{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9SY06","secondaryAccessions":["Q6NKQ3"],"uniProtkbId":"FAF1_ARATH","entryAudit":{"firstPublicDate":"2011-03-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-01","entryVersion":115,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein FANTASTIC FOUR 1"}}},"genes":[{"geneName":{"value":"FAF1"},"orderedLocusNames":[{"value":"At4g02810"}],"orfNames":[{"value":"T5J8.13"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21176196"}],"value":"Able to repress WUS when constitutively overexpressed, but have no effect on CLV3"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21176196"}],"value":"Expressed in the shoot apex, stamens, anthers and young siliques. Detected in provascular and vascular tissue"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21176196"}],"value":"Expressed throughout development. During germination, initially restricted to the hypocotyl, but expression gradually shifts to the root and on day 6, to the vasculature of the cotyledons and then of the leaves. Increased expression in the shoot apex during the transition to flowering. Induced in the inflorescence vasculature and young flower buds as flowering commenced. Expressed in developing embryos from the early heart stage until torpedo stage"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the fantastic four family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"Protein FANTASTIC FOUR 1","featureId":"PRO_0000405260"},{"type":"Domain","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"FAF","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01439"}]},{"type":"Region","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Sequence conflict","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"in Ref. 4; AAT06460 and 5; BAD44084","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10617198","citationType":"journal article","authors":["Mayer K.F.X.","Schueller C.","Wambutt R.","Murphy G.","Volckaert G.","Pohl T.","Duesterhoeft A.","Stiekema W.","Entian K.-D.","Terryn N.","Harris B.","Ansorge W.","Brandt P.","Grivell L.A.","Rieger M.","Weichselgartner M.","de Simone V.","Obermaier B.","Mache R.","Mueller M.","Kreis M.","Delseny M.","Puigdomenech P.","Watson M.","Schmidtheini T.","Reichert B.","Portetelle D.","Perez-Alonso M.","Boutry M.","Bancroft I.","Vos P.","Hoheisel J.","Zimmermann W.","Wedler H.","Ridley P.","Langham S.-A.","McCullagh B.","Bilham L.","Robben J.","van der Schueren J.","Grymonprez B.","Chuang Y.-J.","Vandenbussche F.","Braeken M.","Weltjens I.","Voet M.","Bastiaens I.","Aert R.","Defoor E.","Weitzenegger T.","Bothe G.","Ramsperger U.","Hilbert H.","Braun M.","Holzer E.","Brandt A.","Peters S.","van Staveren M.","Dirkse W.","Mooijman P.","Klein Lankhorst R.","Rose M.","Hauf J.","Koetter P.","Berneiser S.","Hempel S.","Feldpausch M.","Lamberth S.","Van den Daele H.","De Keyser A.","Buysshaert C.","Gielen J.","Villarroel R.","De Clercq R.","van Montagu M.","Rogers J.","Cronin A.","Quail M.A.","Bray-Allen S.","Clark L.","Doggett J.","Hall S.","Kay M.","Lennard N.","McLay K.","Mayes R.","Pettett A.","Rajandream M.A.","Lyne M.","Benes V.","Rechmann S.","Borkova D.","Bloecker H.","Scharfe M.","Grimm M.","Loehnert T.-H.","Dose S.","de Haan M.","Maarse A.C.","Schaefer M.","Mueller-Auer S.","Gabel C.","Fuchs M.","Fartmann B.","Granderath K.","Dauner D.","Herzl A.","Neumann S.","Argiriou A.","Vitale D.","Liguori R.","Piravandi E.","Massenet O.","Quigley F.","Clabauld G.","Muendlein A.","Felber R.","Schnabl S.","Hiller R.","Schmidt W.","Lecharny A.","Aubourg S.","Chefdor F.","Cooke R.","Berger C.","Monfort A.","Casacuberta E.","Gibbons T.","Weber N.","Vandenbol M.","Bargues M.","Terol J.","Torres A.","Perez-Perez A.","Purnelle B.","Bent E.","Johnson S.","Tacon D.","Jesse T.","Heijnen L.","Schwarz S.","Scholler P.","Heber S.","Francs P.","Bielke C.","Frishman D.","Haase D.","Lemcke K.","Mewes H.-W.","Stocker S.","Zaccaria P.","Bevan M.","Wilson R.K.","de la Bastide M.","Habermann K.","Parnell L.","Dedhia N.","Gnoj L.","Schutz K.","Huang E.","Spiegel L.","Sekhon M.","Murray J.","Sheet P.","Cordes M.","Abu-Threideh J.","Stoneking T.","Kalicki J.","Graves T.","Harmon G.","Edwards J.","Latreille P.","Courtney L.","Cloud J.","Abbott A.","Scott K.","Johnson D.","Minx P.","Bentley D.","Fulton B.","Miller N.","Greco T.","Kemp K.","Kramer J.","Fulton L.","Mardis E.","Dante M.","Pepin K.","Hillier L.W.","Nelson J.","Spieth J.","Ryan E.","Andrews S.","Geisel C.","Layman D.","Du H.","Ali J.","Berghoff A.","Jones K.","Drone K.","Cotton M.","Joshu C.","Antonoiu B.","Zidanic M.","Strong C.","Sun H.","Lamar B.","Yordan C.","Ma P.","Zhong J.","Preston R.","Vil D.","Shekher M.","Matero A.","Shah R.","Swaby I.K.","O'Shaughnessy A.","Rodriguez M.","Hoffman J.","Till S.","Granat S.","Shohdy N.","Hasegawa A.","Hameed A.","Lodhi M.","Johnson A.","Chen E.","Marra M.A.","Martienssen R.","McCombie