Dou Y.","Chang H.Y.","Lei M."],"citationCrossReferences":[{"database":"PubMed","id":"21660059"},{"database":"DOI","id":"10.1038/embor.2011.101"}],"title":"Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.","publicationDate":"2011","journal":"EMBO Rep.","firstPage":"797","lastPage":"803","volume":"12"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 96-271 IN COMPLEX WITH ZN(2+)","PHD-TYPE ZINC FINGER","DNA-BINDING REGION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3RSN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF056718","properties":[{"key":"ProteinId","value":"AAC13564.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF056717","properties":[{"key":"ProteinId","value":"AAC13563.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB022785","properties":[{"key":"ProteinId","value":"BAA74520.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB020982","properties":[{"key":"ProteinId","value":"BAA35127.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK291938","properties":[{"key":"ProteinId","value":"BAF84627.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471080","properties":[{"key":"ProteinId","value":"EAW63337.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471080","properties":[{"key":"ProteinId","value":"EAW63336.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471080","properties":[{"key":"ProteinId","value":"EAW63340.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC015936","properties":[{"key":"ProteinId","value":"AAH15936.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS47840.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBL3-3"},{"database":"CCDS","id":"CCDS59100.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBL3-2"},{"database":"CCDS","id":"CCDS6101.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBL3-1"},{"database":"RefSeq","id":"NP_001098684.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001105214.2"}],"isoformId":"Q9UBL3-3"},{"database":"RefSeq","id":"NP_001248761.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001261832.1"}],"isoformId":"Q9UBL3-2"},{"database":"RefSeq","id":"NP_004665.2","properties":[{"key":"NucleotideSequenceId","value":"NM_004674.5"}],"isoformId":"Q9UBL3-1"},{"database":"PDB","id":"3RSN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=96-271"}]},{"database":"PDB","id":"3S32","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"A=95-280"}]},{"database":"PDB","id":"3TOJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.07 A"},{"key":"Chains","value":"A/B=370-496, A/B=516-617"}]},{"database":"PDB","id":"4RIQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.23 A"},{"key":"Chains","value":"C/F/I/L/O/R/U/X=603-618"}]},{"database":"PDB","id":"4X8N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=380-495, A=539-598"}]},{"database":"PDB","id":"4X8P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=380-495, A=539-598"}]},{"database":"PDB","id":"5F6K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.41 A"},{"key":"Chains","value":"A/B=380-496, A/B=516-598"}]},{"database":"PDB","id":"5F6L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"B=380-496, B=516-598"}]},{"database":"PDB","id":"6E2H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.24 A"},{"key":"Chains","value":"D=380-622"}]},{"database":"PDB","id":"6KIU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"T=95-628"}]},{"database":"PDB","id":"6KIV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"T=95-628"}]},{"database":"PDB","id":"6KIW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"T=95-628"}]},{"database":"PDB","id":"6KIX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.10 A"},{"key":"Chains","value":"T=95-628"}]},{"database":"PDB","id":"6KIZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.50 A"},{"key":"Chains","value":"T=95-628"}]},{"database":"PDB","id":"6PWV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.20 A"},{"key":"Chains","value":"D=96-628"}]},{"database":"PDB","id":"6W5I","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.90 A"},{"key":"Chains","value":"D=96-628"}]},{"database":"PDB","id":"6W5M","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.60 A"},{"key":"Chains","value":"D=96-628"}]},{"database":"PDB","id":"6W5N","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.00 A"},{"key":"Chains","value":"D=96-628"}]},{"database":"PDB","id":"7BRE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/D=380-496, A/D=516-598"}]},{"database":"PDB","id":"7MBM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"D=96-628"}]},{"database":"PDB","id":"7MBN","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"D=96-628"}]},{"database":"PDB","id":"7UD5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.25 A"},{"key":"Chains","value":"M=95-628"}]},{"database":"PDB","id":"7W67","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.19 A"},{"key":"Chains","value":"A=380-496, A=516-598"}]},{"database":"PDB","id":"7W6A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.21 A"},{"key":"Chains","value":"A=380-496, A=516-598"}]},{"database":"PDB","id":"7W6I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.56 A"},{"key":"Chains","value":"A=380-496, A=516-598"}]},{"database":"PDB","id":"7W6J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.68 A"},{"key":"Chains","value":"A=380-496, A=516-598"}]},{"database":"PDB","id":"7W6L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.26 A"},{"key":"Chains","value":"A/B=380-496, A/B=516-598"}]},{"database":"PDBsum","id":"3RSN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3S32","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3TOJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4RIQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4X8N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4X8P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5F6K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5F6L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6E2H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KIU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KIV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KIW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KIX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KIZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PWV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6W5I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6W5M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6W5N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7BRE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MBM