{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9QZQ4","uniProtkbId":"UTS2_RAT","entryAudit":{"firstPublicDate":"2000-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-01","entryVersion":130,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Rattus norvegicus","commonName":"Rat","taxonId":10116,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Rattus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Urotensin-2"}},"alternativeNames":[{"fullName":{"value":"Urotensin II"},"shortNames":[{"value":"U-II"},{"value":"UII"}]}],"flag":"Precursor"},"genes":[{"geneName":{"value":"Uts2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Highly potent vasoconstrictor"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"value":"Brain specific"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the urotensin-2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000036355"},{"type":"Peptide","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"Urotensin-2","featureId":"PRO_0000036356"},{"type":"Region","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]}],"keywords":[{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0372","category":"Molecular function","name":"Hormone"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"10486557","citationType":"journal article","authors":["Coulouarn Y.","Jegou S.","Tostivint H.","Vaudry H.","Lihrmann I."],"citationCrossReferences":[{"database":"PubMed","id":"10486557"},{"database":"DOI","id":"10.1016/s0014-5793(99)01003-0"}],"title":"Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors.","publicationDate":"1999","journal":"FEBS Lett.","firstPage":"28","lastPage":"32","volume":"457"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Spinal cord","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF172174","properties":[{"key":"ProteinId","value":"AAD55766.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001416473.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001429544.1"}]},{"database":"RefSeq","id":"NP_062033.1","properties":[{"key":"NucleotideSequenceId","value":"NM_019160.3"}]},{"database":"AlphaFoldDB","id":"Q9QZQ4","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9QZQ4","properties":[{"key":"Number of interactors","value":"1"}]},{"database":"STRING","id":"10116.ENSRNOP00000024798","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9QZQ4","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9QZQ4","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"PaxDb","id":"10116-ENSRNOP00000024798","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSRNOT00000024798.6","properties":[{"key":"ProteinId","value":"ENSRNOP00000024798.3"},{"key":"GeneId","value":"ENSRNOG00000018393.6"}]},{"database":"Ensembl","id":"ENSRNOT00055025476","properties":[{"key":"ProteinId","value":"ENSRNOP00055020790"},{"key":"GeneId","value":"ENSRNOG00055014889"}]},{"database":"Ensembl","id":"ENSRNOT00060005793","properties":[{"key":"ProteinId","value":"ENSRNOP00060004217"},{"key":"GeneId","value":"ENSRNOG00060003537"}]},{"database":"Ensembl","id":"ENSRNOT00065015376","properties":[{"key":"ProteinId","value":"ENSRNOP00065011569"},{"key":"GeneId","value":"ENSRNOG00065009593"}]},{"database":"GeneID","id":"29180","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"rno:29180","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"RGD:3930","properties":[{"key":"OrganismName","value":"rat"}]},{"database":"AGR","id":"RGD:3930","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"10911","properties":[{"key":"Description","value":"-"}]},{"database":"RGD","id":"3930","properties":[{"key":"GeneName","value":"Uts2"}]},{"database":"eggNOG","id":"ENOG502SCRX","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00510000049583","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_156959_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9QZQ4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ETFYGNH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8894951at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9QZQ4","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-RNO-375276","properties":[{"key":"PathwayName","value":"Peptide ligand-binding receptors"}]},{"database":"Reactome","id":"R-RNO-416476","properties":[{"key":"PathwayName","value":"G alpha (q) signalling events"}]},{"database":"PRO","id":"PR:Q9QZQ4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002494","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Bgee","id":"ENSRNOG00000018393","properties":[{"key":"ExpressionPatterns","value":"Expressed in duodenum and 5 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9QZQ4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17184580"}]},{"database":"GO","id":"GO:0097746","properties":[{"key":"GoTerm","value":"P:blood vessel