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May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (By similarity). Also involved in androgen receptor transactivation (PubMed:12077347). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction (By similarity). May play a role in late myogenic differentiation (PubMed:27008887). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15650"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12077347"}],"value":"Interacts with the thyroid hormone receptor/TR (via the ligand-binding domain); this interaction requires the presence of thyroid hormone (By similarity). Interacts with the androgen receptor/AR; in an androgen, testosterone and dihydrotestosterone-dependent manner (By similarity). Interacts with ESR1 (estrogen ligand-bound); competes with UFSP2 (By similarity). Interacts with UFSP2; competes with ligand-bound ESR1 (By similarity). Interacts with DDRGK1 and UFL1; the interaction with DDRGK1 is direct (By similarity). Interacts with NCOA1 (By similarity). Interacts with EP300 (By similarity). Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347). Identified in the RQT (ribosome quality control trigger) complex, that contains ASCC2, ASCC3 and TRIP4 (By similarity). Interacts with NEK6 (By similarity). Interacts with CSRP1 (By similarity). Interacts with ZCCHC4 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15650"}],"value":"Cytoplasmic under conditions of serum deprivation. 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Expressed in the spinal cord, brain, paraspinal ganglia, thyroid, and submandibular glands (PubMed:26924529). Expressed at low level in all the muscles (at protein level) but with higher expression in axial than in limb muscles (PubMed:27008887)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26924529"}],"value":"Expressed in 17.5-day-old embryos"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15650"}],"value":"The C4-type zinc finger mediates a competitive interaction with UFSP2 and ligand-bound nuclear receptors. 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