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MBN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UD5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7W67","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7W6A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7W6I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7W6J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7W6L","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0693","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0694","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0695","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20512","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21542","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21543","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21544","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23738","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23739","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26454","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-9998","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-9999","properties":[{"key":"Description","value":"-"}]},{"database":"SASBDB","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"114528","properties":[{"key":"Interactions","value":"270"}]},{"database":"ComplexPortal","id":"CPX-5850","properties":[{"key":"EntryName","value":"Histone-lysine N-methyltransferase complex, KMT2A variant"}]},{"database":"ComplexPortal","id":"CPX-7062","properties":[{"key":"EntryName","value":"Histone-lysine N-methyltransferase complex, KMT2B variant"}]},{"database":"ComplexPortal","id":"CPX-7091","properties":[{"key":"EntryName","value":"Histone-lysine N-methyltransferase complex, KMT2C variant"}]},{"database":"ComplexPortal","id":"CPX-7104","properties":[{"key":"EntryName","value":"Histone-lysine N-methyltransferase complex, KMT2D variant"}]},{"database":"ComplexPortal","id":"CPX-7110","properties":[{"key":"EntryName","value":"Histone-lysine N-methyltransferase complex, SET1A variant"}]},{"database":"ComplexPortal","id":"CPX-7111","properties":[{"key":"EntryName","value":"Histone-lysine N-methyltransferase complex, SET1B variant"}]},{"database":"CORUM","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-29222N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9UBL3","properties":[{"key":"Number of interactors","value":"3474"}]},{"database":"IntAct","id":"Q9UBL3","properties":[{"key":"Interactions","value":"154"}]},{"database":"MINT","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-ASH2L","properties":[{"key":"Evidences","value":"4 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000340896","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3108650","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9UBL3","properties":[{"key":"glycosylation","value":"2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ASH2L","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"32141382","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000340896","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"83994","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBL3-1"},{"database":"ProteomicsDB","id":"83995","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBL3-2"},{"database":"ProteomicsDB","id":"83996","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9UBL3-3"},{"database":"Pumba","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"10852","properties":[{"key":"antibodies","value":"450 antibodies from 41 providers"}]},{"database":"DNASU","id":"9070","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000343823.11","properties":[{"key":"ProteinId","value":"ENSP00000340896.5"},{"key":"GeneId","value":"ENSG00000129691.17"}],"isoformId":"Q9UBL3-1"},{"database":"Ensembl","id":"ENST00000428278.6","properties":[{"key":"ProteinId","value":"ENSP00000395310.2"},{"key":"GeneId","value":"ENSG00000129691.17"}],"isoformId":"Q9UBL3-3"},{"database":"Ensembl","id":"ENST00000521652.5","properties":[{"key":"ProteinId","value":"ENSP00000430259.1"},{"key":"GeneId","value":"ENSG00000129691.17"}],"isoformId":"Q9UBL3-2"},{"database":"Ensembl","id":"ENST00000899868.1","properties":[{"key":"ProteinId","value":"ENSP00000569927.1"},{"key":"GeneId","value":"ENSG00000129691.17"}],"isoformId":"Q9UBL3-1"},{"database":"Ensembl","id":"ENST00000971637.1","properties":[{"key":"ProteinId","value":"ENSP00000641696.1"},{"key":"GeneId","value":"ENSG00000129691.17"}],"isoformId":"Q9UBL3-1"},{"database":"GeneID","id":"9070","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:9070","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000343823.11","properties":[{"key":"ProteinId","value":"ENSP00000340896.5"},{"key":"RefSeqNucleotideId","value":"NM_004674.5"},{"key":"RefSeqProteinId","value":"NP_004665.2"}]},{"database":"UCSC","id":"uc003xkt.6","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9UBL3-1"},{"database":"AGR","id":"HGNC:744","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA25044","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"9070","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"9070","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ASH2L","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:744","properties":[{"key":"GeneName","value":"ASH2L"}]},{"database":"HPA","id":"ENSG00000129691","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"604782","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000129691","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000129691","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2626","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000010474","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CATCSRW","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10266026at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9UBL3","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-201722","properties":[{"key":"PathwayName","value":"Formation of the beta-catenin:TCF transactivating complex"}]},{"database":"Reactome","id":"R-HSA-3214841","properties":[{"key":"PathwayName","value":"PKMTs methylate histone lysines"}]},{"database":"Reactome","id":"R-HSA-3769402","properties":[{"key":"PathwayName","value":"Deactivation of the beta-catenin transactivating complex"}]},{"database":"Reactome","id":"R-HSA-5617472","properties":[{"key":"PathwayName","value":"Activation of anterior HOX genes in hindbrain development during early embryogenesis"}]},{"database":"Reactome","id":"R-HSA-8936459","properties":[{"key":"PathwayName","value":"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"}]},{"database":"Reactome","id":"R-HSA-9772755","properties":[{"key":"PathwayName","value":"Formation