W.R."],"citationCrossReferences":[{"database":"PubMed","id":"10617198"},{"database":"DOI","id":"10.1038/47134"}],"title":"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.","publicationDate":"1999","journal":"Nature","firstPage":"769","lastPage":"777","volume":"402"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-6LSQ407P4H7FE","citationType":"submission","authors":["Shinn P.","Chen H.","Cheuk R.","Kim C.J.","Carninci P.","Hayashizaki Y.","Ishida J.","Kamiya A.","Kawai J.","Narusaka M.","Sakurai T.","Satou M.","Seki M.","Shinozaki K.","Ecker J.R."],"title":"Arabidopsis ORF clones.","publicationDate":"MAY-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-43D7862RKG1IA","citationType":"submission","authors":["Totoki Y.","Seki M.","Ishida J.","Nakajima M.","Enju A.","Kamiya A.","Narusaka M.","Shin-i T.","Nakagawa M.","Sakamoto N.","Oishi K.","Kohara Y.","Kobayashi M.","Toyoda A.","Sakaki Y.","Sakurai T.","Iida K.","Akiyama K.","Satou M.","Toyoda T.","Konagaya A.","Carninci P.","Kawai J.","Hayashizaki Y.","Shinozaki K."],"title":"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.","publicationDate":"SEP-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"CI-3F9411UNT5URU","citationType":"submission","authors":["Fujita M.","Mizukado S.","Seki M.","Shinozaki K.","Mitsuda N.","Takiguchi Y.","Takagi M."],"title":"ORF cloning and analysis of Arabidopsis transcription factor genes.","publicationDate":"MAR-2009","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"21176196","citationType":"journal article","authors":["Wahl V.","Brand L.H.","Guo Y.L.","Schmid M."],"citationCrossReferences":[{"database":"PubMed","id":"21176196"},{"database":"DOI","id":"10.1186/1471-2229-10-285"}],"title":"The FANTASTIC FOUR proteins influence shoot meristem size in Arabidopsis thaliana.","publicationDate":"2010","journal":"BMC Plant Biol.","firstPage":"285","lastPage":"285","volume":"10"},"referencePositions":["FUNCTION","DEVELOPMENTAL STAGE","TISSUE SPECIFICITY"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC004044","properties":[{"key":"ProteinId","value":"AAD15352.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161495","properties":[{"key":"ProteinId","value":"CAB77766.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002687","properties":[{"key":"ProteinId","value":"AEE82232.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408686","properties":[{"key":"ProteinId","value":"CAO7045961.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BT012641","properties":[{"key":"ProteinId","value":"AAT06460.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK176321","properties":[{"key":"ProteinId","value":"BAD44084.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB493673","properties":[{"key":"ProteinId","value":"BAH30511.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"G85035","properties":[{"key":"EntryName","value":"G85035"}]},{"database":"RefSeq","id":"NP_192190.1","properties":[{"key":"NucleotideSequenceId","value":"NM_116515.4"}]},{"database":"AlphaFoldDB","id":"Q9SY06","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"13459","properties":[{"key":"Interactions","value":"3"}]},{"database":"STRING","id":"3702.Q9SY06","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q9SY06","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"828170","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT4G02810","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT4G02810","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT4G02810","properties":[{"key":"GeneName","value":"FAF1"}]},{"database":"eggNOG","id":"ENOG502RYS2","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_053779_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9SY06","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CFVSERR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PhylomeDB","id":"Q9SY06","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9SY06","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"Gene3D","id":"3.30.70.2850","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR021410","properties":[{"key":"EntryName","value":"FAF"}]},{"database":"InterPro","id":"IPR046431","properties":[{"key":"EntryName","value":"FAF_dom"}]},{"database":"PANTHER","id":"PTHR33155","properties":[{"key":"EntryName","value":"FANTASTIC FOUR-LIKE PROTEIN (DUF3049)"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33155:SF8","properties":[{"key":"EntryName","value":"PROTEIN FANTASTIC FOUR 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11250","properties":[{"key":"EntryName","value":"FAF"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS52095","properties":[{"key":"EntryName","value":"FAF"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSIVVGQAYQHLPKQVSQNPDVGGWSFLQYFSEPKGIVQNREDDTKKTAYVYPIEKRSVAKLSLEMCTESLGTENGSDSGDEMSLLALEATNISKSPRLTTKPQKETSFMTRENSFPPPLNSVNGFNNSRMVKSYKEDGRLVVQAIRVCSPPRCFVSERREGRLRLCLSQNSLNSQDAEEEFEEEDEDDQYDAEEEEEEEEEEEEEEEEEEEEEEEEEEEDEEGIVGNNENFEGKSGNKKVSNRPKRRCNENGCEPKTMLNWKQQQFWVTT","length":271,"molWeight":31197,"crc64":"E2985FA5CD63B504","md5":"7966B6D4511FADE4F2592D14F39387F9"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":1,"Compositional bias":2,"Sequence conflict":1},"uniParcId":"UPI000009D16C"}}