diameter maintenance"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17097764"}]},{"database":"GO","id":"GO:0045776","properties":[{"key":"GoTerm","value":"P:negative regulation of blood pressure"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12217424"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16531985"}]},{"database":"GO","id":"GO:0003105","properties":[{"key":"GoTerm","value":"P:negative regulation of glomerular filtration"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16531985"}]},{"database":"GO","id":"GO:0010459","properties":[{"key":"GoTerm","value":"P:negative regulation of heart rate"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12217424"}]},{"database":"GO","id":"GO:0046676","properties":[{"key":"GoTerm","value":"P:negative regulation of insulin secretion"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17931748"}]},{"database":"GO","id":"GO:0035811","properties":[{"key":"GoTerm","value":"P:negative regulation of urine volume"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16531985"}]},{"database":"GO","id":"GO:0045766","properties":[{"key":"GoTerm","value":"P:positive regulation of angiogenesis"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17089015"}]},{"database":"GO","id":"GO:0045777","properties":[{"key":"GoTerm","value":"P:positive regulation of blood pressure"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12217424"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17184580"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18475149"}]},{"database":"GO","id":"GO:0046005","properties":[{"key":"GoTerm","value":"P:positive regulation of circadian sleep/wake cycle, REM sleep"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15944374"}]},{"database":"GO","id":"GO:0010841","properties":[{"key":"GoTerm","value":"P:positive regulation of circadian sleep/wake cycle, wakefulness"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15944374"}]},{"database":"GO","id":"GO:0032967","properties":[{"key":"GoTerm","value":"P:positive regulation of collagen biosynthetic process"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17184580"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18475149"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18082287"}]},{"database":"GO","id":"GO:0010763","properties":[{"key":"GoTerm","value":"P:positive regulation of fibroblast migration"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18475149"}]},{"database":"GO","id":"GO:0048146","properties":[{"key":"GoTerm","value":"P:positive regulation of fibroblast proliferation"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17184580"}]},{"database":"GO","id":"GO:0010460","properties":[{"key":"GoTerm","value":"P:positive regulation of heart rate"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12217424"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18597948"}]},{"database":"GO","id":"GO:0032224","properties":[{"key":"GoTerm","value":"P:positive regulation of synaptic transmission, cholinergic"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15944374"}]},{"database":"GO","id":"GO:0008217","properties":[{"key":"GoTerm","value":"P:regulation of blood pressure"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0001666","properties":[{"key":"GoTerm","value":"P:response to hypoxia"},{"key":"GoEvidenceType","value":"IEP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"16677483"}]},{"database":"GO","id":"GO:0033574","properties":[{"key":"GoTerm","value":"P:response to testosterone"},{"key":"GoEvidenceType","value":"IEP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"12421619"}]},{"database":"GO","id":"GO:0009410","properties":[{"key":"GoTerm","value":"P:response to xenobiotic stimulus"},{"key":"GoEvidenceType","value":"IEP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"17184580"}]},{"database":"InterPro","id":"IPR001483","properties":[{"key":"EntryName","value":"Urotensin_II"}]},{"database":"PANTHER","id":"PTHR14447","properties":[{"key":"EntryName","value":"UROTENSIN 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14447:SF0","properties":[{"key":"EntryName","value":"UROTENSIN-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02083","properties":[{"key":"EntryName","value":"Urotensin_II"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00984","properties":[{"key":"EntryName","value":"UROTENSIN_II"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDRVPFCCLLFVGLLNPLLSFPVTDTGEMSLQLPVLEENALRALEELERTALLQTLRQTVGTEAEGSLGQADPSAETPTPRGSLRKALTGQDSNTVLSRLLARTRKQRKQHGTAPECFWKYCI","length":123,"molWeight":13614,"crc64":"E4F1A8EE124AF1EA","md5":"FB6D756A8AD8F8302DDC1005A229EB61"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Propeptide":1,"Peptide":1,"Region":1,"Disulfide bond":1},"uniParcId":"UPI0000137D59"}}