of WDR5-containing histone-modifying complexes"}]},{"database":"Reactome","id":"R-HSA-9818564","properties":[{"key":"PathwayName","value":"Epigenetic regulation of gene expression by MLL3 and MLL4 complexes"}]},{"database":"Reactome","id":"R-HSA-9841922","properties":[{"key":"PathwayName","value":"MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"}]},{"database":"Reactome","id":"R-HSA-9909649","properties":[{"key":"PathwayName","value":"Regulation of PD-L1(CD274) transcription"}]},{"database":"Reactome","id":"R-HSA-9944997","properties":[{"key":"PathwayName","value":"Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome"}]},{"database":"Reactome","id":"R-HSA-9976102","properties":[{"key":"PathwayName","value":"Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)"}]},{"database":"SignaLink","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000129691","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"9070","properties":[{"key":"hits","value":"344 hits in 1201 CRISPR screens"}]},{"database":"ChiTaRS","id":"ASH2L","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"ASH2L","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"9070","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9UBL3","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9UBL3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"RNAct","id":"Q9UBL3","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000129691","properties":[{"key":"ExpressionPatterns","value":"Expressed in superficial temporal artery and 211 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9UBL3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0035097","properties":[{"key":"GoTerm","value":"C:histone methyltransferase complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17355966"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19556245"}]},{"database":"GO","id":"GO:0071339","properties":[{"key":"GoTerm","value":"C:MLL1 complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"23508102"}]},{"database":"GO","id":"GO:0044665","properties":[{"key":"GoTerm","value":"C:MLL1/2 complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"23508102"}]},{"database":"GO","id":"GO:0044666","properties":[{"key":"GoTerm","value":"C:MLL3/4 complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17500065"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15199122"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18245475"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0048188","properties":[{"key":"GoTerm","value":"C:Set1C/COMPASS complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17998332"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18838538"}]},{"database":"GO","id":"GO:0008013","properties":[{"key":"GoTerm","value":"F:beta-catenin binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"22723415"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16603732"}]},{"database":"GO","id":"GO:0006974","properties":[{"key":"GoTerm","value":"P:DNA damage response"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17500065"}]},{"database":"GO","id":"GO:0030097","properties":[{"key":"GoTerm","value":"P:hemopoiesis"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11466562"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18245475"}]},{"database":"GO","id":"GO:0043627","properties":[{"key":"GoTerm","value":"P:response to estrogen"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16603732"}]},{"database":"GO","id":"GO:0045815","properties":[{"key":"GoTerm","value":"P:transcription initiation-coupled chromatin remodeling"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19556245"}]},{"database":"CDD","id":"cd15583","properties":[{"key":"EntryName","value":"PHD_ash2p_like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd12872","properties":[{"key":"EntryName","value":"SPRY_Ash2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.980.20:FF:000002","properties":[{"key":"EntryName","value":"Ash2 like, histone lysine methyltransferase complex subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.120.920:FF:000008","properties":[{"key":"EntryName","value":"Set1/Ash2 histone methyltransferase complex subunit ASH2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.920","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.980.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037353","properties":[{"key":"EntryName","value":"ASH2"}]},{"database":"InterPro","id":"IPR049455","properties":[{"key":"EntryName","value":"ASH2-like_PHD"}]},{"database":"InterPro","id":"IPR053835","properties":[{"key":"EntryName","value":"ASH2L-like_WH"}]},{"database":"InterPro","id":"IPR001870","properties":[{"key":"EntryName","value":"B30.2/SPRY"}]},{"database":"InterPro","id":"IPR043136","properties":[{"key":"EntryName","value":"B30.2/SPRY_sf"}]},{"database":"InterPro","id":"IPR013320","properties":[{"key":"EntryName","value":"ConA-like_dom_sf"}]},{"database":"InterPro","id":"IPR003877","properties":[{"key":"EntryName","value":"SPRY_dom"}]},{"database":"PANTHER","id":"PTHR10598","properties":[{"key":"EntryName","value":"SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10598:SF0","properties":[{"key":"EntryName","value":"SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21198","properties":[{"key":"EntryName","value":"ASH2L-like_WH"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21257","properties":[{"key":"EntryName","value":"PHD_ash2p_like"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00622","properties":[{"key":"EntryName","value":"SPRY"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00449","properties":[{"key":"EntryName","value":"SPRY"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49899","properties":[{"key":"EntryName","value":"Concanavalin A-like lectins/glucanases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50188","properties":[{"key":"EntryName","value":"B302_SPRY"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP","length":628,"molWeight":68723,"crc64":"8F5F007430D4B863","md5":"B802ED927D880754E7E79B0A943F0661"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":24,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"PTM":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Domain":1,"Zinc finger":1,"Region":4,"Compositional bias":5,"Binding site":4,"Modified residue":5,"Alternative sequence":2,"Natural variant":1,"Mutagenesis":2,"Sequence conflict":6,"Beta strand":24,"Turn":4,"Helix":14},"uniParcId":"UPI0000038D65"}}